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The map label for this gene is kynU [H]

Identifier: 91789440

GI number: 91789440

Start: 3786837

End: 3788198

Strand: Direct

Name: kynU [H]

Synonym: Bpro_3589

Alternate gene names: 91789440

Gene position: 3786837-3788198 (Clockwise)

Preceding gene: 91789439

Following gene: 91789441

Centisome position: 72.82

GC content: 66.23

Gene sequence:

>1362_bases
ATGAGCACAACTCTGCAAGATTGCCGCGCACTCGATGCGCAAGACCCACTGCGTACCCTGCGCGACCAGTTCACCCTGCC
CGAAGGCGTGATTTACCTGGACGGCAACTCGCTCGGCGTGCTTCCCAAAACCGCAGCGGCCCGCGTGGCCGAGGCAGTGA
CGCAGGAGTGGGGCCAGGGCCTGATCCGCAGCTGGAACAGCGCGGGCTGGTTCAGCCTGCCGCAGCGCCTGGGCGACAAG
ATTGCGCAACTGATAGGTGCAAAACCGGGCGAAGTGGTGGCCACCGACAGCACCTCGATCAATCTCTACAAGGTGCTCAG
CGCAGCACTCCATATCGCCGCGCAGGACGCGCCGCAGCGCAAGCTGGTGGTGAGTGAGCGCAGCAACTTCCCGACCGACC
TCTACATTGCCGAGGCGCTGTGCAAGGAACGCGGCTTGCGGCTGCAACTGGTAGAGCCCGAAGAAATTAACGGCGCGCTG
ACCGCCGACGTGGCGGTGCTGATGCTGACCCATGTGAACTACCGCACCGGCGCCATGCACGACATGGCCGCCGTCACGGC
GGCCGCCCATGCCGCAGGTAGCTTGACGGTCTGGGACCTAGCGCACAGCGCGGGCGCCGTCCCCGTGGACCTGAACGGCG
CAAAGGCCGATTTCTCGATTGGCTGCGGCTACAAGTATTTGAATGGCGGCCCCGGCGCCCCGGCCTTTGTCTGGGTCAAC
CCCAAGCACGCCGACCGCTTCTGGCAGCCGCTGGCCGGTTGGTGGGGCCATGCCGCGCCCTTCGAGTTCACGCCCGACTA
CCGACCCGCCGCCGGCATTTCTCGGTACCTGTGCGGCACGCAGCCGATTCTGAGCATGACGGCGCTGGAATGCGGGCTCG
ACGGCTTTCTGGCGGCCGAGCCACTGGGCGGCATGCAGGCGCTGCGCCGCAAATCGCTGGCCCTCACCGACCTGTTCATT
CAACTGGTTGAAGAGCGCTGCGCAGATCAGGGCCTCGGGCTTGCAACCCCCCGCGAGCACACGCAGCGCGGCTCGCAGGT
TTGCCTCACGCTCGGACACAGCCCCCACGCTCCACCGCTGCGCGGGTCGCTGCCCCCCGAGGGGGCCGTCACCGCCTTGG
GGCGGCCCGGCGGCGGTGAGTCCGGCGCTTACGCCATCGTGCAGGCGCTGATTGCGCGCGGCGTGATTGGTGACTACCGC
GCAGGCGACGGCGGGAAACATCTCGACATCCTGCGCTTCGGCTTCACGCCGCTCTACATCGGCTTTGAAGATGTCTGGAA
CGCCGTGGAGCAGCTCAAGCAGGTACTTGACACCGGTGAATGGCAAAGCGCCGAATTCAACCAGAAACATGCGGTGACCT
GA

Upstream 100 bases:

>100_bases
GCGACTACGAACTGATTGCCCTGCCGCTCAAGCTGATGACGGCCGATGCCTCCCCCGTTCGCGCAGTCTTGCGCGAACTC
CCCTGAAAGATGAACCTGAC

Downstream 100 bases:

>100_bases
TCATGTGCCCCCACGCCCACCCCCCCGCCAAACCCGACCACGGCGCCACCACGACGCCCGAGCGCATTGTTCACGACGAG
AAGGCGCAGCTCGACTTCAG

Product: kynureninase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MSTTLQDCRALDAQDPLRTLRDQFTLPEGVIYLDGNSLGVLPKTAAARVAEAVTQEWGQGLIRSWNSAGWFSLPQRLGDK
IAQLIGAKPGEVVATDSTSINLYKVLSAALHIAAQDAPQRKLVVSERSNFPTDLYIAEALCKERGLRLQLVEPEEINGAL
TADVAVLMLTHVNYRTGAMHDMAAVTAAAHAAGSLTVWDLAHSAGAVPVDLNGAKADFSIGCGYKYLNGGPGAPAFVWVN
PKHADRFWQPLAGWWGHAAPFEFTPDYRPAAGISRYLCGTQPILSMTALECGLDGFLAAEPLGGMQALRRKSLALTDLFI
QLVEERCADQGLGLATPREHTQRGSQVCLTLGHSPHAPPLRGSLPPEGAVTALGRPGGGESGAYAIVQALIARGVIGDYR
AGDGGKHLDILRFGFTPLYIGFEDVWNAVEQLKQVLDTGEWQSAEFNQKHAVT

Sequences:

>Translated_453_residues
MSTTLQDCRALDAQDPLRTLRDQFTLPEGVIYLDGNSLGVLPKTAAARVAEAVTQEWGQGLIRSWNSAGWFSLPQRLGDK
IAQLIGAKPGEVVATDSTSINLYKVLSAALHIAAQDAPQRKLVVSERSNFPTDLYIAEALCKERGLRLQLVEPEEINGAL
TADVAVLMLTHVNYRTGAMHDMAAVTAAAHAAGSLTVWDLAHSAGAVPVDLNGAKADFSIGCGYKYLNGGPGAPAFVWVN
PKHADRFWQPLAGWWGHAAPFEFTPDYRPAAGISRYLCGTQPILSMTALECGLDGFLAAEPLGGMQALRRKSLALTDLFI
QLVEERCADQGLGLATPREHTQRGSQVCLTLGHSPHAPPLRGSLPPEGAVTALGRPGGGESGAYAIVQALIARGVIGDYR
AGDGGKHLDILRFGFTPLYIGFEDVWNAVEQLKQVLDTGEWQSAEFNQKHAVT
>Mature_452_residues
STTLQDCRALDAQDPLRTLRDQFTLPEGVIYLDGNSLGVLPKTAAARVAEAVTQEWGQGLIRSWNSAGWFSLPQRLGDKI
AQLIGAKPGEVVATDSTSINLYKVLSAALHIAAQDAPQRKLVVSERSNFPTDLYIAEALCKERGLRLQLVEPEEINGALT
ADVAVLMLTHVNYRTGAMHDMAAVTAAAHAAGSLTVWDLAHSAGAVPVDLNGAKADFSIGCGYKYLNGGPGAPAFVWVNP
KHADRFWQPLAGWWGHAAPFEFTPDYRPAAGISRYLCGTQPILSMTALECGLDGFLAAEPLGGMQALRRKSLALTDLFIQ
LVEERCADQGLGLATPREHTQRGSQVCLTLGHSPHAPPLRGSLPPEGAVTALGRPGGGESGAYAIVQALIARGVIGDYRA
GDGGKHLDILRFGFTPLYIGFEDVWNAVEQLKQVLDTGEWQSAEFNQKHAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=476, Percent_Identity=25.4201680672269, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI74101437, Length=268, Percent_Identity=26.1194029850746, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17550466, Length=386, Percent_Identity=26.6839378238342, Blast_Score=126, Evalue=3e-29,
Organism=Saccharomyces cerevisiae, GI6323261, Length=480, Percent_Identity=27.2916666666667, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 48507; Mature: 48375

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLQDCRALDAQDPLRTLRDQFTLPEGVIYLDGNSLGVLPKTAAARVAEAVTQEWGQG
CCCCHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LIRSWNSAGWFSLPQRLGDKIAQLIGAKPGEVVATDSTSINLYKVLSAALHIAAQDAPQR
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCC
KLVVSERSNFPTDLYIAEALCKERGLRLQLVEPEEINGALTADVAVLMLTHVNYRTGAMH
EEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHHHHCCCCCCCHH
DMAAVTAAAHAAGSLTVWDLAHSAGAVPVDLNGAKADFSIGCGYKYLNGGPGAPAFVWVN
HHHHHHHHHHCCCCEEEEEHHHCCCCCEEECCCCCCCCEECCCCEECCCCCCCCEEEEEC
PKHADRFWQPLAGWWGHAAPFEFTPDYRPAAGISRYLCGTQPILSMTALECGLDGFLAAE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
PLGGMQALRRKSLALTDLFIQLVEERCADQGLGLATPREHTQRGSQVCLTLGHSPHAPPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCCCCCCCC
RGSLPPEGAVTALGRPGGGESGAYAIVQALIARGVIGDYRAGDGGKHLDILRFGFTPLYI
CCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEE
GFEDVWNAVEQLKQVLDTGEWQSAEFNQKHAVT
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STTLQDCRALDAQDPLRTLRDQFTLPEGVIYLDGNSLGVLPKTAAARVAEAVTQEWGQG
CCCHHHHHHCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHH
LIRSWNSAGWFSLPQRLGDKIAQLIGAKPGEVVATDSTSINLYKVLSAALHIAAQDAPQR
HHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCC
KLVVSERSNFPTDLYIAEALCKERGLRLQLVEPEEINGALTADVAVLMLTHVNYRTGAMH
EEEEECCCCCCHHHHHHHHHHHHCCCEEEEECCHHCCCHHHHHHHHHHHHHCCCCCCCHH
DMAAVTAAAHAAGSLTVWDLAHSAGAVPVDLNGAKADFSIGCGYKYLNGGPGAPAFVWVN
HHHHHHHHHHCCCCEEEEEHHHCCCCCEEECCCCCCCCEECCCCEECCCCCCCCEEEEEC
PKHADRFWQPLAGWWGHAAPFEFTPDYRPAAGISRYLCGTQPILSMTALECGLDGFLAAE
CHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
PLGGMQALRRKSLALTDLFIQLVEERCADQGLGLATPREHTQRGSQVCLTLGHSPHAPPL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEEEECCCCCCCCC
RGSLPPEGAVTALGRPGGGESGAYAIVQALIARGVIGDYRAGDGGKHLDILRFGFTPLYI
CCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCEEEE
GFEDVWNAVEQLKQVLDTGEWQSAEFNQKHAVT
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA