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The map label for this gene is yngI [H]

Identifier: 93005024

GI number: 93005024

Start: 226182

End: 227846

Strand: Reverse

Name: yngI [H]

Synonym: Pcryo_0193

Alternate gene names: 93005024

Gene position: 227846-226182 (Counterclockwise)

Preceding gene: 93005028

Following gene: 93005019

Centisome position: 7.45

GC content: 48.35

Gene sequence:

>1665_bases
ATGACAGACTTCCATACCGGTCTCGGCAAAAATGCTGCCAACCATCAACCGCTTACCCCTATTGATTTTATCATCCGTAG
TGCTCAGGTCTATCCTGACAGAACCGCTATCATCTATGACGACTTAGAACATAATAACCTCACCCAAACGTGGCAACAGA
CTTATGATCGTTGCAGACAACTGGCGGATGGTCTGCGTAAATTAGGCATTGATAAAAATGACACAGTTGCAGTCATGATG
CCAAACACCCCAGCGATGGTCGAATGCGCTTTTGGTGTACCCATGTCAGGTGGCGTGCTTTGTACGCTGAACACCCGCCT
CGACATCAATGCCCTGACCTTTTGTCTACAGCATTCAGAAGCGAAGGTCTTAATTTTAGACAGCGAGTTTGCTGAACATG
CTGAAATGATCGATGAAACCTTTCCAAATCTAATCGTGATTCATGCGACAGATGCGGCGCTCGATATTGAAGGTTTTGGA
CAAATGAGCTACGAAGCATTACTCGCCAGCTCAGACAGTTTGGATAATTGGGAAAAACCATTAGATGAATGGGATGCTAT
CGCGCTCAACTATACCTCTGGCACCACGGGCAAGCCCAAAGGCGTGGTCTATCATCATCGCGGTGCCACCCTCAACGCAA
TCTCTAACATTTTAGATTGGGACATGCCCAAGCACCCTATGTATCTGTGGACGCTGCCATTATTTCATTGTAATGGCTGG
TGCTTTCCGTGGACGATCGCTGAGCGCGCTGGGGTCAATGTCTGCTTGCGGAACATTGATGCCGACTTGATATTGCAGCT
GATTGCCAAGCATCAAGTCAGCCATTATTGTTCAGCGCCTGTGGTGCACAATATGATTGCGGGCGGCAAACCTGAGTATA
AAGAAGCCATCACTCATACGGTCAAAGGCTGGGTCGCTGGTGCGCCGCCATCTGAGACCATGCTCGCAGCCATGGAAGCG
ATGGGCTTTCACATCTCCCACGTTTATGGTCTCACTGAAGTTTATGGGCCCGTCACCGTCTGCGCTGAGCAGCAAGAATG
GGATACGCTTGATGTCGCTGGCCGCGCGCAGAAAAAATCACGTCAAGGGGTGACGTCGCATTTGATGACGGGATTTGACG
TGTTCAAACAAGGCACGACTGAACCCGTTGCCGCTGATGGCGAAGAGATGGGCGAGCTGGCACTGCGCGGTAATATGGTA
ATGAAAGGTTATCTAAAAAGTCGTAAAGCCACCGAAGAAGCCTTGACTGATGGCTGGTTCCGCACCGGTGATTTAGGGGT
CAAATATCCTGACGGCTATATCAAAATCATGGACAGGCTTAAAGATATTATCATATCAGGCGGTGAAAACATCTCTAGTA
TCGAAGTCGAGAACGTCCTATATAAAATGCTAGAAATTCAAAGCTGTGCGGTCGTCGCCGCGCCGCATGATAAATGGGGC
GAAGTACCTGTCGCCTTTATCGAGATTCATGAAGGCAGCACTTTACAGCGCGATCATGTGATGGAACATTGCAAACAGCA
CCTTGCTGGTTTTAAAGTACCAAAATATATTGTCTTTGCTGAAATCCCAAAGACAAGCACTGGTAAAGTGCAGAAGTTTG
AGCTGCGTCAAGCGGCCAAATCCTTAGCACATGAAACGCCAAAAGTAACGGCTAGTGCTAAGTAA

Upstream 100 bases:

>100_bases
ACTGTCTATAATAATCAGATCCTGATACAGTTGATTGGCGACAGCAAAGCCCCATTACTGCGTCATCGACTACAAAAACA
TATGATAAAGGACTATCTGC

Downstream 100 bases:

>100_bases
GTGTTTATCATTAAGCCTTAATAATACGGAAGTATCGTTAATATTAATGAATCATCATTGATAAAAAAGGTCAGCCTAAT
GAATGTAGGCTGACCCTTTT

Product: AMP-dependent synthetase and ligase

Products: D-carnitinyl-CoA; crotonobetainyl-CoA; L-carnitinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTDFHTGLGKNAANHQPLTPIDFIIRSAQVYPDRTAIIYDDLEHNNLTQTWQQTYDRCRQLADGLRKLGIDKNDTVAVMM
PNTPAMVECAFGVPMSGGVLCTLNTRLDINALTFCLQHSEAKVLILDSEFAEHAEMIDETFPNLIVIHATDAALDIEGFG
QMSYEALLASSDSLDNWEKPLDEWDAIALNYTSGTTGKPKGVVYHHRGATLNAISNILDWDMPKHPMYLWTLPLFHCNGW
CFPWTIAERAGVNVCLRNIDADLILQLIAKHQVSHYCSAPVVHNMIAGGKPEYKEAITHTVKGWVAGAPPSETMLAAMEA
MGFHISHVYGLTEVYGPVTVCAEQQEWDTLDVAGRAQKKSRQGVTSHLMTGFDVFKQGTTEPVAADGEEMGELALRGNMV
MKGYLKSRKATEEALTDGWFRTGDLGVKYPDGYIKIMDRLKDIIISGGENISSIEVENVLYKMLEIQSCAVVAAPHDKWG
EVPVAFIEIHEGSTLQRDHVMEHCKQHLAGFKVPKYIVFAEIPKTSTGKVQKFELRQAAKSLAHETPKVTASAK

Sequences:

>Translated_554_residues
MTDFHTGLGKNAANHQPLTPIDFIIRSAQVYPDRTAIIYDDLEHNNLTQTWQQTYDRCRQLADGLRKLGIDKNDTVAVMM
PNTPAMVECAFGVPMSGGVLCTLNTRLDINALTFCLQHSEAKVLILDSEFAEHAEMIDETFPNLIVIHATDAALDIEGFG
QMSYEALLASSDSLDNWEKPLDEWDAIALNYTSGTTGKPKGVVYHHRGATLNAISNILDWDMPKHPMYLWTLPLFHCNGW
CFPWTIAERAGVNVCLRNIDADLILQLIAKHQVSHYCSAPVVHNMIAGGKPEYKEAITHTVKGWVAGAPPSETMLAAMEA
MGFHISHVYGLTEVYGPVTVCAEQQEWDTLDVAGRAQKKSRQGVTSHLMTGFDVFKQGTTEPVAADGEEMGELALRGNMV
MKGYLKSRKATEEALTDGWFRTGDLGVKYPDGYIKIMDRLKDIIISGGENISSIEVENVLYKMLEIQSCAVVAAPHDKWG
EVPVAFIEIHEGSTLQRDHVMEHCKQHLAGFKVPKYIVFAEIPKTSTGKVQKFELRQAAKSLAHETPKVTASAK
>Mature_553_residues
TDFHTGLGKNAANHQPLTPIDFIIRSAQVYPDRTAIIYDDLEHNNLTQTWQQTYDRCRQLADGLRKLGIDKNDTVAVMMP
NTPAMVECAFGVPMSGGVLCTLNTRLDINALTFCLQHSEAKVLILDSEFAEHAEMIDETFPNLIVIHATDAALDIEGFGQ
MSYEALLASSDSLDNWEKPLDEWDAIALNYTSGTTGKPKGVVYHHRGATLNAISNILDWDMPKHPMYLWTLPLFHCNGWC
FPWTIAERAGVNVCLRNIDADLILQLIAKHQVSHYCSAPVVHNMIAGGKPEYKEAITHTVKGWVAGAPPSETMLAAMEAM
GFHISHVYGLTEVYGPVTVCAEQQEWDTLDVAGRAQKKSRQGVTSHLMTGFDVFKQGTTEPVAADGEEMGELALRGNMVM
KGYLKSRKATEEALTDGWFRTGDLGVKYPDGYIKIMDRLKDIIISGGENISSIEVENVLYKMLEIQSCAVVAAPHDKWGE
VPVAFIEIHEGSTLQRDHVMEHCKQHLAGFKVPKYIVFAEIPKTSTGKVQKFELRQAAKSLAHETPKVTASAK

Specific function: Could Catalyze The Transfer Of CoA To Crotonobetaine Or Carnitine. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=548, Percent_Identity=27.7372262773723, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI157311624, Length=490, Percent_Identity=24.6938775510204, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI157311622, Length=490, Percent_Identity=24.6938775510204, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI42544132, Length=530, Percent_Identity=25.4716981132075, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI58082049, Length=494, Percent_Identity=23.8866396761134, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI38505220, Length=488, Percent_Identity=25, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI115511026, Length=522, Percent_Identity=23.7547892720307, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI122937307, Length=538, Percent_Identity=23.2342007434944, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI187761345, Length=151, Percent_Identity=37.0860927152318, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI187761343, Length=151, Percent_Identity=37.0860927152318, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI42794756, Length=170, Percent_Identity=31.7647058823529, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI42794760, Length=170, Percent_Identity=31.7647058823529, Blast_Score=68, Evalue=3e-11,
Organism=Homo sapiens, GI42794758, Length=170, Percent_Identity=31.7647058823529, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI221142682, Length=518, Percent_Identity=25.6756756756757, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI1788107, Length=571, Percent_Identity=25.3940455341506, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI145693145, Length=532, Percent_Identity=25.7518796992481, Blast_Score=119, Evalue=7e-28,
Organism=Escherichia coli, GI1786810, Length=508, Percent_Identity=26.1811023622047, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789201, Length=478, Percent_Identity=21.7573221757322, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71994703, Length=558, Percent_Identity=28.3154121863799, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994694, Length=558, Percent_Identity=28.3154121863799, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71994690, Length=558, Percent_Identity=28.3154121863799, Blast_Score=183, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17560308, Length=553, Percent_Identity=26.5822784810127, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17558820, Length=370, Percent_Identity=28.9189189189189, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17559526, Length=511, Percent_Identity=25.6360078277886, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32563687, Length=552, Percent_Identity=25.3623188405797, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=524, Percent_Identity=23.6641221374046, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=533, Percent_Identity=24.015009380863, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17560140, Length=530, Percent_Identity=21.6981132075472, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17557194, Length=531, Percent_Identity=22.7871939736347, Blast_Score=105, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=533, Percent_Identity=23.2645403377111, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71985884, Length=359, Percent_Identity=28.133704735376, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17510401, Length=479, Percent_Identity=20.8768267223382, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=548, Percent_Identity=24.6350364963504, Blast_Score=116, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319264, Length=568, Percent_Identity=22.5352112676056, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24581924, Length=547, Percent_Identity=25.5941499085923, Blast_Score=143, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21355181, Length=529, Percent_Identity=24.5746691871456, Blast_Score=117, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18859661, Length=520, Percent_Identity=25.5769230769231, Blast_Score=112, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17933690, Length=541, Percent_Identity=23.6598890942699, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21356947, Length=564, Percent_Identity=21.9858156028369, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19921316, Length=178, Percent_Identity=32.0224719101124, Blast_Score=76, Evalue=6e-14,
Organism=Drosophila melanogaster, GI20130357, Length=383, Percent_Identity=23.4986945169713, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24648255, Length=471, Percent_Identity=21.8683651804671, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648253, Length=475, Percent_Identity=21.6842105263158, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.3.2.- [C]

Molecular weight: Translated: 61385; Mature: 61254

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFHTGLGKNAANHQPLTPIDFIIRSAQVYPDRTAIIYDDLEHNNLTQTWQQTYDRCRQ
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LADGLRKLGIDKNDTVAVMMPNTPAMVECAFGVPMSGGVLCTLNTRLDINALTFCLQHSE
HHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCCC
AKVLILDSEFAEHAEMIDETFPNLIVIHATDAALDIEGFGQMSYEALLASSDSLDNWEKP
CEEEEEECHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCCHHHCC
LDEWDAIALNYTSGTTGKPKGVVYHHRGATLNAISNILDWDMPKHPMYLWTLPLFHCNGW
HHCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCE
CFPWTIAERAGVNVCLRNIDADLILQLIAKHQVSHYCSAPVVHNMIAGGKPEYKEAITHT
EEECHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHH
VKGWVAGAPPSETMLAAMEAMGFHISHVYGLTEVYGPVTVCAEQQEWDTLDVAGRAQKKS
HHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCHHHHH
RQGVTSHLMTGFDVFKQGTTEPVAADGEEMGELALRGNMVMKGYLKSRKATEEALTDGWF
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCE
RTGDLGVKYPDGYIKIMDRLKDIIISGGENISSIEVENVLYKMLEIQSCAVVAAPHDKWG
EECCCCEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCC
EVPVAFIEIHEGSTLQRDHVMEHCKQHLAGFKVPKYIVFAEIPKTSTGKVQKFELRQAAK
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
SLAHETPKVTASAK
HHHHCCCCCCCCCC
>Mature Secondary Structure 
TDFHTGLGKNAANHQPLTPIDFIIRSAQVYPDRTAIIYDDLEHNNLTQTWQQTYDRCRQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHHHH
LADGLRKLGIDKNDTVAVMMPNTPAMVECAFGVPMSGGVLCTLNTRLDINALTFCLQHSE
HHHHHHHHCCCCCCEEEEEECCCCCEEEEEECCCCCCCEEEEEECCCCHHHHHHHHCCCC
AKVLILDSEFAEHAEMIDETFPNLIVIHATDAALDIEGFGQMSYEALLASSDSLDNWEKP
CEEEEEECHHHHHHHHHHHCCCCEEEEEECCCEEECCCCCCHHHHHHHHCCCCCCHHHCC
LDEWDAIALNYTSGTTGKPKGVVYHHRGATLNAISNILDWDMPKHPMYLWTLPLFHCNGW
HHCCCEEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCEEEEEEHHHHCCCE
CFPWTIAERAGVNVCLRNIDADLILQLIAKHQVSHYCSAPVVHNMIAGGKPEYKEAITHT
EEECHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHH
VKGWVAGAPPSETMLAAMEAMGFHISHVYGLTEVYGPVTVCAEQQEWDTLDVAGRAQKKS
HHHHCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCCEEECCCCCCCCHHHCCCHHHHH
RQGVTSHLMTGFDVFKQGTTEPVAADGEEMGELALRGNMVMKGYLKSRKATEEALTDGWF
HHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCE
RTGDLGVKYPDGYIKIMDRLKDIIISGGENISSIEVENVLYKMLEIQSCAVVAAPHDKWG
EECCCCEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCCC
EVPVAFIEIHEGSTLQRDHVMEHCKQHLAGFKVPKYIVFAEIPKTSTGKVQKFELRQAAK
CCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHH
SLAHETPKVTASAK
HHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Coenzyme A; D-carnitine; Coenzyme A; crotono-betaine; L-carnitine [C]

Specific reaction: Coenzyme A + D-carnitine = D-carnitinyl-CoA Coenzyme A + crotono-betaine = crotonobetainyl-CoA Coenzyme A + L-carnitine = L-carnitinyl-CoA [C]

General reaction: Ligases; Forming Carbon-Sulfur Bonds; Acid-Thiol Ligases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]