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The map label for this gene is kynA

Identifier: 91789441

GI number: 91789441

Start: 3788201

End: 3789085

Strand: Direct

Name: kynA

Synonym: Bpro_3590

Alternate gene names: 91789441

Gene position: 3788201-3789085 (Clockwise)

Preceding gene: 91789440

Following gene: 91789445

Centisome position: 72.85

GC content: 64.18

Gene sequence:

>885_bases
ATGTGCCCCCACGCCCACCCCCCCGCCAAACCCGACCACGGCGCCACCACGACGCCCGAGCGCATTGTTCACGACGAGAA
GGCGCAGCTCGACTTCAGCCGCGACATGAGCTATGGCGACTACCTGCAGCTGGATGCGATTCTGAACGCGCAAAAACCAC
TCTCGCCCGCACACGACGAGATGCTGTTCATCATCCAGCACCAGACCAGCGAACTCTGGATGAAGCTGATGCTGCACGAG
TTGCGCGCCGCGATTGCGAATGTAGCGGCCGACGAACTGGGCAGCGCCTTCAAGATGCTGGCACGCGTGAGCCGCATCAT
GGAGCAGCTGGTGCACGCCTGGGACGTGCTGGCCACCATGACGCCGCCCGAGTACAGCGCGATGCGCCCCTACCTCGGGG
CGTCGAGCGGCTTTCAGAGCTACCAGTACCGCTGCATCGAATTCGCCTTGGGCAACAAGAACGCCGCCATGCTCCAGCCG
CACGCACACCGGTCGGACCTGCTGGCGCAGGTGCAGGCCGCCTATGAAGCCCCCTCGCTCTATGACGAAGCCCTGCGCCT
GCTGGCGCGGCGCGGCCTGGCCGTTCCCGCCAGCCACACCGAACGCGACTGGACACAGCCCTACCTTGAAAGCGCCGCGG
TCGAACAGGCCTGGCTGACCGTCTACCGCGACCCGAAGCAGTACTGGGACCTGTACCAGCTCGGCGAAGAACTCACCGAC
CTCGAAGACGCGTTTCGCCTCTGGCGTTTCCGCCATGTCACCACGGTCGAGCGCATCATCGGCTTCAAGCCCGGCACCGG
CGGCACCAGCGGCGTGAGTTATTTGCGCAAGATGCTGGATGTGGTGTTGTTTCCGGAGATCTGGAAATTGCGGACGGATT
TGTAG

Upstream 100 bases:

>100_bases
TTGAAGATGTCTGGAACGCCGTGGAGCAGCTCAAGCAGGTACTTGACACCGGTGAATGGCAAAGCGCCGAATTCAACCAG
AAACATGCGGTGACCTGATC

Downstream 100 bases:

>100_bases
GGGAAGTGGATTTACCGGAATAGGTGTCTGCGTGAGGTGCTATTTATTTAATAGCGGGTTGACTCTGCTGAGGGTTGCTG
GCCGGGGGTAGCCCGGCGGC

Product: tryptophan 2,3-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDEMLFIIQHQTSELWMKLMLHE
LRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATMTPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQP
HAHRSDLLAQVQAAYEAPSLYDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTD
LEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL

Sequences:

>Translated_294_residues
MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDEMLFIIQHQTSELWMKLMLHE
LRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATMTPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQP
HAHRSDLLAQVQAAYEAPSLYDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTD
LEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL
>Mature_294_residues
MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDEMLFIIQHQTSELWMKLMLHE
LRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATMTPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQP
HAHRSDLLAQVQAAYEAPSLYDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTD
LEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=142, Percent_Identity=38.0281690140845, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32564651, Length=147, Percent_Identity=35.3741496598639, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17552370, Length=148, Percent_Identity=35.1351351351351, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17530891, Length=335, Percent_Identity=31.044776119403, Blast_Score=118, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_POLSJ (Q126P7)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_550393.1
- ProteinModelPortal:   Q126P7
- SMR:   Q126P7
- STRING:   Q126P7
- GeneID:   4013736
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_3590
- NMPDR:   fig|296591.1.peg.5182
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   QWSVLAT
- ProtClustDB:   CLSK2777355
- BioCyc:   PSP296591:BPRO_3590-MONOMER
- InterPro:   IPR017485
- InterPro:   IPR004981
- PANTHER:   PTHR10138
- TIGRFAMs:   TIGR03036

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 33528; Mature: 33528

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 129-129 BINDING 136-136 BINDING 266-266

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDE
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCC
MLFIIQHQTSELWMKLMLHELRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQPHAHRSDLLAQVQAAYEAPSL
CCCCHHHHCCCCCCCCCHHHHHHHHHHEEECCCCCEEECCCCHHHHHHHHHHHHHCCCHH
YDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTD
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MCPHAHPPAKPDHGATTTPERIVHDEKAQLDFSRDMSYGDYLQLDAILNAQKPLSPAHDE
CCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCHHHCCCCCCHHHHHHHHCCCCCCCCCCCC
MLFIIQHQTSELWMKLMLHELRAAIANVAADELGSAFKMLARVSRIMEQLVHAWDVLATM
EEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
TPPEYSAMRPYLGASSGFQSYQYRCIEFALGNKNAAMLQPHAHRSDLLAQVQAAYEAPSL
CCCCHHHHCCCCCCCCCHHHHHHHHHHEEECCCCCEEECCCCHHHHHHHHHHHHHCCCHH
YDEALRLLARRGLAVPASHTERDWTQPYLESAAVEQAWLTVYRDPKQYWDLYQLGEELTD
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LEDAFRLWRFRHVTTVERIIGFKPGTGGTSGVSYLRKMLDVVLFPEIWKLRTDL
HHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA