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The map label for this gene is sdhA [H]

Identifier: 94311420

GI number: 94311420

Start: 2697552

End: 2699330

Strand: Reverse

Name: sdhA [H]

Synonym: Rmet_2484

Alternate gene names: 94311420

Gene position: 2699330-2697552 (Counterclockwise)

Preceding gene: 94311421

Following gene: 94311419

Centisome position: 68.72

GC content: 63.29

Gene sequence:

>1779_bases
ATGGTCGCAGTCAAGACTGGATTGCCGCGTCGCAAATTTGACGTGGTCATCGTCGGGGCGGGCGGCGCCGGGATGCGCGC
ATCCCTCCAGCTCGCGGAAGCCGGCCTGAACGTGGCCGTGCTGTCGAAGGTTTTCCCGACGCGCTCGCACACCGTGGCGG
CGCAGGGCGGTATCGGTGCTTCGCTTGGCAACATGAGCGAAGACAACTGGCACTATCACTTCTACGACACCATCAAGGGC
TCGGACTGGCTGGGCGACCAGGACGCCATCGAGTTCATGTGTCGTGAAGCACCGAAGGTCGTGTACGAACTCGAACACTT
CGGCATGCCGTTCGACCGTAACGCCGATGGCACGATTTACCAGCGTCCGTTCGGCGGCCACACCGCCAACTACGGCGAAA
AGCCGGTGCAACGCGCTTGCGCGGCCGCTGACCGTACCGGTCACGCGCTGCTGCACACGCTGTACCAGCGCAACGTTCGC
GCCAAGACCCACTTCTTCGTCGAATGGATGGCGCTGGATCTGATCCGCGACGAGGACGGCGACGTGCTGGGCGTGACCGC
GCTGGAAATGGAAACCGGCGAAGTCTATATCCTCGAAGCCAAGACCACGCTGTTCGCGACCGGCGGTGCCGGCCGTATCT
ACGCGGCTTCCACCAATGCCTTCATCAACACCGGTGATGGCCTGGGCATGGCGGCACGTGCCGGCGTCCCGCTGGAAGAC
ATGGAGTTCTGGCAGTTCCACCCGACCGGCGTGGCCGGCGCGGGCGTGCTGATCACGGAAGGCGTGCGCGGCGAGGGCGG
TATCCTGCGTAACAAGGATGGCGAGCGCTTCATGGAGCGCTATGCCCCGACGCTGAAGGATCTGGCTCCGCGTGACTTCG
TGTCGCGTTCGATGGACCAGGAAATCAAGGAAGGCCGCGGCTGCGGTCCGAATGGCGACTACGTGTTGCTCGACCTGACG
CACGTCGGCGCCGAGACGATCATGAAGCGTCTGCCGTCGATCCGCGAAATCGGCATGAAGTTCGCCAACGTCGACGCGAT
CAAGGAACCGATCCCCGTGGTGCCGACCATCCACTACCAGATGGGTGGCATTCCGACGAACTTCCACGGTCAGGTCGTGG
TGCCGAAGAACGGCAACCCGAACGAAGTGGTCAACGGCTTCTACGCCATCGGCGAATGCTCGTGCGTGTCGGTGCACGGC
GCCAACCGTCTGGGCACGAACTCGCTGCTCGACCTCGTGGTGTTCGGCCGTGCGGCCGGTAACCACATCGTCGCCAACGC
GATGAAGCAGAAGGAACACAAGCCGCTGCCGGCAGATGCCGCCGACCGCGCCATGGCCCGTCTGGCCAAGCTGCAGGGCA
CGACCTCGGGTGAATACACCCAGGACGTGGCCAACGATATCCGCCGCAACATGCAATCGCACGCCGGCGTGTTCCGTACG
CAGAAGCTGATGGACGAAGGCGTCGAGCGCATCCTGGAAGTGGCCGAGCGCGCCAACAACATCCACCTGAAGGACAAGTC
GAAGGTCTTTAACACCGCGCTGGTGGAAGCCCTGGAAGTGTCGAACCTGGTGGAAGTGGCCAAGGCAACGATGATCTCGG
CCGCAGCCCGCAAGGAATCGCGTGGCGCCCACGCCCATAGCGACTTCCCGAATCGCGACGACGAGAACTGGCTCAAGCAC
ACGCTGTTCTACAGCGAAGGCAACCGCCTCGACTACAAGCCGGTGAAGATGCAACCGCTGACGGTGGAATCAGTTCCGCC
GAAGGCCCGTACGTTCTGA

Upstream 100 bases:

>100_bases
GAAGCCGATGGCCGTGCGCCTCGTGCTGCAAGTTCTAACGATTCTGTGGCTCGTCGGTTGCGCGGGCTACGCTGCTCAGA
TTCTCTGGAGGGTGTAATAA

Downstream 100 bases:

>100_bases
TACCCGCGTCGTAGAGAAAACAGGACCCACAGAAATGAAGCGTATTTTCGAAGTCTACCGCTACGATCCGGACAAGGACG
CCGCGCCCCGCATGCAGACC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDEDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIVANAMKQKEHKPLPADAADRAMARLAKLQGTTSGEYTQDVANDIRRNMQSHAGVFRT
QKLMDEGVERILEVAERANNIHLKDKSKVFNTALVEALEVSNLVEVAKATMISAAARKESRGAHAHSDFPNRDDENWLKH
TLFYSEGNRLDYKPVKMQPLTVESVPPKARTF

Sequences:

>Translated_592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDEDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIVANAMKQKEHKPLPADAADRAMARLAKLQGTTSGEYTQDVANDIRRNMQSHAGVFRT
QKLMDEGVERILEVAERANNIHLKDKSKVFNTALVEALEVSNLVEVAKATMISAAARKESRGAHAHSDFPNRDDENWLKH
TLFYSEGNRLDYKPVKMQPLTVESVPPKARTF
>Mature_592_residues
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGASLGNMSEDNWHYHFYDTIKG
SDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNADGTIYQRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVR
AKTHFFVEWMALDLIRDEDGDVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQEIKEGRGCGPNGDYVLLDLT
HVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQMGGIPTNFHGQVVVPKNGNPNEVVNGFYAIGECSCVSVHG
ANRLGTNSLLDLVVFGRAAGNHIVANAMKQKEHKPLPADAADRAMARLAKLQGTTSGEYTQDVANDIRRNMQSHAGVFRT
QKLMDEGVERILEVAERANNIHLKDKSKVFNTALVEALEVSNLVEVAKATMISAAARKESRGAHAHSDFPNRDDENWLKH
TLFYSEGNRLDYKPVKMQPLTVESVPPKARTF

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=587, Percent_Identity=51.618398637138, Blast_Score=593, Evalue=1e-169,
Organism=Escherichia coli, GI1786942, Length=586, Percent_Identity=56.1433447098976, Blast_Score=638, Evalue=0.0,
Organism=Escherichia coli, GI1790597, Length=575, Percent_Identity=40.8695652173913, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1788928, Length=557, Percent_Identity=32.8545780969479, Blast_Score=238, Evalue=1e-63,
Organism=Caenorhabditis elegans, GI17550100, Length=589, Percent_Identity=50.5942275042445, Blast_Score=581, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17505833, Length=591, Percent_Identity=49.4077834179357, Blast_Score=566, Evalue=1e-161,
Organism=Saccharomyces cerevisiae, GI6322701, Length=591, Percent_Identity=52.9610829103215, Blast_Score=617, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6322416, Length=590, Percent_Identity=52.7118644067797, Blast_Score=612, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6320788, Length=490, Percent_Identity=26.1224489795918, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI17137288, Length=607, Percent_Identity=50.9060955518946, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655642, Length=607, Percent_Identity=50.9060955518946, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24655647, Length=607, Percent_Identity=50.9060955518946, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24663005, Length=607, Percent_Identity=48.2701812191104, Blast_Score=565, Evalue=1e-161,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 64704; Mature: 64704

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDEDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCEEEEE
MGGIPTNFHGQVVVPKNGNPNEVVNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRAAG
ECCCCCCCCCEEEECCCCCHHHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCC
NHIVANAMKQKEHKPLPADAADRAMARLAKLQGTTSGEYTQDVANDIRRNMQSHAGVFRT
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERILEVAERANNIHLKDKSKVFNTALVEALEVSNLVEVAKATMISAAARKES
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDENWLKHTLFYSEGNRLDYKPVKMQPLTVESVPPKARTF
CCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCCCEECCEEECCCCCCCCCC
>Mature Secondary Structure
MVAVKTGLPRRKFDVVIVGAGGAGMRASLQLAEAGLNVAVLSKVFPTRSHTVAAQGGIGA
CEEECCCCCCCEEEEEEEECCCCCCHHHHHHHHCCCCHHHHHHHCCCCCCEEEECCCCCC
SLGNMSEDNWHYHFYDTIKGSDWLGDQDAIEFMCREAPKVVYELEHFGMPFDRNADGTIY
CCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEE
QRPFGGHTANYGEKPVQRACAAADRTGHALLHTLYQRNVRAKTHFFVEWMALDLIRDEDG
ECCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
DVLGVTALEMETGEVYILEAKTTLFATGGAGRIYAASTNAFINTGDGLGMAARAGVPLED
CEEEEEEEEECCCCEEEEEECEEEEEECCCCEEEEEECCCEEECCCCCCCHHHCCCCCCC
MEFWQFHPTGVAGAGVLITEGVRGEGGILRNKDGERFMERYAPTLKDLAPRDFVSRSMDQ
CHHEEECCCCCCCCCEEEECCCCCCCCEEECCCHHHHHHHHCCHHHHCCCHHHHHHHHHH
EIKEGRGCGPNGDYVLLDLTHVGAETIMKRLPSIREIGMKFANVDAIKEPIPVVPTIHYQ
HHHHCCCCCCCCCEEEEEEHHCCHHHHHHHCCCHHHHHHHHHCHHHHHCCCCCCCEEEEE
MGGIPTNFHGQVVVPKNGNPNEVVNGFYAIGECSCVSVHGANRLGTNSLLDLVVFGRAAG
ECCCCCCCCCEEEECCCCCHHHHHHHHEEECCEEEEEECCCCCCCHHHHHHHHHHHCCCC
NHIVANAMKQKEHKPLPADAADRAMARLAKLQGTTSGEYTQDVANDIRRNMQSHAGVFRT
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
QKLMDEGVERILEVAERANNIHLKDKSKVFNTALVEALEVSNLVEVAKATMISAAARKES
HHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RGAHAHSDFPNRDDENWLKHTLFYSEGNRLDYKPVKMQPLTVESVPPKARTF
CCCCCCCCCCCCCCHHHHHHEEEEECCCCCCCCCCEECCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7698664; 12704232 [H]