Click here to switch to the map view.

The map label for this gene is thrA [H]

Identifier: 94310904

GI number: 94310904

Start: 2141794

End: 2143104

Strand: Reverse

Name: thrA [H]

Synonym: Rmet_1966

Alternate gene names: 94310904

Gene position: 2143104-2141794 (Counterclockwise)

Preceding gene: 335055567

Following gene: 94310903

Centisome position: 54.56

GC content: 64.07

Gene sequence:

>1311_bases
ATGAATCCCATCAAAGTCGGCCTTCTCGGCATCGGTACCGTCGGTAGCGGCACGTTCAACGTGCTCAAGCGCAATCAGGA
GGAAATTCGTCGCCGTGCAGGCCGCGGCATCGAGATTGCGGTGGTGGCTGACCTGAACACCGAGCGCGCCCGCGAGCTGA
CCGGTGGGACGGTGGACGTCGTCAGCGATGCGAACGACGTGGTGACGCGTCCGGACATCGACATCGTCATCGAGCTGATC
GGCGGCTATGGCATCGCCCGCGAGTTGGTGCTCAAGGCGATCGAGAATGGCAAGCACGTGGTCACCGCCAACAAGGCGCT
GCTGGCCGTGCATGGCAACGAGATTTTCGAGGCCGCGCGCAAGAAGGGCGTGATCGTCGCCTTCGAGGCGGCAGTGGCGG
GTGGCATCCCCATCATCAAGGCGCTGCGCGAAGGCCTGACCGCGAACCGCATCCAGTGGATCGCCGGCATCATCAACGGC
ACGACGAACTTCATCCTGTCCGAGATGCGCGACAAGGGTCTGGATTTCGATACCGTGCTCAAGGAAGCGCAGCAACTGGG
CTATGCCGAGGCCGATCCGACCTTCGACATCGAAGGCGTCGACGCCGCGCACAAGGTCACGCTGATGAGCGCGATCGCAT
TCGGTATGCCGGTGCAGTTCGACCGCGCCCACGTGGAAGGCATCACCAAGCTGTCGGCCATCGATATCAAATACGCCGAG
GAACTGGGTTATCGCATCAAGCTGCTCGGCATCACCCGCCGCCGCGAGGAAGGCGTGGAACTGCGCGTGCACCCGACGCT
GGTGCCGGCCTCGCGCCTGATCGCCAACGTGGAAGGCGCGATGAACGCCGTGCTGGTGCAGGGCGATGCCGTGGGCGCCA
CTCTGTACTACGGCAAGGGCGCCGGCGCCGAGCCGACCGCCTCGGCCGTGATTGCCGATCTGGTCGACGTGACCCGCCTG
CACACCGCCGATCCGAACCACCGCGTACCGCACCTGGCATTCCAGCCGGACGAGCTGTCGAACGTGCCCGTGCTGCCGAT
CGACGAAGTCACTAGCTCGTACTACCTGCGTATGCGTGTGTCGGACGAAACTGGCGTGCTGGCAGAGATCACGCGCATCC
TGGCGGAAGCCGGCATCAGCATCGACGCGATGCTGCAGAAGGAATCGCGCGAAGGCGAGCCGCAGACCGACATCATCATC
CTGACGCACCTGACGCGCGAGAAGCACGTCAATGCCGCGATTCGCAGCATCGAAGCGCTCCAGACCGTGCTGTCGCCGGT
CACGCGCCTGCGCATGGAAGAACTGAACTGA

Upstream 100 bases:

>100_bases
GCGTCGGCCGCTTCCTTGAAAGCTATCGCAAACGTCACGGTACGGCCTGAGCCACCGGACGCCCCTATTTCAGAATCAAG
CAAACCAGAGTCAGACGTTC

Downstream 100 bases:

>100_bases
TAGCTGACAGACGGACCTGACTCGCCTCATGAATTACCAGTCGACGCGCGGCCATGACGTGCCGCAATCGTTCTCCGAGA
TCCTGCTCGGTGGCCTGGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTGGTVDVVSDANDVVTRPDIDIVIELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARKKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDRAHVEGITKLSAIDIKYAE
ELGYRIKLLGITRRREEGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIDEVTSSYYLRMRVSDETGVLAEITRILAEAGISIDAMLQKESREGEPQTDIII
LTHLTREKHVNAAIRSIEALQTVLSPVTRLRMEELN

Sequences:

>Translated_436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTGGTVDVVSDANDVVTRPDIDIVIELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARKKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDRAHVEGITKLSAIDIKYAE
ELGYRIKLLGITRRREEGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIDEVTSSYYLRMRVSDETGVLAEITRILAEAGISIDAMLQKESREGEPQTDIII
LTHLTREKHVNAAIRSIEALQTVLSPVTRLRMEELN
>Mature_436_residues
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTGGTVDVVSDANDVVTRPDIDIVIELI
GGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAARKKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIING
TTNFILSEMRDKGLDFDTVLKEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDRAHVEGITKLSAIDIKYAE
ELGYRIKLLGITRRREEGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKGAGAEPTASAVIADLVDVTRL
HTADPNHRVPHLAFQPDELSNVPVLPIDEVTSSYYLRMRVSDETGVLAEITRILAEAGISIDAMLQKESREGEPQTDIII
LTHLTREKHVNAAIRSIEALQTVLSPVTRLRMEELN

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=254, Percent_Identity=25.5905511811024, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=129, Percent_Identity=35.6589147286822, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47154; Mature: 47154

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTGGTVDV
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCEEEE
VSDANDVVTRPDIDIVIELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAAR
ECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHHHHH
KKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDTVL
HCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDRAHVEGITKLSAIDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHEEEEHHHH
ELGYRIKLLGITRRREEGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPNHRVPHLAFQPDELSNVPVLPIDEVTSSYYLRMRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEEEEE
SDETGVLAEITRILAEAGISIDAMLQKESREGEPQTDIIILTHLTREKHVNAAIRSIEAL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
QTVLSPVTRLRMEELN
HHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNPIKVGLLGIGTVGSGTFNVLKRNQEEIRRRAGRGIEIAVVADLNTERARELTGGTVDV
CCCEEEEEEEECCCCCCHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCEEEE
VSDANDVVTRPDIDIVIELIGGYGIARELVLKAIENGKHVVTANKALLAVHGNEIFEAAR
ECCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEECCEEEEEECHHHHHHHH
KKGVIVAFEAAVAGGIPIIKALREGLTANRIQWIAGIINGTTNFILSEMRDKGLDFDTVL
HCCEEEEEECHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHH
KEAQQLGYAEADPTFDIEGVDAAHKVTLMSAIAFGMPVQFDRAHVEGITKLSAIDIKYAE
HHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHEEEEHHHH
ELGYRIKLLGITRRREEGVELRVHPTLVPASRLIANVEGAMNAVLVQGDAVGATLYYGKG
HCCCEEEEEEEEECCCCCCEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEECCC
AGAEPTASAVIADLVDVTRLHTADPNHRVPHLAFQPDELSNVPVLPIDEVTSSYYLRMRV
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCHHHHCCCEEEEEEE
SDETGVLAEITRILAEAGISIDAMLQKESREGEPQTDIIILTHLTREKHVNAAIRSIEAL
CCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHH
QTVLSPVTRLRMEELN
HHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]