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The map label for this gene is hisG [H]

Identifier: 91785382

GI number: 91785382

Start: 4439944

End: 4440642

Strand: Reverse

Name: hisG [H]

Synonym: Bxe_A0397

Alternate gene names: 91785382

Gene position: 4440642-4439944 (Counterclockwise)

Preceding gene: 91785383

Following gene: 91785381

Centisome position: 90.7

GC content: 65.38

Gene sequence:

>699_bases
ATGAGCGCAATGCCGCAAACTTCGTCGTCGCCGGCGGTGAGCGCGCCGCTCACGCTGGCGTTGTCGAAAGGGCGTATCTT
TGAAGAGACGTTGCCGCTGCTCGCCGCAGCCGGCATCGAAGTGGCCGAAGATCCGGAGACCTCGCGCAAGCTGATCCTGC
CGACCACGGACGCGAACCTGCGCGTGATCATCGTGCGCGCCACCGACGTGCCCACTTACGTCGAATACGGCGCGGCCGAC
TTCGGCGTGGCGGGTAAAGACGTGCTGCTCGAACACGGCGGCAGCGGCCTGTATCAGCCGGTCGACCTGGATATTGCGCG
TTGCCGCATGTCGGTCGCGGTCGCGGCCGGTTTCGATTATGCGAATGCGGTGCGCCAGGGCGCCCGCCTGCGCGTGGCGA
CCAAGTACGTCGAAACCGCGCGCGAGCATTTCGCCGCCAAGGGCGTGCACGTCGATCTGATCAAGCTGTACGGTTCGATG
GAACTGGCGCCGCTGGTCGGTCTCGCCGACGCGATCGTCGACCTGGTGAGCTCGGGCAATACCTTGCGCGCCAACAATCT
CGTCGAGGTGGAGGAGATCATGCAGATTTCGTCGCGCCTCGTGGTGAACCAGGCGGCGCTCAAGCTCAAGCGCGCCGCAT
TGCGGCCGATTCTCGACGCGTTCGAACGTGCGTCGAAAGCCGGCTCCACGACGGCCTGA

Upstream 100 bases:

>100_bases
TGATCGACCGGATTTATCACCTCGACCGCGGTTACGACCGCATGGAAACCAAGCTCACCGCTCTCGGCGCGAAGGTGCGC
CGTGTCTCGGGGAGCCAGGC

Downstream 100 bases:

>100_bases
TCGCGTCGGTGCGAACATGCAGTAACGAGCGCCTTACCGGAACGGATACCCGTATGTCTATCAAGATTCGCAAACTCGAT
TCCACCGCTCCCGACTTCCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 232; Mature: 231

Protein sequence:

>232_residues
MSAMPQTSSSPAVSAPLTLALSKGRIFEETLPLLAAAGIEVAEDPETSRKLILPTTDANLRVIIVRATDVPTYVEYGAAD
FGVAGKDVLLEHGGSGLYQPVDLDIARCRMSVAVAAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSM
ELAPLVGLADAIVDLVSSGNTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALRPILDAFERASKAGSTTA

Sequences:

>Translated_232_residues
MSAMPQTSSSPAVSAPLTLALSKGRIFEETLPLLAAAGIEVAEDPETSRKLILPTTDANLRVIIVRATDVPTYVEYGAAD
FGVAGKDVLLEHGGSGLYQPVDLDIARCRMSVAVAAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSM
ELAPLVGLADAIVDLVSSGNTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALRPILDAFERASKAGSTTA
>Mature_231_residues
SAMPQTSSSPAVSAPLTLALSKGRIFEETLPLLAAAGIEVAEDPETSRKLILPTTDANLRVIIVRATDVPTYVEYGAADF
GVAGKDVLLEHGGSGLYQPVDLDIARCRMSVAVAAGFDYANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSME
LAPLVGLADAIVDLVSSGNTLRANNLVEVEEIMQISSRLVVNQAALKLKRAALRPILDAFERASKAGSTTA

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=207, Percent_Identity=31.8840579710145, Blast_Score=88, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320896, Length=185, Percent_Identity=29.1891891891892, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 24588; Mature: 24456

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAMPQTSSSPAVSAPLTLALSKGRIFEETLPLLAAAGIEVAEDPETSRKLILPTTDANL
CCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
RVIIVRATDVPTYVEYGAADFGVAGKDVLLEHGGSGLYQPVDLDIARCRMSVAVAAGFDY
EEEEEEECCCCHHHHCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHHHHHCCCHH
ANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGN
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHCCC
TLRANNLVEVEEIMQISSRLVVNQAALKLKRAALRPILDAFERASKAGSTTA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAMPQTSSSPAVSAPLTLALSKGRIFEETLPLLAAAGIEVAEDPETSRKLILPTTDANL
CCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCE
RVIIVRATDVPTYVEYGAADFGVAGKDVLLEHGGSGLYQPVDLDIARCRMSVAVAAGFDY
EEEEEEECCCCHHHHCCCCCCCCCCHHHHEECCCCCCCCCCCHHHHHHHHHHHHHCCCHH
ANAVRQGARLRVATKYVETAREHFAAKGVHVDLIKLYGSMELAPLVGLADAIVDLVSSGN
HHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHHHHHHHCCC
TLRANNLVEVEEIMQISSRLVVNQAALKLKRAALRPILDAFERASKAGSTTA
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA