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The map label for this gene is phbA [H]

Identifier: 91790025

GI number: 91790025

Start: 4399509

End: 4400690

Strand: Reverse

Name: phbA [H]

Synonym: Bpro_4187

Alternate gene names: 91790025

Gene position: 4400690-4399509 (Counterclockwise)

Preceding gene: 91790026

Following gene: 91790024

Centisome position: 84.62

GC content: 65.65

Gene sequence:

>1182_bases
ATGTCGGATTCCATCGTTATTCTCGGCGCCGCCCGTACCCCCATGGGCGGCTTCCAGGGCGACTTCAGTTCGCTCGCCGC
ACACGACCTCGGCGGCGCAGCCATCAAGGCCGCCATTGAGCGCGCGGGCATCGCGCCTGAAAAAGTCGACGAAGTCCTGT
TCGGCAACTGCCTGATGGCGGGCCAGGGCCAGGCGCCGGCGCGGCAAGCCGGCTTCAAGGGCGGCCTGCCTGCCAGCGCA
GGTGCCGTGACGCTTTCCAAGATGTGCGGCTCCGGCATGGAAGCCACCATGCTGGCGCACGACCAACTGATGGTGGGCAG
CCGTGACGTGATGGTGGCCGGCGGCATGGAAAGCATGACCAACGCACCGCATTTGTTGCTCAAGGGCCGCAGCGGTGTGC
GCATCGGCCACGACCGCATCTTTGACCACATGATGCTGGACGGCCTGGAAGACGCCTACGAGCCCGGCCGCGCCATGGGC
ACCTTTGGCGAGCAGTGCGCCGAAAAATACCAGTTCACCCGTGAAGCGCAGGACGCTTTCGCGGTGGCCAGCGTGCAGCG
CGCCAAGGCGGCCACGGAGTCTGGAGCCTTCAAGGCCGAGATCACGCCGGTCACCGTGAAAGGCCGGGCCGGCGACACCG
TGATTTCCATCGATGAAGGTCCGGGCAAGGTCAAGCTTGACAAGATCGCGGCGCTGCGGCCCGCCTTCAAGAAAGACGGC
ACCATCACCGCCGCATCCAGCTCGTCGATCAATGACGGCGCCGCGGCGCTGGTGCTGACCCGCGAATCCACCGCCAAAGA
GCTGGGCGCCACACCCATCGCCCGCATCGTCGGCCATGCCACCTTTGCCCAGGCGCCCGAGTGGTTCACCACCGCACCGG
TGGGCGCGGTGCAAAAGCTGCTCAAGAAGATCGGCTGGAGCGTGAAAGACGTGGACCTGTGGGAAGTCAACGAAGCCTTT
GCCGTGGTGCCCATGGCCGCGATGAAAGAACTCGGCATCAGCCACGACATCGTGAATGTGAATGGCGGCGCCTGCGCGCT
GGGCCACCCGATTGGCGCCAGCGGTGCCCGCATCATCGTCACGCTGATCCATGCGCTGAAAGCCCGCGGCCTGAAAAAAG
GCGTGGCGACGCTGTGCATCGGCGGCGGAGAAGGCACGGCGCTGGCGGTTGAGCTGATGTAA

Upstream 100 bases:

>100_bases
TGGCATGACCCCCTAAGCGCGGCAAGAGCCTGGCAAGCGCGCAAAAAGCACGGCAAGAACAGCACCACAGTTTTCATTCA
ACCCTGAAAGGACACACATC

Downstream 100 bases:

>100_bases
TGTTTTGTCGTCAGGTCTGCTGGCCGCATCCGCGCGAGGTGGCCCGGACTGGCTTCTACATGAGATCTTTCGCATGAGCA
CGGTGCTGGTCATAGGCGCT

Product: Acetyl-CoA C-acetyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 393; Mature: 392

Protein sequence:

>393_residues
MSDSIVILGAARTPMGGFQGDFSSLAAHDLGGAAIKAAIERAGIAPEKVDEVLFGNCLMAGQGQAPARQAGFKGGLPASA
GAVTLSKMCGSGMEATMLAHDQLMVGSRDVMVAGGMESMTNAPHLLLKGRSGVRIGHDRIFDHMMLDGLEDAYEPGRAMG
TFGEQCAEKYQFTREAQDAFAVASVQRAKAATESGAFKAEITPVTVKGRAGDTVISIDEGPGKVKLDKIAALRPAFKKDG
TITAASSSSINDGAAALVLTRESTAKELGATPIARIVGHATFAQAPEWFTTAPVGAVQKLLKKIGWSVKDVDLWEVNEAF
AVVPMAAMKELGISHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGLKKGVATLCIGGGEGTALAVELM

Sequences:

>Translated_393_residues
MSDSIVILGAARTPMGGFQGDFSSLAAHDLGGAAIKAAIERAGIAPEKVDEVLFGNCLMAGQGQAPARQAGFKGGLPASA
GAVTLSKMCGSGMEATMLAHDQLMVGSRDVMVAGGMESMTNAPHLLLKGRSGVRIGHDRIFDHMMLDGLEDAYEPGRAMG
TFGEQCAEKYQFTREAQDAFAVASVQRAKAATESGAFKAEITPVTVKGRAGDTVISIDEGPGKVKLDKIAALRPAFKKDG
TITAASSSSINDGAAALVLTRESTAKELGATPIARIVGHATFAQAPEWFTTAPVGAVQKLLKKIGWSVKDVDLWEVNEAF
AVVPMAAMKELGISHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGLKKGVATLCIGGGEGTALAVELM
>Mature_392_residues
SDSIVILGAARTPMGGFQGDFSSLAAHDLGGAAIKAAIERAGIAPEKVDEVLFGNCLMAGQGQAPARQAGFKGGLPASAG
AVTLSKMCGSGMEATMLAHDQLMVGSRDVMVAGGMESMTNAPHLLLKGRSGVRIGHDRIFDHMMLDGLEDAYEPGRAMGT
FGEQCAEKYQFTREAQDAFAVASVQRAKAATESGAFKAEITPVTVKGRAGDTVISIDEGPGKVKLDKIAALRPAFKKDGT
ITAASSSSINDGAAALVLTRESTAKELGATPIARIVGHATFAQAPEWFTTAPVGAVQKLLKKIGWSVKDVDLWEVNEAFA
VVPMAAMKELGISHDIVNVNGGACALGHPIGASGARIIVTLIHALKARGLKKGVATLCIGGGEGTALAVELM

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=45.5470737913486, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI4557237, Length=390, Percent_Identity=47.4358974358974, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI167614485, Length=389, Percent_Identity=37.7892030848329, Blast_Score=265, Evalue=5e-71,
Organism=Homo sapiens, GI4501853, Length=397, Percent_Identity=35.5163727959698, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4504327, Length=434, Percent_Identity=28.5714285714286, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI194353979, Length=392, Percent_Identity=27.8061224489796, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1788554, Length=390, Percent_Identity=50.2564102564103, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI87082165, Length=388, Percent_Identity=44.3298969072165, Blast_Score=333, Evalue=1e-92,
Organism=Escherichia coli, GI1787663, Length=390, Percent_Identity=36.9230769230769, Blast_Score=225, Evalue=3e-60,
Organism=Escherichia coli, GI48994986, Length=411, Percent_Identity=36.0097323600973, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1788683, Length=410, Percent_Identity=29.7560975609756, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI25147385, Length=387, Percent_Identity=41.6020671834625, Blast_Score=309, Evalue=1e-84,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=44.1624365482233, Blast_Score=303, Evalue=1e-82,
Organism=Caenorhabditis elegans, GI133906874, Length=388, Percent_Identity=39.9484536082474, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17535917, Length=392, Percent_Identity=33.9285714285714, Blast_Score=198, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17551802, Length=422, Percent_Identity=29.6208530805687, Blast_Score=166, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6325229, Length=397, Percent_Identity=44.5843828715365, Blast_Score=316, Evalue=5e-87,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=33.4177215189873, Blast_Score=196, Evalue=8e-51,
Organism=Drosophila melanogaster, GI24655093, Length=394, Percent_Identity=46.9543147208122, Blast_Score=337, Evalue=7e-93,
Organism=Drosophila melanogaster, GI24640423, Length=389, Percent_Identity=44.7300771208226, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI17648125, Length=390, Percent_Identity=35.6410256410256, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI17137578, Length=424, Percent_Identity=29.2452830188679, Blast_Score=166, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 40463; Mature: 40332

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSIVILGAARTPMGGFQGDFSSLAAHDLGGAAIKAAIERAGIAPEKVDEVLFGNCLMA
CCCCEEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEC
GQGQAPARQAGFKGGLPASAGAVTLSKMCGSGMEATMLAHDQLMVGSRDVMVAGGMESMT
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEEECCCCEEEECCHHHHC
NAPHLLLKGRSGVRIGHDRIFDHMMLDGLEDAYEPGRAMGTFGEQCAEKYQFTREAQDAF
CCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVASVQRAKAATESGAFKAEITPVTVKGRAGDTVISIDEGPGKVKLDKIAALRPAFKKDG
HHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHCCHHCCCC
TITAASSSSINDGAAALVLTRESTAKELGATPIARIVGHATFAQAPEWFTTAPVGAVQKL
CEEEECCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LKKIGWSVKDVDLWEVNEAFAVVPMAAMKELGISHDIVNVNGGACALGHPIGASGARIIV
HHHHCCCEECEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHH
TLIHALKARGLKKGVATLCIGGGEGTALAVELM
HHHHHHHHCCHHCCCEEEEEECCCCCEEEEEEC
>Mature Secondary Structure 
SDSIVILGAARTPMGGFQGDFSSLAAHDLGGAAIKAAIERAGIAPEKVDEVLFGNCLMA
CCCEEEEEECCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHCCEEEC
GQGQAPARQAGFKGGLPASAGAVTLSKMCGSGMEATMLAHDQLMVGSRDVMVAGGMESMT
CCCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEEECCCCEEEECCHHHHC
NAPHLLLKGRSGVRIGHDRIFDHMMLDGLEDAYEPGRAMGTFGEQCAEKYQFTREAQDAF
CCCEEEEECCCCCEECHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
AVASVQRAKAATESGAFKAEITPVTVKGRAGDTVISIDEGPGKVKLDKIAALRPAFKKDG
HHHHHHHHHHHHCCCCEEEEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHCCHHCCCC
TITAASSSSINDGAAALVLTRESTAKELGATPIARIVGHATFAQAPEWFTTAPVGAVQKL
CEEEECCCCCCCCEEEEEEECCHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LKKIGWSVKDVDLWEVNEAFAVVPMAAMKELGISHDIVNVNGGACALGHPIGASGARIIV
HHHHCCCEECEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCEEEECCCCCCCCHHHHH
TLIHALKARGLKKGVATLCIGGGEGTALAVELM
HHHHHHHHCCHHCCCEEEEEECCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7763384 [H]