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The map label for this gene is sdhB [H]

Identifier: 94311419

GI number: 94311419

Start: 2696816

End: 2697517

Strand: Reverse

Name: sdhB [H]

Synonym: Rmet_2483

Alternate gene names: 94311419

Gene position: 2697517-2696816 (Counterclockwise)

Preceding gene: 94311420

Following gene: 94311418

Centisome position: 68.67

GC content: 61.25

Gene sequence:

>702_bases
ATGAAGCGTATTTTCGAAGTCTACCGCTACGATCCGGACAAGGACGCCGCGCCCCGCATGCAGACCTACGAGGTGGAACT
CGACGGTCACGAGCGCATGCTGCTGGATGCGCTGGTCAAGCTGAAGAAGCTCGATGAGACGATCTCGTTCCGTCGCTCGT
GCCGTGAAGGCGTGTGCGGCTCGGACGCGATGAACATCAACGGCAAGAACGGCCTGGCCTGCCTGACGAACATGCGCGAA
CTGCCGGACCGCATCGTGCTGCGTCCGCTGCCCGGCCTGCCCGTGGTGCGCGACCTGATCGTCGACATGACGAACTTCTT
CAAGCAGTACAACTCGATCAAGCCGTTCCTGATCAACGACGAGCCGCCGCCCGAGAAGGAGCGTCTGCAATCGCCGCAGG
AACGTGACGAGCTGGACGGCCTGTACGAGTGCATCTTGTGCGCAAGCTGCTCGACGTCGTGCCCGTCGTTCTGGTGGAAC
CCGGACAAGTTCGTTGGCCCGGCCGGTCTGCTGCAGGCCTACCGCTTTATCGCGGACAGCCGTGACCAGGCCACCAGCGA
GCGTCTGGACAACCTGAACGACCCGTACCGTCTGTTCCGTTGCCATAGCATCATGAACTGCGTCGATGTGTGCCCGAAGG
GCCTCAACCCGACGAAGGCGATTGGCAAGATCAAGGAATTGATGGTTCGCCGCGCTGTTTAA

Upstream 100 bases:

>100_bases
TACAAGCCGGTGAAGATGCAACCGCTGACGGTGGAATCAGTTCCGCCGAAGGCCCGTACGTTCTGATACCCGCGTCGTAG
AGAAAACAGGACCCACAGAA

Downstream 100 bases:

>100_bases
TCTGCCGGTATAAACTGCCTTGTGCGTACCGGGCGGAATCCGTACGAACACAGACAGTCTGTAGTTGAAGTAAGCGGCGC
GTCAGCCCGATGCGGTATCA

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDETISFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPDRIVLRPLPGLPVVRDLIVDMTNFFKQYNSIKPFLINDEPPPEKERLQSPQERDELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLNDPYRLFRCHSIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Sequences:

>Translated_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDETISFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPDRIVLRPLPGLPVVRDLIVDMTNFFKQYNSIKPFLINDEPPPEKERLQSPQERDELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLNDPYRLFRCHSIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
>Mature_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDETISFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPDRIVLRPLPGLPVVRDLIVDMTNFFKQYNSIKPFLINDEPPPEKERLQSPQERDELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLNDPYRLFRCHSIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=56.2231759656652, Blast_Score=272, Evalue=2e-73,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=64.8305084745763, Blast_Score=329, Evalue=1e-91,
Organism=Escherichia coli, GI1790596, Length=226, Percent_Identity=38.0530973451327, Blast_Score=157, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=52.5862068965517, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=53.0701754385965, Blast_Score=254, Evalue=1e-68,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=54.5454545454545, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=54.3103448275862, Blast_Score=261, Evalue=2e-70,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26752; Mature: 26752

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDETISFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPDRIVLRPLPGLPVVRDLIVDMTNFFKQYNSIKPFLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
EPPPEKERLQSPQERDELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLNDPYRLFRCHSIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDETISFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPDRIVLRPLPGLPVVRDLIVDMTNFFKQYNSIKPFLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEECC
EPPPEKERLQSPQERDELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLNDPYRLFRCHSIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]