Click here to switch to the map view.

The map label for this gene is mhpF [C]

Identifier: 94310262

GI number: 94310262

Start: 1433845

End: 1434756

Strand: Reverse

Name: mhpF [C]

Synonym: Rmet_1320

Alternate gene names: 94310262

Gene position: 1434756-1433845 (Counterclockwise)

Preceding gene: 94310263

Following gene: 94310261

Centisome position: 36.53

GC content: 61.51

Gene sequence:

>912_bases
ATGAAAAAGATCAAATGTGCGCTGATCGGACCAGGCAATATCGGCACCGATCTGCTGGCCAAGCTCAAGCGCAGCTCGGT
GCTGGAGCCGGTGTGGATGGTGGGCATCGACCCGGAATCGGAGGGGCTGAACCGAGCCCGTGAGCTCGGCATCAAAACCA
CGGCGGAAGGTGTCGACGGGCTGCTGCCGCATGTGCTGGCCGATGGTGTGCAGATCGCGTTTGATGCCACCAGTGCATAT
GTTCACGCGGAAAACGCGCGCAAGCTTAACGCGCTGGGCGTGATGATGATCGATCTGACGCCGGCGGCAATTGGCCCGTA
CTGCGTACCGCCGGTCAATTTGAAAGAGCACCTGGGCAAACGCGAGATGAATGTAAACATGGTCACCTGTGGCGGGCAGG
CCACCATTCCGATGGTCGCTGCGGTCTCGCGCGTGCAGCCGGTCGCTTACGGAGAAATCGTCGCGACCGTATCGAGCCGA
TCGGTGGGGCCCGGCACGCGCAAAAACATTGACGAATTCACGCGGACCACGGCCGGCGCGGTGGAAAAGGTGGGGGGCGC
GAGGAAGGGCAAAGCCATCATCATCATCAACCCGGCGGAGCCTCCGCTGATGATGCGCGACACGATTCATTGCCTGACCG
AAACCGAGCCGGATCAGCAAAGGATTGCCGAGTCCATCCACGCCATGATCGAAGAGGTCCAGAAGTACGTGCCCGGTTAC
CGGCTGGTCAACGGCCCGGTGTTTGACGGCAAGCGTGTGACGGTCTTCATGGAGGTGGCGGGCCTGGGGGACTATCTGCC
CACGTACGCCGGCAACCTGGACATCATGACCGCTGCCGCGGCCCGGACCGCCGAGATGTTTGCCGAAGAGATGATTGCCG
GCAATCTCACGCTCGAACCGGTTGTCGCTTGA

Upstream 100 bases:

>100_bases
TTGTTCGGTCCGGTTTCACTGAACGCGCCTGGCCAGGCACCACGCCCGGCCGTTGTCGGATGCCGTGCGTAAAAGTCATT
TTTATAGGAAGGACAAGGTC

Downstream 100 bases:

>100_bases
GCCGTCAAGGAGAACAGAGATGAACCTGCAAGGAAAAAAAATCACCGTCCACGACATGACGTTGCGTGACGGCATGCATC
CGAAGCGCCATATGATGACG

Product: acetaldehyde dehydrogenase

Products: NA

Alternate protein names: Acetaldehyde dehydrogenase [acetylating] 1

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MKKIKCALIGPGNIGTDLLAKLKRSSVLEPVWMVGIDPESEGLNRARELGIKTTAEGVDGLLPHVLADGVQIAFDATSAY
VHAENARKLNALGVMMIDLTPAAIGPYCVPPVNLKEHLGKREMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSR
SVGPGTRKNIDEFTRTTAGAVEKVGGARKGKAIIIINPAEPPLMMRDTIHCLTETEPDQQRIAESIHAMIEEVQKYVPGY
RLVNGPVFDGKRVTVFMEVAGLGDYLPTYAGNLDIMTAAAARTAEMFAEEMIAGNLTLEPVVA

Sequences:

>Translated_303_residues
MKKIKCALIGPGNIGTDLLAKLKRSSVLEPVWMVGIDPESEGLNRARELGIKTTAEGVDGLLPHVLADGVQIAFDATSAY
VHAENARKLNALGVMMIDLTPAAIGPYCVPPVNLKEHLGKREMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSR
SVGPGTRKNIDEFTRTTAGAVEKVGGARKGKAIIIINPAEPPLMMRDTIHCLTETEPDQQRIAESIHAMIEEVQKYVPGY
RLVNGPVFDGKRVTVFMEVAGLGDYLPTYAGNLDIMTAAAARTAEMFAEEMIAGNLTLEPVVA
>Mature_303_residues
MKKIKCALIGPGNIGTDLLAKLKRSSVLEPVWMVGIDPESEGLNRARELGIKTTAEGVDGLLPHVLADGVQIAFDATSAY
VHAENARKLNALGVMMIDLTPAAIGPYCVPPVNLKEHLGKREMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSR
SVGPGTRKNIDEFTRTTAGAVEKVGGARKGKAIIIINPAEPPLMMRDTIHCLTETEPDQQRIAESIHAMIEEVQKYVPGY
RLVNGPVFDGKRVTVFMEVAGLGDYLPTYAGNLDIMTAAAARTAEMFAEEMIAGNLTLEPVVA

Specific function: Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds

COG id: COG4569

COG function: function code Q; Acetaldehyde dehydrogenase (acetylating)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetaldehyde dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1786547, Length=311, Percent_Identity=55.6270096463022, Blast_Score=311, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACDH1_RALME (Q1LNS3)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_583472.1
- ProteinModelPortal:   Q1LNS3
- SMR:   Q1LNS3
- STRING:   Q1LNS3
- GeneID:   4038123
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1320
- eggNOG:   COG4569
- HOGENOM:   HBG300125
- OMA:   IGGAQRG
- ProtClustDB:   PRK08300
- BioCyc:   RMET266264:RMET_1320-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01657
- InterPro:   IPR003361
- InterPro:   IPR015426
- InterPro:   IPR016040
- InterPro:   IPR000534
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21123
- PIRSF:   PIRSF015689
- SMART:   SM00859
- TIGRFAMs:   TIGR03215

Pfam domain/function: PF09290 AcetDehyd-dimer; PF01118 Semialdhyde_dh

EC number: =1.2.1.10

Molecular weight: Translated: 32332; Mature: 32332

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: BINDING 272-272

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIKCALIGPGNIGTDLLAKLKRSSVLEPVWMVGIDPESEGLNRARELGIKTTAEGVDG
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHH
LLPHVLADGVQIAFDATSAYVHAENARKLNALGVMMIDLTPAAIGPYCVPPVNLKEHLGK
HHHHHHHCCEEEEEECCEEEEECCCCCEEHEEEEEEEEECHHHCCCCCCCCCCHHHHCCC
REMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSRSVGPGTRKNIDEFTRTTAGA
CCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
VEKVGGARKGKAIIIINPAEPPLMMRDTIHCLTETEPDQQRIAESIHAMIEEVQKYVPGY
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RLVNGPVFDGKRVTVFMEVAGLGDYLPTYAGNLDIMTAAAARTAEMFAEEMIAGNLTLEP
EEECCCEECCCEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEC
VVA
CCC
>Mature Secondary Structure
MKKIKCALIGPGNIGTDLLAKLKRSSVLEPVWMVGIDPESEGLNRARELGIKTTAEGVDG
CCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHCCCCCCHHHHHH
LLPHVLADGVQIAFDATSAYVHAENARKLNALGVMMIDLTPAAIGPYCVPPVNLKEHLGK
HHHHHHHCCEEEEEECCEEEEECCCCCEEHEEEEEEEEECHHHCCCCCCCCCCHHHHCCC
REMNVNMVTCGGQATIPMVAAVSRVQPVAYGEIVATVSSRSVGPGTRKNIDEFTRTTAGA
CCCCEEEEEECCCCHHHHHHHHHHCCCCHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHH
VEKVGGARKGKAIIIINPAEPPLMMRDTIHCLTETEPDQQRIAESIHAMIEEVQKYVPGY
HHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
RLVNGPVFDGKRVTVFMEVAGLGDYLPTYAGNLDIMTAAAARTAEMFAEEMIAGNLTLEP
EEECCCEECCCEEEEEEEECCCCCHHHHHCCCCEEEHHHHHHHHHHHHHHHHHCCCEEEC
VVA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA