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The map label for this gene is phoR [H]

Identifier: 93007039

GI number: 93007039

Start: 2719841

End: 2720911

Strand: Reverse

Name: phoR [H]

Synonym: Pcryo_2215

Alternate gene names: 93007039

Gene position: 2720911-2719841 (Counterclockwise)

Preceding gene: 93007040

Following gene: 93007037

Centisome position: 88.92

GC content: 44.44

Gene sequence:

>1071_bases
ATGCCTATCCAAGACAATGAGCAAGGTGCTACAAATCAACTTAAAAAAATCAGAAGTGCTTTACGAGCATTACGTGATGC
CGTGATTTTGCTCAATGATGATGATGGACTTGAATGGTGGAACCAAGCGGCGCAGGATTTATTATTGTTGCAATCCTCAG
ATAAAGGCAGGCGTATTTTTGACTTCATTCAAGTGCCTGAATTTATCAAGTATTATCAGGAGGCAACGACGCTTAATACT
GATGCCGATGCCGATGAGAGTGTGCATATCGTCTCTTTGCAAGACCCAAACCGCTATCTAAAGTGTGAGCTGACGCCATT
TGGCGATGAAAAACTACTGATCATTTATGATGTGACCCGCTTGCAGCATTTAGAAGCAATGCGCCGCGACTTTGTGGCCA
ATGTTTCGCATGAGCTACGTACACCATTGACGGTCTTGATGGGATATCTGGAGAATTTCTCTGATCAGCCAGATATGCCT
GCGAATTGGCGTCGCGGTTTTGAGCTGATGACTCAGCAAACGGCACGCATGAATAGGGTGGTCAATGACTTATTGCTACT
GTCTCGTATCGAAATCGAAGAAACCCATGCGTTTAATGAAATCGATATGACCAAGCTGCTCACTCATGTCTATGATGATG
CACAGGCGTATAATCAAGAATATAAGCATACGATTCACTTGCATATTGATACCTATGACGGACTATATGGCTCAGAGATG
TACCTAAATAGCGCACTGTCCAATCTAGTGATTAATGCGATTAAATACACACCAAAAGGTGGCAATATCTCTATTAGTTG
GACTAAGACTGCTGAGGGCTGCCGATTTGCTGTTGAAGATAATGGTATCGGTATAGCGCCGCAGCATCTTGCCCGTTTAA
CTGAGCGTTTTTATCGCGTTGACAGCGGGCGCAGCCGAGCAACAGGTGGGACGGGGCTTGGACTGGCAATTGTAAAACAT
GTCTTATATCAGCACGAAGCGAGCTTGCAAATTGAGTCAGTAGAAGGCATTGGCTCGACATTTAGTGCCGTGTTCCCAAA
TAACCATGTACGATCTGCCGCAATAAATTAA

Upstream 100 bases:

>100_bases
AGTAATATGAATATTGTATAGTGTCACCTTTTAATAGTGTCGCCTTTTATCGGGAGCGGCCAATAGTAGAAAAATTATAA
AAAATAATGGATAAATAAAA

Downstream 100 bases:

>100_bases
TGCTTGATACACTTTAATCCTTTTGCAAAAGTGGATAAGGATTTACCGCGCTACCATTAATATAAATTCCATAATGAACA
TGCGGCGGTGTGCCTTTAGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MPIQDNEQGATNQLKKIRSALRALRDAVILLNDDDGLEWWNQAAQDLLLLQSSDKGRRIFDFIQVPEFIKYYQEATTLNT
DADADESVHIVSLQDPNRYLKCELTPFGDEKLLIIYDVTRLQHLEAMRRDFVANVSHELRTPLTVLMGYLENFSDQPDMP
ANWRRGFELMTQQTARMNRVVNDLLLLSRIEIEETHAFNEIDMTKLLTHVYDDAQAYNQEYKHTIHLHIDTYDGLYGSEM
YLNSALSNLVINAIKYTPKGGNISISWTKTAEGCRFAVEDNGIGIAPQHLARLTERFYRVDSGRSRATGGTGLGLAIVKH
VLYQHEASLQIESVEGIGSTFSAVFPNNHVRSAAIN

Sequences:

>Translated_356_residues
MPIQDNEQGATNQLKKIRSALRALRDAVILLNDDDGLEWWNQAAQDLLLLQSSDKGRRIFDFIQVPEFIKYYQEATTLNT
DADADESVHIVSLQDPNRYLKCELTPFGDEKLLIIYDVTRLQHLEAMRRDFVANVSHELRTPLTVLMGYLENFSDQPDMP
ANWRRGFELMTQQTARMNRVVNDLLLLSRIEIEETHAFNEIDMTKLLTHVYDDAQAYNQEYKHTIHLHIDTYDGLYGSEM
YLNSALSNLVINAIKYTPKGGNISISWTKTAEGCRFAVEDNGIGIAPQHLARLTERFYRVDSGRSRATGGTGLGLAIVKH
VLYQHEASLQIESVEGIGSTFSAVFPNNHVRSAAIN
>Mature_355_residues
PIQDNEQGATNQLKKIRSALRALRDAVILLNDDDGLEWWNQAAQDLLLLQSSDKGRRIFDFIQVPEFIKYYQEATTLNTD
ADADESVHIVSLQDPNRYLKCELTPFGDEKLLIIYDVTRLQHLEAMRRDFVANVSHELRTPLTVLMGYLENFSDQPDMPA
NWRRGFELMTQQTARMNRVVNDLLLLSRIEIEETHAFNEIDMTKLLTHVYDDAQAYNQEYKHTIHLHIDTYDGLYGSEMY
LNSALSNLVINAIKYTPKGGNISISWTKTAEGCRFAVEDNGIGIAPQHLARLTERFYRVDSGRSRATGGTGLGLAIVKHV
LYQHEASLQIESVEGIGSTFSAVFPNNHVRSAAIN

Specific function: Member of the two-component regulatory system phoR/phoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates phoB in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=338, Percent_Identity=44.3786982248521, Blast_Score=269, Evalue=2e-73,
Organism=Escherichia coli, GI1786783, Length=262, Percent_Identity=29.0076335877863, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1790346, Length=219, Percent_Identity=30.1369863013699, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1790436, Length=226, Percent_Identity=30.5309734513274, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI1788393, Length=219, Percent_Identity=31.5068493150685, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=219, Percent_Identity=29.6803652968037, Blast_Score=99, Evalue=6e-22,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=29.3617021276596, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790861, Length=220, Percent_Identity=31.3636363636364, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789403, Length=212, Percent_Identity=30.188679245283, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789808, Length=249, Percent_Identity=28.5140562248996, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=23.9819004524887, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=26.8722466960352, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI48994928, Length=226, Percent_Identity=26.1061946902655, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790551, Length=213, Percent_Identity=31.4553990610329, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=24.2677824267782, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=27.7533039647577, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788279, Length=233, Percent_Identity=26.1802575107296, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR021766
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR014310 [H]

Pfam domain/function: PF11808 DUF3329; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 40433; Mature: 40302

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIQDNEQGATNQLKKIRSALRALRDAVILLNDDDGLEWWNQAAQDLLLLQSSDKGRRIF
CCCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHEEEEECCCCCCHHH
DFIQVPEFIKYYQEATTLNTDADADESVHIVSLQDPNRYLKCELTPFGDEKLLIIYDVTR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEHHH
LQHLEAMRRDFVANVSHELRTPLTVLMGYLENFSDQPDMPANWRRGFELMTQQTARMNRV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VNDLLLLSRIEIEETHAFNEIDMTKLLTHVYDDAQAYNQEYKHTIHLHIDTYDGLYGSEM
HHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHH
YLNSALSNLVINAIKYTPKGGNISISWTKTAEGCRFAVEDNGIGIAPQHLARLTERFYRV
HHHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
DSGRSRATGGTGLGLAIVKHVLYQHEASLQIESVEGIGSTFSAVFPNNHVRSAAIN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PIQDNEQGATNQLKKIRSALRALRDAVILLNDDDGLEWWNQAAQDLLLLQSSDKGRRIF
CCCCCCCCHHHHHHHHHHHHHHHHCEEEEEECCCCHHHHHHHHHHEEEEECCCCCCHHH
DFIQVPEFIKYYQEATTLNTDADADESVHIVSLQDPNRYLKCELTPFGDEKLLIIYDVTR
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEEHHH
LQHLEAMRRDFVANVSHELRTPLTVLMGYLENFSDQPDMPANWRRGFELMTQQTARMNRV
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VNDLLLLSRIEIEETHAFNEIDMTKLLTHVYDDAQAYNQEYKHTIHLHIDTYDGLYGSEM
HHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCHHH
YLNSALSNLVINAIKYTPKGGNISISWTKTAEGCRFAVEDNGIGIAPQHLARLTERFYRV
HHHHHHHHHHHHHHEECCCCCCEEEEEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHC
DSGRSRATGGTGLGLAIVKHVLYQHEASLQIESVEGIGSTFSAVFPNNHVRSAAIN
CCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3550103; 9278503; 2187152; 8391104 [H]