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The map label for this gene is thlA [H]

Identifier: 91788973

GI number: 91788973

Start: 3286818

End: 3288068

Strand: Direct

Name: thlA [H]

Synonym: Bpro_3113

Alternate gene names: 91788973

Gene position: 3286818-3288068 (Clockwise)

Preceding gene: 91788972

Following gene: 91788974

Centisome position: 63.2

GC content: 65.79

Gene sequence:

>1251_bases
ATGGCCACCCCAGGCTTTTTCTCCCACTTTGACGACATCTGGATGCTGGACGGCGTGCGCACGCCCATGGTCGATTACTG
TGGCGCACTCGGCCACATTTCGCCCACGGACCTGGGCATCAAGGCCGCGCGCTCCGCCCTGGAACGCAGCGGCGTGCCAG
CCGCGCATATCGGCTCCGTCATTGCCGGCAACATGGCGCCGGGCGACTTTGACCAGTTCATGCTGCCGCGCCACATTGGC
CTGTATGCGGGCGTACCGCTGGAGGTGCCTGCCCTGATGGCGCAGCGTATTTGCGGCACCGGTTTTGAGCTGTTCCGGCA
GGCCGGCGAGCACATCCAGAGCGGCGCCTGCGAGGCGGCCCTGGTGGTGGGCGCCGAGAGCATGACGCGCAACCCGATTG
CCGCCTTTGACCACCGCACCGGCTTCAAACTGGGCGCGCCGGTCGGTTTCAAGGACTACATGTGGGAGGCCTTGAAAGAC
TCGGCGGCGGGTATCAACATGATCCAGACGGCCGAGAACCTGGCCAAAAAATACGGCGTCACGCGCGAGCAGGTCGACGA
ATTTGCCTCGCAATCGTTTGCCAGGGCCGTCGCAGCGCAGCAATCCGGCTTCCACGCGGGCGAGATCGTGCCGGTGGTGT
CTGAAACATTCGGGCTTGAAGGCTACGCATCGCGCAGTATCAAGCTGCAGGGCAAGCTCACCGAAGTGGCGCAGGACACC
CACGCCCGCATTTCACCCGCCGAGGTGCTGGCCAAACTCCGCCCGGTGTATGAAGGCGGCGTCCAGACCGGTGGCAACAG
CGCGGCGCTGGTCGATGCGGCTGCGGCGGCCATTGTGGCCTCCGGCAGCTATGCCAAAGCCCATGACAAAAAGCCACTCG
CACGCGTGGTTGCCGCCGCCGTGGTGGGCGTGCCACCCGAGATCATGGGCATCGGCCCGGCACCAGCCATTCGCCTGCTG
CTGGAGCGCACCGGCATGACGCTGGACCAGATTGGCCGCTTCGAGATCAATGAAGCCCAAGGCGCGCAAACATTGGCCGT
AGGCCGCGAGCTGGAACTGGATTTGAACAGGCTCAACGTCAACGGCGGCGCCATCGCACTCGGCCATCCGCTCGCCACCA
CCGGCGTGCGCCTGACCATCACGCTGGCGCGCGAACTCAGGCGTGCCGGTCTGCGCTGGGGCATTGCATCGGCCTGCATT
GGCGGCGGACAGGGCATCGCCTTGCTGCTGGAAAACCCGGGCGCGGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCCGTGCTGGCGCACCGCGCCGAAACGGTAGAGGCGTTGCATGCCGACAGGCTGCACACCATCCTGAAACCACAAG
CGCTTTAAAGGAACCCCCTC

Downstream 100 bases:

>100_bases
CGCAACCAAATAGCAAACCAGTAGCGAACTAATAGCGAACTAATAGCGAACCAGTAGTAGCAAACCAGAATTTTTGAAAG
CCTGACATGAATATTCAAGG

Product: Acetyl-CoA C-acyltransferase

Products: NA

Alternate protein names: Acetoacetyl-CoA thiolase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MATPGFFSHFDDIWMLDGVRTPMVDYCGALGHISPTDLGIKAARSALERSGVPAAHIGSVIAGNMAPGDFDQFMLPRHIG
LYAGVPLEVPALMAQRICGTGFELFRQAGEHIQSGACEAALVVGAESMTRNPIAAFDHRTGFKLGAPVGFKDYMWEALKD
SAAGINMIQTAENLAKKYGVTREQVDEFASQSFARAVAAQQSGFHAGEIVPVVSETFGLEGYASRSIKLQGKLTEVAQDT
HARISPAEVLAKLRPVYEGGVQTGGNSAALVDAAAAAIVASGSYAKAHDKKPLARVVAAAVVGVPPEIMGIGPAPAIRLL
LERTGMTLDQIGRFEINEAQGAQTLAVGRELELDLNRLNVNGGAIALGHPLATTGVRLTITLARELRRAGLRWGIASACI
GGGQGIALLLENPGAA

Sequences:

>Translated_416_residues
MATPGFFSHFDDIWMLDGVRTPMVDYCGALGHISPTDLGIKAARSALERSGVPAAHIGSVIAGNMAPGDFDQFMLPRHIG
LYAGVPLEVPALMAQRICGTGFELFRQAGEHIQSGACEAALVVGAESMTRNPIAAFDHRTGFKLGAPVGFKDYMWEALKD
SAAGINMIQTAENLAKKYGVTREQVDEFASQSFARAVAAQQSGFHAGEIVPVVSETFGLEGYASRSIKLQGKLTEVAQDT
HARISPAEVLAKLRPVYEGGVQTGGNSAALVDAAAAAIVASGSYAKAHDKKPLARVVAAAVVGVPPEIMGIGPAPAIRLL
LERTGMTLDQIGRFEINEAQGAQTLAVGRELELDLNRLNVNGGAIALGHPLATTGVRLTITLARELRRAGLRWGIASACI
GGGQGIALLLENPGAA
>Mature_415_residues
ATPGFFSHFDDIWMLDGVRTPMVDYCGALGHISPTDLGIKAARSALERSGVPAAHIGSVIAGNMAPGDFDQFMLPRHIGL
YAGVPLEVPALMAQRICGTGFELFRQAGEHIQSGACEAALVVGAESMTRNPIAAFDHRTGFKLGAPVGFKDYMWEALKDS
AAGINMIQTAENLAKKYGVTREQVDEFASQSFARAVAAQQSGFHAGEIVPVVSETFGLEGYASRSIKLQGKLTEVAQDTH
ARISPAEVLAKLRPVYEGGVQTGGNSAALVDAAAAAIVASGSYAKAHDKKPLARVVAAAVVGVPPEIMGIGPAPAIRLLL
ERTGMTLDQIGRFEINEAQGAQTLAVGRELELDLNRLNVNGGAIALGHPLATTGVRLTITLARELRRAGLRWGIASACIG
GGQGIALLLENPGAA

Specific function: Unknown

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=402, Percent_Identity=40.7960199004975, Blast_Score=283, Evalue=2e-76,
Organism=Homo sapiens, GI148539872, Length=405, Percent_Identity=36.0493827160494, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI4501853, Length=408, Percent_Identity=34.5588235294118, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI4557237, Length=406, Percent_Identity=29.5566502463054, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=27.5229357798165, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI194353979, Length=91, Percent_Identity=47.2527472527472, Blast_Score=80, Evalue=5e-15,
Organism=Escherichia coli, GI87082165, Length=408, Percent_Identity=37.2549019607843, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1787663, Length=418, Percent_Identity=36.8421052631579, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788554, Length=405, Percent_Identity=35.8024691358025, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI48994986, Length=410, Percent_Identity=36.8292682926829, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI1788683, Length=442, Percent_Identity=30.5429864253394, Blast_Score=138, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=43.3915211970075, Blast_Score=305, Evalue=3e-83,
Organism=Caenorhabditis elegans, GI17535921, Length=403, Percent_Identity=32.7543424317618, Blast_Score=185, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI25147385, Length=400, Percent_Identity=27.5, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17551802, Length=440, Percent_Identity=26.8181818181818, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17535917, Length=405, Percent_Identity=23.9506172839506, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322031, Length=339, Percent_Identity=34.2182890855457, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6325229, Length=408, Percent_Identity=29.4117647058824, Blast_Score=159, Evalue=7e-40,
Organism=Drosophila melanogaster, GI17648125, Length=402, Percent_Identity=43.0348258706468, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24655093, Length=404, Percent_Identity=36.6336633663366, Blast_Score=237, Evalue=1e-62,
Organism=Drosophila melanogaster, GI24640423, Length=414, Percent_Identity=29.2270531400966, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI17137578, Length=441, Percent_Identity=28.3446712018141, Blast_Score=135, Evalue=6e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.9 [H]

Molecular weight: Translated: 43509; Mature: 43378

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPGFFSHFDDIWMLDGVRTPMVDYCGALGHISPTDLGIKAARSALERSGVPAAHIGSV
CCCCCCHHHCCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
IAGNMAPGDFDQFMLPRHIGLYAGVPLEVPALMAQRICGTGFELFRQAGEHIQSGACEAA
HCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
LVVGAESMTRNPIAAFDHRTGFKLGAPVGFKDYMWEALKDSAAGINMIQTAENLAKKYGV
EEECCHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
TREQVDEFASQSFARAVAAQQSGFHAGEIVPVVSETFGLEGYASRSIKLQGKLTEVAQDT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCCCEEEEECHHHHHHHHH
HARISPAEVLAKLRPVYEGGVQTGGNSAALVDAAAAAIVASGSYAKAHDKKPLARVVAAA
HCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VVGVPPEIMGIGPAPAIRLLLERTGMTLDQIGRFEINEAQGAQTLAVGRELELDLNRLNV
HHCCCHHHCCCCCHHHHHHHHHHHCCCHHHCCCEEECCCCCCEEECCCCEEEEEEEEEEC
NGGAIALGHPLATTGVRLTITLARELRRAGLRWGIASACIGGGQGIALLLENPGAA
CCCEEEECCCCHHCCEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCCCCC
>Mature Secondary Structure 
ATPGFFSHFDDIWMLDGVRTPMVDYCGALGHISPTDLGIKAARSALERSGVPAAHIGSV
CCCCCHHHCCCCEEECCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHH
IAGNMAPGDFDQFMLPRHIGLYAGVPLEVPALMAQRICGTGFELFRQAGEHIQSGACEAA
HCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEE
LVVGAESMTRNPIAAFDHRTGFKLGAPVGFKDYMWEALKDSAAGINMIQTAENLAKKYGV
EEECCHHHCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCC
TREQVDEFASQSFARAVAAQQSGFHAGEIVPVVSETFGLEGYASRSIKLQGKLTEVAQDT
CHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHCCCCCCCCEEEEECHHHHHHHHH
HARISPAEVLAKLRPVYEGGVQTGGNSAALVDAAAAAIVASGSYAKAHDKKPLARVVAAA
HCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
VVGVPPEIMGIGPAPAIRLLLERTGMTLDQIGRFEINEAQGAQTLAVGRELELDLNRLNV
HHCCCHHHCCCCCHHHHHHHHHHHCCCHHHCCCEEECCCCCCEEECCCCEEEEEEEEEEC
NGGAIALGHPLATTGVRLTITLARELRRAGLRWGIASACIGGGQGIALLLENPGAA
CCCEEEECCCCHHCCEEEEHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7867955; 11075929; 11466286; 1685080 [H]