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The map label for this gene is thrC [H]

Identifier: 91788064

GI number: 91788064

Start: 2286979

End: 2288409

Strand: Direct

Name: thrC [H]

Synonym: Bpro_2191

Alternate gene names: 91788064

Gene position: 2286979-2288409 (Clockwise)

Preceding gene: 91788063

Following gene: 91788065

Centisome position: 43.98

GC content: 60.59

Gene sequence:

>1431_bases
ATGATGCGCTACATCTCCACCCGCGCCGCATCCGGCGATATGGCTGACCGCAAGCGCTTTTGCGAAATCCTGCTTGAAGG
TCTGGCGCCTGATGGCGGTTTGTACCTGCCGGAGCGCTATCCGCAGGTGGACGACGCGACGCTGACGAAATGGCGCGGCC
TGTCCTATGGCGACCTTGCGTTTGAAGTCCTGTCGCTCTATGTCGACGATATTCCGCCGGCGGACCTGAAGGCGATCTGC
GAGAAGACCTATACCGAAGAGGTTTTTGGAACGAAAGAGATCGTTCCGCTGAAAAAACTGCAAGAGGGCCTGTACCTCGA
AGCCCTCTCGAACGGCCCCACACTCGCCTTCAAGGACATGGCCATGCAATTGCTGGGCAACCTGTTCGAGTACGAACTGG
CCCGCCGCGGCGAAGAGCTGAACATCTTGGGGGCCACCAGCGGCGATACCGGCAGTGCGGCCGAATACGCGATGCGCGGC
AAAAAGGGCGTGCGGGTTTTCATGACCTCGCCGAATGGCCGCATGAGCCCGTTCCAGCAGGCGCAGATGTTCAGCCTGCA
GGACCCGAACATCCACAATCTCGCGCTGGAAGGCGTGTTTGATGACTGCCAGGACATCGTCAAGGCGGTGTCCAATGACC
TGGATTTCAAGCGCCAGTACAAGATTGGCACGGTCAATTCCATCAACTGGGCGCGCTTGATGGCGCAGGTGGTGTATTAC
TTCGCCGGCTATTTCGAAGCCACGACATCGAACACCGAAAAAGTCAGCTTTACCGTGCCGTCGGGCAACTTCGGCAATGT
CTGCGCCGGCCATGTGGCCCGCATGATGGGTTTGCCCATTGCCAAGCTGGTGGTGGCGACCAACGAGAACGACGTGCTGG
ACGAATTCTTTCGCACCGGGGTCTACCGCGTGCGGGCCGGCGCCGACACGCATGAGACCTCCAGCCCGTCAATGGACATT
TCCAAAGCCTCGAACTTCGAGCGTTTTGTGTTCGACCTGCTGGGCCGGGACGCGACGCGCATCGCCGAACTGTTCGGAAA
CCGGTTGTCGGCACAGGGCAGTTTTGACCTGAGCGGCGATGCCGCCTTCCAGGCAGCCGCGCAGCGCTACGGGTTTGCCA
GCGGCACGAGCACCCACGCCGACCGGTTGCAGACGATTCGCGACACCTTCCAGCGCCTGGGTACCATGATCGATACGCAT
ACCGCCGACGGCCTGAAGGTGGCGCGTACGCACCTGCAGGTGGGTGTGCCCATGATCGTGCTCGAGACGGCCCTGCCGAT
CAAGTTCGCCGAAACCATCGAAGAGGCGTTGGGCCGCTTGCCGACCCGGCCCGCAAAGTTCGAAGGCATAGAGGACTTGC
CCAAGCGTGTGCAGGTCATGCCCGCCGATGTTGACCTGGTCAAGGCCTATATCGCCAACAATGTGCATTGA

Upstream 100 bases:

>100_bases
GTATCCGCAAGGAGGAACTGGCTTAAATGAAATTCCCCCACGTTCACTTTGTTCTCGCCCCCCCGGGGGGCGCATCGGCC
TTCGGGCGGCCGGGCGGTCG

Downstream 100 bases:

>100_bases
GTGGCTCTCCAGTCCTTTTCGGACGGGCATTACCAGCCATTGAATCAGTAGCAAACCAGGATCGGTGAAAAACTGTTTAT
GAACGTGGTTGCATTTGCCG

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MMRYISTRAASGDMADRKRFCEILLEGLAPDGGLYLPERYPQVDDATLTKWRGLSYGDLAFEVLSLYVDDIPPADLKAIC
EKTYTEEVFGTKEIVPLKKLQEGLYLEALSNGPTLAFKDMAMQLLGNLFEYELARRGEELNILGATSGDTGSAAEYAMRG
KKGVRVFMTSPNGRMSPFQQAQMFSLQDPNIHNLALEGVFDDCQDIVKAVSNDLDFKRQYKIGTVNSINWARLMAQVVYY
FAGYFEATTSNTEKVSFTVPSGNFGNVCAGHVARMMGLPIAKLVVATNENDVLDEFFRTGVYRVRAGADTHETSSPSMDI
SKASNFERFVFDLLGRDATRIAELFGNRLSAQGSFDLSGDAAFQAAAQRYGFASGTSTHADRLQTIRDTFQRLGTMIDTH
TADGLKVARTHLQVGVPMIVLETALPIKFAETIEEALGRLPTRPAKFEGIEDLPKRVQVMPADVDLVKAYIANNVH

Sequences:

>Translated_476_residues
MMRYISTRAASGDMADRKRFCEILLEGLAPDGGLYLPERYPQVDDATLTKWRGLSYGDLAFEVLSLYVDDIPPADLKAIC
EKTYTEEVFGTKEIVPLKKLQEGLYLEALSNGPTLAFKDMAMQLLGNLFEYELARRGEELNILGATSGDTGSAAEYAMRG
KKGVRVFMTSPNGRMSPFQQAQMFSLQDPNIHNLALEGVFDDCQDIVKAVSNDLDFKRQYKIGTVNSINWARLMAQVVYY
FAGYFEATTSNTEKVSFTVPSGNFGNVCAGHVARMMGLPIAKLVVATNENDVLDEFFRTGVYRVRAGADTHETSSPSMDI
SKASNFERFVFDLLGRDATRIAELFGNRLSAQGSFDLSGDAAFQAAAQRYGFASGTSTHADRLQTIRDTFQRLGTMIDTH
TADGLKVARTHLQVGVPMIVLETALPIKFAETIEEALGRLPTRPAKFEGIEDLPKRVQVMPADVDLVKAYIANNVH
>Mature_476_residues
MMRYISTRAASGDMADRKRFCEILLEGLAPDGGLYLPERYPQVDDATLTKWRGLSYGDLAFEVLSLYVDDIPPADLKAIC
EKTYTEEVFGTKEIVPLKKLQEGLYLEALSNGPTLAFKDMAMQLLGNLFEYELARRGEELNILGATSGDTGSAAEYAMRG
KKGVRVFMTSPNGRMSPFQQAQMFSLQDPNIHNLALEGVFDDCQDIVKAVSNDLDFKRQYKIGTVNSINWARLMAQVVYY
FAGYFEATTSNTEKVSFTVPSGNFGNVCAGHVARMMGLPIAKLVVATNENDVLDEFFRTGVYRVRAGADTHETSSPSMDI
SKASNFERFVFDLLGRDATRIAELFGNRLSAQGSFDLSGDAAFQAAAQRYGFASGTSTHADRLQTIRDTFQRLGTMIDTH
TADGLKVARTHLQVGVPMIVLETALPIKFAETIEEALGRLPTRPAKFEGIEDLPKRVQVMPADVDLVKAYIANNVH

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=511, Percent_Identity=32.4853228962818, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI149193323, Length=468, Percent_Identity=29.9145299145299, Blast_Score=216, Evalue=3e-56,
Organism=Escherichia coli, GI1786185, Length=463, Percent_Identity=28.2937365010799, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319901, Length=467, Percent_Identity=41.3276231263383, Blast_Score=333, Evalue=2e-92,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52571; Mature: 52571

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRYISTRAASGDMADRKRFCEILLEGLAPDGGLYLPERYPQVDDATLTKWRGLSYGDLA
CCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHCCCCCHHHH
FEVLSLYVDDIPPADLKAICEKTYTEEVFGTKEIVPLKKLQEGLYLEALSNGPTLAFKDM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHH
AMQLLGNLFEYELARRGEELNILGATSGDTGSAAEYAMRGKKGVRVFMTSPNGRMSPFQQ
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFSLQDPNIHNLALEGVFDDCQDIVKAVSNDLDFKRQYKIGTVNSINWARLMAQVVYY
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHHHHHHHHHHH
FAGYFEATTSNTEKVSFTVPSGNFGNVCAGHVARMMGLPIAKLVVATNENDVLDEFFRTG
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
VYRVRAGADTHETSSPSMDISKASNFERFVFDLLGRDATRIAELFGNRLSAQGSFDLSGD
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCH
AAFQAAAQRYGFASGTSTHADRLQTIRDTFQRLGTMIDTHTADGLKVARTHLQVGVPMIV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEE
LETALPIKFAETIEEALGRLPTRPAKFEGIEDLPKRVQVMPADVDLVKAYIANNVH
EHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MMRYISTRAASGDMADRKRFCEILLEGLAPDGGLYLPERYPQVDDATLTKWRGLSYGDLA
CCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCHHHHHCCCCCHHHH
FEVLSLYVDDIPPADLKAICEKTYTEEVFGTKEIVPLKKLQEGLYLEALSNGPTLAFKDM
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCCCCCCHHHHH
AMQLLGNLFEYELARRGEELNILGATSGDTGSAAEYAMRGKKGVRVFMTSPNGRMSPFQQ
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHCCCCCCEEEEECCCCCCCCHHH
AQMFSLQDPNIHNLALEGVFDDCQDIVKAVSNDLDFKRQYKIGTVNSINWARLMAQVVYY
HHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHEEECCCCCCCHHHHHHHHHHHH
FAGYFEATTSNTEKVSFTVPSGNFGNVCAGHVARMMGLPIAKLVVATNENDVLDEFFRTG
HHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHEEEECCCCHHHHHHHHCC
VYRVRAGADTHETSSPSMDISKASNFERFVFDLLGRDATRIAELFGNRLSAQGSFDLSGD
CEEEECCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCH
AAFQAAAQRYGFASGTSTHADRLQTIRDTFQRLGTMIDTHTADGLKVARTHLQVGVPMIV
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEE
LETALPIKFAETIEEALGRLPTRPAKFEGIEDLPKRVQVMPADVDLVKAYIANNVH
EHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2127631; 12948626 [H]