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The map label for this gene is hemC [H]

Identifier: 91789512

GI number: 91789512

Start: 3865187

End: 3866191

Strand: Reverse

Name: hemC [H]

Synonym: Bpro_3664

Alternate gene names: 91789512

Gene position: 3866191-3865187 (Counterclockwise)

Preceding gene: 91789516

Following gene: 91789511

Centisome position: 74.35

GC content: 68.96

Gene sequence:

>1005_bases
GTGTCTGCAGCGTCTCAACCCGGCAACCCGATTGCCCCCCGCAAAATCATCATTGCCACGCGCGAAAGCCGGCTGGCGCT
GTGGCAGGCCGAGCATGTCAAGGCGCTGCTCGAATCCCGCCTGGGCTGGCAGGTGGAACTGCTGGGCATGACGACCCAGG
GCGACCAGATCCTGGACCGCTCGTTGAGCAAGGTCGGTGGCAAGGGGCTGTTCGTCAAGGAGCTGGAAGTGGCCCTCAGC
GAAGGCCGGGCCGACCTGGCCGTGCATTCGCTCAAGGATGTACCCATGGACCTGCCCGACGGATTTGCGCTGGCCTGTGT
GCTGGAGCGCGAAGATCCGCACGACGCTTTCGTGTCCAACCAGTTTGCCTCGCTGGCCGACCTCCCGCAGGGCGCGGTGG
TCGGAACCTCCAGCCTGCGCCGGCTGGTGCTGCTCAAGGCGCTGCGGCCCGATCTGAACATCGAGCCCTTGCGCGGCAAC
CTCGACACGCGCCTGCGCAAGCTCGACGAGGGCCACTACCACGCCATCGTGCTGGCGGCGGCCGGGCTCAAGCGCCTGGG
CCTTCAGGCGCGCATTCGCGGCATCTTTGCGCCCGACGACATGTTGCCGGCTGCGGGGCAGGGCGCCCTGGGCATCGAGG
TGCGGGCCGACCGCCATGATTTGATGCAGGCCCTGGGCACGCTGGCCCATCAGCCGACGTGGCTGGCGGTGACGGCTGAG
CGCACCGTCTCGCGCGCCATGGGTGGCAGCTGCTCCATGCCGCTGGCCGCCTACACCGAAGGCCCGGCGGCAGAAGGCTC
AGAAGGCATGCAACTGCACGCGACCTGGGGCGATCCGGCTACCGCCGACGCGCCGGCCGGCCAGCCGCTGGCTCCGCTGG
TGCGGGTGCAAAAAACCGCGGTGGTGCGCAGTTTTGCCGAAGCCGAGGCGCTTGGCGAAGCGGTCGCGGCGCAGCTGCGT
GCTGGCGGCGCGGTCTGGGCTAGCAACACCCCTTCCGATACCTGA

Upstream 100 bases:

>100_bases
GCGCGCTGAAATGACCATCTCTACCCTCTGGTTCTGGACCTGTTCTTGAACCTCGCATGCTAGCATTCCAGTCTCCCCCA
GGATTACGAACAGGTTACGA

Downstream 100 bases:

>100_bases
CGCCGGGGGCCGAGTGAGCACTCCCCGCCCTGTCCGCGTCATTGTGACCCGGCCCGCTCGCGATGCGCAGCAATGGGTGC
AGCAACTCCAGCAGGACGGC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSAASQPGNPIAPRKIIIATRESRLALWQAEHVKALLESRLGWQVELLGMTTQGDQILDRSLSKVGGKGLFVKELEVALS
EGRADLAVHSLKDVPMDLPDGFALACVLEREDPHDAFVSNQFASLADLPQGAVVGTSSLRRLVLLKALRPDLNIEPLRGN
LDTRLRKLDEGHYHAIVLAAAGLKRLGLQARIRGIFAPDDMLPAAGQGALGIEVRADRHDLMQALGTLAHQPTWLAVTAE
RTVSRAMGGSCSMPLAAYTEGPAAEGSEGMQLHATWGDPATADAPAGQPLAPLVRVQKTAVVRSFAEAEALGEAVAAQLR
AGGAVWASNTPSDT

Sequences:

>Translated_334_residues
MSAASQPGNPIAPRKIIIATRESRLALWQAEHVKALLESRLGWQVELLGMTTQGDQILDRSLSKVGGKGLFVKELEVALS
EGRADLAVHSLKDVPMDLPDGFALACVLEREDPHDAFVSNQFASLADLPQGAVVGTSSLRRLVLLKALRPDLNIEPLRGN
LDTRLRKLDEGHYHAIVLAAAGLKRLGLQARIRGIFAPDDMLPAAGQGALGIEVRADRHDLMQALGTLAHQPTWLAVTAE
RTVSRAMGGSCSMPLAAYTEGPAAEGSEGMQLHATWGDPATADAPAGQPLAPLVRVQKTAVVRSFAEAEALGEAVAAQLR
AGGAVWASNTPSDT
>Mature_333_residues
SAASQPGNPIAPRKIIIATRESRLALWQAEHVKALLESRLGWQVELLGMTTQGDQILDRSLSKVGGKGLFVKELEVALSE
GRADLAVHSLKDVPMDLPDGFALACVLEREDPHDAFVSNQFASLADLPQGAVVGTSSLRRLVLLKALRPDLNIEPLRGNL
DTRLRKLDEGHYHAIVLAAAGLKRLGLQARIRGIFAPDDMLPAAGQGALGIEVRADRHDLMQALGTLAHQPTWLAVTAER
TVSRAMGGSCSMPLAAYTEGPAAEGSEGMQLHATWGDPATADAPAGQPLAPLVRVQKTAVVRSFAEAEALGEAVAAQLRA
GGAVWASNTPSDT

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=263, Percent_Identity=47.148288973384, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI66933009, Length=251, Percent_Identity=48.207171314741, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI48994974, Length=244, Percent_Identity=58.6065573770492, Blast_Score=270, Evalue=8e-74,
Organism=Saccharomyces cerevisiae, GI6319996, Length=324, Percent_Identity=36.7283950617284, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=42.96875, Blast_Score=194, Evalue=6e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 35347; Mature: 35216

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAASQPGNPIAPRKIIIATRESRLALWQAEHVKALLESRLGWQVELLGMTTQGDQILDR
CCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
SLSKVGGKGLFVKELEVALSEGRADLAVHSLKDVPMDLPDGFALACVLEREDPHDAFVSN
HHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHH
QFASLADLPQGAVVGTSSLRRLVLLKALRPDLNIEPLRGNLDTRLRKLDEGHYHAIVLAA
HHHHHHCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEH
AGLKRLGLQARIRGIFAPDDMLPAAGQGALGIEVRADRHDLMQALGTLAHQPTWLAVTAE
HHHHHHCHHHHHEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEHH
RTVSRAMGGSCSMPLAAYTEGPAAEGSEGMQLHATWGDPATADAPAGQPLAPLVRVQKTA
HHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
VVRSFAEAEALGEAVAAQLRAGGAVWASNTPSDT
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
SAASQPGNPIAPRKIIIATRESRLALWQAEHVKALLESRLGWQVELLGMTTQGDQILDR
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHH
SLSKVGGKGLFVKELEVALSEGRADLAVHSLKDVPMDLPDGFALACVLEREDPHDAFVSN
HHHHHCCCCEEHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCHHHHHH
QFASLADLPQGAVVGTSSLRRLVLLKALRPDLNIEPLRGNLDTRLRKLDEGHYHAIVLAA
HHHHHHCCCCCCEECHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEH
AGLKRLGLQARIRGIFAPDDMLPAAGQGALGIEVRADRHDLMQALGTLAHQPTWLAVTAE
HHHHHHCHHHHHEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEEHH
RTVSRAMGGSCSMPLAAYTEGPAAEGSEGMQLHATWGDPATADAPAGQPLAPLVRVQKTA
HHHHHHCCCCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
VVRSFAEAEALGEAVAAQLRAGGAVWASNTPSDT
HHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA