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The map label for this gene is ldh [H]

Identifier: 94309504

GI number: 94309504

Start: 597825

End: 598877

Strand: Reverse

Name: ldh [H]

Synonym: Rmet_0559

Alternate gene names: 94309504

Gene position: 598877-597825 (Counterclockwise)

Preceding gene: 94309505

Following gene: 94309503

Centisome position: 15.25

GC content: 65.91

Gene sequence:

>1053_bases
ATGATGAAAATTACCCTAGACAGCGCGCGGCAGTTCGCGCGCAGCATCCTGGCGGCGCAGGGTGTGCCCGCCGATATCGC
CGATGACGTGGCCGAGCACCTGGTGGAAGCCGATCGCAGCGGCTACGTCAGCCACGGCCTGTCGATCCTGCCGAACTACC
GCCGTGCCATCGAGAGTGGCAACGTGAATCCCACCGGACGCGCTGCGTGCGTGCTCGACCGCGACATGCTGATGGTGTTC
GACGGTAACGGCGGCTTTGGCCAGCACGTCGGCAAGACCGTGATGACGCGTGCCATCGAACGCGTGCGTCAGCACGGCCA
TTGCATCGTGACACTGCGCAAATCGCACCACCTTGGCCGCATGGGCCACTATGGCGAGATGGTGGCCAGCGCAGGCTTCG
TGCTGTTGAGCTTCACCAACGTGATCAACCGGCCGCCCGTGGTCGCGCCCTTCGGCGGCCGCGTGCCACGGCTCACCACC
AATCCGCTTTGCTTTGCCGGGCCGATGCCGAACGGGCGACCGCCGCTCGTCGTCGATATCGCCACCAGCGCCATCGCCAT
CAACAAGGCACGCGTGCTGGCGGAGAAAGGCGAGCCCGCGCCGGAGAACAGCATCATCGACGCCGAAGGCAACCCGACTA
CCGATGCGGGGGTCATGTTCGACGATCAACCGGGATCGCTGCTGCCGTTTGGCGCCCACAAGGGCTACGGTCTCGGCGTG
GTGGCGGAACTGCTGGCCGGGGTGTTGTCCGGCGGTGGCACGATCCAGCCGGACAACCCGCGCGGCGGCGTGGCCACGAA
CAACCTGTTCGCGGTGCTGCTGAATCCCGAACTCGATCTCGGCATCAACTGGGAACGGGAGGAGGTAGAGGCCTTCGTGC
GCTACCTCCACGACACGCCGCCTGCGCCAGGCTTCGACCAGGTGCAGTATCCGGGCGAGTACGAAGCCATGCATCGCGCC
GCGGCGGCAACGCATCTGGAGATCAATCCGAAGATCTGGAGCCATCTGGCAGCGTTGGCGGGGGATCTCGGGGTGGATAT
GCCGGCGGCGTAG

Upstream 100 bases:

>100_bases
CTGTTCGCGTCGACGTACTGGCGCTGGCTTGGCTGGATCTGACCGGCAAACATGCAACCTCGCCGCTGACACAAGCGCCC
CCAAACCTTCGCCCCCAACG

Downstream 100 bases:

>100_bases
GCCATTGACGCACGCTTCGCACGGACCGGTGACAGGAGAGCATCAGAGATTTCCCAGACGCGATAGCCGCCAATGGCACA
ATACGCGCCATGCAACGTCT

Product: L-Lactate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 350; Mature: 350

Protein sequence:

>350_residues
MMKITLDSARQFARSILAAQGVPADIADDVAEHLVEADRSGYVSHGLSILPNYRRAIESGNVNPTGRAACVLDRDMLMVF
DGNGGFGQHVGKTVMTRAIERVRQHGHCIVTLRKSHHLGRMGHYGEMVASAGFVLLSFTNVINRPPVVAPFGGRVPRLTT
NPLCFAGPMPNGRPPLVVDIATSAIAINKARVLAEKGEPAPENSIIDAEGNPTTDAGVMFDDQPGSLLPFGAHKGYGLGV
VAELLAGVLSGGGTIQPDNPRGGVATNNLFAVLLNPELDLGINWEREEVEAFVRYLHDTPPAPGFDQVQYPGEYEAMHRA
AAATHLEINPKIWSHLAALAGDLGVDMPAA

Sequences:

>Translated_350_residues
MMKITLDSARQFARSILAAQGVPADIADDVAEHLVEADRSGYVSHGLSILPNYRRAIESGNVNPTGRAACVLDRDMLMVF
DGNGGFGQHVGKTVMTRAIERVRQHGHCIVTLRKSHHLGRMGHYGEMVASAGFVLLSFTNVINRPPVVAPFGGRVPRLTT
NPLCFAGPMPNGRPPLVVDIATSAIAINKARVLAEKGEPAPENSIIDAEGNPTTDAGVMFDDQPGSLLPFGAHKGYGLGV
VAELLAGVLSGGGTIQPDNPRGGVATNNLFAVLLNPELDLGINWEREEVEAFVRYLHDTPPAPGFDQVQYPGEYEAMHRA
AAATHLEINPKIWSHLAALAGDLGVDMPAA
>Mature_350_residues
MMKITLDSARQFARSILAAQGVPADIADDVAEHLVEADRSGYVSHGLSILPNYRRAIESGNVNPTGRAACVLDRDMLMVF
DGNGGFGQHVGKTVMTRAIERVRQHGHCIVTLRKSHHLGRMGHYGEMVASAGFVLLSFTNVINRPPVVAPFGGRVPRLTT
NPLCFAGPMPNGRPPLVVDIATSAIAINKARVLAEKGEPAPENSIIDAEGNPTTDAGVMFDDQPGSLLPFGAHKGYGLGV
VAELLAGVLSGGGTIQPDNPRGGVATNNLFAVLLNPELDLGINWEREEVEAFVRYLHDTPPAPGFDQVQYPGEYEAMHRA
AAATHLEINPKIWSHLAALAGDLGVDMPAA

Specific function: Unknown

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1787020, Length=310, Percent_Identity=37.0967741935484, Blast_Score=195, Evalue=3e-51,
Organism=Escherichia coli, GI1790000, Length=345, Percent_Identity=26.0869565217391, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786727, Length=349, Percent_Identity=30.945558739255, Blast_Score=127, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17507179, Length=357, Percent_Identity=28.8515406162465, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17536633, Length=252, Percent_Identity=30.1587301587302, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553211, Length=257, Percent_Identity=33.0739299610895, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24667912, Length=257, Percent_Identity=33.0739299610895, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24667908, Length=257, Percent_Identity=33.0739299610895, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24667904, Length=257, Percent_Identity=32.6848249027237, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24658010, Length=322, Percent_Identity=26.3975155279503, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648360, Length=263, Percent_Identity=25.0950570342205, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 37236; Mature: 37236

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKITLDSARQFARSILAAQGVPADIADDVAEHLVEADRSGYVSHGLSILPNYRRAIESG
CEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHCCHHHHHHHCC
NVNPTGRAACVLDRDMLMVFDGNGGFGQHVGKTVMTRAIERVRQHGHCIVTLRKSHHLGR
CCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
MGHYGEMVASAGFVLLSFTNVINRPPVVAPFGGRVPRLTTNPLCFAGPMPNGRPPLVVDI
CCHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEE
ATSAIAINKARVLAEKGEPAPENSIIDAEGNPTTDAGVMFDDQPGSLLPFGAHKGYGLGV
CCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCHHH
VAELLAGVLSGGGTIQPDNPRGGVATNNLFAVLLNPELDLGINWEREEVEAFVRYLHDTP
HHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
PAPGFDQVQYPGEYEAMHRAAAATHLEINPKIWSHLAALAGDLGVDMPAA
CCCCCCCCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MMKITLDSARQFARSILAAQGVPADIADDVAEHLVEADRSGYVSHGLSILPNYRRAIESG
CEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHCHHHCCHHHHHHHCC
NVNPTGRAACVLDRDMLMVFDGNGGFGQHVGKTVMTRAIERVRQHGHCIVTLRKSHHLGR
CCCCCCCEEEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
MGHYGEMVASAGFVLLSFTNVINRPPVVAPFGGRVPRLTTNPLCFAGPMPNGRPPLVVDI
CCHHHHHHHHCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCEEEECCCCCCCCCEEEEE
ATSAIAINKARVLAEKGEPAPENSIIDAEGNPTTDAGVMFDDQPGSLLPFGAHKGYGLGV
CCCHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEECCCCCCEEECCCCCCCCHHH
VAELLAGVLSGGGTIQPDNPRGGVATNNLFAVLLNPELDLGINWEREEVEAFVRYLHDTP
HHHHHHHHHCCCCEECCCCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
PAPGFDQVQYPGEYEAMHRAAAATHLEINPKIWSHLAALAGDLGVDMPAA
CCCCCCCCCCCCHHHHHHHHHHHEEEEECHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8405966 [H]