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The map label for this gene is 91783086

Identifier: 91783086

GI number: 91783086

Start: 1932176

End: 1933489

Strand: Direct

Name: 91783086

Synonym: Bxe_A2724

Alternate gene names: NA

Gene position: 1932176-1933489 (Clockwise)

Preceding gene: 91783085

Following gene: 91783087

Centisome position: 39.47

GC content: 68.26

Gene sequence:

>1314_bases
ATGTCCGTTCTCAACGAAACCCACGATCCGAGTCTCAAGAGCTGGGTCGCCTCGGCCAACGCGGCTGGTAGCGATTTTCC
GATCCAGAACTTGCCGTTCGCGGTGTTTCGCCGTAACGGCAGCCCGGAGGCGTTCCGCGGTGGCGTCGCGATCGGCGAGA
TGATCGTCGATCTCGGCGCGGTCGCGCGCCTGCTAGATGGTGTGGTCGCCGACGCGGCCCGGGCCGGCAGCGAGAGCAGC
CTCAATGCGCTGATGGCGCAGGGCTCGGCCGCGTGGTCGGCGCTACGGCTCGCGCTATCGCGCGCGCTGCGCGAGGGCGC
GCTGCAGCAGGCCGCGTTCGCGAATGCGCTGGTCGCGCAGGCCGACGCCGAATACACGGTGCCCGCGCGGATCGGCGACT
ACACCGACTTCTATACCTCGATCTACCATGCGACCAATATCGGCAGGCTGTTCCGGCCGGACAATCCGCTGATGCCGAAC
TACAAGTGGGTACCGATCGGCTATCACGGCCGCGCCTCGTCGATCGCGGTGTCGGGCCAGCAGTTCCCGCGGCCGGTCGG
GCAGACGTTTCCGCCGGGCTCGGAGCAGCCGAGCTTCGGGCCGAGCAAGCGGCTCGACTACGAGCTCGAGCTCGCCGTCT
ACATTGGCACTGGCAACGCGCTCGGCAGTCCGATCCCGATCGACGATGCGGAGGCGCATGTGTTCGGCATCGGCCTCCTG
AACGACTGGTCCGCCCGCGACGTCCAGGCTTGGGAATATCAGCCGCTCGGGCCGTTCCTCGCGAAGAGCTTCGCGAGCAC
GGTGTCTCCGTGGATCGTCACGCTCGAGGCGCTCGCTCCGTACCGCGTGGCGTTCGAGCGCAACGCGGGCGATCCGCAGC
CGCTGCCTTACCTCGATTCGGTGCGGCAGCGCGAGCGGGGCGCATTCGACATCACGCTCGAGCTCGGGATCGAATCGGCG
CGGCTGCGCTCGCAGGGCCGGCCGGCCGCGCGCGTAAGCCTCACGAACTACCGCCACGCGTACTGGACGATCGCGCAGAT
GGTCGCGCATCACACGGTCAACGGTTGCAACCTGCAGCCGGGCGACCTGCTTGGCACGGGCACGCTGTCGGGTCCGACGC
TGGACCAGGCGGGCGCGCTGATCGAGACCACGAGCGGAGGCAAGAACCCGTTCGAGCTCGGCAATGGCGAGGCGCGGACT
TTCCTCGAGGACGGCGATGCGGTGATCATCCGTGGATGGTGCGAGAAGGCGGGTGCGGCACGCATCGGCTTCGGCGAGTG
TCGTGGCGCGATTTTGCCCGCGCGTGCGGTGTGA

Upstream 100 bases:

>100_bases
TCGAATCGGCCCAACTGCAGCCCGGGTACTACCGCTGCTGGCAGGGCATCAGGAAGCACTTCAACCCGTCGCAAGCGTGA
TGCGCGCAAAGGAATACAGC

Downstream 100 bases:

>100_bases
CGCAATGAAGCTCTACAGCTACTTTCGCAGCTCGGCCTCGTACCGGGTACGCATCGCACTGAACCTCAAGGGCCTCGACT
ACGAGTATGTGCCGATCCAC

Product: fumarylacetoacetate hydrolase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Fumarylacetoacetase Hydrolase; Hydroxylase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MSVLNETHDPSLKSWVASANAAGSDFPIQNLPFAVFRRNGSPEAFRGGVAIGEMIVDLGAVARLLDGVVADAARAGSESS
LNALMAQGSAAWSALRLALSRALREGALQQAAFANALVAQADAEYTVPARIGDYTDFYTSIYHATNIGRLFRPDNPLMPN
YKWVPIGYHGRASSIAVSGQQFPRPVGQTFPPGSEQPSFGPSKRLDYELELAVYIGTGNALGSPIPIDDAEAHVFGIGLL
NDWSARDVQAWEYQPLGPFLAKSFASTVSPWIVTLEALAPYRVAFERNAGDPQPLPYLDSVRQRERGAFDITLELGIESA
RLRSQGRPAARVSLTNYRHAYWTIAQMVAHHTVNGCNLQPGDLLGTGTLSGPTLDQAGALIETTSGGKNPFELGNGEART
FLEDGDAVIIRGWCEKAGAARIGFGECRGAILPARAV

Sequences:

>Translated_437_residues
MSVLNETHDPSLKSWVASANAAGSDFPIQNLPFAVFRRNGSPEAFRGGVAIGEMIVDLGAVARLLDGVVADAARAGSESS
LNALMAQGSAAWSALRLALSRALREGALQQAAFANALVAQADAEYTVPARIGDYTDFYTSIYHATNIGRLFRPDNPLMPN
YKWVPIGYHGRASSIAVSGQQFPRPVGQTFPPGSEQPSFGPSKRLDYELELAVYIGTGNALGSPIPIDDAEAHVFGIGLL
NDWSARDVQAWEYQPLGPFLAKSFASTVSPWIVTLEALAPYRVAFERNAGDPQPLPYLDSVRQRERGAFDITLELGIESA
RLRSQGRPAARVSLTNYRHAYWTIAQMVAHHTVNGCNLQPGDLLGTGTLSGPTLDQAGALIETTSGGKNPFELGNGEART
FLEDGDAVIIRGWCEKAGAARIGFGECRGAILPARAV
>Mature_436_residues
SVLNETHDPSLKSWVASANAAGSDFPIQNLPFAVFRRNGSPEAFRGGVAIGEMIVDLGAVARLLDGVVADAARAGSESSL
NALMAQGSAAWSALRLALSRALREGALQQAAFANALVAQADAEYTVPARIGDYTDFYTSIYHATNIGRLFRPDNPLMPNY
KWVPIGYHGRASSIAVSGQQFPRPVGQTFPPGSEQPSFGPSKRLDYELELAVYIGTGNALGSPIPIDDAEAHVFGIGLLN
DWSARDVQAWEYQPLGPFLAKSFASTVSPWIVTLEALAPYRVAFERNAGDPQPLPYLDSVRQRERGAFDITLELGIESAR
LRSQGRPAARVSLTNYRHAYWTIAQMVAHHTVNGCNLQPGDLLGTGTLSGPTLDQAGALIETTSGGKNPFELGNGEARTF
LEDGDAVIIRGWCEKAGAARIGFGECRGAILPARAV

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=425, Percent_Identity=48.2352941176471, Blast_Score=393, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17568863, Length=431, Percent_Identity=51.0440835266821, Blast_Score=398, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24657182, Length=420, Percent_Identity=48.8095238095238, Blast_Score=392, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 46724; Mature: 46593

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLNETHDPSLKSWVASANAAGSDFPIQNLPFAVFRRNGSPEAFRGGVAIGEMIVDLGA
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHH
VARLLDGVVADAARAGSESSLNALMAQGSAAWSALRLALSRALREGALQQAAFANALVAQ
HHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAEYTVPARIGDYTDFYTSIYHATNIGRLFRPDNPLMPNYKWVPIGYHGRASSIAVSGQ
CCCCEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCCCEEEECCH
QFPRPVGQTFPPGSEQPSFGPSKRLDYELELAVYIGTGNALGSPIPIDDAEAHVFGIGLL
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEE
NDWSARDVQAWEYQPLGPFLAKSFASTVSPWIVTLEALAPYRVAFERNAGDPQPLPYLDS
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHCCEEEEEECCCCCCCCCCHHHH
VRQRERGAFDITLELGIESARLRSQGRPAARVSLTNYRHAYWTIAQMVAHHTVNGCNLQP
HHHHHCCCEEEEEEECCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
GDLLGTGTLSGPTLDQAGALIETTSGGKNPFELGNGEARTFLEDGDAVIIRGWCEKAGAA
CCEEECCCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCC
RIGFGECRGAILPARAV
CCCHHHHCCCCCCCCCC
>Mature Secondary Structure 
SVLNETHDPSLKSWVASANAAGSDFPIQNLPFAVFRRNGSPEAFRGGVAIGEMIVDLGA
CCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCHHHHCCHHHHHHHHHHHH
VARLLDGVVADAARAGSESSLNALMAQGSAAWSALRLALSRALREGALQQAAFANALVAQ
HHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ADAEYTVPARIGDYTDFYTSIYHATNIGRLFRPDNPLMPNYKWVPIGYHGRASSIAVSGQ
CCCCEECCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCEEEEEECCCCCCCEEEECCH
QFPRPVGQTFPPGSEQPSFGPSKRLDYELELAVYIGTGNALGSPIPIDDAEAHVFGIGLL
HCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCEEEEEEEE
NDWSARDVQAWEYQPLGPFLAKSFASTVSPWIVTLEALAPYRVAFERNAGDPQPLPYLDS
CCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHEEHHHHCCEEEEEECCCCCCCCCCHHHH
VRQRERGAFDITLELGIESARLRSQGRPAARVSLTNYRHAYWTIAQMVAHHTVNGCNLQP
HHHHHCCCEEEEEEECCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCC
GDLLGTGTLSGPTLDQAGALIETTSGGKNPFELGNGEARTFLEDGDAVIIRGWCEKAGAA
CCEEECCCCCCCCHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCCCCC
RIGFGECRGAILPARAV
CCCHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA