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The map label for this gene is serA [H]

Identifier: 91790401

GI number: 91790401

Start: 4842059

End: 4843066

Strand: Reverse

Name: serA [H]

Synonym: Bpro_4572

Alternate gene names: 91790401

Gene position: 4843066-4842059 (Counterclockwise)

Preceding gene: 91790402

Following gene: 91790400

Centisome position: 93.13

GC content: 68.65

Gene sequence:

>1008_bases
ATGACAACGGTTTTTGTAAGCCACCCCCGAACCAGCCTGGGCCACTATTTCGGCGCCCGCGCCACCGCTGCATTGCAGGC
GCTGGCCGACGTGCGCTTCAATCCCGGCGACACCGACCTGTCGTCGCGGGAGCTGGCTGCGCTGGCGCAGGACTGCGATG
TGATCATTTCCTACCGGCAGACGCAGGGCGATGAAGCGCTGTTTGCCGCGCTGCCGCGACTCAAGGCCTTTGTCCGCTGC
GCCATCGACATCCGCAATATCGATGTCCCCGCCGCCAGCCGCCACGGCGTCCTGGTGACACAGGCCAGCGCCGGCTTTAT
TGCCTCGGTGTCCGAGTGGATCATCGGCGTGATGATTGACCTGAGCCGGCACATCAGCGCCTCGGCTGCGCTCTACCATG
CGGGCCGCCCGGTGGCGCCGCTGATGGGGCGCGAGTTGCGCGGCGCCACGCTGGGCGTCATTGGCTATGGCCAGATCAGC
CGCTATCTGTGCGATGTGGCGCTGGCCCTGGGCATGCGCATCGTGGTGCACGACCCTTACACCCGCACCGGCCGCCAGGA
ACTGGTGCAGACCGGCCTCGCACCGCTGCTGGCGGAAGCCGACTATGTGGTCTGCCTGGCCGCTGCGACCGAGGCCACCG
AAAACCTGATGAACGCCCAGGCCTTTGCCCTGATGAAGCCCGGCGCGTTTTTCATCAACGCCTCGCGCGGCAACCTGGTC
GATGAGTCGGCGCTGCTGGCCGCGCTGGACGCCGGCACGATGGCTGGCTGCGCCGTCGACGTGGGCCGCGCGCCTGACCA
GATGCCCTCGCCCCGGGTGGCGGCGCATCCACGTGTGATCGCCTCGCCGCACATCGGTGGCCTGACGCCGCCGGCGGTGG
AGCACCAGGCCCTGGAAACGGTGGCGCAGGTCGCCGACATCCTGCAGGGATGCGTGCCCCAGGGCGCGGTGAATGCGGCG
CAGGCGCACCGCTGGCAACAGGCGTTTGGCACGACGCAGCCAGCCTGA

Upstream 100 bases:

>100_bases
AGGGGCTCCGTGGCAGCCCGAAGCTCCGAACAGTGAAGTCCTTTTGAGCATTGAATTTTTTGTGAACTTTTGACGATTGA
ACAATTGAACAAGGCATGGA

Downstream 100 bases:

>100_bases
GCCCGGGCGCTCACGGCCGGTCAGACTTTTTTGACCTCCACGCAAATCCCGGAAGACTTTTATGCAAGCCACCCACAACA
CCACCTACGACGGCGCCTGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 335; Mature: 334

Protein sequence:

>335_residues
MTTVFVSHPRTSLGHYFGARATAALQALADVRFNPGDTDLSSRELAALAQDCDVIISYRQTQGDEALFAALPRLKAFVRC
AIDIRNIDVPAASRHGVLVTQASAGFIASVSEWIIGVMIDLSRHISASAALYHAGRPVAPLMGRELRGATLGVIGYGQIS
RYLCDVALALGMRIVVHDPYTRTGRQELVQTGLAPLLAEADYVVCLAAATEATENLMNAQAFALMKPGAFFINASRGNLV
DESALLAALDAGTMAGCAVDVGRAPDQMPSPRVAAHPRVIASPHIGGLTPPAVEHQALETVAQVADILQGCVPQGAVNAA
QAHRWQQAFGTTQPA

Sequences:

>Translated_335_residues
MTTVFVSHPRTSLGHYFGARATAALQALADVRFNPGDTDLSSRELAALAQDCDVIISYRQTQGDEALFAALPRLKAFVRC
AIDIRNIDVPAASRHGVLVTQASAGFIASVSEWIIGVMIDLSRHISASAALYHAGRPVAPLMGRELRGATLGVIGYGQIS
RYLCDVALALGMRIVVHDPYTRTGRQELVQTGLAPLLAEADYVVCLAAATEATENLMNAQAFALMKPGAFFINASRGNLV
DESALLAALDAGTMAGCAVDVGRAPDQMPSPRVAAHPRVIASPHIGGLTPPAVEHQALETVAQVADILQGCVPQGAVNAA
QAHRWQQAFGTTQPA
>Mature_334_residues
TTVFVSHPRTSLGHYFGARATAALQALADVRFNPGDTDLSSRELAALAQDCDVIISYRQTQGDEALFAALPRLKAFVRCA
IDIRNIDVPAASRHGVLVTQASAGFIASVSEWIIGVMIDLSRHISASAALYHAGRPVAPLMGRELRGATLGVIGYGQISR
YLCDVALALGMRIVVHDPYTRTGRQELVQTGLAPLLAEADYVVCLAAATEATENLMNAQAFALMKPGAFFINASRGNLVD
ESALLAALDAGTMAGCAVDVGRAPDQMPSPRVAAHPRVIASPHIGGLTPPAVEHQALETVAQVADILQGCVPQGAVNAAQ
AHRWQQAFGTTQPA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=289, Percent_Identity=32.5259515570934, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI145580578, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557499, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4557497, Length=281, Percent_Identity=28.1138790035587, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI61743967, Length=281, Percent_Identity=28.1138790035587, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=28.1021897810219, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI6912396, Length=244, Percent_Identity=27.0491803278689, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1789279, Length=297, Percent_Identity=32.3232323232323, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI87082289, Length=262, Percent_Identity=30.1526717557252, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787645, Length=290, Percent_Identity=26.8965517241379, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081824, Length=141, Percent_Identity=31.2056737588652, Blast_Score=66, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=267, Percent_Identity=33.3333333333333, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI25147481, Length=257, Percent_Identity=26.0700389105058, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=255, Percent_Identity=34.1176470588235, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320925, Length=255, Percent_Identity=33.7254901960784, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6325144, Length=170, Percent_Identity=28.8235294117647, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19921140, Length=305, Percent_Identity=31.8032786885246, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24646446, Length=275, Percent_Identity=28, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646448, Length=275, Percent_Identity=28, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646452, Length=275, Percent_Identity=28, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24646450, Length=275, Percent_Identity=28, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI62472511, Length=273, Percent_Identity=28.2051282051282, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24585516, Length=260, Percent_Identity=26.5384615384615, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585514, Length=241, Percent_Identity=26.5560165975104, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574282, Length=241, Percent_Identity=26.5560165975104, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45552429, Length=241, Percent_Identity=26.5560165975104, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574286, Length=243, Percent_Identity=25.1028806584362, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28574284, Length=241, Percent_Identity=26.5560165975104, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI45551003, Length=241, Percent_Identity=26.5560165975104, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571528, Length=244, Percent_Identity=28.2786885245902, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 35265; Mature: 35134

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVFVSHPRTSLGHYFGARATAALQALADVRFNPGDTDLSSRELAALAQDCDVIISYRQ
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEHH
TQGDEALFAALPRLKAFVRCAIDIRNIDVPAASRHGVLVTQASAGFIASVSEWIIGVMID
CCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
LSRHISASAALYHAGRPVAPLMGRELRGATLGVIGYGQISRYLCDVALALGMRIVVHDPY
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCC
TRTGRQELVQTGLAPLLAEADYVVCLAAATEATENLMNAQAFALMKPGAFFINASRGNLV
CCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCC
DESALLAALDAGTMAGCAVDVGRAPDQMPSPRVAAHPRVIASPHIGGLTPPAVEHQALET
CHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
VAQVADILQGCVPQGAVNAAQAHRWQQAFGTTQPA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTVFVSHPRTSLGHYFGARATAALQALADVRFNPGDTDLSSRELAALAQDCDVIISYRQ
CEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCEEEEEHH
TQGDEALFAALPRLKAFVRCAIDIRNIDVPAASRHGVLVTQASAGFIASVSEWIIGVMID
CCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
LSRHISASAALYHAGRPVAPLMGRELRGATLGVIGYGQISRYLCDVALALGMRIVVHDPY
HHHHHHHHHHHHHCCCCCHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHCCEEEEECCC
TRTGRQELVQTGLAPLLAEADYVVCLAAATEATENLMNAQAFALMKPGAFFINASRGNLV
CCCHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHEEECCCEEEEECCCCCCC
DESALLAALDAGTMAGCAVDVGRAPDQMPSPRVAAHPRVIASPHIGGLTPPAVEHQALET
CHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCHHHHHHHHH
VAQVADILQGCVPQGAVNAAQAHRWQQAFGTTQPA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]