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The map label for this gene is hom [H]

Identifier: 91788063

GI number: 91788063

Start: 2285561

End: 2286904

Strand: Direct

Name: hom [H]

Synonym: Bpro_2190

Alternate gene names: 91788063

Gene position: 2285561-2286904 (Clockwise)

Preceding gene: 91788062

Following gene: 91788064

Centisome position: 43.95

GC content: 61.9

Gene sequence:

>1344_bases
ATGAAACCGAAATCGACAAATCTCAAATCCATCCAGGTCGGCTTGCTGGGCATAGGCACCGTAGGCGGCGGCGTGTTCAA
CGTATTGCGGCGTAATCAGGAAGAGATCCTGCGCCGCGCCGGCCGCGGCATTGAAATCACCATGGTGGCAGACCTCGACA
CCGCCCGCGCCCGGGCGGCCGTGGGCGACGGCGTGCAGGTGGTGGCTGATGCCCGCGCGGTGATCGCCAACCCGGAAATC
GACATCGTGGTTGAACTGATCGGCGGGTACGGCATTGCCCGTCAGCTGGTGATGGAAGCCATTGAGGCAGGCAAGCATGT
CGTGACCGCCAACAAGGCCTTGCTGGCGGTGCACGGTACCGAAATCTTTGCCGCAGCGCACCGCAAGGGCGTGATGGTGG
CCTTTGAAGCTGCGGTGGCCGGTGGCATTCCCATCATCAAGTCGCTGCGCGAAGGACTGACGGCCAACCGCATCGAATGG
ATCGCCGGCATCATCAACGGTACGACCAATTTCATCTTGAGCGAAATGCGTGACAAGGGCCTGGACTTCGACGTGGTGCT
CAAGGAGGCGCAACGCCTGGGTTACGCCGAGGCTGATCCGACCTTTGACATTGAAGGCGTGGACGCGGCGCACAAGGTCA
CGCTGATGTCGGCGATTGCCTTCGGCATTCCGGTGCAGTTTGACAAAGCCTATGTCGAAGGCATTACCCGGCTAGGTGCG
CAGGACATCAAGTACGCCGAGCAGCTCGGCTACCGCATCAAGCTGCTGGGCATCACCAAGAATACCGCCAAGGGCATCGA
GCTGCGTGTGCATCCCAGCCTGGTGCCGATGAAGCGCCTGATTGCCAATGTGGAAGGCGCGATGAACGCCGTGATGGTGC
ATGGTGACGCCGTCGGCACCACGATGTATTACGGCAAGGGCGCGGGCAGCGAGCCCACCGCCAGCGCCGTGATTGCCGAC
CTGGTGGACATTGCCCGCCTGCACACCGCCGACGCGGCGCATCGCGTGCCGCATCTGGCGTTCCAGCCCGATTGGATGAG
CGACGCGCCGGTGCTCGCCATGGGTGATGTGGTCACCAGTTATTACCTGCGTCTTAAAGTGGCTGACGAAGCCGGTGTGC
TGGCCAAGGTCACTGGAATTCTGGCTGACGCCGGCATCAGCATAGACGCCGTGTTGCAGCGTGAAGCCGACGAAGTGGGC
GGCGAGGGCTCCACGCAAACCGATCTCATCATCCTCACGCACGATTGTGCGGAGGCGAAGATGAACGACGCGTTGGCGCA
GATGCAGGCACTGCCCACGGTGCTGGCACCGATCACGCGTATCCGCAAGGAGGAACTGGCTTAA

Upstream 100 bases:

>100_bases
GGCCGTGGGCCGGATTGCAAAATTCCTCGAGAATTATCGAAACAACAACATCTGAGCCGGTACTGGCAAGGACTGCAGAT
ATTTTTGACTATTGAGCAAC

Downstream 100 bases:

>100_bases
ATGAAATTCCCCCACGTTCACTTTGTTCTCGCCCCCCCGGGGGGCGCATCGGCCTTCGGGCGGCCGGGCGGTCGATGATG
CGCTACATCTCCACCCGCGC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKPKSTNLKSIQVGLLGIGTVGGGVFNVLRRNQEEILRRAGRGIEITMVADLDTARARAAVGDGVQVVADARAVIANPEI
DIVVELIGGYGIARQLVMEAIEAGKHVVTANKALLAVHGTEIFAAAHRKGVMVAFEAAVAGGIPIIKSLREGLTANRIEW
IAGIINGTTNFILSEMRDKGLDFDVVLKEAQRLGYAEADPTFDIEGVDAAHKVTLMSAIAFGIPVQFDKAYVEGITRLGA
QDIKYAEQLGYRIKLLGITKNTAKGIELRVHPSLVPMKRLIANVEGAMNAVMVHGDAVGTTMYYGKGAGSEPTASAVIAD
LVDIARLHTADAAHRVPHLAFQPDWMSDAPVLAMGDVVTSYYLRLKVADEAGVLAKVTGILADAGISIDAVLQREADEVG
GEGSTQTDLIILTHDCAEAKMNDALAQMQALPTVLAPITRIRKEELA

Sequences:

>Translated_447_residues
MKPKSTNLKSIQVGLLGIGTVGGGVFNVLRRNQEEILRRAGRGIEITMVADLDTARARAAVGDGVQVVADARAVIANPEI
DIVVELIGGYGIARQLVMEAIEAGKHVVTANKALLAVHGTEIFAAAHRKGVMVAFEAAVAGGIPIIKSLREGLTANRIEW
IAGIINGTTNFILSEMRDKGLDFDVVLKEAQRLGYAEADPTFDIEGVDAAHKVTLMSAIAFGIPVQFDKAYVEGITRLGA
QDIKYAEQLGYRIKLLGITKNTAKGIELRVHPSLVPMKRLIANVEGAMNAVMVHGDAVGTTMYYGKGAGSEPTASAVIAD
LVDIARLHTADAAHRVPHLAFQPDWMSDAPVLAMGDVVTSYYLRLKVADEAGVLAKVTGILADAGISIDAVLQREADEVG
GEGSTQTDLIILTHDCAEAKMNDALAQMQALPTVLAPITRIRKEELA
>Mature_447_residues
MKPKSTNLKSIQVGLLGIGTVGGGVFNVLRRNQEEILRRAGRGIEITMVADLDTARARAAVGDGVQVVADARAVIANPEI
DIVVELIGGYGIARQLVMEAIEAGKHVVTANKALLAVHGTEIFAAAHRKGVMVAFEAAVAGGIPIIKSLREGLTANRIEW
IAGIINGTTNFILSEMRDKGLDFDVVLKEAQRLGYAEADPTFDIEGVDAAHKVTLMSAIAFGIPVQFDKAYVEGITRLGA
QDIKYAEQLGYRIKLLGITKNTAKGIELRVHPSLVPMKRLIANVEGAMNAVMVHGDAVGTTMYYGKGAGSEPTASAVIAD
LVDIARLHTADAAHRVPHLAFQPDWMSDAPVLAMGDVVTSYYLRLKVADEAGVLAKVTGILADAGISIDAVLQREADEVG
GEGSTQTDLIILTHDCAEAKMNDALAQMQALPTVLAPITRIRKEELA

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=282, Percent_Identity=24.113475177305, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322599, Length=157, Percent_Identity=31.8471337579618, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 47449; Mature: 47449

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPKSTNLKSIQVGLLGIGTVGGGVFNVLRRNQEEILRRAGRGIEITMVADLDTARARAA
CCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHH
VGDGVQVVADARAVIANPEIDIVVELIGGYGIARQLVMEAIEAGKHVVTANKALLAVHGT
CCCCCEEEECCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEEECC
EIFAAAHRKGVMVAFEAAVAGGIPIIKSLREGLTANRIEWIAGIINGTTNFILSEMRDKG
HHHHHHHCCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCC
LDFDVVLKEAQRLGYAEADPTFDIEGVDAAHKVTLMSAIAFGIPVQFDKAYVEGITRLGA
CCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCH
QDIKYAEQLGYRIKLLGITKNTAKGIELRVHPSLVPMKRLIANVEGAMNAVMVHGDAVGT
HHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCC
TMYYGKGAGSEPTASAVIADLVDIARLHTADAAHRVPHLAFQPDWMSDAPVLAMGDVVTS
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEHHHHHHE
YYLRLKVADEAGVLAKVTGILADAGISIDAVLQREADEVGGEGSTQTDLIILTHDCAEAK
EEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHH
MNDALAQMQALPTVLAPITRIRKEELA
HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKPKSTNLKSIQVGLLGIGTVGGGVFNVLRRNQEEILRRAGRGIEITMVADLDTARARAA
CCCCCCCCCEEEEEEEEEEHHHHHHHHHHHCCHHHHHHHCCCCEEEEEEECCCHHHHHHH
VGDGVQVVADARAVIANPEIDIVVELIGGYGIARQLVMEAIEAGKHVVTANKALLAVHGT
CCCCCEEEECCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECCEEEEEECC
EIFAAAHRKGVMVAFEAAVAGGIPIIKSLREGLTANRIEWIAGIINGTTNFILSEMRDKG
HHHHHHHCCCEEEEEEHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHCC
LDFDVVLKEAQRLGYAEADPTFDIEGVDAAHKVTLMSAIAFGIPVQFDKAYVEGITRLGA
CCHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCH
QDIKYAEQLGYRIKLLGITKNTAKGIELRVHPSLVPMKRLIANVEGAMNAVMVHGDAVGT
HHHHHHHHCCCEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEEEEECCCCCC
TMYYGKGAGSEPTASAVIADLVDIARLHTADAAHRVPHLAFQPDWMSDAPVLAMGDVVTS
EEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCEEEHHHHHHE
YYLRLKVADEAGVLAKVTGILADAGISIDAVLQREADEVGGEGSTQTDLIILTHDCAEAK
EEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCHHHHH
MNDALAQMQALPTVLAPITRIRKEELA
HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]