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The map label for this gene is cbs [H]

Identifier: 91788691

GI number: 91788691

Start: 2982449

End: 2983447

Strand: Direct

Name: cbs [H]

Synonym: Bpro_2830

Alternate gene names: 91788691

Gene position: 2982449-2983447 (Clockwise)

Preceding gene: 91788690

Following gene: 91788692

Centisome position: 57.35

GC content: 66.67

Gene sequence:

>999_bases
ATGAGATATGAAAGCATCCTGGACGCGATCGGCCACACGCCGCTGGTGCGCCTGAACCAGCTGACTCGGCACCTGTCCTG
CGCGGTCTACGCCAAGCTGGAGTTCCTGAGCCCGGGTGGTTCGGTCAAGGACCGCATCGGCATGTACATGATCCAGCAGG
CCGAGCGGCGCGGCGAGATCGGCCCCGGCGCGACCATCGTGGAATGCACCTCGGGCAACACCGGCATGGGCCTGGCGCTG
TTCGCCGCCGGGCGCGGCTACAAGACGGTGTTCACCATCGCCGACAAGCAATCGAAGGAAAAAGTCGACATGCTGCGGGC
CATGGGCGCCGAGGTCATCGTCTGCCCCACCGACGTGCCGCCCGACGATCCGCGCGGCTACATCCAGGCGGCGCAGCGGC
TGGCGCGTGACATCCCCGGCGCCTTCCTCTGCAACCAGTACGACAACCCGGACAACACGCTGGCGCACTACGCGAGCACC
GGCCCCGAAATCTGGAACGACACCGGGGGCATGGTCACCCATTTCGTCTGCGGCATGGGCACTTGCGGCACCATCAGCGG
CGCCGGCCGCTACCTCAAGGAACAAAACGCCATGGTCCGGGTGATTGGCGTCGATCCGCAGGGCTCGATCTTCCATGAGC
TGTTCCACCGCGGGGTGACGGTGCAGCCCCACGTCTACCGGCTCGAAGGCATAGGCGAAGACTTCATCCCCAAGGCGCTG
GACTGGCACGTCATCGACGACGTGATCCAGGTCAGCGACCAGGGCAGCTTCCTGATGGCGCGCCGGCTCGCCCGCGACGA
GGGCATCTTCGCCGGCGGCTCCTCGGGCGCCGCGATGCTGGCCGCGCTGCAGGTGGCTGAAAAGCTGGGCCCGAACGACC
TCATGGTGGTGCTGCTGCCCGACGGCGGCCGCCAGTACCTGGGCAAGCTCTACAACGACGACTGGATGCGGGAGCATGGC
TACCTCGACGCCAAGCCCGATTCAGCACCGCGATCCTGA

Upstream 100 bases:

>100_bases
GCGGCTTCACGAACCGGCGTGAAGCGACTACAGTGGATGAACAGCCCGTGCCGCTCCCACTGCCGGGCTCACATGTCGCA
ACACGCCAATGGGGGCTGCC

Downstream 100 bases:

>100_bases
TTTCAGATTCAGTGAGGCACGCCATGCGCTTTTCCACCCAAGCCATTCACGCCGGCCAGCCGGCGGACCCGACCACCGGC
GCGATCATGACGCCGGTGTA

Product: cystathionine beta-synthase

Products: NA

Alternate protein names: Beta-thionase; Serine sulfhydrase [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MRYESILDAIGHTPLVRLNQLTRHLSCAVYAKLEFLSPGGSVKDRIGMYMIQQAERRGEIGPGATIVECTSGNTGMGLAL
FAAGRGYKTVFTIADKQSKEKVDMLRAMGAEVIVCPTDVPPDDPRGYIQAAQRLARDIPGAFLCNQYDNPDNTLAHYAST
GPEIWNDTGGMVTHFVCGMGTCGTISGAGRYLKEQNAMVRVIGVDPQGSIFHELFHRGVTVQPHVYRLEGIGEDFIPKAL
DWHVIDDVIQVSDQGSFLMARRLARDEGIFAGGSSGAAMLAALQVAEKLGPNDLMVVLLPDGGRQYLGKLYNDDWMREHG
YLDAKPDSAPRS

Sequences:

>Translated_332_residues
MRYESILDAIGHTPLVRLNQLTRHLSCAVYAKLEFLSPGGSVKDRIGMYMIQQAERRGEIGPGATIVECTSGNTGMGLAL
FAAGRGYKTVFTIADKQSKEKVDMLRAMGAEVIVCPTDVPPDDPRGYIQAAQRLARDIPGAFLCNQYDNPDNTLAHYAST
GPEIWNDTGGMVTHFVCGMGTCGTISGAGRYLKEQNAMVRVIGVDPQGSIFHELFHRGVTVQPHVYRLEGIGEDFIPKAL
DWHVIDDVIQVSDQGSFLMARRLARDEGIFAGGSSGAAMLAALQVAEKLGPNDLMVVLLPDGGRQYLGKLYNDDWMREHG
YLDAKPDSAPRS
>Mature_332_residues
MRYESILDAIGHTPLVRLNQLTRHLSCAVYAKLEFLSPGGSVKDRIGMYMIQQAERRGEIGPGATIVECTSGNTGMGLAL
FAAGRGYKTVFTIADKQSKEKVDMLRAMGAEVIVCPTDVPPDDPRGYIQAAQRLARDIPGAFLCNQYDNPDNTLAHYAST
GPEIWNDTGGMVTHFVCGMGTCGTISGAGRYLKEQNAMVRVIGVDPQGSIFHELFHRGVTVQPHVYRLEGIGEDFIPKAL
DWHVIDDVIQVSDQGSFLMARRLARDEGIFAGGSSGAAMLAALQVAEKLGPNDLMVVLLPDGGRQYLGKLYNDDWMREHG
YLDAKPDSAPRS

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=319, Percent_Identity=45.4545454545455, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI295821200, Length=319, Percent_Identity=45.4545454545455, Blast_Score=278, Evalue=4e-75,
Organism=Homo sapiens, GI4557415, Length=319, Percent_Identity=45.4545454545455, Blast_Score=278, Evalue=4e-75,
Organism=Escherichia coli, GI2367138, Length=303, Percent_Identity=38.9438943894389, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1788754, Length=314, Percent_Identity=40.4458598726115, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17534315, Length=330, Percent_Identity=46.6666666666667, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI25147552, Length=329, Percent_Identity=43.7689969604863, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI115535073, Length=307, Percent_Identity=43.9739413680782, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17535051, Length=303, Percent_Identity=40.2640264026403, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17562970, Length=309, Percent_Identity=38.1877022653722, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI32566674, Length=282, Percent_Identity=40.0709219858156, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=282, Percent_Identity=40.7801418439716, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI32566672, Length=218, Percent_Identity=35.7798165137615, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71996324, Length=328, Percent_Identity=27.4390243902439, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6321594, Length=330, Percent_Identity=42.1212121212121, Blast_Score=265, Evalue=5e-72,
Organism=Saccharomyces cerevisiae, GI6321449, Length=335, Percent_Identity=34.0298507462687, Blast_Score=166, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=46.3949843260188, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=46.3949843260188, Blast_Score=260, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005857
- InterPro:   IPR000644
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00571 CBS; PF00291 PALP [H]

EC number: =4.2.1.22 [H]

Molecular weight: Translated: 36148; Mature: 36148

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00142 ZINC_PROTEASE ; PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYESILDAIGHTPLVRLNQLTRHLSCAVYAKLEFLSPGGSVKDRIGMYMIQQAERRGEI
CCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
GPGATIVECTSGNTGMGLALFAAGRGYKTVFTIADKQSKEKVDMLRAMGAEVIVCPTDVP
CCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCC
PDDPRGYIQAAQRLARDIPGAFLCNQYDNPDNTLAHYASTGPEIWNDTGGMVTHFVCGMG
CCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHHHHHHCCC
TCGTISGAGRYLKEQNAMVRVIGVDPQGSIFHELFHRGVTVQPHVYRLEGIGEDFIPKAL
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHCCCHH
DWHVIDDVIQVSDQGSFLMARRLARDEGIFAGGSSGAAMLAALQVAEKLGPNDLMVVLLP
HHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEC
DGGRQYLGKLYNDDWMREHGYLDAKPDSAPRS
CCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MRYESILDAIGHTPLVRLNQLTRHLSCAVYAKLEFLSPGGSVKDRIGMYMIQQAERRGEI
CCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEEEECCCCCHHHHHHHHHHHHHHHCCCC
GPGATIVECTSGNTGMGLALFAAGRGYKTVFTIADKQSKEKVDMLRAMGAEVIVCPTDVP
CCCCEEEEECCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCC
PDDPRGYIQAAQRLARDIPGAFLCNQYDNPDNTLAHYASTGPEIWNDTGGMVTHFVCGMG
CCCCHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHCCCCHHHCCCCCHHHHHHHCCC
TCGTISGAGRYLKEQNAMVRVIGVDPQGSIFHELFHRGVTVQPHVYRLEGIGEDFIPKAL
CCCCCCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHCCCHH
DWHVIDDVIQVSDQGSFLMARRLARDEGIFAGGSSGAAMLAALQVAEKLGPNDLMVVLLP
HHHHHHHHHHHCCCCCHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHCCCCCEEEEEEC
DGGRQYLGKLYNDDWMREHGYLDAKPDSAPRS
CCCHHHHHHHHCCHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]