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The map label for this gene is aatA [H]

Identifier: 335055567

GI number: 335055567

Start: 2143155

End: 2144516

Strand: Reverse

Name: aatA [H]

Synonym: NA

Alternate gene names: 335055567

Gene position: 2144516-2143155 (Counterclockwise)

Preceding gene: 94310911

Following gene: 94310904

Centisome position: 54.59

GC content: 61.82

Gene sequence:

>1362_bases
TTGCCTCCAGGTCTGCCACGCCTCGCGAGCCTCATTGCGGACGCGCCGCCAGACGCGCAGGACAATCCAGAGATTCCCAG
ATTCCGCTGCCGCCAGAGACCGGCAGCTTGCCCTGACATCGCCAACACCGCCGTGAAACCCATCCAGAAATCGCACAAGC
TCCAGAACGTTTGCTATGACATCCGCGGCCCGGTGCTGGAAAAGGCCAAGCAAATGGAGGAAGAGGGGCACAAGATCATC
AAGCTGAACATCGGCAACCTGGCGGTGTTCGGCTTCGACGCGCCGGAGGAGATCCAGCAGGACATGATGCGCAACCTGCC
CAATTCGGCGGGTTACTCGGATTCCAAGGGCATCTTCGCCGCGCGCAAGGCGATCATGCACTACACCCAGGAAAAGAAGA
TCCAGGGCGTGGGGCTGGATGACATCTATGTGGGCAACGGCGCGTCCGAGCTGATCGTGATGGCGATGAATGCGCTGCTC
AACAGTGGCGACGAAATGCTGGTGCCGGCGCCTGACTACCCGTTGTGGACGGCCGCGGTGAGCTTGTCCGGCGGCACGCC
GGTGCACTATGTGTGCGACGAGGCCAACGAGTGGATGCCGGACCTCGATGATATCCGCCGCAAGATCACCCCGAACACGC
GCGGCATCGTCATCATCAACCCGAACAACCCCACCGGGGCGCTGTATTCGGACGAACTGCTGAAGGAGATCGTGGCCATC
GCGCGCGAGCACGGCCTGATCATCTTCGCCGACGAGATCTACGACAAGGTCCTGTACGACGGCAATACGCATACGTCGAT
CGGCTCGCTGTCCACGGACGTCCTGACCGTGACCTTCAACGGCCTGTCGAAGAACTACCGTTCGTGCGGCTACCGCGCGG
GCTGGATGGTGGTGTCGGGCGACAAGCGTCCCGCGCTCGACTACATCGAAGGGCTGAACATGCTCTCGTCGATGCGCCTG
TGCGCCAATGTGCCGGGCCAATGGGCGATCCAGACGGCGCTGGGCGGGTATCAGAGCATCAATGACCTCGTGACCGAAGG
CGGCCGCCTGCGCCGCCAGCGCGATCTGGCCTACGAGCTGATTACCAAGATTCCGGGCGTTACGTGCGTCAAGCCCAAGG
CTGCGCTGTACCTGTTCCCGAAGCTCGACCTGTCCATGTACCCGATCCAGGACGATCAGGAGTTCATTTACGAACTGCTG
CAGGAATCGAAGGTGCTGCTGGTGCAGGGTACCGGCTTCAACTGGGGCGCGCCGGACCATTTCCGGATTGTGTTCCTGCC
ACACGAGGAAGACCTGCGTGAGGCCATCACCCGCGTCGGCCGCTTCCTTGAAAGCTATCGCAAACGTCACGGTACGGCCT
GA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: Aspartate aminotransferase

Products: oxaloacetate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:
NA

Sequences:

>Translated_453_residues
MPPGLPRLASLIADAPPDAQDNPEIPRFRCRQRPAACPDIANTAVKPIQKSHKLQNVCYDIRGPVLEKAKQMEEEGHKII
KLNIGNLAVFGFDAPEEIQQDMMRNLPNSAGYSDSKGIFAARKAIMHYTQEKKIQGVGLDDIYVGNGASELIVMAMNALL
NSGDEMLVPAPDYPLWTAAVSLSGGTPVHYVCDEANEWMPDLDDIRRKITPNTRGIVIINPNNPTGALYSDELLKEIVAI
AREHGLIIFADEIYDKVLYDGNTHTSIGSLSTDVLTVTFNGLSKNYRSCGYRAGWMVVSGDKRPALDYIEGLNMLSSMRL
CANVPGQWAIQTALGGYQSINDLVTEGGRLRRQRDLAYELITKIPGVTCVKPKAALYLFPKLDLSMYPIQDDQEFIYELL
QESKVLLVQGTGFNWGAPDHFRIVFLPHEEDLREAITRVGRFLESYRKRHGTA
>Mature_452_residues
PPGLPRLASLIADAPPDAQDNPEIPRFRCRQRPAACPDIANTAVKPIQKSHKLQNVCYDIRGPVLEKAKQMEEEGHKIIK
LNIGNLAVFGFDAPEEIQQDMMRNLPNSAGYSDSKGIFAARKAIMHYTQEKKIQGVGLDDIYVGNGASELIVMAMNALLN
SGDEMLVPAPDYPLWTAAVSLSGGTPVHYVCDEANEWMPDLDDIRRKITPNTRGIVIINPNNPTGALYSDELLKEIVAIA
REHGLIIFADEIYDKVLYDGNTHTSIGSLSTDVLTVTFNGLSKNYRSCGYRAGWMVVSGDKRPALDYIEGLNMLSSMRLC
ANVPGQWAIQTALGGYQSINDLVTEGGRLRRQRDLAYELITKIPGVTCVKPKAALYLFPKLDLSMYPIQDDQEFIYELLQ
ESKVLLVQGTGFNWGAPDHFRIVFLPHEEDLREAITRVGRFLESYRKRHGTA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI19263340, Length=472, Percent_Identity=27.9661016949153, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI215599424, Length=400, Percent_Identity=29.25, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4507369, Length=417, Percent_Identity=28.0575539568345, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI4885351, Length=448, Percent_Identity=25.4464285714286, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI95147551, Length=170, Percent_Identity=27.0588235294118, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI169881279, Length=170, Percent_Identity=27.0588235294118, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI56713254, Length=167, Percent_Identity=25.748502994012, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI56713256, Length=167, Percent_Identity=25.748502994012, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI169881281, Length=156, Percent_Identity=26.2820512820513, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI187936925, Length=380, Percent_Identity=23.4210526315789, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI14211921, Length=380, Percent_Identity=23.4210526315789, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788627, Length=404, Percent_Identity=66.0891089108911, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI1788722, Length=368, Percent_Identity=27.9891304347826, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1786816, Length=378, Percent_Identity=24.3386243386243, Blast_Score=89, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17567663, Length=382, Percent_Identity=30.8900523560209, Blast_Score=168, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI71981209, Length=477, Percent_Identity=25.3668763102725, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71994476, Length=177, Percent_Identity=31.0734463276836, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994472, Length=177, Percent_Identity=31.0734463276836, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71981215, Length=296, Percent_Identity=27.027027027027, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17567369, Length=165, Percent_Identity=29.6969696969697, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320317, Length=383, Percent_Identity=27.4151436031332, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323118, Length=404, Percent_Identity=27.4752475247525, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322401, Length=403, Percent_Identity=24.5657568238213, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI18859735, Length=380, Percent_Identity=28.9473684210526, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24641770, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641760, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641768, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641766, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24641764, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI45551451, Length=470, Percent_Identity=25.7446808510638, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI28573069, Length=166, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24646114, Length=166, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573067, Length=166, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28573065, Length=166, Percent_Identity=23.4939759036145, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21356535, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: 2.6.1.1

Molecular weight: Translated: 50377; Mature: 50246

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPGLPRLASLIADAPPDAQDNPEIPRFRCRQRPAACPDIANTAVKPIQKSHKLQNVCYD
CCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRGPVLEKAKQMEEEGHKIIKLNIGNLAVFGFDAPEEIQQDMMRNLPNSAGYSDSKGIFA
HCCHHHHHHHHHHHCCCEEEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHH
ARKAIMHYTQEKKIQGVGLDDIYVGNGASELIVMAMNALLNSGDEMLVPAPDYPLWTAAV
HHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEE
SLSGGTPVHYVCDEANEWMPDLDDIRRKITPNTRGIVIINPNNPTGALYSDELLKEIVAI
ECCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
AREHGLIIFADEIYDKVLYDGNTHTSIGSLSTDVLTVTFNGLSKNYRSCGYRAGWMVVSG
HHHCCEEEEEHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEC
DKRPALDYIEGLNMLSSMRLCANVPGQWAIQTALGGYQSINDLVTEGGRLRRQRDLAYEL
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHH
ITKIPGVTCVKPKAALYLFPKLDLSMYPIQDDQEFIYELLQESKVLLVQGTGFNWGAPDH
HHHCCCCEEECCCCEEEEEECCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCC
FRIVFLPHEEDLREAITRVGRFLESYRKRHGTA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PPGLPRLASLIADAPPDAQDNPEIPRFRCRQRPAACPDIANTAVKPIQKSHKLQNVCYD
CCCHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
IRGPVLEKAKQMEEEGHKIIKLNIGNLAVFGFDAPEEIQQDMMRNLPNSAGYSDSKGIFA
HCCHHHHHHHHHHHCCCEEEEEEECCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCHHH
ARKAIMHYTQEKKIQGVGLDDIYVGNGASELIVMAMNALLNSGDEMLVPAPDYPLWTAAV
HHHHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEE
SLSGGTPVHYVCDEANEWMPDLDDIRRKITPNTRGIVIINPNNPTGALYSDELLKEIVAI
ECCCCCCEEEEECCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHH
AREHGLIIFADEIYDKVLYDGNTHTSIGSLSTDVLTVTFNGLSKNYRSCGYRAGWMVVSG
HHHCCEEEEEHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCHHHHHHHCCCCCCEEEEEC
DKRPALDYIEGLNMLSSMRLCANVPGQWAIQTALGGYQSINDLVTEGGRLRRQRDLAYEL
CCCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHH
ITKIPGVTCVKPKAALYLFPKLDLSMYPIQDDQEFIYELLQESKVLLVQGTGFNWGAPDH
HHHCCCCEEECCCCEEEEEECCCCEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCC
FRIVFLPHEEDLREAITRVGRFLESYRKRHGTA
EEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate; 2-oxoglutarate

Specific reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]