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The map label for this gene is hldD [H]

Identifier: 92112144

GI number: 92112144

Start: 10507

End: 11508

Strand: Direct

Name: hldD [H]

Synonym: Csal_0008

Alternate gene names: 92112144

Gene position: 10507-11508 (Clockwise)

Preceding gene: 92112140

Following gene: 92112145

Centisome position: 0.28

GC content: 60.58

Gene sequence:

>1002_bases
ATGCACGCTTCCCGCGTGGGTGCACGACTTGAAGGAATCGACGACATGATCGTAGTGACGGGCGGTGCCGGGTTCATCGG
CGCCAATCTAGTGAAGGCTTTGAACGCACGCGGCCGCGAGGATGTCCTCGTGGTCGACGACCTTTCCGACGGCACCAAGT
TCGTCAATCTCGCCGACTGCACGCTGGGGGATTATCTCGACAAGGATGATTTCCTGGCGCGCGTGAAGGCCGAACTGCGC
GGCGAACCCAGCGAGCTGCCGCCGATCGAGGCGATTTTCCACGAAGGCGCCTGTTCGGATACCACCGAGTGGGACGGCAA
GTTCATGCTCGAGAACAACTTCGAGTATTCCAAGGTGCTGCTGCATTTCTGCCAGTACAAGCGTATCCCCTTCCTGTATG
CCTCGTCGGCGGCCACCTATGGCGGCAGCGAGGTGTTCGTGGAAGCGCCGGAGCACGAGAAGCCGCTCAACGTCTACGGC
TACTCCAAGCTGCTGTTCGACCAGTACGTGCGCGTCCACTGGGAGTCGTTCGACGCTCAGGTGGTGGGCTTTCGCTATTT
CAATGTCTATGGTCCCCGCGAGCAGCACAAGGGCAAGATGGCCAGCGTCGCCTATCATCACCACAGTCAGGTGAAGCGGG
GCGAGAATCCCAAGCTGTTCGGTGCCTGGGACGGCTATGAAGCCGGCATGCAAAGCCGCGACTTCGTCTATGTCGGCGAT
GTCGTCGACGTCAACCTGTGGTGCCTCGATCACCCCGAGGTCTCGGGTATCTTCAACCTGGGGACCGGCCGCGCCGAGCC
GTTCAAGGCCATCGCCGAGACGGTGATCGATTACTATGCGACCGGCAAGATCGACTACATCGACTTTCCCGAGGAGCTGA
AAGGGCGCTATCAGAGCTATACCCGGGCGGATATCTCGCGGCTGCGCGAGGCGGGGTACAAGGCGGAATTCAAGACGGTT
CGCGAAGGCGTCAGCGCCTACCTGGATTGGCTGAATGGCTGA

Upstream 100 bases:

>100_bases
TGGCGTCGACTGTGTCATTGGTGAAGTACCGTTGGCCCATGAATTCACGAACCGCCAAGTATACAATTAGCGGTTAATCG
GTTATAGGCACCGTGACGAA

Downstream 100 bases:

>100_bases
CGATACCGCCACCTCCCCGCGCCTGCTCGTCGTCGGCCCCTCGTGGGTCGGCGACATGGTCATGGCCCAGAGTCTGTTCA
TGACGCTCAAGGCGCATCAC

Product: ADP-glyceromanno-heptose 6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MHASRVGARLEGIDDMIVVTGGAGFIGANLVKALNARGREDVLVVDDLSDGTKFVNLADCTLGDYLDKDDFLARVKAELR
GEPSELPPIEAIFHEGACSDTTEWDGKFMLENNFEYSKVLLHFCQYKRIPFLYASSAATYGGSEVFVEAPEHEKPLNVYG
YSKLLFDQYVRVHWESFDAQVVGFRYFNVYGPREQHKGKMASVAYHHHSQVKRGENPKLFGAWDGYEAGMQSRDFVYVGD
VVDVNLWCLDHPEVSGIFNLGTGRAEPFKAIAETVIDYYATGKIDYIDFPEELKGRYQSYTRADISRLREAGYKAEFKTV
REGVSAYLDWLNG

Sequences:

>Translated_333_residues
MHASRVGARLEGIDDMIVVTGGAGFIGANLVKALNARGREDVLVVDDLSDGTKFVNLADCTLGDYLDKDDFLARVKAELR
GEPSELPPIEAIFHEGACSDTTEWDGKFMLENNFEYSKVLLHFCQYKRIPFLYASSAATYGGSEVFVEAPEHEKPLNVYG
YSKLLFDQYVRVHWESFDAQVVGFRYFNVYGPREQHKGKMASVAYHHHSQVKRGENPKLFGAWDGYEAGMQSRDFVYVGD
VVDVNLWCLDHPEVSGIFNLGTGRAEPFKAIAETVIDYYATGKIDYIDFPEELKGRYQSYTRADISRLREAGYKAEFKTV
REGVSAYLDWLNG
>Mature_333_residues
MHASRVGARLEGIDDMIVVTGGAGFIGANLVKALNARGREDVLVVDDLSDGTKFVNLADCTLGDYLDKDDFLARVKAELR
GEPSELPPIEAIFHEGACSDTTEWDGKFMLENNFEYSKVLLHFCQYKRIPFLYASSAATYGGSEVFVEAPEHEKPLNVYG
YSKLLFDQYVRVHWESFDAQVVGFRYFNVYGPREQHKGKMASVAYHHHSQVKRGENPKLFGAWDGYEAGMQSRDFVYVGD
VVDVNLWCLDHPEVSGIFNLGTGRAEPFKAIAETVIDYYATGKIDYIDFPEELKGRYQSYTRADISRLREAGYKAEFKTV
REGVSAYLDWLNG

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=347, Percent_Identity=25.0720461095101, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790049, Length=318, Percent_Identity=62.2641509433962, Blast_Score=405, Evalue=1e-114,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 37548; Mature: 37548

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHASRVGARLEGIDDMIVVTGGAGFIGANLVKALNARGREDVLVVDDLSDGTKFVNLADC
CCCHHHCCHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECC
TLGDYLDKDDFLARVKAELRGEPSELPPIEAIFHEGACSDTTEWDGKFMLENNFEYSKVL
CHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHH
LHFCQYKRIPFLYASSAATYGGSEVFVEAPEHEKPLNVYGYSKLLFDQYVRVHWESFDAQ
HHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
VVGFRYFNVYGPREQHKGKMASVAYHHHSQVKRGENPKLFGAWDGYEAGMQSRDFVYVGD
EEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCEEEECC
VVDVNLWCLDHPEVSGIFNLGTGRAEPFKAIAETVIDYYATGKIDYIDFPEELKGRYQSY
EEEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
TRADISRLREAGYKAEFKTVREGVSAYLDWLNG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHASRVGARLEGIDDMIVVTGGAGFIGANLVKALNARGREDVLVVDDLSDGTKFVNLADC
CCCHHHCCHHCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEEEECC
TLGDYLDKDDFLARVKAELRGEPSELPPIEAIFHEGACSDTTEWDGKFMLENNFEYSKVL
CHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHH
LHFCQYKRIPFLYASSAATYGGSEVFVEAPEHEKPLNVYGYSKLLFDQYVRVHWESFDAQ
HHHHHHCCCCEEEECCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCE
VVGFRYFNVYGPREQHKGKMASVAYHHHSQVKRGENPKLFGAWDGYEAGMQSRDFVYVGD
EEEEEEEEECCCCHHHCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCEEEECC
VVDVNLWCLDHPEVSGIFNLGTGRAEPFKAIAETVIDYYATGKIDYIDFPEELKGRYQSY
EEEEEEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHH
TRADISRLREAGYKAEFKTVREGVSAYLDWLNG
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA