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The map label for this gene is pcaR [H]

Identifier: 94311522

GI number: 94311522

Start: 2812199

End: 2813176

Strand: Direct

Name: pcaR [H]

Synonym: Rmet_2586

Alternate gene names: 94311522

Gene position: 2812199-2813176 (Clockwise)

Preceding gene: 94311519

Following gene: 94311524

Centisome position: 71.59

GC content: 63.39

Gene sequence:

>978_bases
GTGATCACCTTCATCGCTGTCTCCTGGTTCTTCTGGTTTTTTCTGGCGTTTCCGGACTGTCCTGCCATCGTGGTTTTCGC
CGAACCACGTTTTGCGAACATTTGTTCGGAAAACGCATATCATACGGATCGGCAGCCCGGACGCAAGCCCGGTTTGACCC
TCGGATACCTTTCATTGATTTCCACGCCAATGCCTGACGACCACGCTCCGGAGATCCCGAAGAAGGAAGAACTGCTCGAC
TCGCTGACCAAGGGGCTTGCCCTGTTGCGGCTGTACGCCAGCGGCGTGGAGCGTCTGACGATGCAGGAGGTGGCGGACGA
ACTCGACGTCACCCGCGCGGCCGCGCGCCGGCTGCTGCTGACGCTGGCGCACAACGGCTACCTGGCCCAGGAAGGCCGGC
AGTTCGCCCTGACACCAAAAGTGATGGATCTGGGCTACGCGTACTTTGCGTCGATGAACCTGCCGCAACTGGCCCGGCCC
TACTTGCAGGCACTCTGCGCCGAAGTCGGCGAAAGCTGCTCGGTCGGGATGCTCGACCAGGAATCCGTGGTGCTGGTCGC
GCGCGAGGAACCCAGCCAGCTACTGCGCGTGGACATGGCGATCGGGCGCCGGATGCCGGCATATGCACACTCGCTCGGCC
GCGTGCTGCTGGCGGGGCTCGACGCCGAAGCGCTCGACGCCTATCTCGCGCAAGCTGAACTCAGGCAACTGACGCCATTC
ACGATCAGTTCGCGCCCCGCGCTGGCGCGCAAGCTCGAAGCGGTGCGCGCCGACGGCTTCTGCACGTTGATCAGTGAATT
GGCGGATGGCTTCGCCGGCATCTCGGTGCCGCTGCATGACCAGACCGGCAAGACCGCGGCTGGCCTCGGTTTGAGCATGG
TGCTGGGCAGCCGCGATCAGGCTTATCTCGAGAAACACTACCTGCCGCCTCTGCGACGCACGGCGGCGCAGATCGAGTCC
ATCCTGAAAGCACGCTGA

Upstream 100 bases:

>100_bases
CTCGAGCGCCTCGGTCACCCCTTCGGCGTGCCCCGCCCCGACAAACCCGGCGCTAGCCACGGTCCAGCCGCTCTGCACGA
GCGCGGCCGCCTGCGCGGTG

Downstream 100 bases:

>100_bases
CGGCACACTGCCCACGCGCAAACGCCCCGAAAGGAAAAAGCCCCGCTGGCCGGGGAGGTCGCGGGGCTGAAGTGGTAGCG
GGGCAAGGATCCAGTCGCCC

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MITFIAVSWFFWFFLAFPDCPAIVVFAEPRFANICSENAYHTDRQPGRKPGLTLGYLSLISTPMPDDHAPEIPKKEELLD
SLTKGLALLRLYASGVERLTMQEVADELDVTRAAARRLLLTLAHNGYLAQEGRQFALTPKVMDLGYAYFASMNLPQLARP
YLQALCAEVGESCSVGMLDQESVVLVAREEPSQLLRVDMAIGRRMPAYAHSLGRVLLAGLDAEALDAYLAQAELRQLTPF
TISSRPALARKLEAVRADGFCTLISELADGFAGISVPLHDQTGKTAAGLGLSMVLGSRDQAYLEKHYLPPLRRTAAQIES
ILKAR

Sequences:

>Translated_325_residues
MITFIAVSWFFWFFLAFPDCPAIVVFAEPRFANICSENAYHTDRQPGRKPGLTLGYLSLISTPMPDDHAPEIPKKEELLD
SLTKGLALLRLYASGVERLTMQEVADELDVTRAAARRLLLTLAHNGYLAQEGRQFALTPKVMDLGYAYFASMNLPQLARP
YLQALCAEVGESCSVGMLDQESVVLVAREEPSQLLRVDMAIGRRMPAYAHSLGRVLLAGLDAEALDAYLAQAELRQLTPF
TISSRPALARKLEAVRADGFCTLISELADGFAGISVPLHDQTGKTAAGLGLSMVLGSRDQAYLEKHYLPPLRRTAAQIES
ILKAR
>Mature_325_residues
MITFIAVSWFFWFFLAFPDCPAIVVFAEPRFANICSENAYHTDRQPGRKPGLTLGYLSLISTPMPDDHAPEIPKKEELLD
SLTKGLALLRLYASGVERLTMQEVADELDVTRAAARRLLLTLAHNGYLAQEGRQFALTPKVMDLGYAYFASMNLPQLARP
YLQALCAEVGESCSVGMLDQESVVLVAREEPSQLLRVDMAIGRRMPAYAHSLGRVLLAGLDAEALDAYLAQAELRQLTPF
TISSRPALARKLEAVRADGFCTLISELADGFAGISVPLHDQTGKTAAGLGLSMVLGSRDQAYLEKHYLPPLRRTAAQIES
ILKAR

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=225, Percent_Identity=30.6666666666667, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1786468, Length=228, Percent_Identity=27.1929824561404, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1789999, Length=247, Percent_Identity=27.9352226720648, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786715, Length=222, Percent_Identity=24.7747747747748, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87082359, Length=218, Percent_Identity=26.1467889908257, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1788581, Length=221, Percent_Identity=24.4343891402715, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 35712; Mature: 35712

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITFIAVSWFFWFFLAFPDCPAIVVFAEPRFANICSENAYHTDRQPGRKPGLTLGYLSLI
CEEEHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
STPMPDDHAPEIPKKEELLDSLTKGLALLRLYASGVERLTMQEVADELDVTRAAARRLLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAHNGYLAQEGRQFALTPKVMDLGYAYFASMNLPQLARPYLQALCAEVGESCSVGMLDQ
HHHCCCEECCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ESVVLVAREEPSQLLRVDMAIGRRMPAYAHSLGRVLLAGLDAEALDAYLAQAELRQLTPF
CCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
TISSRPALARKLEAVRADGFCTLISELADGFAGISVPLHDQTGKTAAGLGLSMVLGSRDQ
CCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHCCCHHHHHCCCHH
AYLEKHYLPPLRRTAAQIESILKAR
HHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MITFIAVSWFFWFFLAFPDCPAIVVFAEPRFANICSENAYHTDRQPGRKPGLTLGYLSLI
CEEEHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHH
STPMPDDHAPEIPKKEELLDSLTKGLALLRLYASGVERLTMQEVADELDVTRAAARRLLL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLAHNGYLAQEGRQFALTPKVMDLGYAYFASMNLPQLARPYLQALCAEVGESCSVGMLDQ
HHHCCCEECCCCCEEEECHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCC
ESVVLVAREEPSQLLRVDMAIGRRMPAYAHSLGRVLLAGLDAEALDAYLAQAELRQLTPF
CCEEEEECCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
TISSRPALARKLEAVRADGFCTLISELADGFAGISVPLHDQTGKTAAGLGLSMVLGSRDQ
CCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEECCCCCCHHHCCCHHHHHCCCHH
AYLEKHYLPPLRRTAAQIESILKAR
HHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]