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The map label for this gene is ctaB [H]

Identifier: 94309215

GI number: 94309215

Start: 286254

End: 287192

Strand: Direct

Name: ctaB [H]

Synonym: Rmet_0270

Alternate gene names: 94309215

Gene position: 286254-287192 (Clockwise)

Preceding gene: 94309214

Following gene: 94309216

Centisome position: 7.29

GC content: 64.75

Gene sequence:

>939_bases
ATGAAGGACAAGATGCCCCCCGTGGTAACTGCTACCCACTCCCAATCCTCCGTGGGCCGATTACGCCATCTGGCCCGCCA
ATACGCCGCGCTGACCAAGCCGCGCGTGACCCAACTCGCCGTGTTCTGCGCCATCATCGGCATGTTCCTGGCCACGCCGG
GCATGGTGCCGTGGTCGGTGCTGATCGGCGGCGCGGCCGGTATCTGGCTGCTGGCCGGCGCGGCTTTCGCCATCAACTGC
CTGGTGGAACAGAAGATCGACGCGCTGATGCGCCGCACCGCGTGGCGCCCGTCGGCCACCGGCGAGATCACCACCACCCA
GACGCTGATCTTCTCGGCCGTGCTGGGCGGTGCCGGCATGTGGCTGCTGCACGTCTTCGCCAACGACCTGACGATGTGGC
TCACCTTCGCCACGTTCCTTGGCTACGCCGTGGTCTATACGATCCTTCTGAAGCCGGCGACGCCGCAGAACATCGTAATC
GGTGGCCTGTCGGGCGCCATGCCCCCGGCGCTGGGCTGGTCCGCGGTATCGGGCACGGTGCCTGCCGAGGCCTGGTTCCT
GGTGCTGATCATCTTCACCTGGACGCCGCCGCACTTCTGGGCGCTGGCTCTGTACCGCCGCGCTGACTACGCCAAGTCCG
GCCTGCCGATGCTGCCGATCACGCACGGCGAGCGCTACACGCTGCTGCATATCCTGCTGTACACGCTGATCATGATCGCG
GCCACGCTGCTGCCGTTCGTGTACGGTATGAGTGGCTACATCTACCTTGTGGCGGCACTGGGGCTGGGCCTGGTGTTCCT
GGGCTATGCCTGGAAGCTGTACCGCAACTACTCCGACGGTCTCGCCCAGCGCACCTTCCGTTATTCGATCCTGTACCTGT
CGCTGCTGTTTGCGGTGTTGCTTGTGGATCACTACTTCAAGTTCGTGCCGCAGGTCTGA

Upstream 100 bases:

>100_bases
CCCTGCTGCTGATGTTGTTGCTCCGTCTCAACTACAATATCGGCCTCGCCACTCGCTCCGCCGGCGCCGCCACGCAACCC
TCGATTGCCGCGCGCGCCAC

Downstream 100 bases:

>100_bases
CCGCCTGCGGCATCTTGCCGCGCCCGGAAGTCATCGGCGGCCCGATCGGCGATACTTTCGGGCAACTCCTCCCAATTCTT
GCGCATGTCGACCTCTTCCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MKDKMPPVVTATHSQSSVGRLRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWSVLIGGAAGIWLLAGAAFAINC
LVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVI
GGLSGAMPPALGWSAVSGTVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGERYTLLHILLYTLIMIA
ATLLPFVYGMSGYIYLVAALGLGLVFLGYAWKLYRNYSDGLAQRTFRYSILYLSLLFAVLLVDHYFKFVPQV

Sequences:

>Translated_312_residues
MKDKMPPVVTATHSQSSVGRLRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWSVLIGGAAGIWLLAGAAFAINC
LVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVI
GGLSGAMPPALGWSAVSGTVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGERYTLLHILLYTLIMIA
ATLLPFVYGMSGYIYLVAALGLGLVFLGYAWKLYRNYSDGLAQRTFRYSILYLSLLFAVLLVDHYFKFVPQV
>Mature_312_residues
MKDKMPPVVTATHSQSSVGRLRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWSVLIGGAAGIWLLAGAAFAINC
LVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGMWLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVI
GGLSGAMPPALGWSAVSGTVPAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGERYTLLHILLYTLIMIA
ATLLPFVYGMSGYIYLVAALGLGLVFLGYAWKLYRNYSDGLAQRTFRYSILYLSLLFAVLLVDHYFKFVPQV

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=194, Percent_Identity=34.020618556701, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786631, Length=279, Percent_Identity=32.9749103942652, Blast_Score=144, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71998235, Length=297, Percent_Identity=30.3030303030303, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325085, Length=261, Percent_Identity=29.5019157088123, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI19921064, Length=280, Percent_Identity=29.6428571428571, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34372; Mature: 34372

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDKMPPVVTATHSQSSVGRLRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWSV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LIGGAAGIWLLAGAAFAINCLVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHH
WLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIGGLSGAMPPALGWSAVSGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHCCCCC
PAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGERYTLLHILLYTLIMIA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
ATLLPFVYGMSGYIYLVAALGLGLVFLGYAWKLYRNYSDGLAQRTFRYSILYLSLLFAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVDHYFKFVPQV
HHHHHHHHCCCC
>Mature Secondary Structure
MKDKMPPVVTATHSQSSVGRLRHLARQYAALTKPRVTQLAVFCAIIGMFLATPGMVPWSV
CCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHH
LIGGAAGIWLLAGAAFAINCLVEQKIDALMRRTAWRPSATGEITTTQTLIFSAVLGGAGM
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHH
WLLHVFANDLTMWLTFATFLGYAVVYTILLKPATPQNIVIGGLSGAMPPALGWSAVSGTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCHHCCCCC
PAEAWFLVLIIFTWTPPHFWALALYRRADYAKSGLPMLPITHGERYTLLHILLYTLIMIA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHH
ATLLPFVYGMSGYIYLVAALGLGLVFLGYAWKLYRNYSDGLAQRTFRYSILYLSLLFAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVDHYFKFVPQV
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA