Click here to switch to the map view.

The map label for this gene is mltA [H]

Identifier: 91785314

GI number: 91785314

Start: 4374367

End: 4375491

Strand: Reverse

Name: mltA [H]

Synonym: Bxe_A0465

Alternate gene names: 91785314

Gene position: 4375491-4374367 (Counterclockwise)

Preceding gene: 91785315

Following gene: 91785308

Centisome position: 89.37

GC content: 65.69

Gene sequence:

>1125_bases
ATGCGTTTTGTCCGCACGGCCGCAGGGTGGCTCGGTGCGCTTTCGGTCGCGGTATTGCTGGCGTCCTGCGGCGGCAGCGG
CGCGGTCCGGCCTTCAGTTTCGCCACCCACGGGTGCGGCGATCATACCAGGACAGATTGCCGCGACCCGGCTGACGGCAG
TTGCATGGCAGCAGGTGCCGGGCTGGCAGGACGATTCGCTGATCGGCGCGACCGCCGCATTGCGGCAAAACTGCGTGAGG
CTGGCGCGTCAACCGAACTGGTCGCGCGCATGTGCGGCGGCCTCGCACATCGACGACCTCGACGTCACCAGTGCGCGGGC
TTTCTTTGAAGCTTATTTCACGCCCTTCCAGCTAGCGAATACCGACGGCACGGTGGACGGCCTGGTTACCGGTTACTACG
AGCCCTTGCTGCGTGGTTCGCGCACGCGGCACGGCGTGTATCAGACCGCGCTGTATCGCTGGCCAAGCGGTTATCGCGCG
GGCGCACCGCTGCCGGCGCGCGCGCAACTCGAGCGCGCGGGGGTGCTCAACGGTAATGAAATCGTATGGGTCGATGATCC
AATCGAGGCGTTCTTCCTGCAGGTGCAGGGCTCGGGGCGCATCGTGATGGAAGACGGCAGCGTGATGCGTCTTGGCTTTG
GCGGCACCAACAATCAGCCGTACAAATCGATTGGTCGCTGGCTGCTGGATCGCGGCGAACTTACGCCGGCGCAGGCGACC
ATGCAGGGTATCAAGGCATGGGCGCGTGCGAACCCGAGCCGGGTCGATGCGCTGCTCGATACGAATCCGCGTTTTGTGTT
CTTCCGTGAGATGCCGTCCGGCGAAAGCGTGCCGAACGGCAGCGCGGACGGCCCGATCGGCGCGCTGGGTGTGCCGCTGA
CGCCGGAGCGGTCGATCGCGGTCGATCCGACGGCGATTCCACTCGGCACGCCGGTGTTTTTGCAGACCACGCGCCCGCTG
ACCAATTCGCCAATGAATCGCCTCGTCTTCGCGCAGGATACGGGCTCCGCGATCAAGGGCGGTGTGCGCGCGGATTACTT
CTGGGGCTTGGGCGACGACGCCGGCGACCTTGCCGGCAAGATGAAGCAGGGCGGCCGGATGTGGCTGTTGCTGCCGAATT
CCTGA

Upstream 100 bases:

>100_bases
GAGCAGGAAGAGCGCGAGGAGCGATTCCAGCGCGAAGATAAGCATCGGGTATTCGTCGAACAGATCAGACATGGCGGTTT
CCATCAAGAACGAACATTGT

Downstream 100 bases:

>100_bases
TGTGTAAGTAGCGCACGGCGCGGCGTTATCCGCCGTGTCGCGCGCTCATTCCTGTTTGTTACAGCCCCGACTTGCGCTTG
TCGACCACACGCCGCGCCTT

Product: putative membrane-bound lytic murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MRFVRTAAGWLGALSVAVLLASCGGSGAVRPSVSPPTGAAIIPGQIAATRLTAVAWQQVPGWQDDSLIGATAALRQNCVR
LARQPNWSRACAAASHIDDLDVTSARAFFEAYFTPFQLANTDGTVDGLVTGYYEPLLRGSRTRHGVYQTALYRWPSGYRA
GAPLPARAQLERAGVLNGNEIVWVDDPIEAFFLQVQGSGRIVMEDGSVMRLGFGGTNNQPYKSIGRWLLDRGELTPAQAT
MQGIKAWARANPSRVDALLDTNPRFVFFREMPSGESVPNGSADGPIGALGVPLTPERSIAVDPTAIPLGTPVFLQTTRPL
TNSPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGKMKQGGRMWLLLPNS

Sequences:

>Translated_374_residues
MRFVRTAAGWLGALSVAVLLASCGGSGAVRPSVSPPTGAAIIPGQIAATRLTAVAWQQVPGWQDDSLIGATAALRQNCVR
LARQPNWSRACAAASHIDDLDVTSARAFFEAYFTPFQLANTDGTVDGLVTGYYEPLLRGSRTRHGVYQTALYRWPSGYRA
GAPLPARAQLERAGVLNGNEIVWVDDPIEAFFLQVQGSGRIVMEDGSVMRLGFGGTNNQPYKSIGRWLLDRGELTPAQAT
MQGIKAWARANPSRVDALLDTNPRFVFFREMPSGESVPNGSADGPIGALGVPLTPERSIAVDPTAIPLGTPVFLQTTRPL
TNSPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGKMKQGGRMWLLLPNS
>Mature_374_residues
MRFVRTAAGWLGALSVAVLLASCGGSGAVRPSVSPPTGAAIIPGQIAATRLTAVAWQQVPGWQDDSLIGATAALRQNCVR
LARQPNWSRACAAASHIDDLDVTSARAFFEAYFTPFQLANTDGTVDGLVTGYYEPLLRGSRTRHGVYQTALYRWPSGYRA
GAPLPARAQLERAGVLNGNEIVWVDDPIEAFFLQVQGSGRIVMEDGSVMRLGFGGTNNQPYKSIGRWLLDRGELTPAQAT
MQGIKAWARANPSRVDALLDTNPRFVFFREMPSGESVPNGSADGPIGALGVPLTPERSIAVDPTAIPLGTPVFLQTTRPL
TNSPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGKMKQGGRMWLLLPNS

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=262, Percent_Identity=33.969465648855, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39956; Mature: 39956

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFVRTAAGWLGALSVAVLLASCGGSGAVRPSVSPPTGAAIIPGQIAATRLTAVAWQQVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
GWQDDSLIGATAALRQNCVRLARQPNWSRACAAASHIDDLDVTSARAFFEAYFTPFQLAN
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEC
TDGTVDGLVTGYYEPLLRGSRTRHGVYQTALYRWPSGYRAGAPLPARAQLERAGVLNGNE
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCE
IVWVDDPIEAFFLQVQGSGRIVMEDGSVMRLGFGGTNNQPYKSIGRWLLDRGELTPAQAT
EEEECCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHH
MQGIKAWARANPSRVDALLDTNPRFVFFREMPSGESVPNGSADGPIGALGVPLTPERSIA
HHHHHHHHHCCHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCEE
VDPTAIPLGTPVFLQTTRPLTNSPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGK
ECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCHHHCCCCCEEEEECCCCCHHHHHHH
MKQGGRMWLLLPNS
HHCCCEEEEEECCC
>Mature Secondary Structure
MRFVRTAAGWLGALSVAVLLASCGGSGAVRPSVSPPTGAAIIPGQIAATRLTAVAWQQVP
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHCC
GWQDDSLIGATAALRQNCVRLARQPNWSRACAAASHIDDLDVTSARAFFEAYFTPFQLAN
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCEEEEC
TDGTVDGLVTGYYEPLLRGSRTRHGVYQTALYRWPSGYRAGAPLPARAQLERAGVLNGNE
CCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCCCCE
IVWVDDPIEAFFLQVQGSGRIVMEDGSVMRLGFGGTNNQPYKSIGRWLLDRGELTPAQAT
EEEECCCCEEEEEEECCCCEEEEECCCEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHH
MQGIKAWARANPSRVDALLDTNPRFVFFREMPSGESVPNGSADGPIGALGVPLTPERSIA
HHHHHHHHHCCHHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCEECCCCCCCCCEE
VDPTAIPLGTPVFLQTTRPLTNSPMNRLVFAQDTGSAIKGGVRADYFWGLGDDAGDLAGK
ECCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCHHHCCCCCEEEEECCCCCHHHHHHH
MKQGGRMWLLLPNS
HHCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]