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The map label for this gene is rnc [H]

Identifier: 94311354

GI number: 94311354

Start: 2627596

End: 2628366

Strand: Reverse

Name: rnc [H]

Synonym: Rmet_2418

Alternate gene names: 94311354

Gene position: 2628366-2627596 (Counterclockwise)

Preceding gene: 94311355

Following gene: 94311353

Centisome position: 66.91

GC content: 62.78

Gene sequence:

>771_bases
ATGACCCTCGACGCCTTGCAGCAACGTCTCGGCTACCGATTCAGCAAGCCCGAATTGCTGCAGCAGGCGCTCACGCATCG
CAGCCATAGCGCCCAGCACAACGAGCGCCTGGAATTCCTGGGCGACTCGGTATTGAACTGCGCCGTGGCCGATATGCTCT
TTGGCATGTTTGGCAAGCTCGACGAAGGCGATCTTTCACGGGTGCGGGCCAATCTGGTCAAGCAGCAGGCGCTCTACGAG
ATCGCCCAGATGCTGCAGCTTTCCGATGCGCTGCGTCTGGGTGAAGGCGAGTTGAAGAGCGGCGGTTTCCGCCGCCCCTC
GATTCTTGCCGATGCGCTCGAGGCTATCGTTGGTGCCGTGTTTCTCGATGCGGGGTTCGACGCGGCGCGCGCGTTGATCC
GCAAGCTGTATATCCCGATTCTGGAGCAGGTGGACCCGCGCACGCTGGGCAAGGACGCCAAGACGCTGCTCCAGGAGTAT
CTGCAGGGCCACAAGATTGCCCTGCCGCAATACAACGTCATCGCCACGCACGGTGCGGCGCACAGCCAGCAATTTGAAGT
CGAATGCATCGTGCCTAAACTGGAGGTGCGCGTGTTCGGAACCGGCGCGTCGCGTCGCGCCGCCGAACAGGCCGCGGCCA
AGCTCGCGCTCGACGAAGTCCAGAAGCTCGTGCCGCAGTTGCTCAAGCGCAGCCGTGCCGAACGTACGGGCAAGACGCGC
AAGCAGCCGGTGCCGCCCGATCCCCAGTTGTCTCTCAGGTTGAAGGAATGA

Upstream 100 bases:

>100_bases
ACCGGGCGGATCCGCGCGGTCGGCTTCGAGTACCGGACCGAAGTTCAGATTTATGGTCCGTTGAGTTTTTTGATTACCTA
CTCGGGAACGCAGTAACGAC

Downstream 100 bases:

>100_bases
CCGATTCTCTCCCTCCGCAGCAAGATGCGGCGGAACCCTCAGGTGCCGTGGCATTTCGCTGCGGCACAGTGGCCATCGTT
GGCCGTCCGAATGTTGGCAA

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MTLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLSDALRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYNVIATHGAAHSQQFEVECIVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
KQPVPPDPQLSLRLKE

Sequences:

>Translated_256_residues
MTLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYE
IAQMLQLSDALRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEY
LQGHKIALPQYNVIATHGAAHSQQFEVECIVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
KQPVPPDPQLSLRLKE
>Mature_255_residues
TLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKLDEGDLSRVRANLVKQQALYEI
AQMLQLSDALRLGEGELKSGGFRRPSILADALEAIVGAVFLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEYL
QGHKIALPQYNVIATHGAAHSQQFEVECIVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTRK
QPVPPDPQLSLRLKE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=261, Percent_Identity=26.0536398467433, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI155030236, Length=261, Percent_Identity=26.0536398467433, Blast_Score=79, Evalue=5e-15,
Organism=Escherichia coli, GI1788920, Length=206, Percent_Identity=52.4271844660194, Blast_Score=218, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17506883, Length=237, Percent_Identity=29.535864978903, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202651, Length=237, Percent_Identity=29.535864978903, Blast_Score=90, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323895, Length=202, Percent_Identity=29.2079207920792, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17137682, Length=243, Percent_Identity=27.5720164609054, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28412; Mature: 28281

Theoretical pI: Translated: 9.63; Mature: 9.63

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKL
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLSDALRLGEGELKSGGFRRPSILADALEAIVGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAA
HHHCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HSQQFEVECIVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
CCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KQPVPPDPQLSLRLKE
CCCCCCCCCCCEEECC
>Mature Secondary Structure 
TLDALQQRLGYRFSKPELLQQALTHRSHSAQHNERLEFLGDSVLNCAVADMLFGMFGKL
CHHHHHHHHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
DEGDLSRVRANLVKQQALYEIAQMLQLSDALRLGEGELKSGGFRRPSILADALEAIVGAV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
FLDAGFDAARALIRKLYIPILEQVDPRTLGKDAKTLLQEYLQGHKIALPQYNVIATHGAA
HHHCCHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCCC
HSQQFEVECIVPKLEVRVFGTGASRRAAEQAAAKLALDEVQKLVPQLLKRSRAERTGKTR
CCCCEEEEEECCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KQPVPPDPQLSLRLKE
CCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA