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The map label for this gene is pyrH

Identifier: 92112698

GI number: 92112698

Start: 627440

End: 628201

Strand: Direct

Name: pyrH

Synonym: Csal_0565

Alternate gene names: 92112698

Gene position: 627440-628201 (Clockwise)

Preceding gene: 92112697

Following gene: 92112699

Centisome position: 16.97

GC content: 63.12

Gene sequence:

>762_bases
ATGTCTGCCCCTACCGATCGTAGCGCCACGCCTGCCGAGCGTAACGAGAAGTCCAAGTACAAGCGCATTCTACTGAAACT
GTCCGGCGAAGCCCTGATAGGCGAGCACGAGTTCGGGATCGATCCCAAGGTGCTCGACCGCATGGCGCTGGAAATCGGCC
AACTGGTCGGGATCGGCGTGCAGGTCGGCATCGTGATCGGCGGGGGTAACCTGTTTCGTGGCGCGGCGCTGCATGCCGCG
GGCATGGAGCGTGTGACCGGCGACCACATGGGGATGCTGGCGACGGTGATGAACGGCCTGGCGATGCGCGACGCGCTGGA
GCGCTCCAACATCCGTTCGCGCGTGATGTCGGCGATTCCCATGAGCGGCGTCGTCGAGCATTACGACCGGCGCACCGCGA
TCCGGTACCTGACGTCGGGCGATGTGGTGATTTTCTCCGCCGGCACCGGCAACCCCTTCTTCACGACCGATTCGGCGGCG
TGCCTGCGTGGCATCGAGATCGACGCCAATGTCGTGCTCAAGGCCACCAAGGTGGACGGCGTCTACGACAAGGATCCCGT
CAAGCATGCCGATGCCGCCAAGTACGAGCGCCTGACCTACGATGACGTGCTCGATCAGAAGCTCGGGGTGATGGATTTGA
CCGCCATCTGCCTGGTGCGGGACCATGACATGCCGGTGCGCGTGTTCGATATGACCAAGCCGGGAGCCTTGCTCAACCTG
GTAGTGGGTGGCAAGGAAGGAACGCTGGTAGACAGAGGCTGA

Upstream 100 bases:

>100_bases
CGTGCGCAACTGCGCACGCCATCGCGTATCCGGCCGTCACGCGGCCACGCCGTTCCCACCCCCTGCCGATACAGTCCGCT
GAGACGAAGGAGAGTCCCGA

Downstream 100 bases:

>100_bases
AACCGTGATCAACGACATCAAGAAAGACGCCGACGCGCGCATGAAGAAAAGCGTCGAGGCGTTGAACGCCAATTTTCACA
AGATTCGTACCGGGCGCGCG

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGVQVGIVIGGGNLFRGAALHAA
GMERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIPMSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAA
CLRGIEIDANVVLKATKVDGVYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNL
VVGGKEGTLVDRG

Sequences:

>Translated_253_residues
MSAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGVQVGIVIGGGNLFRGAALHAA
GMERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIPMSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAA
CLRGIEIDANVVLKATKVDGVYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNL
VVGGKEGTLVDRG
>Mature_252_residues
SAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGVQVGIVIGGGNLFRGAALHAAG
MERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIPMSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAAC
LRGIEIDANVVLKATKVDGVYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNLV
VGGKEGTLVDRG

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=66.9491525423729, Blast_Score=319, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHRSD (Q1R031)

Other databases:

- EMBL:   CP000285
- RefSeq:   YP_572626.1
- ProteinModelPortal:   Q1R031
- SMR:   Q1R031
- STRING:   Q1R031
- GeneID:   4026166
- GenomeReviews:   CP000285_GR
- KEGG:   csa:Csal_0565
- NMPDR:   fig|290398.4.peg.232
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CSAL290398:CSAL_0565-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27286; Mature: 27155

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: BINDING 68-68 BINDING 69-69 BINDING 73-73 BINDING 88-88 BINDING 176-176 BINDING 182-182 BINDING 185-185

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGV
CCCCCCCCCCCCCCHHHHHHHHHHHEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
QVGIVIGGGNLFRGAALHAAGMERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIP
EEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAACLRGIEIDANVVLKATKVDG
HHHHHHHHHHHHEEEEEECCCEEEEECCCCCCCEECCHHHHHCCCEECCEEEEEEEEECC
VYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNL
CCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHEEEEEEECCCCCEEEEECCCCCCEEEE
VVGGKEGTLVDRG
EECCCCCCEECCC
>Mature Secondary Structure 
SAPTDRSATPAERNEKSKYKRILLKLSGEALIGEHEFGIDPKVLDRMALEIGQLVGIGV
CCCCCCCCCCCCCHHHHHHHHHHHEECCCEEECCCCCCCCHHHHHHHHHHHHHHHCCCE
QVGIVIGGGNLFRGAALHAAGMERVTGDHMGMLATVMNGLAMRDALERSNIRSRVMSAIP
EEEEEEECCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MSGVVEHYDRRTAIRYLTSGDVVIFSAGTGNPFFTTDSAACLRGIEIDANVVLKATKVDG
HHHHHHHHHHHHEEEEEECCCEEEEECCCCCCCEECCHHHHHCCCEECCEEEEEEEEECC
VYDKDPVKHADAAKYERLTYDDVLDQKLGVMDLTAICLVRDHDMPVRVFDMTKPGALLNL
CCCCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHEEEEEEECCCCCEEEEECCCCCCEEEE
VVGGKEGTLVDRG
EECCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA