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The map label for this gene is lpxA [H]

Identifier: 94310389

GI number: 94310389

Start: 1568781

End: 1569584

Strand: Direct

Name: lpxA [H]

Synonym: Rmet_1447

Alternate gene names: 94310389

Gene position: 1568781-1569584 (Clockwise)

Preceding gene: 94310388

Following gene: 94310390

Centisome position: 39.94

GC content: 62.31

Gene sequence:

>804_bases
ATGACGCAAATCCATTCCACCGCACTAGTCGATCCGAAGGCGGAACTGGCTGACGATGTTACTGTCGGCCCGTTTTCGAT
CGTCGGCCCGAATGTGCGGATCGGTAGCGGCACGCGGATCGGTTCCCATACCACGGTCGAAGGCCACACCACGATCGGCG
CCGGTAACCGCATTGGTCCGTATGCCTCCGTGGGTGGCGTGCCGCAGGATATGAAGTACGCCAACGAGCCGACGCAGCTC
GTGATCGGCGATCGCAACACGATTCGTGAATTCACGACGATCCACACGGGCACCGTGCAGGATCGCGGCGTGACCAGTCT
CGGTAACGACAACTGGATCATGGCCTATGTGCACATCGCGCACGACTGCTCTGTGGGCAACCACACGGTGTTCTCCAGCA
ACGCGCAGATTGCCGGCCACGTGGAGGTCGGGGACTGGGCAATTCTGGGCGGCATGAGCGGCGTGCACCAGTACGTCCGC
ATCGGTGCCCATGCGATGCTTGGCGGTGCTTCGGCATTGGTGCAGGACGTGCCGCCTTTCGTTATCGCGGCCAGCGACAA
GAACGGCAACAAGGCGACCCCGCACGGAATCAACGTCGAAGGTCTTCGTCGTCGCGGATTCGATGCTGGCCAGATCGCGG
CGCTGCGTCAGGCGTACAAGTTGCTGTACAAGTCTGATCTGAGCTTCGACGACGCGCGGGCGGAAATCACGGCGATGCTA
GGTCAGGTCGACGCCACTACCGCTGTGCCGCTGCAGGCGTTCGTGGAGTTCCTCGCCGCGACCCAGCGCGGTATCGTTCG
CTGA

Upstream 100 bases:

>100_bases
GGACGGTGAGGTGGCCTGCGAGGCCGAACTGATGTGCACCGTGAAGCAAGCCGAAGGCTAAGCACGGACCCAAAGCAGAA
CAGACCACAGGACAGCACGT

Downstream 100 bases:

>100_bases
TTCCGGCGCGACATGGTCGACACCGTGCAGGCAGTGCTTCCCGCCGATGCGGGTGCTAATGGGAACAAGCGAGGTAGTAT
CGCCATGGTTGCCGGTGAGG

Product: UDP-N-acetylglucosamine acyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine acyltransferase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTQIHSTALVDPKAELADDVTVGPFSIVGPNVRIGSGTRIGSHTTVEGHTTIGAGNRIGPYASVGGVPQDMKYANEPTQL
VIGDRNTIREFTTIHTGTVQDRGVTSLGNDNWIMAYVHIAHDCSVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQYVR
IGAHAMLGGASALVQDVPPFVIAASDKNGNKATPHGINVEGLRRRGFDAGQIAALRQAYKLLYKSDLSFDDARAEITAML
GQVDATTAVPLQAFVEFLAATQRGIVR

Sequences:

>Translated_267_residues
MTQIHSTALVDPKAELADDVTVGPFSIVGPNVRIGSGTRIGSHTTVEGHTTIGAGNRIGPYASVGGVPQDMKYANEPTQL
VIGDRNTIREFTTIHTGTVQDRGVTSLGNDNWIMAYVHIAHDCSVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQYVR
IGAHAMLGGASALVQDVPPFVIAASDKNGNKATPHGINVEGLRRRGFDAGQIAALRQAYKLLYKSDLSFDDARAEITAML
GQVDATTAVPLQAFVEFLAATQRGIVR
>Mature_266_residues
TQIHSTALVDPKAELADDVTVGPFSIVGPNVRIGSGTRIGSHTTVEGHTTIGAGNRIGPYASVGGVPQDMKYANEPTQLV
IGDRNTIREFTTIHTGTVQDRGVTSLGNDNWIMAYVHIAHDCSVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQYVRI
GAHAMLGGASALVQDVPPFVIAASDKNGNKATPHGINVEGLRRRGFDAGQIAALRQAYKLLYKSDLSFDDARAEITAMLG
QVDATTAVPLQAFVEFLAATQRGIVR

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG1043

COG function: function code M; Acyl-[acyl carrier protein]--UDP-N-acetylglucosamine O-acyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786378, Length=264, Percent_Identity=51.5151515151515, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1786376, Length=167, Percent_Identity=29.940119760479, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018357
- InterPro:   IPR010137
- InterPro:   IPR011004 [H]

Pfam domain/function: NA

EC number: =2.3.1.129 [H]

Molecular weight: Translated: 28208; Mature: 28077

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQIHSTALVDPKAELADDVTVGPFSIVGPNVRIGSGTRIGSHTTVEGHTTIGAGNRIGP
CCCCCCEEEECCHHHHCCCCEECCEEEECCCEEECCCCCCCCCEEECCCEEECCCCCCCC
YASVGGVPQDMKYANEPTQLVIGDRNTIREFTTIHTGTVQDRGVTSLGNDNWIMAYVHIA
CHHCCCCCHHHHHCCCCCEEEECCCHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEEEEE
HDCSVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQYVRIGAHAMLGGASALVQDVPPF
EECCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCE
VIAASDKNGNKATPHGINVEGLRRRGFDAGQIAALRQAYKLLYKSDLSFDDARAEITAML
EEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GQVDATTAVPLQAFVEFLAATQRGIVR
HCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQIHSTALVDPKAELADDVTVGPFSIVGPNVRIGSGTRIGSHTTVEGHTTIGAGNRIGP
CCCCCEEEECCHHHHCCCCEECCEEEECCCEEECCCCCCCCCEEECCCEEECCCCCCCC
YASVGGVPQDMKYANEPTQLVIGDRNTIREFTTIHTGTVQDRGVTSLGNDNWIMAYVHIA
CHHCCCCCHHHHHCCCCCEEEECCCHHHHHHHEEECCCCCCCCCCCCCCCCEEEEEEEEE
HDCSVGNHTVFSSNAQIAGHVEVGDWAILGGMSGVHQYVRIGAHAMLGGASALVQDVPPF
EECCCCCEEEEECCCEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCE
VIAASDKNGNKATPHGINVEGLRRRGFDAGQIAALRQAYKLLYKSDLSFDDARAEITAML
EEEECCCCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
GQVDATTAVPLQAFVEFLAATQRGIVR
HCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA