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The map label for this gene is era [H]

Identifier: 94311353

GI number: 94311353

Start: 2626661

End: 2627599

Strand: Reverse

Name: era [H]

Synonym: Rmet_2417

Alternate gene names: 94311353

Gene position: 2627599-2626661 (Counterclockwise)

Preceding gene: 94311354

Following gene: 94311352

Centisome position: 66.89

GC content: 60.92

Gene sequence:

>939_bases
ATGACCGATTCTCTCCCTCCGCAGCAAGATGCGGCGGAACCCTCAGGTGCCGTGGCATTTCGCTGCGGCACAGTGGCCAT
CGTTGGCCGTCCGAATGTTGGCAAGTCCACGCTGATGAACGCGCTGGTCGGCCAGAAGATCAGCATCACGTCCCGCAAGG
CACAGACCACGCGGCATCGTATCGTCGGTATTCAGACGACCGATGATACCCAGTATGTGTTCGCGGATACACCTGGTTTC
CAGACCCGCCACGCCAGCGCGCTGAACCGCTCCCTGAACCGCGCCGTGACGTCGACGCTGTCGTCGGTCGATATCGTGCT
ATTTGTCGTCGAAGCCGGCTATTTTGGCCCCGATGACGAGAAGGTGCTGTCGCTGCTCCCCAAGAACGTTCCGGTGCTGC
TGGTCTGCAACAAGCTCGACCGAATCGGCGAAGGCCGCAGCGAAGTCATGATGCCGTTCCTCGAGCAGATGGGGCAGCGT
TTCCCGTTCCGGGAGGTGGTGCCGATGTCGGCCAAGACGCGCGATCATATCCAGCGTCTGCTGGCGATCATCCGGCCGTA
TCTGCCGGAAGGCGAGCCGATGTACGACGTCGATGCTATGACCGATCGCAGCGAGCGATTCCTGGCGTCCGAGATCATCC
GCGAAAAGGTGTTCCGCTGGACCGGCGACGAACTGCCGTACACCAGCACTGTCGTGATCGACAAATTCGAGACCGAAGGG
CGCCTGCGCAGGATCTTCGCGACGATCCTGGTCGAACGCGACGCGCACAAGGCGATGATCATCGGCAACAAGGGCGCCAA
GCTCAAGCAGATCTCCACCGAGGCACGCCTGGATATGGAGAAGCTGTTTGATGGCAAGGTCTACCTGGAGATGTGGATCA
AGGTCAAGAGCGGCTGGGCCGATAACGAAGCCGGACTGCGCGCCTACGGCTACGAGTGA

Upstream 100 bases:

>100_bases
TCGTGCCGCAGTTGCTCAAGCGCAGCCGTGCCGAACGTACGGGCAAGACGCGCAAGCAGCCGGTGCCGCCCGATCCCCAG
TTGTCTCTCAGGTTGAAGGA

Downstream 100 bases:

>100_bases
GCAAGATGCCTGACGTGCGCCGCGCTGCCGCGCCGCGTGCGCGCAGTGCCGACCCGATTGCCGAGGAAGCGGCGGAGCTG
CTGGGGTCTGGCGCGGTACC

Product: GTPase Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTDSLPPQQDAAEPSGAVAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRIVGIQTTDDTQYVFADTPGF
QTRHASALNRSLNRAVTSTLSSVDIVLFVVEAGYFGPDDEKVLSLLPKNVPVLLVCNKLDRIGEGRSEVMMPFLEQMGQR
FPFREVVPMSAKTRDHIQRLLAIIRPYLPEGEPMYDVDAMTDRSERFLASEIIREKVFRWTGDELPYTSTVVIDKFETEG
RLRRIFATILVERDAHKAMIIGNKGAKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE

Sequences:

>Translated_312_residues
MTDSLPPQQDAAEPSGAVAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRIVGIQTTDDTQYVFADTPGF
QTRHASALNRSLNRAVTSTLSSVDIVLFVVEAGYFGPDDEKVLSLLPKNVPVLLVCNKLDRIGEGRSEVMMPFLEQMGQR
FPFREVVPMSAKTRDHIQRLLAIIRPYLPEGEPMYDVDAMTDRSERFLASEIIREKVFRWTGDELPYTSTVVIDKFETEG
RLRRIFATILVERDAHKAMIIGNKGAKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE
>Mature_311_residues
TDSLPPQQDAAEPSGAVAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHRIVGIQTTDDTQYVFADTPGFQ
TRHASALNRSLNRAVTSTLSSVDIVLFVVEAGYFGPDDEKVLSLLPKNVPVLLVCNKLDRIGEGRSEVMMPFLEQMGQRF
PFREVVPMSAKTRDHIQRLLAIIRPYLPEGEPMYDVDAMTDRSERFLASEIIREKVFRWTGDELPYTSTVVIDKFETEGR
LRRIFATILVERDAHKAMIIGNKGAKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWADNEAGLRAYGYE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=323, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1788919, Length=292, Percent_Identity=51.3698630136986, Blast_Score=300, Evalue=8e-83,
Organism=Drosophila melanogaster, GI24646434, Length=324, Percent_Identity=25.9259259259259, Blast_Score=92, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 35019; Mature: 34888

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSLPPQQDAAEPSGAVAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHR
CCCCCCCCCCCCCCCCCEEEEECEEEEEECCCCCHHHHHHHHHCCEEEECCHHHHHCCEE
IVGIQTTDDTQYVFADTPGFQTRHASALNRSLNRAVTSTLSSVDIVLFVVEAGYFGPDDE
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHH
KVLSLLPKNVPVLLVCNKLDRIGEGRSEVMMPFLEQMGQRFPFREVVPMSAKTRDHIQRL
HHHHHCCCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHH
LAIIRPYLPEGEPMYDVDAMTDRSERFLASEIIREKVFRWTGDELPYTSTVVIDKFETEG
HHHHHHCCCCCCCCEECHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
RLRRIFATILVERDAHKAMIIGNKGAKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHCCEEEEEEEEEEECCCC
DNEAGLRAYGYE
CCCCCCEECCCC
>Mature Secondary Structure 
TDSLPPQQDAAEPSGAVAFRCGTVAIVGRPNVGKSTLMNALVGQKISITSRKAQTTRHR
CCCCCCCCCCCCCCCCEEEEECEEEEEECCCCCHHHHHHHHHCCEEEECCHHHHHCCEE
IVGIQTTDDTQYVFADTPGFQTRHASALNRSLNRAVTSTLSSVDIVLFVVEAGYFGPDDE
EEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHH
KVLSLLPKNVPVLLVCNKLDRIGEGRSEVMMPFLEQMGQRFPFREVVPMSAKTRDHIQRL
HHHHHCCCCCCEEEEECHHHHHCCCHHHHHHHHHHHHHCCCCCHHHCCCCCCHHHHHHHH
LAIIRPYLPEGEPMYDVDAMTDRSERFLASEIIREKVFRWTGDELPYTSTVVIDKFETEG
HHHHHHCCCCCCCCEECHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCH
RLRRIFATILVERDAHKAMIIGNKGAKLKQISTEARLDMEKLFDGKVYLEMWIKVKSGWA
HHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHCHHHHHCCEEEEEEEEEEECCCC
DNEAGLRAYGYE
CCCCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]