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The map label for this gene is hom [H]

Identifier: 93005110

GI number: 93005110

Start: 332957

End: 334303

Strand: Reverse

Name: hom [H]

Synonym: Pcryo_0279

Alternate gene names: 93005110

Gene position: 334303-332957 (Counterclockwise)

Preceding gene: 93005111

Following gene: 93005109

Centisome position: 10.93

GC content: 46.18

Gene sequence:

>1347_bases
GTGAGCAAATCCATCAAACTAGCGATACTTGGTTTAGGCACCGTCGGAACGGGCGTGGTCAATCTAATCAATGATAATTT
AGATGAACTAAAACGTCGTAGCGGACGCGACATTGTGATTACCGAAGTTGGTATTCGTCGTCAGCGTGATGACATTAATC
CCAATATTATGCAAAACAGTGATCTGATGGCAACCGCTGCCAGTGACAATGTCGATATTGTCATCGAATTGATTGGCGGT
ACGACCCTTGCAAAAGACGTTATTATGCACGCCATCAAAAATGGCAAGCATGTGGTGACCGCCAATAAAGCGTTATTGGC
TGAGCATGGTAATGAGATTTTTGCTTTTGCTGAACAGCATAATGTTCATGTCGCCTATGAAGCAGCCGTAGCAGGTGGTA
TTCCAATTATTAAGGTCATGCGTGAAGGTTTAGCTGCCAATAAAATTGATTGGCTAGCGGGTATCATTAATGGTACGGGC
AACTTTATCATGACAGAGATGCGCGATAAAGGTCGTCCGTTTGCCGATGTACTGAACGAGGCGCAAGCACTTGGTTATGC
TGAGGCCGACCCTACTTTTGACGTAGAAGGTATCGATGCGGCGCACAAGCTGGCGCTACTTGCCTCTATCGCCTTTGGTA
TTCCATTGCAGTTTGACAAAGTCTATTGTGAAGGTATTACCGGTATTACTTTGCAGGATGTCAATTACGCTGAAGAGCTT
GGCTATCGTATCAAGCACTTGGGCTTTGCAGTTCGCCGTGCAGGAAATGGCAGTGGGGACGACAGCGCTGGTATTGAGCT
GCGTGTACACCCAACACTGATTCCACAGAACGCCCTGCTTGCTAATGTTAATGGCGTAAAGAATGCCGTACTGGTGAACT
CTCACCCTCTCGGTCAGACGTTATATTGCGGTGACGGCGCGGGTGCAGGCGCAACGGCTTCTGCAGTGATGGCAGATGTG
ATGGATTTAGTGCGTGTGTTAGGATGTAAAGATGCTGACCAACAAAACAGCAATGGTCATCATGTACCGCACTTAGCCTT
TATCCCTGAAAAATTGTCAGATACGCCGATATTGCGTGCTGAACAAATGATTACTGGATATTATTTACGTGTACATGCGT
ACGATAGCCCTGGTGTGTTGGCAGATATTACCCGTATCTTGAGTGATGCCGGTATCAATATCGATGCTATTTTACAAAAA
CCGGCGCATAAGCTCGGGCAAGTGCCAGTGATTATTTTAACGCTGCCAGTGGGTGAGAGTCAGATGAATCTTGCCATCGA
AAAAATCGAGAAGTTAGACACCATTATTGATAAAGTAGTACGCATACGCTTAGATGAGCTGGCGTAA

Upstream 100 bases:

>100_bases
AATTTCTATATAAGCGCTTATTTATGTTAGTGATTCTTGTAGTTTCAAGATCTTTCATAGCAGCGTTTTTTATCCCACTA
TTTAATCTCTTGAGGATCCT

Downstream 100 bases:

>100_bases
AAATATACTTTAATCAATCAAATATGTTGGATTAAAATACTCAAAAAAGGAAATAACAATGTCACATGATGCAATTGTAA
TCTTAAACGGCGCTCGCACC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSKSIKLAILGLGTVGTGVVNLINDNLDELKRRSGRDIVITEVGIRRQRDDINPNIMQNSDLMATAASDNVDIVIELIGG
TTLAKDVIMHAIKNGKHVVTANKALLAEHGNEIFAFAEQHNVHVAYEAAVAGGIPIIKVMREGLAANKIDWLAGIINGTG
NFIMTEMRDKGRPFADVLNEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITGITLQDVNYAEEL
GYRIKHLGFAVRRAGNGSGDDSAGIELRVHPTLIPQNALLANVNGVKNAVLVNSHPLGQTLYCGDGAGAGATASAVMADV
MDLVRVLGCKDADQQNSNGHHVPHLAFIPEKLSDTPILRAEQMITGYYLRVHAYDSPGVLADITRILSDAGINIDAILQK
PAHKLGQVPVIILTLPVGESQMNLAIEKIEKLDTIIDKVVRIRLDELA

Sequences:

>Translated_448_residues
MSKSIKLAILGLGTVGTGVVNLINDNLDELKRRSGRDIVITEVGIRRQRDDINPNIMQNSDLMATAASDNVDIVIELIGG
TTLAKDVIMHAIKNGKHVVTANKALLAEHGNEIFAFAEQHNVHVAYEAAVAGGIPIIKVMREGLAANKIDWLAGIINGTG
NFIMTEMRDKGRPFADVLNEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITGITLQDVNYAEEL
GYRIKHLGFAVRRAGNGSGDDSAGIELRVHPTLIPQNALLANVNGVKNAVLVNSHPLGQTLYCGDGAGAGATASAVMADV
MDLVRVLGCKDADQQNSNGHHVPHLAFIPEKLSDTPILRAEQMITGYYLRVHAYDSPGVLADITRILSDAGINIDAILQK
PAHKLGQVPVIILTLPVGESQMNLAIEKIEKLDTIIDKVVRIRLDELA
>Mature_447_residues
SKSIKLAILGLGTVGTGVVNLINDNLDELKRRSGRDIVITEVGIRRQRDDINPNIMQNSDLMATAASDNVDIVIELIGGT
TLAKDVIMHAIKNGKHVVTANKALLAEHGNEIFAFAEQHNVHVAYEAAVAGGIPIIKVMREGLAANKIDWLAGIINGTGN
FIMTEMRDKGRPFADVLNEAQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITGITLQDVNYAEELG
YRIKHLGFAVRRAGNGSGDDSAGIELRVHPTLIPQNALLANVNGVKNAVLVNSHPLGQTLYCGDGAGAGATASAVMADVM
DLVRVLGCKDADQQNSNGHHVPHLAFIPEKLSDTPILRAEQMITGYYLRVHAYDSPGVLADITRILSDAGINIDAILQKP
AHKLGQVPVIILTLPVGESQMNLAIEKIEKLDTIIDKVVRIRLDELA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790376, Length=371, Percent_Identity=24.7978436657682, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786183, Length=262, Percent_Identity=28.2442748091603, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 48003; Mature: 47872

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSIKLAILGLGTVGTGVVNLINDNLDELKRRSGRDIVITEVGIRRQRDDINPNIMQNS
CCCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCEECCC
DLMATAASDNVDIVIELIGGTTLAKDVIMHAIKNGKHVVTANKALLAEHGNEIFAFAEQH
CEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEECC
NVHVAYEAAVAGGIPIIKVMREGLAANKIDWLAGIINGTGNFIMTEMRDKGRPFADVLNE
CEEEEEEEHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITGITLQDVNYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCEEECCCCCEEEECCCHHHHH
GYRIKHLGFAVRRAGNGSGDDSAGIELRVHPTLIPQNALLANVNGVKNAVLVNSHPLGQT
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECEECCCCCEEEECCCCCCEEEEECCCCCCE
LYCGDGAGAGATASAVMADVMDLVRVLGCKDADQQNSNGHHVPHLAFIPEKLSDTPILRA
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHCCCCCCHHH
EQMITGYYLRVHAYDSPGVLADITRILSDAGINIDAILQKPAHKLGQVPVIILTLPVGES
HHHHEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCH
QMNLAIEKIEKLDTIIDKVVRIRLDELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKSIKLAILGLGTVGTGVVNLINDNLDELKRRSGRDIVITEVGIRRQRDDINPNIMQNS
CCCEEEEEEECCCHHHHHHHHHHCCHHHHHHHCCCEEEEEECCCCCCCCCCCCCEECCC
DLMATAASDNVDIVIELIGGTTLAKDVIMHAIKNGKHVVTANKALLAEHGNEIFAFAEQH
CEEEEECCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECHHHHHHCCCEEEEEEECC
NVHVAYEAAVAGGIPIIKVMREGLAANKIDWLAGIINGTGNFIMTEMRDKGRPFADVLNE
CEEEEEEEHHHCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCEEEEECHHCCCCHHHHHHH
AQALGYAEADPTFDVEGIDAAHKLALLASIAFGIPLQFDKVYCEGITGITLQDVNYAEEL
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEECCEEECCCCCEEEECCCHHHHH
GYRIKHLGFAVRRAGNGSGDDSAGIELRVHPTLIPQNALLANVNGVKNAVLVNSHPLGQT
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEECEECCCCCEEEECCCCCCEEEEECCCCCCE
LYCGDGAGAGATASAVMADVMDLVRVLGCKDADQQNSNGHHVPHLAFIPEKLSDTPILRA
EEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCHHCCCCCCHHH
EQMITGYYLRVHAYDSPGVLADITRILSDAGINIDAILQKPAHKLGQVPVIILTLPVGES
HHHHEEEEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCH
QMNLAIEKIEKLDTIIDKVVRIRLDELA
HHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]