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The map label for this gene is 92115286

Identifier: 92115286

GI number: 92115286

Start: 3536168

End: 3537463

Strand: Direct

Name: 92115286

Synonym: Csal_3171

Alternate gene names: NA

Gene position: 3536168-3537463 (Clockwise)

Preceding gene: 92115285

Following gene: 92115292

Centisome position: 95.66

GC content: 68.52

Gene sequence:

>1296_bases
ATGCTAGGCCCATGTTCCCCTGCCCAGGAGGCCGCCATGACATTCTCTCCCCCCACGACCGCCCCGCTCGACGCCTTGCC
GGCGACACCGGACTACGATGCCTGGCCTATCGAGGTCGCCATCCAGCACGTGAGCCACACTCCCCGCCAGGTCGAAGTGC
GCTGGGAAGACGGTCGCGTCAGTCGATACCACAGCATCTGGCTGCGCGAAAACGCCGCCGACGACAGCACCGTCAATCCG
GCCACCCGCGAGCGCATCCTCGACCTGTCACGCCTCGGGGCGTGGCCCACGGTCAGCGAGGCGCGCCTCGACGACGCCGG
TGCGCTGGAGATCGTCTTCGCCCCGGAGCAACGCCGCCTGCGATTTCATCCCGGCTGGCTGCGAGCCCACGATTACGCCA
ACCTGGACACGCCAGAAGCGCCACTGGTCCCCACGACGCTGTGGAAAGGCAGCGAGCGCGACGCGCCCACCACTCTCGAT
GCGCATGACTGGCTAAGCGCCGACGACGATCCCCTGGCACCGGACGCCTGCCTCGAAAGCGCCCTCGAGGCCGTCATCGG
CGAAGGCCTGGTGAGGCTACGCAATCTGCCCACCGACCCCGGCAGCCTGGATGCCATCGCCCGGCGCATCGGCCCGCCGC
GCACCACCAACTTCGGCACGCTGTTCGACGTGCGTGCCAAGCCCGACCCCGACTCCAATGCCTACACCTCGATCGCCCTG
CCACCGCACGTCGATCTGCCGACCCGCGAGTACCAGCCCGGTCTGCAGTTGCTGCATTGCCTGGAAAACGACACCGTCGG
CGGCGATGCCGTGATGATGGACGGTTTCGCCGTGGCCGAGGCCCTGCGCGAGCGTCATCCCGAACATTTCGCGACGCTCA
CGCGCGTGCGCTGGTGCTACGCCAACACGGCCCGCACCACCGACCACGTATGGTTCGACCCGATGATCAAGCTGGACGCC
AACGGCCACTTCGACGAGGTACGCATCGCCGACTTTCTGCGCGGCCCGCTGATGGCGCCGTTCGAGGACGTGGAGCCTGC
CTATGCCGCCTTGATGGCGCTGCAGCGCCTGCTGCGCGAGCCGGAGTTTGCGTTGCGTTTCAGTTACGCGCCCGGCGACA
TGGTGATCTTCGACAACCGCCGCTTGTTGCACGCCCGCGATGCCTTCGATGTCGGCCAGGGCGGGCGCCGCTGGCTGCAG
GGCTGCTACCTGGAGCGCGACGAGGCCCGCTCGCGGCTGCGCATGTTGCGCCGTGCCCACCGCCGGCAATGCGTCGACGC
CCTCGCGCACGGCTGA

Upstream 100 bases:

>100_bases
CGCGACACGCCCGCCGCGGCCCCGACACTCCCCCCACGGCATGACGACTGACGGCAAGAAGACGTCGCCTGAGGTGTAAA
CGGCGGTGACGAGGGACGCC

Downstream 100 bases:

>100_bases
CCACGCGAGCCCCGGCCACAAAAAACCCCCATGGCACGCCATGGGGGTTTTTTTGCCTCGCGCATGCTCAGCGACGCGGT
ATGCCGATGCGCCGCCCGGC

Product: taurine catabolism dioxygenase TauD/TfdA

Products: NA

Alternate protein names: Gamma-butyrobetaine hydroxylase; Gamma-BBH; Gamma-butyrobetaine,2-oxoglutarate dioxygenase [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MLGPCSPAQEAAMTFSPPTTAPLDALPATPDYDAWPIEVAIQHVSHTPRQVEVRWEDGRVSRYHSIWLRENAADDSTVNP
ATRERILDLSRLGAWPTVSEARLDDAGALEIVFAPEQRRLRFHPGWLRAHDYANLDTPEAPLVPTTLWKGSERDAPTTLD
AHDWLSADDDPLAPDACLESALEAVIGEGLVRLRNLPTDPGSLDAIARRIGPPRTTNFGTLFDVRAKPDPDSNAYTSIAL
PPHVDLPTREYQPGLQLLHCLENDTVGGDAVMMDGFAVAEALRERHPEHFATLTRVRWCYANTARTTDHVWFDPMIKLDA
NGHFDEVRIADFLRGPLMAPFEDVEPAYAALMALQRLLREPEFALRFSYAPGDMVIFDNRRLLHARDAFDVGQGGRRWLQ
GCYLERDEARSRLRMLRRAHRRQCVDALAHG

Sequences:

>Translated_431_residues
MLGPCSPAQEAAMTFSPPTTAPLDALPATPDYDAWPIEVAIQHVSHTPRQVEVRWEDGRVSRYHSIWLRENAADDSTVNP
ATRERILDLSRLGAWPTVSEARLDDAGALEIVFAPEQRRLRFHPGWLRAHDYANLDTPEAPLVPTTLWKGSERDAPTTLD
AHDWLSADDDPLAPDACLESALEAVIGEGLVRLRNLPTDPGSLDAIARRIGPPRTTNFGTLFDVRAKPDPDSNAYTSIAL
PPHVDLPTREYQPGLQLLHCLENDTVGGDAVMMDGFAVAEALRERHPEHFATLTRVRWCYANTARTTDHVWFDPMIKLDA
NGHFDEVRIADFLRGPLMAPFEDVEPAYAALMALQRLLREPEFALRFSYAPGDMVIFDNRRLLHARDAFDVGQGGRRWLQ
GCYLERDEARSRLRMLRRAHRRQCVDALAHG
>Mature_431_residues
MLGPCSPAQEAAMTFSPPTTAPLDALPATPDYDAWPIEVAIQHVSHTPRQVEVRWEDGRVSRYHSIWLRENAADDSTVNP
ATRERILDLSRLGAWPTVSEARLDDAGALEIVFAPEQRRLRFHPGWLRAHDYANLDTPEAPLVPTTLWKGSERDAPTTLD
AHDWLSADDDPLAPDACLESALEAVIGEGLVRLRNLPTDPGSLDAIARRIGPPRTTNFGTLFDVRAKPDPDSNAYTSIAL
PPHVDLPTREYQPGLQLLHCLENDTVGGDAVMMDGFAVAEALRERHPEHFATLTRVRWCYANTARTTDHVWFDPMIKLDA
NGHFDEVRIADFLRGPLMAPFEDVEPAYAALMALQRLLREPEFALRFSYAPGDMVIFDNRRLLHARDAFDVGQGGRRWLQ
GCYLERDEARSRLRMLRRAHRRQCVDALAHG

Specific function: Catalyzes the formation of L-carnitine from gamma- butyrobetaine [H]

COG id: COG2175

COG function: function code Q; Probable taurine catabolism dioxygenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-BBH/TMLD family [H]

Homologues:

Organism=Homo sapiens, GI4502369, Length=379, Percent_Identity=28.7598944591029, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI8922625, Length=366, Percent_Identity=25.4098360655738, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI296317249, Length=240, Percent_Identity=24.5833333333333, Blast_Score=90, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17534641, Length=399, Percent_Identity=29.5739348370927, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI71992672, Length=390, Percent_Identity=23.5897435897436, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI221329931, Length=369, Percent_Identity=31.1653116531165, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI24639015, Length=389, Percent_Identity=30.3341902313625, Blast_Score=158, Evalue=7e-39,
Organism=Drosophila melanogaster, GI19922166, Length=402, Percent_Identity=30.3482587064677, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI24648401, Length=247, Percent_Identity=27.1255060728745, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012775
- InterPro:   IPR010376
- InterPro:   IPR003819 [H]

Pfam domain/function: PF06155 DUF971; PF02668 TauD [H]

EC number: =1.14.11.1 [H]

Molecular weight: Translated: 48391; Mature: 48391

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGPCSPAQEAAMTFSPPTTAPLDALPATPDYDAWPIEVAIQHVSHTPRQVEVRWEDGRV
CCCCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
SRYHSIWLRENAADDSTVNPATRERILDLSRLGAWPTVSEARLDDAGALEIVFAPEQRRL
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCCCCE
RFHPGWLRAHDYANLDTPEAPLVPTTLWKGSERDAPTTLDAHDWLSADDDPLAPDACLES
EECCCEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHH
ALEAVIGEGLVRLRNLPTDPGSLDAIARRIGPPRTTNFGTLFDVRAKPDPDSNAYTSIAL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEC
PPHVDLPTREYQPGLQLLHCLENDTVGGDAVMMDGFAVAEALRERHPEHFATLTRVRWCY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHHH
ANTARTTDHVWFDPMIKLDANGHFDEVRIADFLRGPLMAPFEDVEPAYAALMALQRLLRE
CCCCCCCCCEEECCEEEECCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCC
PEFALRFSYAPGDMVIFDNRRLLHARDAFDVGQGGRRWLQGCYLERDEARSRLRMLRRAH
CCEEEEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
RRQCVDALAHG
HHHHHHHHHCC
>Mature Secondary Structure
MLGPCSPAQEAAMTFSPPTTAPLDALPATPDYDAWPIEVAIQHVSHTPRQVEVRWEDGRV
CCCCCCCHHHCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCCC
SRYHSIWLRENAADDSTVNPATRERILDLSRLGAWPTVSEARLDDAGALEIVFAPEQRRL
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCEEEEECCCCCCE
RFHPGWLRAHDYANLDTPEAPLVPTTLWKGSERDAPTTLDAHDWLSADDDPLAPDACLES
EECCCEEEECCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHHHH
ALEAVIGEGLVRLRNLPTDPGSLDAIARRIGPPRTTNFGTLFDVRAKPDPDSNAYTSIAL
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCEEEEEC
PPHVDLPTREYQPGLQLLHCLENDTVGGDAVMMDGFAVAEALRERHPEHFATLTRVRWCY
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHCHHHHHHHHHHHHHH
ANTARTTDHVWFDPMIKLDANGHFDEVRIADFLRGPLMAPFEDVEPAYAALMALQRLLRE
CCCCCCCCCEEECCEEEECCCCCCCHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHCC
PEFALRFSYAPGDMVIFDNRRLLHARDAFDVGQGGRRWLQGCYLERDEARSRLRMLRRAH
CCEEEEEEECCCCEEEECCCEEEEECCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHH
RRQCVDALAHG
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8504802 [H]