Click here to switch to the map view.

The map label for this gene is fumC [H]

Identifier: 91787923

GI number: 91787923

Start: 2127460

End: 2128884

Strand: Direct

Name: fumC [H]

Synonym: Bpro_2047

Alternate gene names: 91787923

Gene position: 2127460-2128884 (Clockwise)

Preceding gene: 91787920

Following gene: 91787925

Centisome position: 40.91

GC content: 63.86

Gene sequence:

>1425_bases
ATGAAAACCCGTACCGGCACACATAGCAGCACGCATAGCAAGGCACGCATTGAGAGCGATACCTTCGGCCCGATTGAAGT
GCCTGCCAACCGGCTGTGGGGTGCACAAACCCAGCGCTCCCTGCAGAATTTCGACATCTCCGGCGAGCAGCAGCCGCGCG
AAATTATCCGGGCGCTGGCGGAAATCAAGCGCTCGTCCGCACGGGTGAACCACGCGCTGGGTTTGCAGGGCGAAAAAAAG
ACGGAGGCGATTGTGGCCGCCGCCGATGAGGTGATCGCCGGCCGGCATCCCGACGAATTCCCGCTCGTGGTCTGGCAGAC
CGGCTCGGGCACCCAGACCAACATGAACGTCAATGAAGTGCTGGCCAACCGCGCCAGCGAGCTGCTGGGCGGCGAGCGTG
GCGAAGGCCGGCTGGTGCACCCCAATGACGACGTGAACCGCAGCCAATCCTCCAATGATGTGTTTCCCACGGCCATGCAT
GTCTCGGCGGTCGAGGCCATCACGCGCCGGCTGTTGCCGGCCATCGCGAAGCTGCGCGCCACGCTGGCACAGAAGGCCAG
CGACTTTGATGACATTGTCAAGATTGGACGAACCCACCTGCAGGACGCCACACCGCTGACGCTGGGCCAGGAGTTCTCGG
GCTATGCGGCGCAACTGGAGCAGTGTGAAAGGCACGTGGCCGCGGCTCTGCCGCACCTCTATGAACTGGCACTGGGCGGC
ACGGCGGTGGGTACCGGCCTGAATGCACCGAAGGGTTATGCTGAAAAGGTAGCGGACGAGCTGGCCAGCCTGACCGGGCT
GCCGTTTGTGACGGCACCCAACAAATTCGAGGCGATGGCAGCTGCCGATGCGCTGGTGCACGCGCACGGTGCGCTCAAGA
CGCTGGCCGCCAGCCTGATGAAGATTGCCAATGACGTGCGCTGGCTGGCCAGCGGGCCGCGTAGCGGCATTGGCGAGCTG
AGCATTCCGGAAAACGAGCCCGGCTCGTCCATCATGCCGGGCAAGGTCAACCCGACGCAAAGCGAGGCGGTCACCATGCT
GGCCGCGCAGGTGTTCGGCAACGACGTGGCCATCAACTTTGGAGGGGCATCGGGCAACTTCGAGCTCAATGTGTTCCGGC
CCATGATTGCGCACAACTTCCTGCAGAGCGTGCGCCTGCTGGCCGACGGCATGGTGAGCTTTAACGACCAGTGCGCCGCC
GGCATTGAGCCCAACCGGGCGCGCATCACCGAACTGGTGGGGCGGTCATTGATGCTGGTGACGGCGCTCAACCCTCACAT
TGGCTACGACAAGGCGGCGTTCATTGCCAAAAAAGCGCACAAGGAGGGCAGCACGCTGCGCGATGCCGCACTCGCCTCGG
GTTATGTCACGGGCGAGCAGTTTGACCAGTGGGTGGTGCCGGCCGATATGGTGGGCCGGCGTTAG

Upstream 100 bases:

>100_bases
CGGGGCGGTCTTTTCGGGGCGGTCACTCTGTGCTACGGTAGCCGCAACCCCGTATTTTGACAGGTGTGAACAGGTGGCCC
AGCGCCATGAGGAAATGACC

Downstream 100 bases:

>100_bases
TGCAGTGTTCCATCAAGCATGCAACACGGCACTAGCCCCGGTCCCGGTGGATGACGGGTCGCCCGCCGCTCAGTGTTTTT
GCGCCGCAATGGCCGACATT

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MKTRTGTHSSTHSKARIESDTFGPIEVPANRLWGAQTQRSLQNFDISGEQQPREIIRALAEIKRSSARVNHALGLQGEKK
TEAIVAAADEVIAGRHPDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEGRLVHPNDDVNRSQSSNDVFPTAMH
VSAVEAITRRLLPAIAKLRATLAQKASDFDDIVKIGRTHLQDATPLTLGQEFSGYAAQLEQCERHVAAALPHLYELALGG
TAVGTGLNAPKGYAEKVADELASLTGLPFVTAPNKFEAMAAADALVHAHGALKTLAASLMKIANDVRWLASGPRSGIGEL
SIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINFGGASGNFELNVFRPMIAHNFLQSVRLLADGMVSFNDQCAA
GIEPNRARITELVGRSLMLVTALNPHIGYDKAAFIAKKAHKEGSTLRDAALASGYVTGEQFDQWVVPADMVGRR

Sequences:

>Translated_474_residues
MKTRTGTHSSTHSKARIESDTFGPIEVPANRLWGAQTQRSLQNFDISGEQQPREIIRALAEIKRSSARVNHALGLQGEKK
TEAIVAAADEVIAGRHPDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEGRLVHPNDDVNRSQSSNDVFPTAMH
VSAVEAITRRLLPAIAKLRATLAQKASDFDDIVKIGRTHLQDATPLTLGQEFSGYAAQLEQCERHVAAALPHLYELALGG
TAVGTGLNAPKGYAEKVADELASLTGLPFVTAPNKFEAMAAADALVHAHGALKTLAASLMKIANDVRWLASGPRSGIGEL
SIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINFGGASGNFELNVFRPMIAHNFLQSVRLLADGMVSFNDQCAA
GIEPNRARITELVGRSLMLVTALNPHIGYDKAAFIAKKAHKEGSTLRDAALASGYVTGEQFDQWVVPADMVGRR
>Mature_474_residues
MKTRTGTHSSTHSKARIESDTFGPIEVPANRLWGAQTQRSLQNFDISGEQQPREIIRALAEIKRSSARVNHALGLQGEKK
TEAIVAAADEVIAGRHPDEFPLVVWQTGSGTQTNMNVNEVLANRASELLGGERGEGRLVHPNDDVNRSQSSNDVFPTAMH
VSAVEAITRRLLPAIAKLRATLAQKASDFDDIVKIGRTHLQDATPLTLGQEFSGYAAQLEQCERHVAAALPHLYELALGG
TAVGTGLNAPKGYAEKVADELASLTGLPFVTAPNKFEAMAAADALVHAHGALKTLAASLMKIANDVRWLASGPRSGIGEL
SIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINFGGASGNFELNVFRPMIAHNFLQSVRLLADGMVSFNDQCAA
GIEPNRARITELVGRSLMLVTALNPHIGYDKAAFIAKKAHKEGSTLRDAALASGYVTGEQFDQWVVPADMVGRR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=467, Percent_Identity=61.6702355460385, Blast_Score=571, Evalue=1e-163,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1787896, Length=457, Percent_Identity=71.9912472647702, Blast_Score=664, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=450, Percent_Identity=40, Blast_Score=339, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17553882, Length=464, Percent_Identity=61.8534482758621, Blast_Score=582, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI32565146, Length=327, Percent_Identity=64.8318042813456, Blast_Score=441, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6324993, Length=465, Percent_Identity=56.989247311828, Blast_Score=535, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24640179, Length=462, Percent_Identity=60.6060606060606, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24640177, Length=462, Percent_Identity=60.6060606060606, Blast_Score=582, Evalue=1e-166,
Organism=Drosophila melanogaster, GI78710009, Length=463, Percent_Identity=58.7473002159827, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24662684, Length=468, Percent_Identity=58.7606837606838, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=51.8438177874187, Blast_Score=489, Evalue=1e-138,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50669; Mature: 50669

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRTGTHSSTHSKARIESDTFGPIEVPANRLWGAQTQRSLQNFDISGEQQPREIIRALA
CCCCCCCCCCCCCHHEECCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHH
EIKRSSARVNHALGLQGEKKTEAIVAAADEVIAGRHPDEFPLVVWQTGSGTQTNMNVNEV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHH
LANRASELLGGERGEGRLVHPNDDVNRSQSSNDVFPTAMHVSAVEAITRRLLPAIAKLRA
HHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLAQKASDFDDIVKIGRTHLQDATPLTLGQEFSGYAAQLEQCERHVAAALPHLYELALGG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TAVGTGLNAPKGYAEKVADELASLTGLPFVTAPNKFEAMAAADALVHAHGALKTLAASLM
CHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KIANDVRWLASGPRSGIGELSIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
GGASGNFELNVFRPMIAHNFLQSVRLLADGMVSFNDQCAAGIEPNRARITELVGRSLMLV
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEE
TALNPHIGYDKAAFIAKKAHKEGSTLRDAALASGYVTGEQFDQWVVPADMVGRR
EECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHCCC
>Mature Secondary Structure
MKTRTGTHSSTHSKARIESDTFGPIEVPANRLWGAQTQRSLQNFDISGEQQPREIIRALA
CCCCCCCCCCCCCHHEECCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHH
EIKRSSARVNHALGLQGEKKTEAIVAAADEVIAGRHPDEFPLVVWQTGSGTQTNMNVNEV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHH
LANRASELLGGERGEGRLVHPNDDVNRSQSSNDVFPTAMHVSAVEAITRRLLPAIAKLRA
HHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TLAQKASDFDDIVKIGRTHLQDATPLTLGQEFSGYAAQLEQCERHVAAALPHLYELALGG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TAVGTGLNAPKGYAEKVADELASLTGLPFVTAPNKFEAMAAADALVHAHGALKTLAASLM
CHHCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KIANDVRWLASGPRSGIGELSIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINF
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEE
GGASGNFELNVFRPMIAHNFLQSVRLLADGMVSFNDQCAAGIEPNRARITELVGRSLMLV
CCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEE
TALNPHIGYDKAAFIAKKAHKEGSTLRDAALASGYVTGEQFDQWVVPADMVGRR
EECCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHCCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]