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The map label for this gene is trpC

Identifier: 91790284

GI number: 91790284

Start: 4705220

End: 4706014

Strand: Reverse

Name: trpC

Synonym: Bpro_4451

Alternate gene names: 91790284

Gene position: 4706014-4705220 (Counterclockwise)

Preceding gene: 91790285

Following gene: 91790283

Centisome position: 90.5

GC content: 64.03

Gene sequence:

>795_bases
ATGTCCGACATCCTCGACAAGATCATTGCCGTCAAGCGCGAAGAAATCGCGCAGGCCATCAAACGCAAGCCGCTGGCCGT
GGTGCGCGAAGACGCCGAATCGCGTGTGCTCACGCGGGACTTTGTCGGCGCGCTGCGCGCCAAAATCTCGGCGGGCAAGC
CGGCGGTGATTGCCGAAGTCAAAAAGGCCAGCCCGTCCAAGGGCGTGCTGCGGGCCGACTTCATTCCGGCCGACATTGCG
CAAAGCTATGCGGAGCATGGCGCGGCCTGCCTGTCCGTGCTCACCGACCGGCAGTTTTTCCAGGGCAGTGTGGACTACCT
GAAACAGGCCCGGGCCTCGTGCGCCCTGCCGGTGCTGCGCAAGGATTTCATGGTCGACGCCTACCAGGTGTACGAGGCCC
GCGTGATGGGGGCCGACTGCATTTTGCTGATTGTCGCCTGCCTGGACGACGCGCAGATGAAGGCGCTGGAAGCGCTGGCG
TTCTCGCTGGACATGGCGGTGCTGGTCGAGGTGCACGACGAGGCCGAGCTGGAGCGGGCGCTGAAGCTCAGGACACCGCT
GGTCGGCATCAACAACCGCAACCTCAAGACCTTTGAGGTCTCGCTGGACAATACCCTGAGTCTGCTCGGCAAAGTACCGG
CAGACCGCCTGCTGGTCACGGAATCCGGCATTTCCACCCCGGCCGACGTCAAGCGCTTGCGTGAGGCCAGGGTCAACGCC
TTCCTGGTCGGCGAAGCCTTCATGCGGGCAGAAGATCCCGGCGTCGCGCTGGCTCAACTTTTCGGGCTGGACTGA

Upstream 100 bases:

>100_bases
AGGGCATCGTCAAGGCGCGTGCCGCGCTCGAGTCCGGTGCGGCCAAGGCCCGCCTCGCGCAGCTTGTTTCCATCACCCAA
ACCCTGGCAGCCTGAACACC

Downstream 100 bases:

>100_bases
CTGGCGCCGGCCATGACGGACCTGTTTCTGGATGAGGCGTCGGCGCTGGGCGTCGCGGACCGCCTGACCAGCGCGGACCC
CTTGGCCTGGCCGGTAGCGC

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSDILDKIIAVKREEIAQAIKRKPLAVVREDAESRVLTRDFVGALRAKISAGKPAVIAEVKKASPSKGVLRADFIPADIA
QSYAEHGAACLSVLTDRQFFQGSVDYLKQARASCALPVLRKDFMVDAYQVYEARVMGADCILLIVACLDDAQMKALEALA
FSLDMAVLVEVHDEAELERALKLRTPLVGINNRNLKTFEVSLDNTLSLLGKVPADRLLVTESGISTPADVKRLREARVNA
FLVGEAFMRAEDPGVALAQLFGLD

Sequences:

>Translated_264_residues
MSDILDKIIAVKREEIAQAIKRKPLAVVREDAESRVLTRDFVGALRAKISAGKPAVIAEVKKASPSKGVLRADFIPADIA
QSYAEHGAACLSVLTDRQFFQGSVDYLKQARASCALPVLRKDFMVDAYQVYEARVMGADCILLIVACLDDAQMKALEALA
FSLDMAVLVEVHDEAELERALKLRTPLVGINNRNLKTFEVSLDNTLSLLGKVPADRLLVTESGISTPADVKRLREARVNA
FLVGEAFMRAEDPGVALAQLFGLD
>Mature_263_residues
SDILDKIIAVKREEIAQAIKRKPLAVVREDAESRVLTRDFVGALRAKISAGKPAVIAEVKKASPSKGVLRADFIPADIAQ
SYAEHGAACLSVLTDRQFFQGSVDYLKQARASCALPVLRKDFMVDAYQVYEARVMGADCILLIVACLDDAQMKALEALAF
SLDMAVLVEVHDEAELERALKLRTPLVGINNRNLKTFEVSLDNTLSLLGKVPADRLLVTESGISTPADVKRLREARVNAF
LVGEAFMRAEDPGVALAQLFGLD

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=252, Percent_Identity=42.4603174603175, Blast_Score=181, Evalue=4e-47,
Organism=Saccharomyces cerevisiae, GI6322638, Length=265, Percent_Identity=37.7358490566038, Blast_Score=158, Evalue=7e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_POLSJ (Q123F4)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_551236.1
- ProteinModelPortal:   Q123F4
- SMR:   Q123F4
- STRING:   Q123F4
- GeneID:   4012877
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_4451
- NMPDR:   fig|296591.1.peg.1055
- eggNOG:   COG0134
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- PhylomeDB:   Q123F4
- ProtClustDB:   PRK00278
- BioCyc:   PSP296591:BPRO_4451-MONOMER
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 28768; Mature: 28637

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDILDKIIAVKREEIAQAIKRKPLAVVREDAESRVLTRDFVGALRAKISAGKPAVIAEV
CHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVLRADFIPADIAQSYAEHGAACLSVLTDRQFFQGSVDYLKQARASCALPVLR
HHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KDFMVDAYQVYEARVMGADCILLIVACLDDAQMKALEALAFSLDMAVLVEVHDEAELERA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
LKLRTPLVGINNRNLKTFEVSLDNTLSLLGKVPADRLLVTESGISTPADVKRLREARVNA
HHHHCCEEECCCCCEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCE
FLVGEAFMRAEDPGVALAQLFGLD
EEEHHHHHHCCCCCHHHHHHHCCC
>Mature Secondary Structure 
SDILDKIIAVKREEIAQAIKRKPLAVVREDAESRVLTRDFVGALRAKISAGKPAVIAEV
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
KKASPSKGVLRADFIPADIAQSYAEHGAACLSVLTDRQFFQGSVDYLKQARASCALPVLR
HHCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
KDFMVDAYQVYEARVMGADCILLIVACLDDAQMKALEALAFSLDMAVLVEVHDEAELERA
HHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHH
LKLRTPLVGINNRNLKTFEVSLDNTLSLLGKVPADRLLVTESGISTPADVKRLREARVNA
HHHHCCEEECCCCCEEEEEEEHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCE
FLVGEAFMRAEDPGVALAQLFGLD
EEEHHHHHHCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA