Click here to switch to the map view.

The map label for this gene is nuoD [H]

Identifier: 94309875

GI number: 94309875

Start: 1014006

End: 1015259

Strand: Direct

Name: nuoD [H]

Synonym: Rmet_0930

Alternate gene names: 94309875

Gene position: 1014006-1015259 (Clockwise)

Preceding gene: 94309874

Following gene: 94309876

Centisome position: 25.81

GC content: 60.05

Gene sequence:

>1254_bases
ATGGCAGATATCAAGAACTACACCCTCAACTTCGGCCCCCAACACCCTGCAGCGCACGGCGTGCTGCGTCTGGTGCTTGA
ACTGGACGGCGAAGTCATCCAGCGCGCCGACCCCCATATCGGCCTGCTGCATCGAGCCACCGAAAAGCTGGCCGAGCAGA
AGACCTGGATTCAAAGCGTCCCCTACATGGATCGTCTCGACTACGTGTCGATGATGGTCAACGAACACGCGTACGTGATG
GCGATCGAGCGCTTGCTGGGCCTCGAGGTGCCGATTCGCGCCCAGTACATCCGCGTAATGTTCGACGAAATCACCCGTCT
GCTGAACCACCTGATGTGGATCGGCTCGCACGCGCTGGACGTGGGTGCGATGGCGGTGTTCCTCTACGCGTTCCGCGAGC
GTGAGGACATGTTCGACATGTACGAGGCGGTGTCGGGCGCGCGTATGCACGCGGCCTACTACCGTCCGGGCGGCGTCTAC
CGCGACCTGCCTGACACGATGCCGCAATATCGTGCGTCGAAAGTCCACAACGAGAAGGCCATCAAGGTCATGAACGAAGC
CCGTTCGGGCTCGCTGCTGGACTTCATCGAGGACTTCACGAACCGTTTCCCGACCTATGTCGATGAATACGAGACGCTGC
TGACCGATAACCGTATCTGGAAGCAACGTCTGGTCGATATCGGTGTGGTCACGCCGGAGCGTGCGCTGCAGATGGGTTTC
ACCGGTCCGATGCTGCGTGGCTCGGGTATCGAGTGGGATCTGCGCAAGAAGCAGCCGTACGAGGTCTACGACAAGATGGA
CTTCGATATCCCCGTGGGTACGGCGGGCGACTGCTATTCGCGTTACCTGGTGCGTGTTGAAGAAATGCGCCAGTCGAACC
GCATCATCAAGCAGTGCATTGACTGGCTGCGTCGCAACCCGGGTCCGGTGATTACCGAGAACCACAAGGTGGCGCCGCCG
TCGCGTGTGGACATGAAGTCGAACATGGAAGAGCTGATTCACCACTTCAAGCTCTTCACCGAAGGTATCCACGTGCCGGC
AGGCGAGGCCTACGCAGCGGTGGAGCACCCGAAGGGCGAGTTCGGCATCTATGCGATTTCGGATGGCGCGAACAAGCCGT
ACCGTCTGAAGATCCGTGCCCCGGGCTTTGTCCACCTGGCCGCGCTCGACGAAATGGCCAGGGGACACATGATTGCGGAT
GCGGTCACGATCATCGGTACACAGGACATCGTGTTCGGCGAGATCGACCGCTAA

Upstream 100 bases:

>100_bases
GCGGGTCATCTACCAGCCGGTGACGATCGAGCCGCGCGAAGTCACGCCGCGCGTGATTCGCGAGGAAAACTACGGCGGCA
CGCAGCACTGAGATCGCGTC

Downstream 100 bases:

>100_bases
GGGATACCGGAAGACGAGTATCCCGTCACAGGCCGTTGCCCGGACGACGTTCCGGGCGTGTTCGGCCGGCCCCGGCTGTA
ACGGTGGCGGCAGGCGATGC

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D [H]

Number of amino acids: Translated: 417; Mature: 416

Protein sequence:

>417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVM
AIERLLGLEVPIRAQYIRVMFDEITRLLNHLMWIGSHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYRASKVHNEKAIKVMNEARSGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVDIGVVTPERALQMGF
TGPMLRGSGIEWDLRKKQPYEVYDKMDFDIPVGTAGDCYSRYLVRVEEMRQSNRIIKQCIDWLRRNPGPVITENHKVAPP
SRVDMKSNMEELIHHFKLFTEGIHVPAGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMARGHMIAD
AVTIIGTQDIVFGEIDR

Sequences:

>Translated_417_residues
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVM
AIERLLGLEVPIRAQYIRVMFDEITRLLNHLMWIGSHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVY
RDLPDTMPQYRASKVHNEKAIKVMNEARSGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVDIGVVTPERALQMGF
TGPMLRGSGIEWDLRKKQPYEVYDKMDFDIPVGTAGDCYSRYLVRVEEMRQSNRIIKQCIDWLRRNPGPVITENHKVAPP
SRVDMKSNMEELIHHFKLFTEGIHVPAGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMARGHMIAD
AVTIIGTQDIVFGEIDR
>Mature_416_residues
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSVPYMDRLDYVSMMVNEHAYVMA
IERLLGLEVPIRAQYIRVMFDEITRLLNHLMWIGSHALDVGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYR
DLPDTMPQYRASKVHNEKAIKVMNEARSGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVDIGVVTPERALQMGFT
GPMLRGSGIEWDLRKKQPYEVYDKMDFDIPVGTAGDCYSRYLVRVEEMRQSNRIIKQCIDWLRRNPGPVITENHKVAPPS
RVDMKSNMEELIHHFKLFTEGIHVPAGEAYAAVEHPKGEFGIYAISDGANKPYRLKIRAPGFVHLAALDEMARGHMIADA
VTIIGTQDIVFGEIDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=61.1111111111111, Blast_Score=525, Evalue=1e-149,
Organism=Homo sapiens, GI260898743, Length=408, Percent_Identity=60.2941176470588, Blast_Score=509, Evalue=1e-144,
Organism=Escherichia coli, GI145693162, Length=410, Percent_Identity=37.3170731707317, Blast_Score=298, Evalue=5e-82,
Organism=Escherichia coli, GI1789076, Length=419, Percent_Identity=28.4009546539379, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788832, Length=408, Percent_Identity=27.2058823529412, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17555284, Length=415, Percent_Identity=57.1084337349398, Blast_Score=492, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568379, Length=415, Percent_Identity=55.9036144578313, Blast_Score=487, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24638644, Length=415, Percent_Identity=60.2409638554217, Blast_Score=528, Evalue=1e-150,
Organism=Drosophila melanogaster, GI221459469, Length=412, Percent_Identity=54.3689320388349, Blast_Score=462, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885 [H]

Pfam domain/function: PF00346 Complex1_49kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47834; Mature: 47703

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSV
CCCCCCCEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIERLLGLEVPIRAQYIRVMFDEITRLLNHLMWIGSHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYRASKVHNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHCCHHH
IKVMNEARSGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVDIGVVTPERALQMGF
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCC
TGPMLRGSGIEWDLRKKQPYEVYDKMDFDIPVGTAGDCYSRYLVRVEEMRQSNRIIKQCI
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DWLRRNPGPVITENHKVAPPSRVDMKSNMEELIHHFKLFTEGIHVPAGEAYAAVEHPKGE
HHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCC
FGIYAISDGANKPYRLKIRAPGFVHLAALDEMARGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
ADIKNYTLNFGPQHPAAHGVLRLVLELDGEVIQRADPHIGLLHRATEKLAEQKTWIQSV
CCCCCCEECCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
PYMDRLDYVSMMVNEHAYVMAIERLLGLEVPIRAQYIRVMFDEITRLLNHLMWIGSHALD
CCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
VGAMAVFLYAFREREDMFDMYEAVSGARMHAAYYRPGGVYRDLPDTMPQYRASKVHNEKA
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEECCCCCCCCCHHHHHHHHHHHHCCHHH
IKVMNEARSGSLLDFIEDFTNRFPTYVDEYETLLTDNRIWKQRLVDIGVVTPERALQMGF
HHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHCCC
TGPMLRGSGIEWDLRKKQPYEVYDKMDFDIPVGTAGDCYSRYLVRVEEMRQSNRIIKQCI
CCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DWLRRNPGPVITENHKVAPPSRVDMKSNMEELIHHFKLFTEGIHVPAGEAYAAVEHPKGE
HHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCC
FGIYAISDGANKPYRLKIRAPGFVHLAALDEMARGHMIADAVTIIGTQDIVFGEIDR
EEEEEEECCCCCCEEEEEECCCEEEHHHHHHHHCCCHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA