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The map label for this gene is parE [H]

Identifier: 94311457

GI number: 94311457

Start: 2738387

End: 2740459

Strand: Reverse

Name: parE [H]

Synonym: Rmet_2521

Alternate gene names: 94311457

Gene position: 2740459-2738387 (Counterclockwise)

Preceding gene: 94311459

Following gene: 94311456

Centisome position: 69.77

GC content: 65.03

Gene sequence:

>2073_bases
GTGCCGCGCCCATCCATTACAATGCTGCGCATTCCGGCCGCCGACGGCCGGGCGTCCCACTTTCCGCAAAACGACTCCAT
GGCGAGCAAAACCAGTCAGTACAGCGAATCTTCCATCCGGGTCCTGAAGGGTCTGGAGCCGGTCAAGCAACGGCCCGGCA
TGTACACCCGTACCGATAACCCCCTGCATGTCGTGCAGGAGGTGATCGACAACGCGTCCGACGAAGCGCTCGGCGGCTAC
GGCACCGAAATCCTGGTCACGCTGCATCGTGACGGCAGCATCAGCGTGGAAGACGATGGCCGTGGCATCCCGGTGGGCAT
CCACCCGGAAGAGCAGGTGCCGGTCGTGGAAATCGTCTTCACCCGCCTGCACGCGGGCGGCAAGTTCGACAAGGGCAAGG
GCGGCGCCTACGCGTTCTCGGGCGGCCTGCATGGCGTGGGCGTGTCGGTGACCAACGCGCTGGCCACGCGCCTGGACGTC
ACGGTCTGGCGCGACGGGGCGGTGTCCACGCTGACGTTCGAGCATGGCGGCGAAGTGACCCGCCCGCTGGCGACGCGCAA
GATCGAGCGCGGCGAGAAGAAGAGCGGCACGCGCGTGCAGGTGTGGCCGGATGCGAAGTATTTCGATTCGGCCGCAATCC
CGATGGCCGAACTGCAGCGCCTGCTGCGCAGCAAGGCCGTGCTGCTGCCGGGCGTGAAGGTCACGCTGGTGCTCGAGAAG
ACTGGCGAGCAGACGGTGTGGCAGTACGAGCAGGGTCTGAAGGGCTATCTGGTCGAGGCCCTGGCCCAGGGCAGCGGCGC
CGAACTCGTGATCCCGATGTTCGAGGGCGAGCACTTTGCCGACCCGGACAAGAACGCCGGCGAGGAAGGCTTTGCCGAAG
GCGAAGGCGCGTCGTGGGTGGTGGCGTGGACCGAGGAAGGCGCGCCGGTGCGCGAATCCTACGTCAACCTGATTCCCACG
CCAGCCGGCGGCACGCACGAATCCGGCCTGCGCGAAGGCCTGTTCCTGGCGGTGAAGAGCTTTATCGAGATGCACTCGCT
GCAGCCAAAGGGCGTGAAGCTGATGAGCGAAGACGTGTTCGCGCGCGCATCGTTTGTGCTGTCGGCCAAGGTGCTCGATC
CGCAGTTCCAGGGCCAGATCAAGGAACGCCTGAACAGCCGTGATGCCGTGCGTCTGGTTTCCACGTTCAGCCGCCCGGCG
CTCGAACTCTGGCTCAACCATCATGTCGATTTCGGCAAGAAGCTGGCGGAACTGGTGATTCGCCAGGCTCAGGCCCGCAC
GCGTGCCGCGCAGAAGGTCGAGAAAAAGAAGGGCTCCGGCGTGGCTGTGCTGCCCGGCAAGCTGACCGATTGCGAATCGA
CCGATGTCGAGCGCAACGAGATCTTCCTGGTGGAGGGCGACTCCGCCGGCGGTTCGGCCAAAATGGGCCGCGACAAGGAA
TTCCAGGCCATCCTGCCGCTGCGCGGCAAGGTGCTCAATACCTGGGAGACCGAGCGCGACCGCCTGTTCGCCAACAACGA
AGTGCATGACATCGCGGTGGCGATCGGCGTCGACCCGCATGGCCCGGACGACGAGCCCGACCTGTCGAACCTGCGGTACG
GCAAGATCTGCATCCTGTCCGATGCGGACGTCGACGGGGCGCACATCCAGGTGCTGCTGCTGACGCTGTTCTTCCGCCAC
TTCCCGAAACTGATGGCCAACGGCAACGTCTGCGTGGCACGCCCGCCACTGTTCCGCGTGGATGCGCCGGCGCGTGGCAA
GAAGCCGGCGCAGAAGCTCTATGCGCTGGACGAAGGCGAGCTTGAAGCCATCCAGGACAAGTTGCTCAAGGATGGCGTCA
AGGAAGGCGCGTGGCAGATTTCGCGCTTCAAGGGCCTTGGCGAGATGAGCGCCGGGCAGCTCTGGGAGACGACGATGAAT
CCCGATACGCGCCGGCTGCTGCCGGTGTCGCTGGGTGAGTTCGACATGCCGCAGACCGTCACGATGATGAACATGCTGAT
GGGCAAGGGCGAGGCCTCGCAACGACGCAGCTGGCTGGAAGAGAAGGGCAACGAAGTGGAGGCCGACATCTGA

Upstream 100 bases:

>100_bases
CTATTGTTATGTCGACGGCTGTTATAGCGACTGCGGGGGTGCCGTATGCGCGGTCCGGCGAGTTTACTCCGCGCCATTCA
ATCTTGCCGGCGCGGGATTC

Downstream 100 bases:

>100_bases
CGGCGATGCGCAATGAGGCAGGGCAGCAACAACATCGGACGATTCGATCGATTCCGCCGATCTGGGCGAATGGTGGCGCG
GGTGGCAGCGCGGGTGGCAG

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 690; Mature: 689

Protein sequence:

>690_residues
MPRPSITMLRIPAADGRASHFPQNDSMASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHVVQEVIDNASDEALGGY
GTEILVTLHRDGSISVEDDGRGIPVGIHPEEQVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALATRLDV
TVWRDGAVSTLTFEHGGEVTRPLATRKIERGEKKSGTRVQVWPDAKYFDSAAIPMAELQRLLRSKAVLLPGVKVTLVLEK
TGEQTVWQYEQGLKGYLVEALAQGSGAELVIPMFEGEHFADPDKNAGEEGFAEGEGASWVVAWTEEGAPVRESYVNLIPT
PAGGTHESGLREGLFLAVKSFIEMHSLQPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPA
LELWLNHHVDFGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGKLTDCESTDVERNEIFLVEGDSAGGSAKMGRDKE
FQAILPLRGKVLNTWETERDRLFANNEVHDIAVAIGVDPHGPDDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRH
FPKLMANGNVCVARPPLFRVDAPARGKKPAQKLYALDEGELEAIQDKLLKDGVKEGAWQISRFKGLGEMSAGQLWETTMN
PDTRRLLPVSLGEFDMPQTVTMMNMLMGKGEASQRRSWLEEKGNEVEADI

Sequences:

>Translated_690_residues
MPRPSITMLRIPAADGRASHFPQNDSMASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHVVQEVIDNASDEALGGY
GTEILVTLHRDGSISVEDDGRGIPVGIHPEEQVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALATRLDV
TVWRDGAVSTLTFEHGGEVTRPLATRKIERGEKKSGTRVQVWPDAKYFDSAAIPMAELQRLLRSKAVLLPGVKVTLVLEK
TGEQTVWQYEQGLKGYLVEALAQGSGAELVIPMFEGEHFADPDKNAGEEGFAEGEGASWVVAWTEEGAPVRESYVNLIPT
PAGGTHESGLREGLFLAVKSFIEMHSLQPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPA
LELWLNHHVDFGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGKLTDCESTDVERNEIFLVEGDSAGGSAKMGRDKE
FQAILPLRGKVLNTWETERDRLFANNEVHDIAVAIGVDPHGPDDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRH
FPKLMANGNVCVARPPLFRVDAPARGKKPAQKLYALDEGELEAIQDKLLKDGVKEGAWQISRFKGLGEMSAGQLWETTMN
PDTRRLLPVSLGEFDMPQTVTMMNMLMGKGEASQRRSWLEEKGNEVEADI
>Mature_689_residues
PRPSITMLRIPAADGRASHFPQNDSMASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDNPLHVVQEVIDNASDEALGGYG
TEILVTLHRDGSISVEDDGRGIPVGIHPEEQVPVVEIVFTRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALATRLDVT
VWRDGAVSTLTFEHGGEVTRPLATRKIERGEKKSGTRVQVWPDAKYFDSAAIPMAELQRLLRSKAVLLPGVKVTLVLEKT
GEQTVWQYEQGLKGYLVEALAQGSGAELVIPMFEGEHFADPDKNAGEEGFAEGEGASWVVAWTEEGAPVRESYVNLIPTP
AGGTHESGLREGLFLAVKSFIEMHSLQPKGVKLMSEDVFARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPAL
ELWLNHHVDFGKKLAELVIRQAQARTRAAQKVEKKKGSGVAVLPGKLTDCESTDVERNEIFLVEGDSAGGSAKMGRDKEF
QAILPLRGKVLNTWETERDRLFANNEVHDIAVAIGVDPHGPDDEPDLSNLRYGKICILSDADVDGAHIQVLLLTLFFRHF
PKLMANGNVCVARPPLFRVDAPARGKKPAQKLYALDEGELEAIQDKLLKDGVKEGAWQISRFKGLGEMSAGQLWETTMNP
DTRRLLPVSLGEFDMPQTVTMMNMLMGKGEASQRRSWLEEKGNEVEADI

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=650, Percent_Identity=23.5384615384615, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI19913406, Length=660, Percent_Identity=22.2727272727273, Blast_Score=111, Evalue=3e-24,
Organism=Escherichia coli, GI1789408, Length=661, Percent_Identity=48.5627836611195, Blast_Score=607, Evalue=1e-175,
Organism=Escherichia coli, GI48994957, Length=595, Percent_Identity=37.4789915966387, Blast_Score=350, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI212645845, Length=637, Percent_Identity=23.5478806907378, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17535065, Length=644, Percent_Identity=22.360248447205, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI212645657, Length=212, Percent_Identity=28.7735849056604, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=647, Percent_Identity=24.2658423493045, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136538, Length=659, Percent_Identity=23.9757207890744, Blast_Score=112, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005737 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: 5.99.1.-

Molecular weight: Translated: 75582; Mature: 75451

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPSITMLRIPAADGRASHFPQNDSMASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDN
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEECCCC
PLHVVQEVIDNASDEALGGYGTEILVTLHRDGSISVEDDGRGIPVGIHPEEQVPVVEIVF
HHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCEECCCCCCCCCHHHHHH
TRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALATRLDVTVWRDGAVSTLTFEHGGEVT
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCC
RPLATRKIERGEKKSGTRVQVWPDAKYFDSAAIPMAELQRLLRSKAVLLPGVKVTLVLEK
CHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHCCEECCCCEEEEEEEC
TGEQTVWQYEQGLKGYLVEALAQGSGAELVIPMFEGEHFADPDKNAGEEGFAEGEGASWV
CCCHHHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
VAWTEEGAPVRESYVNLIPTPAGGTHESGLREGLFLAVKSFIEMHSLQPKGVKLMSEDVF
EEECCCCCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNHHVDFGKKLAELVI
HHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
RQAQARTRAAQKVEKKKGSGVAVLPGKLTDCESTDVERNEIFLVEGDSAGGSAKMGRDKE
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
FQAILPLRGKVLNTWETERDRLFANNEVHDIAVAIGVDPHGPDDEPDLSNLRYGKICILS
CEEECCCCCEEECCCCCCCHHEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
DADVDGAHIQVLLLTLFFRHFPKLMANGNVCVARPPLFRVDAPARGKKPAQKLYALDEGE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCCCCCHHHHHHCCCCCH
LEAIQDKLLKDGVKEGAWQISRFKGLGEMSAGQLWETTMNPDTRRLLPVSLGEFDMPQTV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCHHH
TMMNMLMGKGEASQRRSWLEEKGNEVEADI
HHHHHHHCCCCHHHHHHHHHHCCCEECCCC
>Mature Secondary Structure 
PRPSITMLRIPAADGRASHFPQNDSMASKTSQYSESSIRVLKGLEPVKQRPGMYTRTDN
CCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCEECCCC
PLHVVQEVIDNASDEALGGYGTEILVTLHRDGSISVEDDGRGIPVGIHPEEQVPVVEIVF
HHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEECCCCCCCEECCCCCCCCCHHHHHH
TRLHAGGKFDKGKGGAYAFSGGLHGVGVSVTNALATRLDVTVWRDGAVSTLTFEHGGEVT
HHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHEEEEEECCCCEEEEEECCCCCCC
RPLATRKIERGEKKSGTRVQVWPDAKYFDSAAIPMAELQRLLRSKAVLLPGVKVTLVLEK
CHHHHHHHHCCCCCCCCEEEECCCCHHCCCCCCCHHHHHHHHHHCCEECCCCEEEEEEEC
TGEQTVWQYEQGLKGYLVEALAQGSGAELVIPMFEGEHFADPDKNAGEEGFAEGEGASWV
CCCHHHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEE
VAWTEEGAPVRESYVNLIPTPAGGTHESGLREGLFLAVKSFIEMHSLQPKGVKLMSEDVF
EEECCCCCCHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
ARASFVLSAKVLDPQFQGQIKERLNSRDAVRLVSTFSRPALELWLNHHVDFGKKLAELVI
HHHHHEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHH
RQAQARTRAAQKVEKKKGSGVAVLPGKLTDCESTDVERNEIFLVEGDSAGGSAKMGRDKE
HHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCC
FQAILPLRGKVLNTWETERDRLFANNEVHDIAVAIGVDPHGPDDEPDLSNLRYGKICILS
CEEECCCCCEEECCCCCCCHHEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCEEEEEE
DADVDGAHIQVLLLTLFFRHFPKLMANGNVCVARPPLFRVDAPARGKKPAQKLYALDEGE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEECCCCCCCCHHHHHHCCCCCH
LEAIQDKLLKDGVKEGAWQISRFKGLGEMSAGQLWETTMNPDTRRLLPVSLGEFDMPQTV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCEEEEECCCCCCCCHHH
TMMNMLMGKGEASQRRSWLEEKGNEVEADI
HHHHHHHCCCCHHHHHHHHHHCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]