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The map label for this gene is lpxB

Identifier: 94310390

GI number: 94310390

Start: 1569597

End: 1570802

Strand: Direct

Name: lpxB

Synonym: Rmet_1448

Alternate gene names: 94310390

Gene position: 1569597-1570802 (Clockwise)

Preceding gene: 94310389

Following gene: 94310391

Centisome position: 39.96

GC content: 62.35

Gene sequence:

>1206_bases
ATGGTCGACACCGTGCAGGCAGTGCTTCCCGCCGATGCGGGTGCTAATGGGAACAAGCGAGGTAGTATCGCCATGGTTGC
CGGTGAGGCATCTGGCGACCTGCTCGCTTCGCTGCTGCTGGAAGGCCTGCGCGCGAGGCTTGGCGAATCGGTGGATTACG
CCGGTATCGGTGGCCATCGCATGATGGCGCAGGGATTTGTCTCGCATTGGCCGATGGAAACGCTATCGGTCAATGGCTAT
GTCGAGGTTCTCGGCTCGCTACGCGAAATTCTGGCCACGCGGCGTGAGATTCGCGAGCAATTACTGGCGCGACCGCCGCT
ATGCTTCATCGGCGTCGACGCTCCCGACTTCAACTTCGGTCTGGAAGTGCCGCTGCGCCGCGCGGGCATTCCGGTTGTCC
ATTTTGTCAGCCCGTCGATCTGGGCTTGGCGCGGAGGCCGCATCCGCACGATAGCGCGGGCCGTGGACCATATCCTCTGC
CTGTTCCCGTTCGAGCCCGAGATCTATGCGAAGGCTGGCATTCCGGCGACCTATGTCGGCCATCCGCTAGCTGACGTAAT
CCCGATGGTGCCTGACGTAGCGGGTGCGAGGGCGAAGCTGGCTTTGCCAGAAGGCAAGCGGATCGTGGCGGTGTTGCCTG
GCAGTCGGCAGTCGGAGGTGCGCAATCTCGGCGCGACGTTCTTCGCCGCGATGGACCGTATGCATCGCATGGACGGCAAC
CTCGCTTTCGTGCTGCCTGTTGCAAGCGCACCGCTGCGGGAGATCGTTGCTGGCTTGCACGCGCAGTATCCGGACATCGA
CCTGACCGTGGTTGACGGCCAATCGCATCTCGCGATGGAGTCCGCCGACGTGGTGCTGCTTGCAAGTGGCACGGCAACGC
TCGAGGCCGCGCTGTACAAGAAACCCATGGTGATCTCGTACAAGGTGCCCTGGCTAACGGCGCAGATCATGAAACGGCAG
GGTTATCTGCCGTATGTCGGGCTGCCCAATATCCTGTCGGGACGCTTTGTTGTTCCCGAACTCCTACAGGACGACGCGAC
GCCGGAGGCGCTGGCGCGCGAGACGCTGCTGCAACTCAATGACGAGGGCAATATTGCCTTCCTGCGGCAGCATTTCACGA
CGATGCACGAAACCCTGAAGCGCGACACGGCGAAGCTGGCTGCCGGCGTAGTCGTCGATCTGATGCGCAGCCGTGGAGTG
GTCTGA

Upstream 100 bases:

>100_bases
GCTAGGTCAGGTCGACGCCACTACCGCTGTGCCGCTGCAGGCGTTCGTGGAGTTCCTCGCCGCGACCCAGCGCGGTATCG
TTCGCTGATTCCGGCGCGAC

Downstream 100 bases:

>100_bases
TGGCGCGAACGAAAGCTGCGGCTTCTAGCCAGTTGGGCCTGGAACTAACTCAAACCGTTGCTGTGGTGCAGCGCTTGTGT
GGGGTAGATGAGGCTGGGCG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MVDTVQAVLPADAGANGNKRGSIAMVAGEASGDLLASLLLEGLRARLGESVDYAGIGGHRMMAQGFVSHWPMETLSVNGY
VEVLGSLREILATRREIREQLLARPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILC
LFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAKLALPEGKRIVAVLPGSRQSEVRNLGATFFAAMDRMHRMDGN
LAFVLPVASAPLREIVAGLHAQYPDIDLTVVDGQSHLAMESADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKRQ
GYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDEGNIAFLRQHFTTMHETLKRDTAKLAAGVVVDLMRSRGV
V

Sequences:

>Translated_401_residues
MVDTVQAVLPADAGANGNKRGSIAMVAGEASGDLLASLLLEGLRARLGESVDYAGIGGHRMMAQGFVSHWPMETLSVNGY
VEVLGSLREILATRREIREQLLARPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILC
LFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAKLALPEGKRIVAVLPGSRQSEVRNLGATFFAAMDRMHRMDGN
LAFVLPVASAPLREIVAGLHAQYPDIDLTVVDGQSHLAMESADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKRQ
GYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDEGNIAFLRQHFTTMHETLKRDTAKLAAGVVVDLMRSRGV
V
>Mature_401_residues
MVDTVQAVLPADAGANGNKRGSIAMVAGEASGDLLASLLLEGLRARLGESVDYAGIGGHRMMAQGFVSHWPMETLSVNGY
VEVLGSLREILATRREIREQLLARPPLCFIGVDAPDFNFGLEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILC
LFPFEPEIYAKAGIPATYVGHPLADVIPMVPDVAGARAKLALPEGKRIVAVLPGSRQSEVRNLGATFFAAMDRMHRMDGN
LAFVLPVASAPLREIVAGLHAQYPDIDLTVVDGQSHLAMESADVVLLASGTATLEAALYKKPMVISYKVPWLTAQIMKRQ
GYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLNDEGNIAFLRQHFTTMHETLKRDTAKLAAGVVVDLMRSRGV
V

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family

Homologues:

Organism=Escherichia coli, GI1786379, Length=374, Percent_Identity=38.7700534759358, Blast_Score=262, Evalue=3e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXB_RALME (Q1LNE5)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_583600.1
- ProteinModelPortal:   Q1LNE5
- STRING:   Q1LNE5
- GeneID:   4038251
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1448
- eggNOG:   COG0763
- HOGENOM:   HBG584837
- OMA:   DFTHRVA
- PhylomeDB:   Q1LNE5
- ProtClustDB:   PRK00025
- BioCyc:   RMET266264:RMET_1448-MONOMER
- HAMAP:   MF_00392
- InterPro:   IPR003835
- TIGRFAMs:   TIGR00215

Pfam domain/function: PF02684 LpxB

EC number: =2.4.1.182

Molecular weight: Translated: 43417; Mature: 43417

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDTVQAVLPADAGANGNKRGSIAMVAGEASGDLLASLLLEGLRARLGESVDYAGIGGHR
CCCCHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
MMAQGFVSHWPMETLSVNGYVEVLGSLREILATRREIREQLLARPPLCFIGVDAPDFNFG
HHHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
LEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILCLFPFEPEIYAKAGIPATYVG
CCCCHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCEEECCCCHHHCC
HPLADVIPMVPDVAGARAKLALPEGKRIVAVLPGSRQSEVRNLGATFFAAMDRMHRMDGN
CCHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LAFVLPVASAPLREIVAGLHAQYPDIDLTVVDGQSHLAMESADVVLLASGTATLEAALYK
EEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCEEEEECCCHHHHHHHHC
KPMVISYKVPWLTAQIMKRQGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLN
CCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHCC
DEGNIAFLRQHFTTMHETLKRDTAKLAAGVVVDLMRSRGVV
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MVDTVQAVLPADAGANGNKRGSIAMVAGEASGDLLASLLLEGLRARLGESVDYAGIGGHR
CCCCHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
MMAQGFVSHWPMETLSVNGYVEVLGSLREILATRREIREQLLARPPLCFIGVDAPDFNFG
HHHHHHHHHCCHHHEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCC
LEVPLRRAGIPVVHFVSPSIWAWRGGRIRTIARAVDHILCLFPFEPEIYAKAGIPATYVG
CCCCHHHCCCCEEEECCCCEEEECCCCHHHHHHHHHHEEEEECCCCCCEEECCCCHHHCC
HPLADVIPMVPDVAGARAKLALPEGKRIVAVLPGSRQSEVRNLGATFFAAMDRMHRMDGN
CCHHHHHHHCCCCCCCCEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCC
LAFVLPVASAPLREIVAGLHAQYPDIDLTVVDGQSHLAMESADVVLLASGTATLEAALYK
EEEEEECCCCCHHHHHHHHHCCCCCCEEEEECCCCCEEECCCCEEEEECCCHHHHHHHHC
KPMVISYKVPWLTAQIMKRQGYLPYVGLPNILSGRFVVPELLQDDATPEALARETLLQLN
CCEEEEEECCHHHHHHHHHCCCCCCCCCCHHHCCCEECHHHHCCCCCHHHHHHHHHHHCC
DEGNIAFLRQHFTTMHETLKRDTAKLAAGVVVDLMRSRGVV
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA