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The map label for this gene is hisD [H]

Identifier: 91785381

GI number: 91785381

Start: 4438568

End: 4439890

Strand: Reverse

Name: hisD [H]

Synonym: Bxe_A0398

Alternate gene names: 91785381

Gene position: 4439890-4438568 (Counterclockwise)

Preceding gene: 91785382

Following gene: 91785380

Centisome position: 90.69

GC content: 66.36

Gene sequence:

>1323_bases
ATGTCTATCAAGATTCGCAAACTCGATTCCACCGCTCCCGACTTCCAGAAGTCGCTGCACGCGGTGCTCGCGTTCGAGGC
GAGCGAAGACGAAGCAATCGAGCGCTCGGTCGCGCAGATTCTGAACGACGTGAAGGCGCGCGGCGATGCTGCGGTGCTGG
AGTACACGAGCCGCTTCGACCGTGTCGAGGCGAAGAGCGTCGACGCGCTCGAACTGCCGATGTCGGAGCTGGAAGCGGCG
CTGGAAGGCCTCGAACCGAAGCGTCGCGCGGCGCTCGAAGCGGCGGCGGCGCGGGTGCGCGGCTACCACGAGAAGCAGAA
GATCGAATGCGGCAGCCATAGCTGGCGGTACACGGAAGCCGACGGCACCGTGCTCGGCCAGAAGGTCACGCCGCTCGATC
GCGCGGGTATCTACGTGCCGGGCGGCAAGGCGGCGTATCCGTCGTCAGTGCTGATGAACGCGATTCCGGCGCGAGTGGCC
GGCGTGCGCGAAATCGTCATGGTGGTGCCGACGCCGGACGGCGTGAAGAATCCGCTGGTGCTCGCGGCCGCGCTGCTCGG
CGGCGTGGATCGCGTGTTCACGATTGGCGGCGCGCAGGCGGTGGGCGCGCTGGCGTACGGCACGGCGACCATTCCCGCGG
TCGACAAGATCTGCGGTCCGGGCAACGCGTACGTCGCGTCGGCCAAGCGCCGCGTGTTCGGCACGGTCGGTATCGACATG
ATCGCCGGGCCGTCCGAAATCCTGGTGCTGTGCGACGGCACCACGGATCCGCGCTGGGTGGCGATGGACCTGTTCTCGCA
GGCCGAGCACGACGAGCTCGCGCAGTCCATTCTGCTGTGCCCGGACGACGCGTTCATCGGCCGCGTGAAAGATGCGATCG
ACGAACTGCTGCCCACCATGCCGCGCCGCGATGTGATCAGCGCGTCGCTGGAAGGCCGCGGCGCGTTGATCAAGGTGCGC
GATATGGCGGAAGCCTGCGCGATCGCCAACGACATCGCTCCGGAACACCTCGAAATTTCCGCGCTGGAACCGCAGCAGTG
GGGCCAGCTGATCCGCCATGCCGGTGCGATCTTTCTCGGCCGCTACACCAGCGAAAGCCTCGGCGACTACTGTGCGGGGC
CAAATCACGTTTTGCCTACGTCTCGTACCGCACGGTTCTCGTCTCCTTTGGGCGTCTATGATTTCTTCAAGCGTTCGAGC
GTGATCGAGGTCAGCGCGGAGGGCGCGCAGACGCTGGGCGAGATCGCCGCCGAACTCGCTTACGGCGAAGGCCTGCAGGC
GCATGCCCGCAGCGCCGAATACCGGATGCGGCAAAACGGCTGA

Upstream 100 bases:

>100_bases
TCGACGCGTTCGAACGTGCGTCGAAAGCCGGCTCCACGACGGCCTGATCGCGTCGGTGCGAACATGCAGTAACGAGCGCC
TTACCGGAACGGATACCCGT

Downstream 100 bases:

>100_bases
GTGCGTCGGGTCCGACGCCGAGGCCGAGCGGGCATCGAGCCGATGCCCTCGAACGCCGGCGACGGATTGCGTGCGGTTCC
ACGTTAAATACAGACAAGAC

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MSIKIRKLDSTAPDFQKSLHAVLAFEASEDEAIERSVAQILNDVKARGDAAVLEYTSRFDRVEAKSVDALELPMSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWRYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVA
GVREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTATIPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVKDAIDELLPTMPRRDVISASLEGRGALIKVR
DMAEACAIANDIAPEHLEISALEPQQWGQLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
VIEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMRQNG

Sequences:

>Translated_440_residues
MSIKIRKLDSTAPDFQKSLHAVLAFEASEDEAIERSVAQILNDVKARGDAAVLEYTSRFDRVEAKSVDALELPMSELEAA
LEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWRYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVA
GVREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTATIPAVDKICGPGNAYVASAKRRVFGTVGIDM
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVKDAIDELLPTMPRRDVISASLEGRGALIKVR
DMAEACAIANDIAPEHLEISALEPQQWGQLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSS
VIEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMRQNG
>Mature_439_residues
SIKIRKLDSTAPDFQKSLHAVLAFEASEDEAIERSVAQILNDVKARGDAAVLEYTSRFDRVEAKSVDALELPMSELEAAL
EGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWRYTEADGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVAG
VREIVMVVPTPDGVKNPLVLAAALLGGVDRVFTIGGAQAVGALAYGTATIPAVDKICGPGNAYVASAKRRVFGTVGIDMI
AGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVKDAIDELLPTMPRRDVISASLEGRGALIKVRD
MAEACAIANDIAPEHLEISALEPQQWGQLIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSV
IEVSAEGAQTLGEIAAELAYGEGLQAHARSAEYRMRQNG

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=414, Percent_Identity=41.0628019323672, Blast_Score=278, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6319819, Length=412, Percent_Identity=36.1650485436893, Blast_Score=239, Evalue=9e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47055; Mature: 46924

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIKIRKLDSTAPDFQKSLHAVLAFEASEDEAIERSVAQILNDVKARGDAAVLEYTSRFD
CCEEEEECCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RVEAKSVDALELPMSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWRYTEA
HHHHCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVAGVREIVMVVPTPDGVKNPLV
CCCEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATIPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVKDAIDELLPTM
ECCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PRRDVISASLEGRGALIKVRDMAEACAIANDIAPEHLEISALEPQQWGQLIRHAGAIFLG
CCCHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSVIEVSAEGAQTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
YGEGLQAHARSAEYRMRQNG
HCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIKIRKLDSTAPDFQKSLHAVLAFEASEDEAIERSVAQILNDVKARGDAAVLEYTSRFD
CEEEEECCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
RVEAKSVDALELPMSELEAALEGLEPKRRAALEAAAARVRGYHEKQKIECGSHSWRYTEA
HHHHCCCCHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCEEECC
DGTVLGQKVTPLDRAGIYVPGGKAAYPSSVLMNAIPARVAGVREIVMVVPTPDGVKNPLV
CCCEECCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHH
LAAALLGGVDRVFTIGGAQAVGALAYGTATIPAVDKICGPGNAYVASAKRRVFGTVGIDM
HHHHHHCCCHHEEEECCHHHHHHHHHCCCCCHHHHHHCCCCCHHHHHHHHHHHEECCHHE
IAGPSEILVLCDGTTDPRWVAMDLFSQAEHDELAQSILLCPDDAFIGRVKDAIDELLPTM
ECCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
PRRDVISASLEGRGALIKVRDMAEACAIANDIAPEHLEISALEPQQWGQLIRHAGAIFLG
CCCHHHHHCCCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHCCCEEEE
RYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFFKRSSVIEVSAEGAQTLGEIAAELA
CCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCHHHHHHHHHHHHH
YGEGLQAHARSAEYRMRQNG
HCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA