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The map label for this gene is purM [H]

Identifier: 91789420

GI number: 91789420

Start: 3765641

End: 3766681

Strand: Direct

Name: purM [H]

Synonym: Bpro_3566

Alternate gene names: 91789420

Gene position: 3765641-3766681 (Clockwise)

Preceding gene: 91789413

Following gene: 91789421

Centisome position: 72.41

GC content: 64.65

Gene sequence:

>1041_bases
ATGACCACCTCCTCCTCTTCTCCCCTGAGCTACAAAGACGCCGGCGTTGACATTGACGCAGGCGACGCCCTGGTTGAACG
CATCAAGCCGCTGGCCAAGAAAACCATGCGCGAAGGCGTGCTGGCCGGCATTGGCGGTTTTGGCGCGCTGTTTGAGGTGC
CCAAGCGCTACAAGGAACCGGTGCTGGTGAGCGGCACGGACGGCGTGGGCACCAAGCTGCGCCTGGCCTTTGAATGGAAC
ATGCACGATACCGTCGGCATCGACCTGGTGGCGATGAGCGTCAATGACGTACTGGTGCAAGGCGCCGAGCCGCTGTTTTT
CCTGGATTACTTCGCCTGCGGCAAGCTCGATGTGGACACCGCCGCGGCGGTGGTCGGCGGCATTGCCAAAGGCTGCGAAT
TGAGCGGTTGCGCGCTGATTGGCGGCGAAACCGCCGAAATGCCCGGCATGTACCCCGAGGGCGAGTACGACCTGGCCGGT
TTTGCCGTGGGTGCCGTGGAAAAGTCGAAGATCCTGACCGGCAAGGAAGTGCAGCCCGGCGATGTGGTGCTGGGCCTGGC
CAGCAGCGGCGTGCACTCCAACGGCTTCAGCCTGGTGCGCAAATGCATCGAGCGTGCCGGCGCCGACCGCCCCGCCACGC
TGGACGGCAAGCCCTTCAAGCAGGCCCTGATGGAGCCGACCCGGCTGTACGTCAAAAACGTGCTGGCCGCGCTGGCCGCG
CATCCGATCAAGGCGCTGGCCCACATCACCGGTGGCGGCCTGCTGGAAAACATCCCACGCGTGCTGCCCGAGGGCACGGC
GGCCCACCTCAAAAAAGGCAGCTGGCCGCAAACGGAGCTGTTTGCCTGGCTGCAAAAGACGGCCGGCATCGATGACTTTG
AGATGAACCGCACCTTCAACAACGGCATCGGCATGGTGGTCGTGGTGGATGCCGCCAACGCCCAGGCCACGGCCAAAACC
CTGCGCGACGCCGGTGAACAGGTTTATGAGATTGGCGTGATTGCCCCCCGCGGCGAGGGCGCCGCCGTCATCGTCGGCTG
A

Upstream 100 bases:

>100_bases
AGAATCTAAGGCTGAATTCTATCGGGCTTGCAGGGCTGCTCCAGACTGCAGCCCCCGCCCACCCGACCGACCGCACCCCA
TCGCATCAGAGCCCCACCCC

Downstream 100 bases:

>100_bases
TCCGGCTGCGATGGCTGGCCGGCAACAAGCGCTTCCGGTAAAGCCCACGGCCCATGGCTGATAAACCCGGCCACTCGCAG
CGTCTTCCGGCGGGCATCTG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTTSSSSPLSYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLRLAFEWN
MHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDTAAAVVGGIAKGCELSGCALIGGETAEMPGMYPEGEYDLAG
FAVGAVEKSKILTGKEVQPGDVVLGLASSGVHSNGFSLVRKCIERAGADRPATLDGKPFKQALMEPTRLYVKNVLAALAA
HPIKALAHITGGGLLENIPRVLPEGTAAHLKKGSWPQTELFAWLQKTAGIDDFEMNRTFNNGIGMVVVVDAANAQATAKT
LRDAGEQVYEIGVIAPRGEGAAVIVG

Sequences:

>Translated_346_residues
MTTSSSSPLSYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLRLAFEWN
MHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDTAAAVVGGIAKGCELSGCALIGGETAEMPGMYPEGEYDLAG
FAVGAVEKSKILTGKEVQPGDVVLGLASSGVHSNGFSLVRKCIERAGADRPATLDGKPFKQALMEPTRLYVKNVLAALAA
HPIKALAHITGGGLLENIPRVLPEGTAAHLKKGSWPQTELFAWLQKTAGIDDFEMNRTFNNGIGMVVVVDAANAQATAKT
LRDAGEQVYEIGVIAPRGEGAAVIVG
>Mature_345_residues
TTSSSSPLSYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLRLAFEWNM
HDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDTAAAVVGGIAKGCELSGCALIGGETAEMPGMYPEGEYDLAGF
AVGAVEKSKILTGKEVQPGDVVLGLASSGVHSNGFSLVRKCIERAGADRPATLDGKPFKQALMEPTRLYVKNVLAALAAH
PIKALAHITGGGLLENIPRVLPEGTAAHLKKGSWPQTELFAWLQKTAGIDDFEMNRTFNNGIGMVVVVDAANAQATAKTL
RDAGEQVYEIGVIAPRGEGAAVIVG

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=339, Percent_Identity=52.212389380531, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI209869995, Length=339, Percent_Identity=52.212389380531, Blast_Score=348, Evalue=4e-96,
Organism=Homo sapiens, GI209869993, Length=339, Percent_Identity=52.212389380531, Blast_Score=348, Evalue=4e-96,
Organism=Escherichia coli, GI1788845, Length=346, Percent_Identity=57.514450867052, Blast_Score=397, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI17567511, Length=344, Percent_Identity=45.9302325581395, Blast_Score=270, Evalue=6e-73,
Organism=Saccharomyces cerevisiae, GI6321203, Length=348, Percent_Identity=48.2758620689655, Blast_Score=325, Evalue=8e-90,
Organism=Drosophila melanogaster, GI24582400, Length=318, Percent_Identity=47.1698113207547, Blast_Score=247, Evalue=7e-66,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36200; Mature: 36069

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSSSSPLSYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
VLVSGTDGVGTKLRLAFEWNMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDT
EEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHH
AAAVVGGIAKGCELSGCALIGGETAEMPGMYPEGEYDLAGFAVGAVEKSKILTGKEVQPG
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCCC
DVVLGLASSGVHSNGFSLVRKCIERAGADRPATLDGKPFKQALMEPTRLYVKNVLAALAA
CEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HPIKALAHITGGGLLENIPRVLPEGTAAHLKKGSWPQTELFAWLQKTAGIDDFEMNRTFN
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEC
NGIGMVVVVDAANAQATAKTLRDAGEQVYEIGVIAPRGEGAAVIVG
CCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEC
>Mature Secondary Structure 
TTSSSSPLSYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
VLVSGTDGVGTKLRLAFEWNMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLDVDT
EEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHHHCCCCCHHH
AAAVVGGIAKGCELSGCALIGGETAEMPGMYPEGEYDLAGFAVGAVEKSKILTGKEVQPG
HHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCEEEECCCCHHHCCCCCCCCCC
DVVLGLASSGVHSNGFSLVRKCIERAGADRPATLDGKPFKQALMEPTRLYVKNVLAALAA
CEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
HPIKALAHITGGGLLENIPRVLPEGTAAHLKKGSWPQTELFAWLQKTAGIDDFEMNRTFN
HHHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCEEC
NGIGMVVVVDAANAQATAKTLRDAGEQVYEIGVIAPRGEGAAVIVG
CCCCEEEEEECCCCHHHHHHHHHHHHHEEEEEEEEECCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA