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The map label for this gene is glyA [H]

Identifier: 91788735

GI number: 91788735

Start: 3035027

End: 3036271

Strand: Direct

Name: glyA [H]

Synonym: Bpro_2874

Alternate gene names: 91788735

Gene position: 3035027-3036271 (Clockwise)

Preceding gene: 91788734

Following gene: 91788736

Centisome position: 58.36

GC content: 60.88

Gene sequence:

>1245_bases
ATGTACCATCGCAATATTCTGGTCGAACAGACCGACCCCGAAATTTTCGCTGCCATCCAGGCTGAAAACGCCCGGCAGGA
ACACCACATCGAGCTGATTGCCAGCGAGAACTACGCCTCGCCCGCCGTCATGGCAGCCCAAGGCTCGCAGCTCACCAATA
AATACGCCGAAGGCTACCCCGGCCGCCGTTATTACGGTGGTTGCGAGTATGTGGACGTGGCGGAGCAGCTGGCGATTGAC
CGCATCAAGCAGATTTTTGGCGCGGATGCCGCCAATGTGCAGCCGCATTGCGGCGCTTCCGCCAATGAGGCGGTGTTTCT
TGCCTTCCTGAAGCCCGGCGACACCATCATGGGGATGAGCCTGGCCGAAGGCGGTCACCTGACCCACGGCATGGCACTCA
ACATGAGCGGCAAGTGGTTTAACGTTGTCTCCTACGGACTCAACGACAAGGAAGAGATCGACTACGACGCGATGGAGCGC
AAGGCGCACGAGACCCGCCCCAAGCTCATCATCGCCGGCGCCTCGGCCTACAGCCTGCGCATCGATTTCGAGCGTTTTGC
CAAAGTCGCCAAAGCCGTAGGCGCCATCTTCATGGTTGACATTGCGCACTACGCGGGCCTGGTTGCTGCGGGCGTGTACC
CGAACCCGGTGCCGCACGCCGACGTCGTGACGTCCACTACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCATCATCCTG
ATGAAAGCCGAGCACGAGAAAGCCATCAACAGCGCGATCTTCCCCGGCCTGCAGGGTGGCCCGCTGATGCACGTGATTGC
CGCGAAGGCGGTGGCTTTCAAGGAAGCGCTCTCCCCCGAATTCAAGACATATCAGCAGCAGGTGCTGACGAACGCGCGCA
TCGTGGCCGAAACGCTGACGCAACGCGGTTTGCGTATTGTCAGCGGCCGAACAGAGAGCCACTTGATGCTGGTCGACCTG
CGCGCCAAGGGAATCACCGGCAAGGAAGCTGAAGCCGTACTGGGAAGCGCCCACATGACTATCAATAAAAACGCGATTCC
GAATGACCCGGAAAAGCCGATGGTCACCAGTGGCGTGCGCATCGGTACACCAGCGATGACCACGCGCGGCTTCAAGGACG
AAGAGGCACGCGTCACGGCCAACCTGATTGCAGATGTGCTGGACAACCCCCGCGATGCCGCCAATATCGAAGCGGTTCGC
GCCAAGGTCAATGCCCTGACCAGCCGCTTCCCTGTTTACCGCTGA

Upstream 100 bases:

>100_bases
ACCGCTCAAAGCCGTTTGGCCACAGCGTTCAGCCGTTCGCCTGGGCAGCCCTTGCTTCCTTGCTACCCAAGGACAAGGAT
CAAAGTCTTGAAGGACTGCC

Downstream 100 bases:

>100_bases
AGCGCATTTCGACGTCTTGGCAAACCAATGAAATGCCCTTTCTGCGGCAACCTCGAGACCCAGGTGGTCGAAACCCGGGT
GTCGGAAGATGCAGATTTCA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MYHRNILVEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYPGRRYYGGCEYVDVAEQLAID
RIKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMER
KAHETRPKLIIAGASAYSLRIDFERFAKVAKAVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALSPEFKTYQQQVLTNARIVAETLTQRGLRIVSGRTESHLMLVDL
RAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKDEEARVTANLIADVLDNPRDAANIEAVR
AKVNALTSRFPVYR

Sequences:

>Translated_414_residues
MYHRNILVEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYPGRRYYGGCEYVDVAEQLAID
RIKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMER
KAHETRPKLIIAGASAYSLRIDFERFAKVAKAVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALSPEFKTYQQQVLTNARIVAETLTQRGLRIVSGRTESHLMLVDL
RAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKDEEARVTANLIADVLDNPRDAANIEAVR
AKVNALTSRFPVYR
>Mature_414_residues
MYHRNILVEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYPGRRYYGGCEYVDVAEQLAID
RIKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMER
KAHETRPKLIIAGASAYSLRIDFERFAKVAKAVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIIL
MKAEHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALSPEFKTYQQQVLTNARIVAETLTQRGLRIVSGRTESHLMLVDL
RAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVRIGTPAMTTRGFKDEEARVTANLIADVLDNPRDAANIEAVR
AKVNALTSRFPVYR

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=401, Percent_Identity=45.8852867830424, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI261862352, Length=401, Percent_Identity=45.8852867830424, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI261862350, Length=401, Percent_Identity=45.8852867830424, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI261862348, Length=401, Percent_Identity=45.8852867830424, Blast_Score=337, Evalue=8e-93,
Organism=Homo sapiens, GI261862346, Length=400, Percent_Identity=45, Blast_Score=328, Evalue=8e-90,
Organism=Homo sapiens, GI22547186, Length=453, Percent_Identity=42.1633554083885, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI22547189, Length=438, Percent_Identity=40.1826484018265, Blast_Score=291, Evalue=1e-78,
Organism=Escherichia coli, GI1788902, Length=416, Percent_Identity=60.5769230769231, Blast_Score=516, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI25144732, Length=408, Percent_Identity=45.5882352941176, Blast_Score=351, Evalue=5e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=408, Percent_Identity=45.5882352941176, Blast_Score=350, Evalue=5e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=46.1346633416459, Blast_Score=355, Evalue=8e-99,
Organism=Saccharomyces cerevisiae, GI6323087, Length=427, Percent_Identity=42.8571428571429, Blast_Score=335, Evalue=7e-93,
Organism=Drosophila melanogaster, GI24640005, Length=390, Percent_Identity=45.3846153846154, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221329721, Length=390, Percent_Identity=45.3846153846154, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44921; Mature: 44921

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYHRNILVEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GRRYYGGCEYVDVAEQLAIDRIKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMERKAHETRPKLIIAGASAYSLR
ECCCCCEECCEEEECCCCEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEEECCEEEEE
IDFERFAKVAKAVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALSPEFKTYQQQVLTNARIVAETLT
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRGLRIVSGRTESHLMLVDLRAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVR
HCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCEEECCEE
IGTPAMTTRGFKDEEARVTANLIADVLDNPRDAANIEAVRAKVNALTSRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYHRNILVEQTDPEIFAAIQAENARQEHHIELIASENYASPAVMAAQGSQLTNKYAEGYP
CCCCCEEEECCCCCEEEEEECCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GRRYYGGCEYVDVAEQLAIDRIKQIFGADAANVQPHCGASANEAVFLAFLKPGDTIMGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEE
LAEGGHLTHGMALNMSGKWFNVVSYGLNDKEEIDYDAMERKAHETRPKLIIAGASAYSLR
ECCCCCEECCEEEECCCCEEEEEEECCCCHHHCCHHHHHHHHHHCCCCEEEEECCEEEEE
IDFERFAKVAKAVGAIFMVDIAHYAGLVAAGVYPNPVPHADVVTSTTHKSLRGPRGGIIL
ECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHCCCCCCEEE
MKAEHEKAINSAIFPGLQGGPLMHVIAAKAVAFKEALSPEFKTYQQQVLTNARIVAETLT
EECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
QRGLRIVSGRTESHLMLVDLRAKGITGKEAEAVLGSAHMTINKNAIPNDPEKPMVTSGVR
HCCEEEECCCCCCEEEEEEEECCCCCCCHHHHHHCCEEEEEECCCCCCCCCCCEEECCEE
IGTPAMTTRGFKDEEARVTANLIADVLDNPRDAANIEAVRAKVNALTSRFPVYR
ECCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA