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The map label for this gene is fabG [C]

Identifier: 91782058

GI number: 91782058

Start: 765674

End: 766414

Strand: Reverse

Name: fabG [C]

Synonym: Bxe_A3786

Alternate gene names: 91782058

Gene position: 766414-765674 (Counterclockwise)

Preceding gene: 91782059

Following gene: 91782057

Centisome position: 15.65

GC content: 61.0

Gene sequence:

>741_bases
ATGAAAAACATTCTTATCGTCGGCGCTACGTCGGCGATTGCCATTGCTTGTGCCCGCAAATGGGCTTCAGAAGGCGCACG
CTTTTTTCTGGTGGCTCGCAATGGCGAACGCCTCCAGCAGATCGCCGACGATCTGACCTCGCGCGGCGCTCAACTCGCCG
CGTGCCATCAACTCGACATCGACAGTCTGGATCGTCATGCGGGCATGCTCGAGCGCTGCAAGACCGAACTGGGCGCGCTC
GATATCGTACTGGTCGCGCCCGGCACGCTGCCGGACCAGGCCAGGTGCCAAGCGGATCCCGCACTGGCGGTGCGCGAATT
TAACACCAATGCCGTCTCGGTCATTGCCCTGTTGACGCCAATCGCGAACATCCTCGAAGCGCAAAAGCGCGGCGCGTTGG
CGGTAATCTCGTCCGTGGCGGGTGATCGCGGCCGTCCGTCGAACTATCTGTACGGCAGCGCGAAGGCGGCGCTTTCCGCA
TTCTGCGAAGGATTGAATGCAAGGCTATTCAAGTCTGGCGTACATGTCATGACGGTCAAGCCCGGGTTCGTCGCTACGCC
GATGACGGCAGGTTTGCCTTTGCCGGGACCACTCGTTGCAACGCCCGATCAAGTGGCGACCGACATCGTACGGGCGGTCG
AAAAGCGCAAGGACGTCCTGTACACCCGCTGGTTCTGGGCAATCATCATGCTGATCATCCGCTGCGTGCCGCGATTCCTG
TTCAAGCGCGCGTCGCTGTGA

Upstream 100 bases:

>100_bases
CTGGCGCCGACTTTCGCACCGCCTACCCTCAATGGCATCAACTCGAAGCGCTGCGCGACCCTGCCCTGCTTTCGCGCTTC
TGGGAACGGACTACTCGAAC

Downstream 100 bases:

>100_bases
GGCGGCGGTAACTATGAGTCGAGGAGAAAGAATTGGTAACTTTGCAGTGTTCGCACTGGGCGTCTTTACGCTCACGACAA
CGACACTCGGGGTTTGGCAG

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKNILIVGATSAIAIACARKWASEGARFFLVARNGERLQQIADDLTSRGAQLAACHQLDIDSLDRHAGMLERCKTELGAL
DIVLVAPGTLPDQARCQADPALAVREFNTNAVSVIALLTPIANILEAQKRGALAVISSVAGDRGRPSNYLYGSAKAALSA
FCEGLNARLFKSGVHVMTVKPGFVATPMTAGLPLPGPLVATPDQVATDIVRAVEKRKDVLYTRWFWAIIMLIIRCVPRFL
FKRASL

Sequences:

>Translated_246_residues
MKNILIVGATSAIAIACARKWASEGARFFLVARNGERLQQIADDLTSRGAQLAACHQLDIDSLDRHAGMLERCKTELGAL
DIVLVAPGTLPDQARCQADPALAVREFNTNAVSVIALLTPIANILEAQKRGALAVISSVAGDRGRPSNYLYGSAKAALSA
FCEGLNARLFKSGVHVMTVKPGFVATPMTAGLPLPGPLVATPDQVATDIVRAVEKRKDVLYTRWFWAIIMLIIRCVPRFL
FKRASL
>Mature_246_residues
MKNILIVGATSAIAIACARKWASEGARFFLVARNGERLQQIADDLTSRGAQLAACHQLDIDSLDRHAGMLERCKTELGAL
DIVLVAPGTLPDQARCQADPALAVREFNTNAVSVIALLTPIANILEAQKRGALAVISSVAGDRGRPSNYLYGSAKAALSA
FCEGLNARLFKSGVHVMTVKPGFVATPMTAGLPLPGPLVATPDQVATDIVRAVEKRKDVLYTRWFWAIIMLIIRCVPRFL
FKRASL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=193, Percent_Identity=28.4974093264249, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI87082100, Length=224, Percent_Identity=27.6785714285714, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=197, Percent_Identity=28.9340101522843, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=199, Percent_Identity=27.6381909547739, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562904, Length=200, Percent_Identity=25.5, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=200, Percent_Identity=29, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26464; Mature: 26464

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILIVGATSAIAIACARKWASEGARFFLVARNGERLQQIADDLTSRGAQLAACHQLDI
CCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCH
DSLDRHAGMLERCKTELGALDIVLVAPGTLPDQARCQADPALAVREFNTNAVSVIALLTP
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHH
IANILEAQKRGALAVISSVAGDRGRPSNYLYGSAKAALSAFCEGLNARLFKSGVHVMTVK
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGFVATPMTAGLPLPGPLVATPDQVATDIVRAVEKRKDVLYTRWFWAIIMLIIRCVPRFL
CCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKRASL
HHHCCC
>Mature Secondary Structure
MKNILIVGATSAIAIACARKWASEGARFFLVARNGERLQQIADDLTSRGAQLAACHQLDI
CCCEEEEECHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHCCH
DSLDRHAGMLERCKTELGALDIVLVAPGTLPDQARCQADPALAVREFNTNAVSVIALLTP
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHCCCCCCEEEECCCCHHHHHHHHHH
IANILEAQKRGALAVISSVAGDRGRPSNYLYGSAKAALSAFCEGLNARLFKSGVHVMTVK
HHHHHHHHHCCHHHHHHHHCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEC
PGFVATPMTAGLPLPGPLVATPDQVATDIVRAVEKRKDVLYTRWFWAIIMLIIRCVPRFL
CCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKRASL
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]