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The map label for this gene is serS

Identifier: 94309640

GI number: 94309640

Start: 767102

End: 768409

Strand: Direct

Name: serS

Synonym: Rmet_0695

Alternate gene names: 94309640

Gene position: 767102-768409 (Clockwise)

Preceding gene: 94309639

Following gene: 94309645

Centisome position: 19.53

GC content: 64.14

Gene sequence:

>1308_bases
ATGCTCGACATCCAGCTGCTCCGCAAAGACATCGACGCCGTGGCCCAGCGCCTCGCCACGCGCGGTTTTCAACTCGATGT
GGCCCTGTTCCAGGCCCTTGAGGCCGAACGCAAGCAACTGCAGACCCAGACCGAGGATCTGCAGGCGCGCCGCAACAGCC
TCTCCAAGCAGATCGGGATGCTCAAGGGCAAGGGCGAAGACGCCTCGGGCCCGATGGCCGAAGTGGCCGGTATCGGCGAC
ACGCTGAAGGCATCCGCCCAGCGCCTGGCCGAGATCCAGGACCAGATCAGCGACGCGATGCTCTCGATCCCGAACCTGCC
ACACGAAAGCGTGCCGACGGGCAAGGACGAAACCGAGAACGTCGAAGTGCGCCGCGTGGGCACGCCGCGCACGTTCGATT
TCGAGATCAAGGATCACGTGGATGTCGGCGCCCGTCTCGGCCTGGATTTCGAGACGGCCACGAAGGTCACTGGCTCGCGC
TTCGCCTTCCTGCGGGGTGGCGTGGCACGCATGCATCGCGCGCTGGTCCAGCTCATGGTGGACACGCACACGCTTGAACA
TGGCTACACCGAGATGTACGTGCCGTACATCGTCAATGCCGCGTCGATGCGTGGTACCGGCCAGCTACCGAAGTTCGAGG
ACGACCTGTTCAAGGTGCCGCGCAAGGTCGGCGGTGAGGATGGCCAGGACGCTATCGAGAACTTCTACCTGATCCCGACC
GCTGAAGTGCCGCTGACCAACGTGGTCCGCGACGCGATCGTTGCCGCGGAAAAACTGCCGCTGCGCTTCGTGGCCCACAC
ACCATGCTTCCGTTCGGAAGCCGGCTCGTACGGCAAGGACACGCGCGGCATGATCCGCCAGCATCAGTTCGACAAGGTCG
AGATGGTGCAGGTGGTGCCGTCCGAGCAGTCGATGGACGCGCTCGAGCAGATGACTGGTCACGCCGAGACGATTCTGAAG
AAGCTTGAGTTGCCGTTCCGTACCGTCGTGCTGTGCACGGGCGACATGGGCTTCGGCAGCACCAAGACCTACGACATCGA
AGTGTGGATTCCGGCGCAGAACACGTACCGCGAAATCAGCTCGTGTTCGAGCATGGGCGACTTCCAGGCGCGCCGCATGC
AGGCACGTATGCGCGCCGGACAGGGCAAGCCGGAACTGGTGCACACGCTGAACGGCTCCGGCCTGGCCGTGGGCCGCACG
CTGGTGGCGATCCTGGAGAACTACCAGAACGCGGACGGTTCGGTGACGGTGCCGAAGGCGCTGCAACCGTACATGGGCGG
CATCACGCGCCTGGAACCGGAAGCGTAA

Upstream 100 bases:

>100_bases
AAGGCAAAATCCAGCCGGATTTGCTCCCGGCGGGTCGTGCCAGTGCAGTAAAATGTTCCGTTCGCCGGCATGTTGCCGGC
ACTGCACATGACCAAGCAAC

Downstream 100 bases:

>100_bases
AAATAGTTACAGAAGGGGCTTGCGCTCCGGATATGGATATCCCTATAATCTTGGTTTCGCCGCTAACGCAGCGACGACCA
AGTTACCGGAGAGGTGGCAG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDIQLLRKDIDAVAQRLATRGFQLDVALFQALEAERKQLQTQTEDLQARRNSLSKQIGMLKGKGEDASGPMAEVAGIGD
TLKASAQRLAEIQDQISDAMLSIPNLPHESVPTGKDETENVEVRRVGTPRTFDFEIKDHVDVGARLGLDFETATKVTGSR
FAFLRGGVARMHRALVQLMVDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEDDLFKVPRKVGGEDGQDAIENFYLIPT
AEVPLTNVVRDAIVAAEKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQVVPSEQSMDALEQMTGHAETILK
KLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSSMGDFQARRMQARMRAGQGKPELVHTLNGSGLAVGRT
LVAILENYQNADGSVTVPKALQPYMGGITRLEPEA

Sequences:

>Translated_435_residues
MLDIQLLRKDIDAVAQRLATRGFQLDVALFQALEAERKQLQTQTEDLQARRNSLSKQIGMLKGKGEDASGPMAEVAGIGD
TLKASAQRLAEIQDQISDAMLSIPNLPHESVPTGKDETENVEVRRVGTPRTFDFEIKDHVDVGARLGLDFETATKVTGSR
FAFLRGGVARMHRALVQLMVDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEDDLFKVPRKVGGEDGQDAIENFYLIPT
AEVPLTNVVRDAIVAAEKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQVVPSEQSMDALEQMTGHAETILK
KLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSSMGDFQARRMQARMRAGQGKPELVHTLNGSGLAVGRT
LVAILENYQNADGSVTVPKALQPYMGGITRLEPEA
>Mature_435_residues
MLDIQLLRKDIDAVAQRLATRGFQLDVALFQALEAERKQLQTQTEDLQARRNSLSKQIGMLKGKGEDASGPMAEVAGIGD
TLKASAQRLAEIQDQISDAMLSIPNLPHESVPTGKDETENVEVRRVGTPRTFDFEIKDHVDVGARLGLDFETATKVTGSR
FAFLRGGVARMHRALVQLMVDTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEDDLFKVPRKVGGEDGQDAIENFYLIPT
AEVPLTNVVRDAIVAAEKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQVVPSEQSMDALEQMTGHAETILK
KLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREISSCSSMGDFQARRMQARMRAGQGKPELVHTLNGSGLAVGRT
LVAILENYQNADGSVTVPKALQPYMGGITRLEPEA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=361, Percent_Identity=35.1800554016621, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI8923421, Length=439, Percent_Identity=31.4350797266515, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI225579074, Length=443, Percent_Identity=31.3769751693002, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=61.8604651162791, Blast_Score=539, Evalue=1e-154,
Organism=Caenorhabditis elegans, GI17539260, Length=338, Percent_Identity=34.6153846153846, Blast_Score=214, Evalue=6e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=329, Percent_Identity=25.8358662613982, Blast_Score=131, Evalue=8e-31,
Organism=Saccharomyces cerevisiae, GI6320226, Length=411, Percent_Identity=32.360097323601, Blast_Score=212, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6321799, Length=397, Percent_Identity=30.2267002518892, Blast_Score=179, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24581334, Length=475, Percent_Identity=32.8421052631579, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17737985, Length=343, Percent_Identity=29.7376093294461, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_RALME (Q1LQJ5)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_582850.1
- ProteinModelPortal:   Q1LQJ5
- SMR:   Q1LQJ5
- STRING:   Q1LQJ5
- GeneID:   4037484
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_0695
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- PhylomeDB:   Q1LQJ5
- ProtClustDB:   PRK05431
- BioCyc:   RMET266264:RMET_0695-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48013; Mature: 48013

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 294-294 BINDING 393-393

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDIDAVAQRLATRGFQLDVALFQALEAERKQLQTQTEDLQARRNSLSKQIGM
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASGPMAEVAGIGDTLKASAQRLAEIQDQISDAMLSIPNLPHESVPTGKDETEN
HCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGTPRTFDFEIKDHVDVGARLGLDFETATKVTGSRFAFLRGGVARMHRALVQLMV
EEEEECCCCCEEEEEECCCCCCCHHCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHH
DTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEDDLFKVPRKVGGEDGQDAIENFYLIPT
HHHHHHCCCHHEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCEEEEEC
AEVPLTNVVRDAIVAAEKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQVVP
CCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECC
SEQSMDALEQMTGHAETILKKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREIS
CCHHHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHH
SCSSMGDFQARRMQARMRAGQGKPELVHTLNGSGLAVGRTLVAILENYQNADGSVTVPKA
HHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHH
LQPYMGGITRLEPEA
HHHHHCCCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDIDAVAQRLATRGFQLDVALFQALEAERKQLQTQTEDLQARRNSLSKQIGM
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKGKGEDASGPMAEVAGIGDTLKASAQRLAEIQDQISDAMLSIPNLPHESVPTGKDETEN
HCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRVGTPRTFDFEIKDHVDVGARLGLDFETATKVTGSRFAFLRGGVARMHRALVQLMV
EEEEECCCCCEEEEEECCCCCCCHHCCCCHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHH
DTHTLEHGYTEMYVPYIVNAASMRGTGQLPKFEDDLFKVPRKVGGEDGQDAIENFYLIPT
HHHHHHCCCHHEEHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHCEEEEEC
AEVPLTNVVRDAIVAAEKLPLRFVAHTPCFRSEAGSYGKDTRGMIRQHQFDKVEMVQVVP
CCCCHHHHHHHHHHHHHHCCEEEEECCCCHHHCCCCCCCCHHHHHHHHCCCCEEEEEECC
SEQSMDALEQMTGHAETILKKLELPFRTVVLCTGDMGFGSTKTYDIEVWIPAQNTYREIS
CCHHHHHHHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHH
SCSSMGDFQARRMQARMRAGQGKPELVHTLNGSGLAVGRTLVAILENYQNADGSVTVPKA
HHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHH
LQPYMGGITRLEPEA
HHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA