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The map label for this gene is hmgA [H]

Identifier: 91783085

GI number: 91783085

Start: 1930860

End: 1932155

Strand: Direct

Name: hmgA [H]

Synonym: Bxe_A2725

Alternate gene names: 91783085

Gene position: 1930860-1932155 (Clockwise)

Preceding gene: 91783084

Following gene: 91783086

Centisome position: 39.44

GC content: 64.97

Gene sequence:

>1296_bases
ATGACCTACGAATACATGACCGGTTTCGCGAACGAATTTGCGACCGAAACGCTGCCCGGCGCCCTCCCCGAAAGTCGGAA
CTCGCCGCAGCGCGCGCCTTATGGCCTCTATGCAGAGCAGTTTTCGGGCACGGCCTTCACGGCACCGCGCCACAGCAACC
GCCGCTCGTGGCTCTACCGGATCCGCCCGGCCGCCGTGCACGAGCCGTTCGCGCCGCTTGTCAACACGCGCCTGCTGTCG
CGCTTCGACGAGGTGCCGCCGCCGCCGAACCAGCTGCGCTGGAATCCACTGCCTTACCCCGACACGCCGCTTGACTTCAT
CGACGGCCTCGTCACGATGGCTGGCAACGGCTCGCCCGAGGCCGGCACCGGCTGTGGCATCCATCTCTACACGGCCACCC
GTTCGATGCAGGGCCGCTTCTTCTACGACGCCGACGGCGAGCTGCTGATCGTGCCGCAGGAAGGTCGCCTGCTGATCTCG
ACCGAACTTGGCGCGCTCGAGGTGGAACCGCAGGAGATCGTCGTAATTCCGCGCGGCGTGCGCTTCAAGGTCGAGCTGCC
CGACCACCGCGCGCGCGGTTACGTTTGCGAGAACTACGGCGCCCTCTTCAAGCTGCCTGACCTCGGCGTGATCGGCTCGA
ACGGCCTCGCGAACCCGCGCGACTTTCAGACGCCGGTCGCGCGCTATGAGGACGTCGAAGGTGATTTCGAGCTTGTCGCG
AAGTTCCAGGGCAACCTATGGACAACCCGCATCGGCCACTCGCCGCTTGATGTGGTTGCCTGGCACGGCAACTACGCGCC
CTACAAGTACGATCTGCGCCGCTTCAACACGATTGGCTCGATCAGCTACGACCATCCTGATCCGTCGATTTTCCTCGTGC
TGCAGGCGCCGAGCGATACGCCGGGCGTCGACACGGTCGACTTCGTGATCTTTCCGCCGCGATGGCTCGCGGCCGAGAAT
ACATTCCGCCCGCCGTGGTTCCACCGCAATGTCGCGAGCGAGTTCATGGGACTGATCTATGGCATCTATGATGCGAAGGC
CGAGGGTTTCACGCCGGGCGGGGCGTCGCTGCACAACTGCGTGAGCGGCCACGGCCCCGATGCCGAGACCTTCGAGAAGG
CGAGCGCATCCGATACCACGATGCCGCATGCCGTGAAGGACACGATGGCCTTCATGTTCGAGACGCCGGCCGTGATCCGG
CCGACCCGCCATGCGCTCGAATCGGCCCAACTGCAGCCCGGGTACTACCGCTGCTGGCAGGGCATCAGGAAGCACTTCAA
CCCGTCGCAAGCGTGA

Upstream 100 bases:

>100_bases
CTGATGCCGTGCTGAACCTGATCGCCGAAGCGGGCGAGGGTATGGGTGGCGGCGTTGCCACCGCAACCGCCTGAGCGTCC
TTCCGGAAGAGAGACCTGAG

Downstream 100 bases:

>100_bases
TGCGCGCAAAGGAATACAGCATGTCCGTTCTCAACGAAACCCACGATCCGAGTCTCAAGAGCTGGGTCGCCTCGGCCAAC
GCGGCTGGTAGCGATTTTCC

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTYEYMTGFANEFATETLPGALPESRNSPQRAPYGLYAEQFSGTAFTAPRHSNRRSWLYRIRPAAVHEPFAPLVNTRLLS
RFDEVPPPPNQLRWNPLPYPDTPLDFIDGLVTMAGNGSPEAGTGCGIHLYTATRSMQGRFFYDADGELLIVPQEGRLLIS
TELGALEVEPQEIVVIPRGVRFKVELPDHRARGYVCENYGALFKLPDLGVIGSNGLANPRDFQTPVARYEDVEGDFELVA
KFQGNLWTTRIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISYDHPDPSIFLVLQAPSDTPGVDTVDFVIFPPRWLAAEN
TFRPPWFHRNVASEFMGLIYGIYDAKAEGFTPGGASLHNCVSGHGPDAETFEKASASDTTMPHAVKDTMAFMFETPAVIR
PTRHALESAQLQPGYYRCWQGIRKHFNPSQA

Sequences:

>Translated_431_residues
MTYEYMTGFANEFATETLPGALPESRNSPQRAPYGLYAEQFSGTAFTAPRHSNRRSWLYRIRPAAVHEPFAPLVNTRLLS
RFDEVPPPPNQLRWNPLPYPDTPLDFIDGLVTMAGNGSPEAGTGCGIHLYTATRSMQGRFFYDADGELLIVPQEGRLLIS
TELGALEVEPQEIVVIPRGVRFKVELPDHRARGYVCENYGALFKLPDLGVIGSNGLANPRDFQTPVARYEDVEGDFELVA
KFQGNLWTTRIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISYDHPDPSIFLVLQAPSDTPGVDTVDFVIFPPRWLAAEN
TFRPPWFHRNVASEFMGLIYGIYDAKAEGFTPGGASLHNCVSGHGPDAETFEKASASDTTMPHAVKDTMAFMFETPAVIR
PTRHALESAQLQPGYYRCWQGIRKHFNPSQA
>Mature_430_residues
TYEYMTGFANEFATETLPGALPESRNSPQRAPYGLYAEQFSGTAFTAPRHSNRRSWLYRIRPAAVHEPFAPLVNTRLLSR
FDEVPPPPNQLRWNPLPYPDTPLDFIDGLVTMAGNGSPEAGTGCGIHLYTATRSMQGRFFYDADGELLIVPQEGRLLIST
ELGALEVEPQEIVVIPRGVRFKVELPDHRARGYVCENYGALFKLPDLGVIGSNGLANPRDFQTPVARYEDVEGDFELVAK
FQGNLWTTRIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISYDHPDPSIFLVLQAPSDTPGVDTVDFVIFPPRWLAAENT
FRPPWFHRNVASEFMGLIYGIYDAKAEGFTPGGASLHNCVSGHGPDAETFEKASASDTTMPHAVKDTMAFMFETPAVIRP
TRHALESAQLQPGYYRCWQGIRKHFNPSQA

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=434, Percent_Identity=50.6912442396313, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17507969, Length=428, Percent_Identity=51.8691588785047, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24583650, Length=436, Percent_Identity=50, Blast_Score=441, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 48118; Mature: 47986

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYEYMTGFANEFATETLPGALPESRNSPQRAPYGLYAEQFSGTAFTAPRHSNRRSWLYR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCCEEEE
IRPAAVHEPFAPLVNTRLLSRFDEVPPPPNQLRWNPLPYPDTPLDFIDGLVTMAGNGSPE
ECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCC
AGTGCGIHLYTATRSMQGRFFYDADGELLIVPQEGRLLISTELGALEVEPQEIVVIPRGV
CCCCCCEEEEEECCCCCCCEEECCCCCEEEEECCCCEEEEECCCEEEECCCEEEEECCCE
RFKVELPDHRARGYVCENYGALFKLPDLGVIGSNGLANPRDFQTPVARYEDVEGDFELVA
EEEEECCCCCCCCEEEECCCCEEECCCCCEECCCCCCCCHHHCCHHHHHHCCCCCCEEHE
KFQGNLWTTRIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISYDHPDPSIFLVLQAPSDT
ECCCCEEEEECCCCCCEEEEECCCCCCEEHHHHHHCCCCCCEECCCCCEEEEEEECCCCC
PGVDTVDFVIFPPRWLAAENTFRPPWFHRNVASEFMGLIYGIYDAKAEGFTPGGASLHNC
CCCCEEEEEEECCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VSGHGPDAETFEKASASDTTMPHAVKDTMAFMFETPAVIRPTRHALESAQLQPGYYRCWQ
HCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHH
GIRKHFNPSQA
HHHHHCCCCCC
>Mature Secondary Structure 
TYEYMTGFANEFATETLPGALPESRNSPQRAPYGLYAEQFSGTAFTAPRHSNRRSWLYR
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCEEECCCCCCCCCEEEE
IRPAAVHEPFAPLVNTRLLSRFDEVPPPPNQLRWNPLPYPDTPLDFIDGLVTMAGNGSPE
ECHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCC
AGTGCGIHLYTATRSMQGRFFYDADGELLIVPQEGRLLISTELGALEVEPQEIVVIPRGV
CCCCCCEEEEEECCCCCCCEEECCCCCEEEEECCCCEEEEECCCEEEECCCEEEEECCCE
RFKVELPDHRARGYVCENYGALFKLPDLGVIGSNGLANPRDFQTPVARYEDVEGDFELVA
EEEEECCCCCCCCEEEECCCCEEECCCCCEECCCCCCCCHHHCCHHHHHHCCCCCCEEHE
KFQGNLWTTRIGHSPLDVVAWHGNYAPYKYDLRRFNTIGSISYDHPDPSIFLVLQAPSDT
ECCCCEEEEECCCCCCEEEEECCCCCCEEHHHHHHCCCCCCEECCCCCEEEEEEECCCCC
PGVDTVDFVIFPPRWLAAENTFRPPWFHRNVASEFMGLIYGIYDAKAEGFTPGGASLHNC
CCCCEEEEEEECCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHH
VSGHGPDAETFEKASASDTTMPHAVKDTMAFMFETPAVIRPTRHALESAQLQPGYYRCWQ
HCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCCHHHHHHH
GIRKHFNPSQA
HHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA