Click here to switch to the map view.

The map label for this gene is acdA [H]

Identifier: 91789690

GI number: 91789690

Start: 4037008

End: 4038123

Strand: Direct

Name: acdA [H]

Synonym: Bpro_3846

Alternate gene names: 91789690

Gene position: 4037008-4038123 (Clockwise)

Preceding gene: 91789689

Following gene: 91789692

Centisome position: 77.63

GC content: 64.87

Gene sequence:

>1116_bases
ATGGATTTCGATTTCACCGATGACCAGGAACAGCTTCGCGACGCGGTTCGCAAATGGGTGGACAAGGGCTACGACTTCGA
GCGCCGCCGCAGCATTGAAAAAGCCGGTGGCTTCTCACGCGAGGCCTATGGCCAGCTGGCCGAACTGGGGCTGACAGGCC
TGTACATCCCCGAGGACGATGGTGGCATGGGCATGGGGCCGGTTGAAGGCATGGTGGTCATGGAAGAACTGGGGCGCGGC
ATGGTGCTGGAGCCCCTGGCCCAGACCCTGCTCACCAGCGCTGTGCTCTCCGGCTACGCACCCGATGCCGTCAAGGCCGC
CTGGCTGCCGAACATTGCCTCGGGCGAGAGCCTGGTGGTGCTGGCCTATCAGGAACGGGCTGCCCGCTACCGGCTTGAAC
AATGCGAAGCAACAGCAGTTGCAAGCGGCGACGCCTGGTCGCTGACTGCTGTCAAAAGCATAGTACCGGCAGGTGACCAG
GCCGACGCCTTCCTTGTGCCGGCCATGGCCAGCGGCAAGCTGGCGCTGTTTCTGGTGGAGCGCACCGCAACAGGCGTTGC
CACCCGCGGCTACAGCACCCAGGACGGCGCGCGCGCCGCGGAGGTGACGCTCGCGAATGCGCCGGCCAGCCTGGTCACGC
TGGATGGCCTCACCGCGCTCTCGCACGCCGTCGACATCGGCATTGCCGCCATCTGCGCCGAGGCGGTGGGCGTGATGGAC
AAAACGCTGGCTGTCACGGTCGAGTACATGAACACGCGCAAGCAGTTTGGCGTGGCCATCAGCAGCTTCCAGGCACTGCG
CCACCGCGTGGCCGACATGAAGATGCAGCTGGAGCTGGCCCGCTCCATGAGCTACTACGCTTCGCTCAAGCTCAATGCGC
CGACGGACGAACGCCGCCGGGCGTTGGCCCGCGCCAAGTACCAGCTGGGCGTTTCCATGCGTTTTGTCGGCCAGCAGGCC
GTGCAGCTGCATGGCGGCATCGGCGTGACCGACGAATACATCGTCAGTCACTACTTCAAGAAACTCACCCAGCTGGAGAT
GACGTTTGGCGACACGCTGCACCACCTGGGCGAGGTGTCCAGCCGGATGCAGGAGACGGCCGGCGTGTTTGCCTGA

Upstream 100 bases:

>100_bases
AACATGCGCAAAACCACGATTTACGGCGGCTCCAACGAGGTCCAGCGAAATATCGTTTCACAAGTCGTTTTGGGTTAATG
CTGGTTTAAAGGAAAGCATC

Downstream 100 bases:

>100_bases
AGGATGAAGGAACAGGCGTGGACCGCCTGGAGCGTCACGCGTGCAGGCGTGAAGGCATCAGATCGTCACGCGTGCAGGCG
TGACGTTTTGGGAATGTGCG

Product: acyl-CoA dehydrogenase-like protein

Products: 6-carboxyhex-2-enoyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MDFDFTDDQEQLRDAVRKWVDKGYDFERRRSIEKAGGFSREAYGQLAELGLTGLYIPEDDGGMGMGPVEGMVVMEELGRG
MVLEPLAQTLLTSAVLSGYAPDAVKAAWLPNIASGESLVVLAYQERAARYRLEQCEATAVASGDAWSLTAVKSIVPAGDQ
ADAFLVPAMASGKLALFLVERTATGVATRGYSTQDGARAAEVTLANAPASLVTLDGLTALSHAVDIGIAAICAEAVGVMD
KTLAVTVEYMNTRKQFGVAISSFQALRHRVADMKMQLELARSMSYYASLKLNAPTDERRRALARAKYQLGVSMRFVGQQA
VQLHGGIGVTDEYIVSHYFKKLTQLEMTFGDTLHHLGEVSSRMQETAGVFA

Sequences:

>Translated_371_residues
MDFDFTDDQEQLRDAVRKWVDKGYDFERRRSIEKAGGFSREAYGQLAELGLTGLYIPEDDGGMGMGPVEGMVVMEELGRG
MVLEPLAQTLLTSAVLSGYAPDAVKAAWLPNIASGESLVVLAYQERAARYRLEQCEATAVASGDAWSLTAVKSIVPAGDQ
ADAFLVPAMASGKLALFLVERTATGVATRGYSTQDGARAAEVTLANAPASLVTLDGLTALSHAVDIGIAAICAEAVGVMD
KTLAVTVEYMNTRKQFGVAISSFQALRHRVADMKMQLELARSMSYYASLKLNAPTDERRRALARAKYQLGVSMRFVGQQA
VQLHGGIGVTDEYIVSHYFKKLTQLEMTFGDTLHHLGEVSSRMQETAGVFA
>Mature_371_residues
MDFDFTDDQEQLRDAVRKWVDKGYDFERRRSIEKAGGFSREAYGQLAELGLTGLYIPEDDGGMGMGPVEGMVVMEELGRG
MVLEPLAQTLLTSAVLSGYAPDAVKAAWLPNIASGESLVVLAYQERAARYRLEQCEATAVASGDAWSLTAVKSIVPAGDQ
ADAFLVPAMASGKLALFLVERTATGVATRGYSTQDGARAAEVTLANAPASLVTLDGLTALSHAVDIGIAAICAEAVGVMD
KTLAVTVEYMNTRKQFGVAISSFQALRHRVADMKMQLELARSMSYYASLKLNAPTDERRRALARAKYQLGVSMRFVGQQA
VQLHGGIGVTDEYIVSHYFKKLTQLEMTFGDTLHHLGEVSSRMQETAGVFA

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=368, Percent_Identity=24.4565217391304, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4557233, Length=360, Percent_Identity=23.6111111111111, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4501859, Length=355, Percent_Identity=24.2253521126761, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI226958414, Length=331, Percent_Identity=24.773413897281, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4501857, Length=354, Percent_Identity=24.2937853107345, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI21361497, Length=356, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI7656849, Length=319, Percent_Identity=24.1379310344828, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4557235, Length=322, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI76496475, Length=322, Percent_Identity=26.0869565217391, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=24.6073298429319, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=24.6073298429319, Blast_Score=70, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17506239, Length=355, Percent_Identity=25.0704225352113, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17538396, Length=349, Percent_Identity=24.9283667621776, Blast_Score=88, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17569725, Length=375, Percent_Identity=25.0666666666667, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17508101, Length=314, Percent_Identity=25.796178343949, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17534899, Length=361, Percent_Identity=24.0997229916898, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17570075, Length=362, Percent_Identity=26.5193370165746, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71985184, Length=322, Percent_Identity=26.3975155279503, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17533517, Length=333, Percent_Identity=21.021021021021, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71985192, Length=299, Percent_Identity=25.752508361204, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71990804, Length=259, Percent_Identity=22.7799227799228, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24666513, Length=363, Percent_Identity=25.068870523416, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356377, Length=338, Percent_Identity=24.8520710059172, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21355753, Length=354, Percent_Identity=25.7062146892655, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24646207, Length=331, Percent_Identity=23.5649546827795, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24660351, Length=394, Percent_Identity=24.6192893401015, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363737, Length=308, Percent_Identity=23.7012987012987, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.1.62

Molecular weight: Translated: 40067; Mature: 40067

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFDFTDDQEQLRDAVRKWVDKGYDFERRRSIEKAGGFSREAYGQLAELGLTGLYIPEDD
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCC
GGMGMGPVEGMVVMEELGRGMVLEPLAQTLLTSAVLSGYAPDAVKAAWLPNIASGESLVV
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEE
LAYQERAARYRLEQCEATAVASGDAWSLTAVKSIVPAGDQADAFLVPAMASGKLALFLVE
EEEHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEE
RTATGVATRGYSTQDGARAAEVTLANAPASLVTLDGLTALSHAVDIGIAAICAEAVGVMD
CCCCCCEECCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
KTLAVTVEYMNTRKQFGVAISSFQALRHRVADMKMQLELARSMSYYASLKLNAPTDERRR
HHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHH
ALARAKYQLGVSMRFVGQQAVQLHGGIGVTDEYIVSHYFKKLTQLEMTFGDTLHHLGEVS
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRMQETAGVFA
HHHHHHHCCCC
>Mature Secondary Structure
MDFDFTDDQEQLRDAVRKWVDKGYDFERRRSIEKAGGFSREAYGQLAELGLTGLYIPEDD
CCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCC
GGMGMGPVEGMVVMEELGRGMVLEPLAQTLLTSAVLSGYAPDAVKAAWLPNIASGESLVV
CCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCCCCEEE
LAYQERAARYRLEQCEATAVASGDAWSLTAVKSIVPAGDQADAFLVPAMASGKLALFLVE
EEEHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCEEEEEEE
RTATGVATRGYSTQDGARAAEVTLANAPASLVTLDGLTALSHAVDIGIAAICAEAVGVMD
CCCCCCEECCCCCCCCCCEEEEEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHH
KTLAVTVEYMNTRKQFGVAISSFQALRHRVADMKMQLELARSMSYYASLKLNAPTDERRR
HHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCHHHHH
ALARAKYQLGVSMRFVGQQAVQLHGGIGVTDEYIVSHYFKKLTQLEMTFGDTLHHLGEVS
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SRMQETAGVFA
HHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pimeloyl-CoA; NAD+

Specific reaction: pimeloyl-CoA + NAD+ = 6-carboxyhex-2-enoyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]