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The map label for this gene is purM

Identifier: 92114234

GI number: 92114234

Start: 2381839

End: 2382915

Strand: Direct

Name: purM

Synonym: Csal_2112

Alternate gene names: 92114234

Gene position: 2381839-2382915 (Clockwise)

Preceding gene: 92114231

Following gene: 92114235

Centisome position: 64.43

GC content: 66.57

Gene sequence:

>1077_bases
ATGACTCGCAGTTCGGACACGCCCTCCTCTTCCCGCGCATCGCTCAGCTACAAGGATGCTGGCGTGGACATCGACGCCGG
CAACGCGCTCGTCGAACGCATCAAGGGCGTCGCCAAGCGTACCTCCCGCCCCGAAGTGATGGGCGGCCTGGGAGGCTTCG
GCGCGCTGTGCCAATTGCCCACCGGTTATCGCGAGCCGGTGCTGGTCTCCGGCACCGACGGCGTCGGCACCAAGCTTCGT
CTGGCCATGGACCTCGCACGCCATGACACCATCGGCATCGATCTGGTGGCCATGTGCGTCAACGACCTGGTCGTCGCCGG
CGCCGAACCCTTGTTCTTCCTCGACTACTATGCCACCGGCAAGCTGGATGTCGATATCGCCGCCGACGTCGTCACCGGCA
TCGGCGAAGGTTGCGCCCAGGCCGGATGCGCGCTGATCGGCGGCGAGACCGCGGAAATGCCCGGCATGTACGCGGGCAGC
GATTACGATCTGGCCGGCTTCTGTGTCGGCGTGGTCGAGAAGTCCGAGATTCTCGATGGCAGCCGCGTCGCCGAGGGCGA
CGTGCTGTTGGGCCTGGCGTCTTCCGGCCCGCATTCCAACGGCTACTCGCTGATCCGCAAGATCATCGAGCGGGGCCAGG
CCGACCTCGAGCAGGAGATCGACGGCATTCCCCTGCGCGACGCCCTGCTCGCGCCGACCCGCATTTACGTGAAGTCGCTG
CTGTCGCTGATCAAGGAAAGCGACGTGACCGTCCACGCGCTCTCCCACATCACCGGCGGGGGTCTGCTCGAGAACGTGCC
CCGCGTGCTGCCCGATACGCTCGCGGCGCGCATCGATGCGGCGAGCTGGACGCGCCCTGCGGTCTTCGACTGGCTGCAGC
GCGAAGGCAACGTCGACGAACACGAAATGCATCGCGTGCTCAATTGCGGTATCGGCATGGTCGTCGTCGTCCCCGCCGCT
CAGGCCGAACGCGCCCAGGCCGCGCTCGAAGCGGCCGGCGAAACGGTGCATCGTCTCGGCGAGATCGTCCCGCGCCAGGA
CGAGGAAGAACAAGTCCGATTGGAGAACGTCCGCTGA

Upstream 100 bases:

>100_bases
TGCGGGCTTCCCTTATTCCGCTCTGGCCTCGGGCGCCAGGCGGCGCCATCGGCTTCGCTCGGTCGCCTCCGCGACCGGCT
CACTGTTGACAGGAATGCCC

Downstream 100 bases:

>100_bases
TGAACGACATGCCTCACGCCGATAACGCCGAAGCCGACACCAACGGCTTCACCCCCGAACCGGTGGACAAGCGTCGCGTC
GTGGTGCTGATTTCAGGCAA

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MTRSSDTPSSSRASLSYKDAGVDIDAGNALVERIKGVAKRTSRPEVMGGLGGFGALCQLPTGYREPVLVSGTDGVGTKLR
LAMDLARHDTIGIDLVAMCVNDLVVAGAEPLFFLDYYATGKLDVDIAADVVTGIGEGCAQAGCALIGGETAEMPGMYAGS
DYDLAGFCVGVVEKSEILDGSRVAEGDVLLGLASSGPHSNGYSLIRKIIERGQADLEQEIDGIPLRDALLAPTRIYVKSL
LSLIKESDVTVHALSHITGGGLLENVPRVLPDTLAARIDAASWTRPAVFDWLQREGNVDEHEMHRVLNCGIGMVVVVPAA
QAERAQAALEAAGETVHRLGEIVPRQDEEEQVRLENVR

Sequences:

>Translated_358_residues
MTRSSDTPSSSRASLSYKDAGVDIDAGNALVERIKGVAKRTSRPEVMGGLGGFGALCQLPTGYREPVLVSGTDGVGTKLR
LAMDLARHDTIGIDLVAMCVNDLVVAGAEPLFFLDYYATGKLDVDIAADVVTGIGEGCAQAGCALIGGETAEMPGMYAGS
DYDLAGFCVGVVEKSEILDGSRVAEGDVLLGLASSGPHSNGYSLIRKIIERGQADLEQEIDGIPLRDALLAPTRIYVKSL
LSLIKESDVTVHALSHITGGGLLENVPRVLPDTLAARIDAASWTRPAVFDWLQREGNVDEHEMHRVLNCGIGMVVVVPAA
QAERAQAALEAAGETVHRLGEIVPRQDEEEQVRLENVR
>Mature_357_residues
TRSSDTPSSSRASLSYKDAGVDIDAGNALVERIKGVAKRTSRPEVMGGLGGFGALCQLPTGYREPVLVSGTDGVGTKLRL
AMDLARHDTIGIDLVAMCVNDLVVAGAEPLFFLDYYATGKLDVDIAADVVTGIGEGCAQAGCALIGGETAEMPGMYAGSD
YDLAGFCVGVVEKSEILDGSRVAEGDVLLGLASSGPHSNGYSLIRKIIERGQADLEQEIDGIPLRDALLAPTRIYVKSLL
SLIKESDVTVHALSHITGGGLLENVPRVLPDTLAARIDAASWTRPAVFDWLQREGNVDEHEMHRVLNCGIGMVVVVPAAQ
AERAQAALEAAGETVHRLGEIVPRQDEEEQVRLENVR

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=350, Percent_Identity=50.8571428571429, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI209869995, Length=350, Percent_Identity=50.8571428571429, Blast_Score=346, Evalue=2e-95,
Organism=Homo sapiens, GI209869993, Length=350, Percent_Identity=50.8571428571429, Blast_Score=346, Evalue=2e-95,
Organism=Escherichia coli, GI1788845, Length=347, Percent_Identity=69.4524495677233, Blast_Score=499, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17567511, Length=356, Percent_Identity=41.5730337078652, Blast_Score=244, Evalue=3e-65,
Organism=Saccharomyces cerevisiae, GI6321203, Length=362, Percent_Identity=46.6850828729282, Blast_Score=319, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24582400, Length=308, Percent_Identity=43.8311688311688, Blast_Score=250, Evalue=9e-67,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_CHRSD (Q1QVP5)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_574162.1
- ProteinModelPortal:   Q1QVP5
- SMR:   Q1QVP5
- STRING:   Q1QVP5
- GeneID:   4029257
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_2112
- NMPDR:   fig|290398.4.peg.2128
- eggNOG:   COG0150
- HOGENOM:   HBG531222
- OMA:   DMYGADD
- BioCyc:   CSAL290398:CSAL_2112-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 37887; Mature: 37756

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRSSDTPSSSRASLSYKDAGVDIDAGNALVERIKGVAKRTSRPEVMGGLGGFGALCQLP
CCCCCCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCC
TGYREPVLVSGTDGVGTKLRLAMDLARHDTIGIDLVAMCVNDLVVAGAEPLFFLDYYATG
CCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
KLDVDIAADVVTGIGEGCAQAGCALIGGETAEMPGMYAGSDYDLAGFCVGVVEKSEILDG
CEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SRVAEGDVLLGLASSGPHSNGYSLIRKIIERGQADLEQEIDGIPLRDALLAPTRIYVKSL
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHCHHHHHHHHH
LSLIKESDVTVHALSHITGGGLLENVPRVLPDTLAARIDAASWTRPAVFDWLQREGNVDE
HHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
HEMHRVLNCGIGMVVVVPAAQAERAQAALEAAGETVHRLGEIVPRQDEEEQVRLENVR
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC
>Mature Secondary Structure 
TRSSDTPSSSRASLSYKDAGVDIDAGNALVERIKGVAKRTSRPEVMGGLGGFGALCQLP
CCCCCCCCCCCCEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCC
TGYREPVLVSGTDGVGTKLRLAMDLARHDTIGIDLVAMCVNDLVVAGAEPLFFLDYYATG
CCCCCCEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECC
KLDVDIAADVVTGIGEGCAQAGCALIGGETAEMPGMYAGSDYDLAGFCVGVVEKSEILDG
CEEHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
SRVAEGDVLLGLASSGPHSNGYSLIRKIIERGQADLEQEIDGIPLRDALLAPTRIYVKSL
CCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCHHHHHHHCCCCCCHHHHHCHHHHHHHHH
LSLIKESDVTVHALSHITGGGLLENVPRVLPDTLAARIDAASWTRPAVFDWLQREGNVDE
HHHHHHCCCEEEHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCH
HEMHRVLNCGIGMVVVVPAAQAERAQAALEAAGETVHRLGEIVPRQDEEEQVRLENVR
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA