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The map label for this gene is metC [H]

Identifier: 91788692

GI number: 91788692

Start: 2983471

End: 2984616

Strand: Direct

Name: metC [H]

Synonym: Bpro_2831

Alternate gene names: 91788692

Gene position: 2983471-2984616 (Clockwise)

Preceding gene: 91788691

Following gene: 91788693

Centisome position: 57.37

GC content: 67.98

Gene sequence:

>1146_bases
ATGCGCTTTTCCACCCAAGCCATTCACGCCGGCCAGCCGGCGGACCCGACCACCGGCGCGATCATGACGCCGGTGTACCT
GAGTTCAACTTTCGTGCAGCAAGCGCCCGGCCAGCACAAGGGCTACGACTACGGGCGCACCGCCAATCCCACACGCAGCG
CGCTGGAGGCGAACATCGCGGCGCTGGAGGACGGGACTTACGGCCTGGCCTTCGCCAGCGGCCTGGCGGCGGAGTCCACC
GTGCTGCAATCGCTCAGCAGCGGCGACCATGTGGTCTGCGGGCAGGACCTGTATGGCGGGACCTACCGGCTGATGACCAA
GGTCTTTGCGCGCTTCGGCATCGAGGCCAGCTTCGTCGACGCGACTTCGCCGGGCGCGATCCGCGCCGCGCTGCGCCCGC
AAACCCGGCTGGTCTGGCTGGAGACCCCGAGCAATCCGCTGCTGACCGTGTGCGACATCGCCGCCATCGCCCAGCTCGCG
CACGAACACCAGGCCAGGCTCGCGGTCGACAACACCTTCGCCTCGCCCTACCTGCAGCAGCCGCTGCGCCTGGGCGCGGA
CATCGTCATCCACAGCACCACCAAGTACCTGGGCGGCCACTCGGATGTGATAGGCGGCGCCCTTGTGATGAATGACGAAG
CGCTGTACCAGGAGCTCAAGTTCCTGCAAAACGCGGTGGGCGCGGTGCCGGGTCCGCTGGACTGCTTCCTCGTGCTGCGC
GGCATCAAAACCCTGGCCGTGCGCATGCGCCAGCATTGCGACAACGCGCTGCAGCTGGCGCGCCACCTGGCCGCCCACCC
CGAGGTCAAACAGCTCGCCTACCCCGGCCTGGAGTCCAGCCCCCATCACGCGCTCGCCAGCCGGCAGATGCGCGCCTACG
GCGGCATGATCTCGCTGGAACTGCAAGGCGGCGTGGAGCGTAACATTCGGTTCACGACCCAGACGAAGCTGTTCGCGCTG
GCCGAGAGCCTGGGCGGCGTCGAGTCCCTGATCGGCCTGCCCACGGTGATGACGCACGCCGCTATCCCGCCCGCGCAACG
CCAGCAGGCCGGATTGCCCGACGCGCTGGTGCGCCTGTCGGTCGGTCTCGAAGACATCGAGGACCTGATCGAAGACGTGG
ACCGGGCGATCGAAACATCGCGCTAA

Upstream 100 bases:

>100_bases
GCAAGCTCTACAACGACGACTGGATGCGGGAGCATGGCTACCTCGACGCCAAGCCCGATTCAGCACCGCGATCCTGATTT
CAGATTCAGTGAGGCACGCC

Downstream 100 bases:

>100_bases
GGGCGGTGTTGCGGCATGATCCAGTCGCCGGGCGGCGGCTGGCCGGGTTTCGATGCGACGTTTCATAGGGGGCATAACGG
ATGCTCCGGCAGACCTGCGC

Product: cystathionine gamma-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MRFSTQAIHAGQPADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIAALEDGTYGLAFASGLAAEST
VLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVDATSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLA
HEHQARLAVDNTFASPYLQQPLRLGADIVIHSTTKYLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLR
GIKTLAVRMRQHCDNALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLELQGGVERNIRFTTQTKLFAL
AESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLSVGLEDIEDLIEDVDRAIETSR

Sequences:

>Translated_381_residues
MRFSTQAIHAGQPADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIAALEDGTYGLAFASGLAAEST
VLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVDATSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLA
HEHQARLAVDNTFASPYLQQPLRLGADIVIHSTTKYLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLR
GIKTLAVRMRQHCDNALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLELQGGVERNIRFTTQTKLFAL
AESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLSVGLEDIEDLIEDVDRAIETSR
>Mature_381_residues
MRFSTQAIHAGQPADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIAALEDGTYGLAFASGLAAEST
VLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVDATSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLA
HEHQARLAVDNTFASPYLQQPLRLGADIVIHSTTKYLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLR
GIKTLAVRMRQHCDNALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLELQGGVERNIRFTTQTKLFAL
AESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLSVGLEDIEDLIEDVDRAIETSR

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=363, Percent_Identity=49.3112947658402, Blast_Score=371, Evalue=1e-103,
Organism=Homo sapiens, GI299473759, Length=362, Percent_Identity=44.7513812154696, Blast_Score=318, Evalue=7e-87,
Organism=Homo sapiens, GI25453487, Length=361, Percent_Identity=42.9362880886427, Blast_Score=301, Evalue=5e-82,
Organism=Escherichia coli, GI1790375, Length=378, Percent_Identity=42.0634920634921, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1789383, Length=387, Percent_Identity=30.4909560723514, Blast_Score=173, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17538055, Length=366, Percent_Identity=48.0874316939891, Blast_Score=366, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17560056, Length=366, Percent_Identity=47.5409836065574, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71980708, Length=388, Percent_Identity=37.6288659793814, Blast_Score=253, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6319307, Length=385, Percent_Identity=48.0519480519481, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6323333, Length=437, Percent_Identity=32.4942791762014, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321254, Length=400, Percent_Identity=33.5, Blast_Score=194, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=330, Percent_Identity=32.1212121212121, Blast_Score=165, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6321904, Length=395, Percent_Identity=31.1392405063291, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6322590, Length=274, Percent_Identity=29.1970802919708, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19922554, Length=379, Percent_Identity=51.1873350923483, Blast_Score=417, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 40855; Mature: 40855

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSTQAIHAGQPADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIA
CCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
ALEDGTYGLAFASGLAAESTVLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVD
HCCCCCCHHHHHHCHHHHHHHHHHHCCCCEEEECCHHCCCHHHHHHHHHHHHCCCEEEEC
ATSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLAHEHQARLAVDNTFASPYLQQ
CCCCCCEEHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHH
PLRLGADIVIHSTTKYLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLR
HHHCCCEEEEECCHHHHCCCCHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GIKTLAVRMRQHCDNALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEE
LQGGVERNIRFTTQTKLFALAESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLS
ECCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHH
VGLEDIEDLIEDVDRAIETSR
CCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRFSTQAIHAGQPADPTTGAIMTPVYLSSTFVQQAPGQHKGYDYGRTANPTRSALEANIA
CCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
ALEDGTYGLAFASGLAAESTVLQSLSSGDHVVCGQDLYGGTYRLMTKVFARFGIEASFVD
HCCCCCCHHHHHHCHHHHHHHHHHHCCCCEEEECCHHCCCHHHHHHHHHHHHCCCEEEEC
ATSPGAIRAALRPQTRLVWLETPSNPLLTVCDIAAIAQLAHEHQARLAVDNTFASPYLQQ
CCCCCCEEHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHH
PLRLGADIVIHSTTKYLGGHSDVIGGALVMNDEALYQELKFLQNAVGAVPGPLDCFLVLR
HHHCCCEEEEECCHHHHCCCCHHHCCEEEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHH
GIKTLAVRMRQHCDNALQLARHLAAHPEVKQLAYPGLESSPHHALASRQMRAYGGMISLE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHCCEEEEE
LQGGVERNIRFTTQTKLFALAESLGGVESLIGLPTVMTHAAIPPAQRQQAGLPDALVRLS
ECCCCCCCEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHH
VGLEDIEDLIEDVDRAIETSR
CCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]