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The map label for this gene is ung [H]

Identifier: 93006500

GI number: 93006500

Start: 2062106

End: 2062843

Strand: Reverse

Name: ung [H]

Synonym: Pcryo_1676

Alternate gene names: 93006500

Gene position: 2062843-2062106 (Counterclockwise)

Preceding gene: 93006501

Following gene: 93006499

Centisome position: 67.42

GC content: 41.06

Gene sequence:

>738_bases
ATGGAATTATTTGACGTACAACCCACAAAAACAGTCGCGCAAAAGCAAGCGATTCTCGACAATGTACGCTTGCCAGAAGA
TTGGAAGCAGGCGTTGTCAGAAGAATTAACTTCTGACAATATGGATAGCTTGCGAGCTTTTTTAAAAGGAGCCTATCAGT
CAGAGGATGGTATTTATCCTCCAGCACAGCTGATATTTAATGCGTTTAATTTGACACCTTTATCACAGGTGAAGGTTGTT
ATCTTAGGGCAAGATCCTTATCATCGTCCTGGACAGGCAATGGGGCTGTCCTTTTCTGTCCCTAAAGTGATCCCAAAGCC
ACCGTCACTTAACAATTTATTGAAAGAGATGGCGGACGATATTGGCATTAAACCTTCAGCACATGGTGATTTAACGTATT
GGGCACAGCAAGGCGTATTATTGTTAAATAGTTCCTTGACAGTAAGAGAAGGCGAGCCAAACAGTCATCAAAATCAAGGC
TGGGAGAAGTTCACTGATGCGGTTATTGATGTTATTAATGAGCAGACTGAACATACTGTGTTTATTTTATGGGGCAGTAA
AGCTCAGAAAAAAGGCAAGTATATCAATACTGATAAACATCTGATTTTAACGGCAGTACACCCATCACCACTTGCTGCTA
ATCGTGGTGGTTTTTTTGGTTCTAAGCCGTTTTCAAAAACCAATGATTATCTGGTGCAATATGGTCAAACGCCTATCGAC
TGGCAATTACCACAGTAA

Upstream 100 bases:

>100_bases
TAACCGTTTTTTTATTGCTAATATATATGACAACGCAACCCTAATATTTTGTTAATATCACCCTTCACGCATCCTGATAA
CAAATAAAAAAGGATTCATC

Downstream 100 bases:

>100_bases
ATGAAAAATTTTCTAAACGCTAATTTATTGCCTTACCAGCTAATACATAGTCCATTTACTAATGGTAATCCGCTGATAGG
TGAGCAGATTAAAACAGCTC

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MELFDVQPTKTVAQKQAILDNVRLPEDWKQALSEELTSDNMDSLRAFLKGAYQSEDGIYPPAQLIFNAFNLTPLSQVKVV
ILGQDPYHRPGQAMGLSFSVPKVIPKPPSLNNLLKEMADDIGIKPSAHGDLTYWAQQGVLLLNSSLTVREGEPNSHQNQG
WEKFTDAVIDVINEQTEHTVFILWGSKAQKKGKYINTDKHLILTAVHPSPLAANRGGFFGSKPFSKTNDYLVQYGQTPID
WQLPQ

Sequences:

>Translated_245_residues
MELFDVQPTKTVAQKQAILDNVRLPEDWKQALSEELTSDNMDSLRAFLKGAYQSEDGIYPPAQLIFNAFNLTPLSQVKVV
ILGQDPYHRPGQAMGLSFSVPKVIPKPPSLNNLLKEMADDIGIKPSAHGDLTYWAQQGVLLLNSSLTVREGEPNSHQNQG
WEKFTDAVIDVINEQTEHTVFILWGSKAQKKGKYINTDKHLILTAVHPSPLAANRGGFFGSKPFSKTNDYLVQYGQTPID
WQLPQ
>Mature_245_residues
MELFDVQPTKTVAQKQAILDNVRLPEDWKQALSEELTSDNMDSLRAFLKGAYQSEDGIYPPAQLIFNAFNLTPLSQVKVV
ILGQDPYHRPGQAMGLSFSVPKVIPKPPSLNNLLKEMADDIGIKPSAHGDLTYWAQQGVLLLNSSLTVREGEPNSHQNQG
WEKFTDAVIDVINEQTEHTVFILWGSKAQKKGKYINTDKHLILTAVHPSPLAANRGGFFGSKPFSKTNDYLVQYGQTPID
WQLPQ

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=223, Percent_Identity=48.4304932735426, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI6224979, Length=223, Percent_Identity=48.4304932735426, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=52.5581395348837, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17556304, Length=228, Percent_Identity=44.2982456140351, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6323620, Length=240, Percent_Identity=40.4166666666667, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 27341; Mature: 27341

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELFDVQPTKTVAQKQAILDNVRLPEDWKQALSEELTSDNMDSLRAFLKGAYQSEDGIYP
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
PAQLIFNAFNLTPLSQVKVVILGQDPYHRPGQAMGLSFSVPKVIPKPPSLNNLLKEMADD
HHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHH
IGIKPSAHGDLTYWAQQGVLLLNSSLTVREGEPNSHQNQGWEKFTDAVIDVINEQTEHTV
CCCCCCCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
FILWGSKAQKKGKYINTDKHLILTAVHPSPLAANRGGFFGSKPFSKTNDYLVQYGQTPID
EEEECCCCHHCCCEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCC
WQLPQ
CCCCC
>Mature Secondary Structure
MELFDVQPTKTVAQKQAILDNVRLPEDWKQALSEELTSDNMDSLRAFLKGAYQSEDGIYP
CCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCC
PAQLIFNAFNLTPLSQVKVVILGQDPYHRPGQAMGLSFSVPKVIPKPPSLNNLLKEMADD
HHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHH
IGIKPSAHGDLTYWAQQGVLLLNSSLTVREGEPNSHQNQGWEKFTDAVIDVINEQTEHTV
CCCCCCCCCCEEEECCCCEEEEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCCCCEE
FILWGSKAQKKGKYINTDKHLILTAVHPSPLAANRGGFFGSKPFSKTNDYLVQYGQTPID
EEEECCCCHHCCCEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHEECCCCCCC
WQLPQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA