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The map label for this gene is phbA [H]

Identifier: 93005109

GI number: 93005109

Start: 331717

End: 332898

Strand: Reverse

Name: phbA [H]

Synonym: Pcryo_0278

Alternate gene names: 93005109

Gene position: 332898-331717 (Counterclockwise)

Preceding gene: 93005110

Following gene: 93005108

Centisome position: 10.88

GC content: 47.97

Gene sequence:

>1182_bases
ATGTCACATGATGCAATTGTAATCTTAAACGGCGCTCGCACCCCGATGGGCGGCTTCCAAGGCGCATTGACAGACATAAG
CGCCACAGATTTGGGCGCAGCGGCTATCAAAGCAGCTGTTGCGCGTTCAGGCGTTAATGTTGATAATATTGATGAAGTTA
TTATGGGCTGTATCTTAACCGCAGGTTTGGGTCAAGGTCCTGCGCGTCAAGCGATGCGCAAAGCTGGCTTGTCTGATGCA
ACGGGTGCGGTTACCATCAATAAGCTGTGCGGCTCAGGTCTAAAAGCAGTTATGCAAGCTCATGACGGTATCAAAGCCGG
AAGCTTTAAGGTTGCTGTTGCTGGCGGTATGGAGTCGATGACCAATGCGCCTTATATCATGCCAGGGTCGCGTGGTGGCT
ATCGCATGGGACATAAAGAAGTCAAAGATCATATGTTCTTAGACGGTCTAGAAGATGCCGATACTGGCAAGCTAATGGGT
CAATTTGCACAAGAAATGGCGGATGAAAAAGGCTATACGCGCGAACAAATGGATGATTTTGCTATTGAGTCGCTAAATCG
TGCACTAACAGCGATCAAAGACAATCATTTCAAAGATGAAATTGAACCAGTTACGTTCAAAACTCGTAAAGGCGAGCAAA
CGGTTGATACCGATGAGCAGCCTGCCCTTGCTAATGCTGAGCGCATCCCTACTTTGCGTCCTGCCTTTGCAAAAGACGGT
ACCATCACCGCAGCAAACGCTAGCTCTATCTCAGACGGTGCTGCAGCTGTTGTATTGATGAAAGAGTCACAAGCCAAAGA
AGAAGGTCTAGAGTATCAAGCGCGTATCATCGCGACTGCCTCTAATTCTCGTCATCCAAGCGAGTTCACTATTGCCCCTG
TTGGCGCAATTGAAAAAGTATTGGCAAGTGCTAGCTGGTCAGTCGCTGATGTCGATTTATGGGAAATCAATGAAGCATTT
GCCATGGTTACGATGGCAGCAATGGATGAGCTAAACATCGAACATGCTAAAGTAAACATAGAAGGCGGTGCTTGTGCCCT
TGGTCATCCAGTGGGCTGTTCAGGCGCTCGTATCCTAGTGACGCTTATTAACTCTCTAAAGCGTACTGGTGGCAAAAAAG
GCGTTGCTACACTATGTATCGGTGGCGGCGAAGCAGTAGCAGTAGCAATCGAATTGGCTTAA

Upstream 100 bases:

>100_bases
ATTGATAAAGTAGTACGCATACGCTTAGATGAGCTGGCGTAAAAATATACTTTAATCAATCAAATATGTTGGATTAAAAT
ACTCAAAAAAGGAAATAACA

Downstream 100 bases:

>100_bases
GTTATTTTAAAATGATCGGTATGCTGTAAATCTTTAGCTTATTATTAGAATCTAAAACCGCATTGCTTTGAGCAATGCGG
TTTTTTTATGTCAAAATATT

Product: Acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSHDAIVILNGARTPMGGFQGALTDISATDLGAAAIKAAVARSGVNVDNIDEVIMGCILTAGLGQGPARQAMRKAGLSDA
TGAVTINKLCGSGLKAVMQAHDGIKAGSFKVAVAGGMESMTNAPYIMPGSRGGYRMGHKEVKDHMFLDGLEDADTGKLMG
QFAQEMADEKGYTREQMDDFAIESLNRALTAIKDNHFKDEIEPVTFKTRKGEQTVDTDEQPALANAERIPTLRPAFAKDG
TITAANASSISDGAAAVVLMKESQAKEEGLEYQARIIATASNSRHPSEFTIAPVGAIEKVLASASWSVADVDLWEINEAF
AMVTMAAMDELNIEHAKVNIEGGACALGHPVGCSGARILVTLINSLKRTGGKKGVATLCIGGGEAVAVAIELA

Sequences:

>Translated_393_residues
MSHDAIVILNGARTPMGGFQGALTDISATDLGAAAIKAAVARSGVNVDNIDEVIMGCILTAGLGQGPARQAMRKAGLSDA
TGAVTINKLCGSGLKAVMQAHDGIKAGSFKVAVAGGMESMTNAPYIMPGSRGGYRMGHKEVKDHMFLDGLEDADTGKLMG
QFAQEMADEKGYTREQMDDFAIESLNRALTAIKDNHFKDEIEPVTFKTRKGEQTVDTDEQPALANAERIPTLRPAFAKDG
TITAANASSISDGAAAVVLMKESQAKEEGLEYQARIIATASNSRHPSEFTIAPVGAIEKVLASASWSVADVDLWEINEAF
AMVTMAAMDELNIEHAKVNIEGGACALGHPVGCSGARILVTLINSLKRTGGKKGVATLCIGGGEAVAVAIELA
>Mature_392_residues
SHDAIVILNGARTPMGGFQGALTDISATDLGAAAIKAAVARSGVNVDNIDEVIMGCILTAGLGQGPARQAMRKAGLSDAT
GAVTINKLCGSGLKAVMQAHDGIKAGSFKVAVAGGMESMTNAPYIMPGSRGGYRMGHKEVKDHMFLDGLEDADTGKLMGQ
FAQEMADEKGYTREQMDDFAIESLNRALTAIKDNHFKDEIEPVTFKTRKGEQTVDTDEQPALANAERIPTLRPAFAKDGT
ITAANASSISDGAAAVVLMKESQAKEEGLEYQARIIATASNSRHPSEFTIAPVGAIEKVLASASWSVADVDLWEINEAFA
MVTMAAMDELNIEHAKVNIEGGACALGHPVGCSGARILVTLINSLKRTGGKKGVATLCIGGGEAVAVAIELA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=391, Percent_Identity=46.0358056265985, Blast_Score=317, Evalue=2e-86,
Organism=Homo sapiens, GI4557237, Length=389, Percent_Identity=42.159383033419, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI167614485, Length=392, Percent_Identity=37.7551020408163, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI4501853, Length=399, Percent_Identity=35.0877192982456, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI4504327, Length=421, Percent_Identity=29.2161520190024, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI194353979, Length=90, Percent_Identity=48.8888888888889, Blast_Score=89, Evalue=7e-18,
Organism=Escherichia coli, GI87082165, Length=387, Percent_Identity=45.2196382428941, Blast_Score=324, Evalue=7e-90,
Organism=Escherichia coli, GI1788554, Length=387, Percent_Identity=48.3204134366925, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI1787663, Length=396, Percent_Identity=36.8686868686869, Blast_Score=221, Evalue=8e-59,
Organism=Escherichia coli, GI48994986, Length=400, Percent_Identity=36.25, Blast_Score=198, Evalue=6e-52,
Organism=Escherichia coli, GI1788683, Length=413, Percent_Identity=29.0556900726392, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17535921, Length=393, Percent_Identity=43.2569974554707, Blast_Score=306, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI25147385, Length=391, Percent_Identity=39.6419437340153, Blast_Score=287, Evalue=6e-78,
Organism=Caenorhabditis elegans, GI133906874, Length=392, Percent_Identity=38.265306122449, Blast_Score=271, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17535917, Length=395, Percent_Identity=30.8860759493671, Blast_Score=178, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=421, Percent_Identity=28.2660332541568, Blast_Score=157, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6325229, Length=398, Percent_Identity=45.2261306532663, Blast_Score=315, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6322031, Length=390, Percent_Identity=34.6153846153846, Blast_Score=183, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24655093, Length=387, Percent_Identity=45.4780361757106, Blast_Score=327, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24640423, Length=388, Percent_Identity=43.5567010309278, Blast_Score=305, Evalue=4e-83,
Organism=Drosophila melanogaster, GI17648125, Length=392, Percent_Identity=34.9489795918367, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI17137578, Length=421, Percent_Identity=28.7410926365796, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40962; Mature: 40831

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00098 THIOLASE_1 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHDAIVILNGARTPMGGFQGALTDISATDLGAAAIKAAVARSGVNVDNIDEVIMGCILT
CCCCEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGLGQGPARQAMRKAGLSDATGAVTINKLCGSGLKAVMQAHDGIKAGSFKVAVAGGMESM
HCCCCCHHHHHHHHCCCCCCCCCEEHHHHHCHHHHHHHHHHCCCCCCCEEEEEECCHHHH
TNAPYIMPGSRGGYRMGHKEVKDHMFLDGLEDADTGKLMGQFAQEMADEKGYTREQMDDF
CCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AIESLNRALTAIKDNHFKDEIEPVTFKTRKGEQTVDTDEQPALANAERIPTLRPAFAKDG
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC
TITAANASSISDGAAAVVLMKESQAKEEGLEYQARIIATASNSRHPSEFTIAPVGAIEKV
EEEECCCCCCCCCCEEEEEEECCCCHHHCCCEEEEEEEEECCCCCCCCEEEECHHHHHHH
LASASWSVADVDLWEINEAFAMVTMAAMDELNIEHAKVNIEGGACALGHPVGCSGARILV
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCCCCCHHHHH
TLINSLKRTGGKKGVATLCIGGGEAVAVAIELA
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure 
SHDAIVILNGARTPMGGFQGALTDISATDLGAAAIKAAVARSGVNVDNIDEVIMGCILT
CCCEEEEEECCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AGLGQGPARQAMRKAGLSDATGAVTINKLCGSGLKAVMQAHDGIKAGSFKVAVAGGMESM
HCCCCCHHHHHHHHCCCCCCCCCEEHHHHHCHHHHHHHHHHCCCCCCCEEEEEECCHHHH
TNAPYIMPGSRGGYRMGHKEVKDHMFLDGLEDADTGKLMGQFAQEMADEKGYTREQMDDF
CCCCEEECCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHH
AIESLNRALTAIKDNHFKDEIEPVTFKTRKGEQTVDTDEQPALANAERIPTLRPAFAKDG
HHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCC
TITAANASSISDGAAAVVLMKESQAKEEGLEYQARIIATASNSRHPSEFTIAPVGAIEKV
EEEECCCCCCCCCCEEEEEEECCCCHHHCCCEEEEEEEEECCCCCCCCEEEECHHHHHHH
LASASWSVADVDLWEINEAFAMVTMAAMDELNIEHAKVNIEGGACALGHPVGCSGARILV
HHHCCCCEEEEEHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEECCCCCCCCCHHHHH
TLINSLKRTGGKKGVATLCIGGGEAVAVAIELA
HHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1396692 [H]