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The map label for this gene is merA [H]

Identifier: 93005805

GI number: 93005805

Start: 1163995

End: 1166163

Strand: Reverse

Name: merA [H]

Synonym: Pcryo_0977

Alternate gene names: 93005805

Gene position: 1166163-1163995 (Counterclockwise)

Preceding gene: 93005806

Following gene: 93005804

Centisome position: 38.11

GC content: 44.54

Gene sequence:

>2169_bases
ATGATTAAAAAAATAGTTTTGATATTCGCGGTCTTGATTGGCGTCATTGGCTTTTTTTATTTTGACCTCAATGAATTATT
AACACTTGAGGGCTTAAAAGGCTCGATGGATCAGTTTGAGCAATACAAAACACAGTCGCCATGGTTAGTCATCGGCGGCT
TTTTTTTGGTCTACATCTTAGTTACCGCATTATCTTTACCCGGCGCCGCTATTTTAACTTTGGCAGCCGGTGCTTTATTT
GGTTTAGTACAAGGTGTATTGGTCGCCTCATTTGCCTCCAGTATCGGTGCCACCCTCGCCTTTTTGACTTCGCGTTATTT
GTTACGCGATACCATTAAACAGCGTTTTCCTGACCGTCTTGCTTCCATCGATGCTGGGGTAAAAAAAGAAGGCGGATTTT
ATTTATTTACGTTACGTTTGGTACCGATATTCCCCTTTTTCCTTATCAACTTATTGATGGGTCTGACTGCTATCAAAGCA
AGGACCTTTTATTGGGTCAGCCAAATCGGTATGCTTGCCGGCACTTTTGTATTTGTGAATGCTGGTACGCAATTGGCACA
AATCGAGCAGTTATCTGGCATTTTGTCTTTTAATCTTCTGGCTTCATTTGCATTATTAGGATTATTTCCGCTAATAGCGA
AAGGCATATTAACGATACTAAAAAAACGCCGTGTCTATAAGAACTATAATAAACCAAAAAAATTCGACCGGAATATGATT
GTGATTGGTGCTGGTGCTGGCGGACTTGTTACCAGCTATATTGCTGCGACCGTCAAAGCAAAAGTCACCTTGATTGAGGC
AGGTGAGATGGGCGGCGACTGCTTAAACTATGGCTGCGTCCCCAGTAAAGCGCTGATAAAAAGTGCAAAAGTAGTCGAAC
AGATACGCCATGGCGAACGTTATGGACTCAATAATAGCCAACCGGATTTTGCATTCAAGAACATCATGTCTCGCATTCAT
AAAGTCATTGCTGATATCGCCCCAAATGACAGTGTTGAGCGTTATACAGATTTGGGTGTCGAGGTATTGAAAGGCTATGC
AAAGCTCATTGATCCATGGACGGTTGAGATTGCCCTCAATGATGGTAGCACTCAGACATTAACCGCGCGCTCTATCGTTA
TCGCGACGGGCGCACGTCCCTTTGTCCCAGATCTACCGGGTTTAGATGAGACAGGTTATGTGACAAGCGATACTCTCTGG
GATAAGTTTGCAAAACTTGATAAAGCGCCGAGCAAGCTGGTCGTACTTGGCGGCGGACCCATTGGCTGTGAGCTGGCACA
AGCCTTTGCTCGTTTAGGTTCTGCTGTGACCCAAATCGAAAGAGGCACGCGACTGATGAAAAAAGAGGATGTCGAGGTTT
CTGTATTTGCGCAAGAAGCACTGACTGAGAGTGGCGTTACTATCCTAACCTCACAGCAAGCAATTCGCTGTGAAACTCGT
GATGGCAAAAAACATATTATCGTTGCACCAAAAGGCAGCACTGATGATCAACAAGAAACTGCCATTGAGTATGACGAGTT
GATTTGTGCAGTCGGTCGTAGTGCGCGCTTAGAAGGTTACGGGCTTGACACCTTGGGCATCGATACTGAGCGTACCATCA
GTACAGATGAGTATCTTGAAACGCTTTACCCCAATATCTATGCGGCAGGTGATGTCGTAGGTCCCTATCAATTCACCCAT
GTGGCTGCCCATCAAGCATGGTACGCTGCGGTCAATGGCTTATTTGGTCATCTTAAAAAATTCAAAGTAGATTATCGGGT
GATTCCATGGACGACGTTTATTGACCCAGAAGTAGCACGAGTGGGCTTAAATGAGCAAGAAGCGATTGATAAAGGCATCG
ATTTTGAAATCACACGTTATGACTTTAAAGACTTAGATCGGGCGGTAACCGAAAGCGCCAATCATGGCTTTATCAAGGTC
ATTACCCCAAAGGGCAAAGATAAAATATTGGGTGTGACCATCGTCGCTGAACATGCCGGCGACTTGATGGCTGAGTTTGT
ATTGGCCATGAAACACAATCTAGGGCTGAATAAAATACTGGGTACCATTCATATCTATCCAACATGGGCGGAAGGCAATA
AGTATGCAGCTGGCGAATGGAAACGCAATCATGCGCCTAAAAAAGCGCTACAGTTGCTTGAGAAGTATCATACTTGGCGT
CGAGGTTAA

Upstream 100 bases:

>100_bases
TAACTATATGAAAAACTAGCTTATAGTAGGAATACAGCGTTATTCTTTGCTAAGTGATTCTTTATTACATGATGTTTTAT
ATTATTTATCTGGATAATCC

Downstream 100 bases:

>100_bases
TTCATGCAACCTCCTAGCTTGCCAGCAGCCTTTACAATACCAAAAAAACTGAGCCGCTATAGCGCCTTTATCATAGTGCT
TGGTATATGTGTTGGCATCT

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: Hg(II) reductase [H]

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MIKKIVLIFAVLIGVIGFFYFDLNELLTLEGLKGSMDQFEQYKTQSPWLVIGGFFLVYILVTALSLPGAAILTLAAGALF
GLVQGVLVASFASSIGATLAFLTSRYLLRDTIKQRFPDRLASIDAGVKKEGGFYLFTLRLVPIFPFFLINLLMGLTAIKA
RTFYWVSQIGMLAGTFVFVNAGTQLAQIEQLSGILSFNLLASFALLGLFPLIAKGILTILKKRRVYKNYNKPKKFDRNMI
VIGAGAGGLVTSYIAATVKAKVTLIEAGEMGGDCLNYGCVPSKALIKSAKVVEQIRHGERYGLNNSQPDFAFKNIMSRIH
KVIADIAPNDSVERYTDLGVEVLKGYAKLIDPWTVEIALNDGSTQTLTARSIVIATGARPFVPDLPGLDETGYVTSDTLW
DKFAKLDKAPSKLVVLGGGPIGCELAQAFARLGSAVTQIERGTRLMKKEDVEVSVFAQEALTESGVTILTSQQAIRCETR
DGKKHIIVAPKGSTDDQQETAIEYDELICAVGRSARLEGYGLDTLGIDTERTISTDEYLETLYPNIYAAGDVVGPYQFTH
VAAHQAWYAAVNGLFGHLKKFKVDYRVIPWTTFIDPEVARVGLNEQEAIDKGIDFEITRYDFKDLDRAVTESANHGFIKV
ITPKGKDKILGVTIVAEHAGDLMAEFVLAMKHNLGLNKILGTIHIYPTWAEGNKYAAGEWKRNHAPKKALQLLEKYHTWR
RG

Sequences:

>Translated_722_residues
MIKKIVLIFAVLIGVIGFFYFDLNELLTLEGLKGSMDQFEQYKTQSPWLVIGGFFLVYILVTALSLPGAAILTLAAGALF
GLVQGVLVASFASSIGATLAFLTSRYLLRDTIKQRFPDRLASIDAGVKKEGGFYLFTLRLVPIFPFFLINLLMGLTAIKA
RTFYWVSQIGMLAGTFVFVNAGTQLAQIEQLSGILSFNLLASFALLGLFPLIAKGILTILKKRRVYKNYNKPKKFDRNMI
VIGAGAGGLVTSYIAATVKAKVTLIEAGEMGGDCLNYGCVPSKALIKSAKVVEQIRHGERYGLNNSQPDFAFKNIMSRIH
KVIADIAPNDSVERYTDLGVEVLKGYAKLIDPWTVEIALNDGSTQTLTARSIVIATGARPFVPDLPGLDETGYVTSDTLW
DKFAKLDKAPSKLVVLGGGPIGCELAQAFARLGSAVTQIERGTRLMKKEDVEVSVFAQEALTESGVTILTSQQAIRCETR
DGKKHIIVAPKGSTDDQQETAIEYDELICAVGRSARLEGYGLDTLGIDTERTISTDEYLETLYPNIYAAGDVVGPYQFTH
VAAHQAWYAAVNGLFGHLKKFKVDYRVIPWTTFIDPEVARVGLNEQEAIDKGIDFEITRYDFKDLDRAVTESANHGFIKV
ITPKGKDKILGVTIVAEHAGDLMAEFVLAMKHNLGLNKILGTIHIYPTWAEGNKYAAGEWKRNHAPKKALQLLEKYHTWR
RG
>Mature_722_residues
MIKKIVLIFAVLIGVIGFFYFDLNELLTLEGLKGSMDQFEQYKTQSPWLVIGGFFLVYILVTALSLPGAAILTLAAGALF
GLVQGVLVASFASSIGATLAFLTSRYLLRDTIKQRFPDRLASIDAGVKKEGGFYLFTLRLVPIFPFFLINLLMGLTAIKA
RTFYWVSQIGMLAGTFVFVNAGTQLAQIEQLSGILSFNLLASFALLGLFPLIAKGILTILKKRRVYKNYNKPKKFDRNMI
VIGAGAGGLVTSYIAATVKAKVTLIEAGEMGGDCLNYGCVPSKALIKSAKVVEQIRHGERYGLNNSQPDFAFKNIMSRIH
KVIADIAPNDSVERYTDLGVEVLKGYAKLIDPWTVEIALNDGSTQTLTARSIVIATGARPFVPDLPGLDETGYVTSDTLW
DKFAKLDKAPSKLVVLGGGPIGCELAQAFARLGSAVTQIERGTRLMKKEDVEVSVFAQEALTESGVTILTSQQAIRCETR
DGKKHIIVAPKGSTDDQQETAIEYDELICAVGRSARLEGYGLDTLGIDTERTISTDEYLETLYPNIYAAGDVVGPYQFTH
VAAHQAWYAAVNGLFGHLKKFKVDYRVIPWTTFIDPEVARVGLNEQEAIDKGIDFEITRYDFKDLDRAVTESANHGFIKV
ITPKGKDKILGVTIVAEHAGDLMAEFVLAMKHNLGLNKILGTIHIYPTWAEGNKYAAGEWKRNHAPKKALQLLEKYHTWR
RG

Specific function: Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0) [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=502, Percent_Identity=30.2788844621514, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI50301238, Length=471, Percent_Identity=28.4501061571125, Blast_Score=143, Evalue=6e-34,
Organism=Homo sapiens, GI22035672, Length=432, Percent_Identity=26.8518518518519, Blast_Score=119, Evalue=1e-26,
Organism=Homo sapiens, GI148277065, Length=482, Percent_Identity=26.1410788381743, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI33519430, Length=482, Percent_Identity=26.1410788381743, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI33519428, Length=482, Percent_Identity=26.1410788381743, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI33519426, Length=482, Percent_Identity=26.1410788381743, Blast_Score=111, Evalue=3e-24,
Organism=Homo sapiens, GI148277071, Length=482, Percent_Identity=26.1410788381743, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI291045266, Length=434, Percent_Identity=25.8064516129032, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI291045268, Length=432, Percent_Identity=23.1481481481481, Blast_Score=76, Evalue=1e-13,
Organism=Escherichia coli, GI1786307, Length=469, Percent_Identity=29.637526652452, Blast_Score=176, Evalue=4e-45,
Organism=Escherichia coli, GI87082354, Length=476, Percent_Identity=27.9411764705882, Blast_Score=155, Evalue=9e-39,
Organism=Escherichia coli, GI1789915, Length=454, Percent_Identity=29.295154185022, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI87081717, Length=457, Percent_Identity=25.382932166302, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1789065, Length=182, Percent_Identity=33.5164835164835, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI87081964, Length=210, Percent_Identity=30.4761904761905, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI32565766, Length=482, Percent_Identity=32.1576763485477, Blast_Score=213, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17557007, Length=498, Percent_Identity=29.3172690763052, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI71982272, Length=443, Percent_Identity=26.1851015801354, Blast_Score=119, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=444, Percent_Identity=26.3513513513513, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=444, Percent_Identity=26.3513513513513, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17532687, Length=192, Percent_Identity=28.6458333333333, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI115533785, Length=170, Percent_Identity=25.8823529411765, Blast_Score=66, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6325166, Length=473, Percent_Identity=29.5983086680761, Blast_Score=172, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6321091, Length=508, Percent_Identity=27.755905511811, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6325240, Length=477, Percent_Identity=25.7861635220126, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21358499, Length=471, Percent_Identity=31.2101910828025, Blast_Score=208, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24640553, Length=495, Percent_Identity=28.4848484848485, Blast_Score=158, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24640551, Length=492, Percent_Identity=28.6585365853659, Blast_Score=156, Evalue=4e-38,
Organism=Drosophila melanogaster, GI24640549, Length=479, Percent_Identity=28.6012526096033, Blast_Score=156, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17737741, Length=478, Percent_Identity=27.4058577405858, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017969
- InterPro:   IPR006121
- InterPro:   IPR000815
- InterPro:   IPR021179
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00403 HMA; PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.16.1.1 [H]

Molecular weight: Translated: 79337; Mature: 79337

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKIVLIFAVLIGVIGFFYFDLNELLTLEGLKGSMDQFEQYKTQSPWLVIGGFFLVYIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHH
VTALSLPGAAILTLAAGALFGLVQGVLVASFASSIGATLAFLTSRYLLRDTIKQRFPDRL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ASIDAGVKKEGGFYLFTLRLVPIFPFFLINLLMGLTAIKARTFYWVSQIGMLAGTFVFVN
HHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
AGTQLAQIEQLSGILSFNLLASFALLGLFPLIAKGILTILKKRRVYKNYNKPKKFDRNMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
VIGAGAGGLVTSYIAATVKAKVTLIEAGEMGGDCLNYGCVPSKALIKSAKVVEQIRHGER
EEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCC
YGLNNSQPDFAFKNIMSRIHKVIADIAPNDSVERYTDLGVEVLKGYAKLIDPWTVEIALN
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DGSTQTLTARSIVIATGARPFVPDLPGLDETGYVTSDTLWDKFAKLDKAPSKLVVLGGGP
CCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
IGCELAQAFARLGSAVTQIERGTRLMKKEDVEVSVFAQEALTESGVTILTSQQAIRCETR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCEEEECCCCEEEECC
DGKKHIIVAPKGSTDDQQETAIEYDELICAVGRSARLEGYGLDTLGIDTERTISTDEYLE
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHHHH
TLYPNIYAAGDVVGPYQFTHVAAHQAWYAAVNGLFGHLKKFKVDYRVIPWTTFIDPEVAR
HHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEECEEEECCCHHHH
VGLNEQEAIDKGIDFEITRYDFKDLDRAVTESANHGFIKVITPKGKDKILGVTIVAEHAG
CCCCHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEHHHH
DLMAEFVLAMKHNLGLNKILGTIHIYPTWAEGNKYAAGEWKRNHAPKKALQLLEKYHTWR
HHHHHHHHHHHHCCCHHHHEEEEEEEEEECCCCCEECCCCHHCCCHHHHHHHHHHHHHHC
RG
CC
>Mature Secondary Structure
MIKKIVLIFAVLIGVIGFFYFDLNELLTLEGLKGSMDQFEQYKTQSPWLVIGGFFLVYIL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEHHHHHHHHHH
VTALSLPGAAILTLAAGALFGLVQGVLVASFASSIGATLAFLTSRYLLRDTIKQRFPDRL
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
ASIDAGVKKEGGFYLFTLRLVPIFPFFLINLLMGLTAIKARTFYWVSQIGMLAGTFVFVN
HHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
AGTQLAQIEQLSGILSFNLLASFALLGLFPLIAKGILTILKKRRVYKNYNKPKKFDRNMI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCEE
VIGAGAGGLVTSYIAATVKAKVTLIEAGEMGGDCLNYGCVPSKALIKSAKVVEQIRHGER
EEECCCCHHHHHHHHHHHHEEEEEEECCCCCCCHHCCCCCCHHHHHHHHHHHHHHHCCCC
YGLNNSQPDFAFKNIMSRIHKVIADIAPNDSVERYTDLGVEVLKGYAKLIDPWTVEIALN
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEEC
DGSTQTLTARSIVIATGARPFVPDLPGLDETGYVTSDTLWDKFAKLDKAPSKLVVLGGGP
CCCCCEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCC
IGCELAQAFARLGSAVTQIERGTRLMKKEDVEVSVFAQEALTESGVTILTSQQAIRCETR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHCCCCEEEECCCCEEEECC
DGKKHIIVAPKGSTDDQQETAIEYDELICAVGRSARLEGYGLDTLGIDTERTISTDEYLE
CCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCHHHHHH
TLYPNIYAAGDVVGPYQFTHVAAHQAWYAAVNGLFGHLKKFKVDYRVIPWTTFIDPEVAR
HHCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEECEEEECEEEECCCHHHH
VGLNEQEAIDKGIDFEITRYDFKDLDRAVTESANHGFIKVITPKGKDKILGVTIVAEHAG
CCCCHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEEEEHHHH
DLMAEFVLAMKHNLGLNKILGTIHIYPTWAEGNKYAAGEWKRNHAPKKALQLLEKYHTWR
HHHHHHHHHHHHCCCHHHHEEEEEEEEEECCCCCEECCCCHHCCCHHHHHHHHHHHHHHC
RG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2067577 [H]