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The map label for this gene is acsA [H]

Identifier: 91787925

GI number: 91787925

Start: 2129728

End: 2131725

Strand: Direct

Name: acsA [H]

Synonym: Bpro_2049

Alternate gene names: 91787925

Gene position: 2129728-2131725 (Clockwise)

Preceding gene: 91787923

Following gene: 91787927

Centisome position: 40.95

GC content: 62.06

Gene sequence:

>1998_bases
ATGAGTTCCGCCCCGTCGAACATCGAGTCCGTGCTGGTTGAAAACCGCGTATTTCCCCCCGGGCCGGCTACCGTCAAGGC
CGCCCGCATTTCCGGCATGGAGGCTTACAACGCGATGTGCCGGGAGGCCGACAAGGATTTTGACCGCTTCTGGGCCAGGC
TGGCCAGGGACAATCTCAGCTGGAAAAAACCTTTCAGCCAGGTTCTGGACGAGTCCAATGCACCGTTTTACCAATGGTTT
GCCGATGGTGAACTGAACGCCTCCTACAACTGCCTGGACCGCCACCTGGGTACGCCGACAGAGAGCAAGAAGGCCATTAT
TTTCGAGAGCGATGATGGCAAGGCGACCAGCGTCACTTATAAGGAACTGCATGCCAGGGTCAGTCAGTTTGCCAGTGCGC
TCAAGGGCCTGGGGGTGAAGAAGGGCGACCGCGTCATCATCTACATGCCAATGACCATTGAAGGCGTTGTTGCCATGCAG
GCCTGTGCCCGCATTGGTGCCACGCACTCGGTGGTGTTCGGTGGTTTCTCGGCCAAGAGCCTGCAGGAGCGCATCCAGGA
CGCCGGTGCAGTCGCAGTCATTACCGCCAACTACCAGTTGCGCGGCGGCAAGGAGCTGCCGCTCAAGGCGATTGTGGACG
AAGGCATCGCCATGGGCGGCTGCGAGTCGATCAAGAACGTGGTGGTCTACCAGCGCACCGCCACGCCCTGCAACATGGTG
GCCGGGCGCGACAGCCTGATGCACGAGATCACCGCCAGGGCCGCAGCCACCTGCGAGCCGGAATTTGTGGGCGCCGAGCA
TCCGCTGTTCATCCTGTACACGTCGGGCTCCACCGGCAAGCCCAAGGGCGTGCAGCACAGCACGGGCGGCTACCTGCTGT
GGGCCAAGCTCACCATGGACTGGACCTTTGACATCCAGCCCGCCGATGTGTTCTGGTGCACCGCCGACATCGGCTGGATC
ACCGGCCACACCTATGTGGCGTATGGCCCGCTGGCCGCTGGTGCGACGCAGGTCATCTTTGAAGGCATTCCGACTTACCC
GAACGCCGGCCGGTTCTGGCAGATGATCGAGAAGCACAAGGTCACGATTTTTTACACAGCACCCACCGCCATCCGTTCAC
TGATCAAGGCCGCTGAAGGCGATGAAAAAATACACCCGGCCCGCTCGGATCTGAGCAGCCTGCGCATTCTGGGCACGGTG
GGCGAACCCATCAACCCCGAGGCCTGGATGTGGTACTACAAAAACATTGGTGGCGAGCGCTGCCCGATTGTGGATACCTT
CTGGCAAACCGAGTCGGGCGGACACATGATCACGCCGCTGCCCGGCGCGACGCCGCTGGTTCCTGGCAGCTGCACCTTGC
CGCTGCCCGGCATCATGGCCGCCATCGTCGACGAAACCGGCAAGGACTTGCCCAACGGCTCGGGCGGCCTGCTGGTGGTC
AAACGCCCGTGGCCGTCCATGATTCGCGGCATCTGGAATGACCCCGAGCGCTTCAAGAAGAGCTACTTTCCGGAAGAAAT
GGGCGGCACGATGTACCTGGCCGGCGACGGCGCGGTCCGCAATGCTGACAACGGCTATTTCCGCATCACCGGCCGGATTG
ACGATGTGCTGAATGTGTCGGGCCACCGCATGGGCACCATGGAAATCGAATCGGCACTGGTGGCGCACTCGACCCTGGTG
GCGGAGGCTGCCGTGGTAGGCCGCCCTGATGACCTGACCGGCGAGGCGATCGTGGCGTTTGTGGTGCTCAAGCGCTCGCG
GCCCACGGGCGATGAGGCCAAGGCGATTGCCAAGGAGCTGCGCGACTGGGTCGGCAAGGAGATTGGCCCGATTGCCAAGC
CCAAGGACATCCGGTTTGGTGACAACCTGCCCAAGACGCGCAGCGGCAAAATCATGCGCCGCCTGTTGCGCGGCATTGCC
AAGGGTGAGGCTCTTACGCAGGACACCTCGACGCTGGAGAATCCGGCGATCCTCGATCAGTTGTCTGAAAACCTCTGA

Upstream 100 bases:

>100_bases
CCGGATTTTGTAAGGTTCAAGCCAGTCAGTGGCTTGTAAGTGCGGGATATGACAGTATCGGCAGTATCACGCATCCCAAT
GACAAACAGGAGACAAAGTA

Downstream 100 bases:

>100_bases
GGAGGTCCTGGAGGGGCTGAAATTCACCCAACCGGGCCCCATTTCAAAACCGCAAAACCGCAAAACCGGTCAGGCCGCAG
CGCCCACAAAAAAAGCCCGT

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSSAPSNIESVLVENRVFPPGPATVKAARISGMEAYNAMCREADKDFDRFWARLARDNLSWKKPFSQVLDESNAPFYQWF
ADGELNASYNCLDRHLGTPTESKKAIIFESDDGKATSVTYKELHARVSQFASALKGLGVKKGDRVIIYMPMTIEGVVAMQ
ACARIGATHSVVFGGFSAKSLQERIQDAGAVAVITANYQLRGGKELPLKAIVDEGIAMGGCESIKNVVVYQRTATPCNMV
AGRDSLMHEITARAAATCEPEFVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKLTMDWTFDIQPADVFWCTADIGWI
TGHTYVAYGPLAAGATQVIFEGIPTYPNAGRFWQMIEKHKVTIFYTAPTAIRSLIKAAEGDEKIHPARSDLSSLRILGTV
GEPINPEAWMWYYKNIGGERCPIVDTFWQTESGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGKDLPNGSGGLLVV
KRPWPSMIRGIWNDPERFKKSYFPEEMGGTMYLAGDGAVRNADNGYFRITGRIDDVLNVSGHRMGTMEIESALVAHSTLV
AEAAVVGRPDDLTGEAIVAFVVLKRSRPTGDEAKAIAKELRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRGIA
KGEALTQDTSTLENPAILDQLSENL

Sequences:

>Translated_665_residues
MSSAPSNIESVLVENRVFPPGPATVKAARISGMEAYNAMCREADKDFDRFWARLARDNLSWKKPFSQVLDESNAPFYQWF
ADGELNASYNCLDRHLGTPTESKKAIIFESDDGKATSVTYKELHARVSQFASALKGLGVKKGDRVIIYMPMTIEGVVAMQ
ACARIGATHSVVFGGFSAKSLQERIQDAGAVAVITANYQLRGGKELPLKAIVDEGIAMGGCESIKNVVVYQRTATPCNMV
AGRDSLMHEITARAAATCEPEFVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKLTMDWTFDIQPADVFWCTADIGWI
TGHTYVAYGPLAAGATQVIFEGIPTYPNAGRFWQMIEKHKVTIFYTAPTAIRSLIKAAEGDEKIHPARSDLSSLRILGTV
GEPINPEAWMWYYKNIGGERCPIVDTFWQTESGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGKDLPNGSGGLLVV
KRPWPSMIRGIWNDPERFKKSYFPEEMGGTMYLAGDGAVRNADNGYFRITGRIDDVLNVSGHRMGTMEIESALVAHSTLV
AEAAVVGRPDDLTGEAIVAFVVLKRSRPTGDEAKAIAKELRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRGIA
KGEALTQDTSTLENPAILDQLSENL
>Mature_664_residues
SSAPSNIESVLVENRVFPPGPATVKAARISGMEAYNAMCREADKDFDRFWARLARDNLSWKKPFSQVLDESNAPFYQWFA
DGELNASYNCLDRHLGTPTESKKAIIFESDDGKATSVTYKELHARVSQFASALKGLGVKKGDRVIIYMPMTIEGVVAMQA
CARIGATHSVVFGGFSAKSLQERIQDAGAVAVITANYQLRGGKELPLKAIVDEGIAMGGCESIKNVVVYQRTATPCNMVA
GRDSLMHEITARAAATCEPEFVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKLTMDWTFDIQPADVFWCTADIGWIT
GHTYVAYGPLAAGATQVIFEGIPTYPNAGRFWQMIEKHKVTIFYTAPTAIRSLIKAAEGDEKIHPARSDLSSLRILGTVG
EPINPEAWMWYYKNIGGERCPIVDTFWQTESGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGKDLPNGSGGLLVVK
RPWPSMIRGIWNDPERFKKSYFPEEMGGTMYLAGDGAVRNADNGYFRITGRIDDVLNVSGHRMGTMEIESALVAHSTLVA
EAAVVGRPDDLTGEAIVAFVVLKRSRPTGDEAKAIAKELRDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRGIAK
GEALTQDTSTLENPAILDQLSENL

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=678, Percent_Identity=46.0176991150442, Blast_Score=570, Evalue=1e-162,
Organism=Homo sapiens, GI253970489, Length=693, Percent_Identity=45.3102453102453, Blast_Score=567, Evalue=1e-161,
Organism=Homo sapiens, GI28416953, Length=633, Percent_Identity=46.7614533965245, Blast_Score=539, Evalue=1e-153,
Organism=Homo sapiens, GI13375727, Length=629, Percent_Identity=37.3608903020668, Blast_Score=388, Evalue=1e-107,
Organism=Homo sapiens, GI31982927, Length=655, Percent_Identity=25.8015267175572, Blast_Score=186, Evalue=9e-47,
Organism=Homo sapiens, GI42544132, Length=553, Percent_Identity=28.3905967450271, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI38505220, Length=538, Percent_Identity=28.996282527881, Blast_Score=169, Evalue=6e-42,
Organism=Homo sapiens, GI122937307, Length=538, Percent_Identity=27.1375464684015, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI58082049, Length=544, Percent_Identity=27.2058823529412, Blast_Score=162, Evalue=7e-40,
Organism=Homo sapiens, GI157311624, Length=556, Percent_Identity=25.7194244604317, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI157311622, Length=556, Percent_Identity=25.7194244604317, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI115511026, Length=584, Percent_Identity=25.8561643835616, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI187761345, Length=406, Percent_Identity=27.0935960591133, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI187761343, Length=406, Percent_Identity=27.0935960591133, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI195947378, Length=422, Percent_Identity=24.1706161137441, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI156151445, Length=593, Percent_Identity=23.2715008431703, Blast_Score=84, Evalue=6e-16,
Organism=Escherichia coli, GI1790505, Length=647, Percent_Identity=51.0046367851623, Blast_Score=633, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=629, Percent_Identity=38.79173290938, Blast_Score=420, Evalue=1e-118,
Organism=Escherichia coli, GI1788107, Length=559, Percent_Identity=25.9391771019678, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI145693145, Length=545, Percent_Identity=25.1376146788991, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1786810, Length=533, Percent_Identity=22.7016885553471, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71982997, Length=672, Percent_Identity=43.452380952381, Blast_Score=508, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71983001, Length=675, Percent_Identity=43.4074074074074, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569507, Length=660, Percent_Identity=23.3333333333333, Blast_Score=132, Evalue=7e-31,
Organism=Caenorhabditis elegans, GI71985884, Length=606, Percent_Identity=23.1023102310231, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71994690, Length=570, Percent_Identity=24.9122807017544, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71994694, Length=568, Percent_Identity=24.8239436619718, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=568, Percent_Identity=24.8239436619718, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=565, Percent_Identity=24.6017699115044, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=554, Percent_Identity=24.3682310469314, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115534440, Length=560, Percent_Identity=23.2142857142857, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323182, Length=645, Percent_Identity=48.5271317829457, Blast_Score=576, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319264, Length=666, Percent_Identity=48.4984984984985, Blast_Score=568, Evalue=1e-162,
Organism=Saccharomyces cerevisiae, GI6319699, Length=552, Percent_Identity=22.6449275362319, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24667955, Length=675, Percent_Identity=46.962962962963, Blast_Score=580, Evalue=1e-166,
Organism=Drosophila melanogaster, GI62472339, Length=568, Percent_Identity=50.8802816901408, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI24667959, Length=531, Percent_Identity=51.2241054613936, Blast_Score=510, Evalue=1e-144,
Organism=Drosophila melanogaster, GI21355225, Length=672, Percent_Identity=33.3333333333333, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI21355181, Length=560, Percent_Identity=24.1071428571429, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24648260, Length=416, Percent_Identity=26.4423076923077, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24656500, Length=376, Percent_Identity=27.3936170212766, Blast_Score=86, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24581924, Length=552, Percent_Identity=24.4565217391304, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI18859661, Length=396, Percent_Identity=25.2525252525253, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72409; Mature: 72277

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAPSNIESVLVENRVFPPGPATVKAARISGMEAYNAMCREADKDFDRFWARLARDNLS
CCCCCCHHHHHHHHCCCCCCCCCCEEHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCC
WKKPFSQVLDESNAPFYQWFADGELNASYNCLDRHLGTPTESKKAIIFESDDGKATSVTY
HHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHH
KELHARVSQFASALKGLGVKKGDRVIIYMPMTIEGVVAMQACARIGATHSVVFGGFSAKS
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
LQERIQDAGAVAVITANYQLRGGKELPLKAIVDEGIAMGGCESIKNVVVYQRTATPCNMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCHHHHCCEEEEEECCCCHHHH
AGRDSLMHEITARAAATCEPEFVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKLTMD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDIQPADVFWCTADIGWITGHTYVAYGPLAAGATQVIFEGIPTYPNAGRFWQMIEKHK
EEEECCCCCEEEEECCCCEEECCCEEEECCHHCCHHHHHHCCCCCCCCCHHHHHHHHHCC
VTIFYTAPTAIRSLIKAAEGDEKIHPARSDLSSLRILGTVGEPINPEAWMWYYKNIGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCEEHEECCCCCCC
CPIVDTFWQTESGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGKDLPNGSGGLLVV
CCEEEHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEE
KRPWPSMIRGIWNDPERFKKSYFPEEMGGTMYLAGDGAVRNADNGYFRITGRIDDVLNVS
ECCCHHHHHHCCCCHHHHHHHCCHHHHCCEEEEECCCCEECCCCCEEEEEECCCHHHCCC
GHRMGTMEIESALVAHSTLVAEAAVVGRPDDLTGEAIVAFVVLKRSRPTGDEAKAIAKEL
CCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
RDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRGIAKGEALTQDTSTLENPAILDQ
HHHHCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
LSENL
HHHCC
>Mature Secondary Structure 
SSAPSNIESVLVENRVFPPGPATVKAARISGMEAYNAMCREADKDFDRFWARLARDNLS
CCCCCHHHHHHHHCCCCCCCCCCEEHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHCCCC
WKKPFSQVLDESNAPFYQWFADGELNASYNCLDRHLGTPTESKKAIIFESDDGKATSVTY
HHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCEEEHHH
KELHARVSQFASALKGLGVKKGDRVIIYMPMTIEGVVAMQACARIGATHSVVFGGFSAKS
HHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
LQERIQDAGAVAVITANYQLRGGKELPLKAIVDEGIAMGGCESIKNVVVYQRTATPCNMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCHHHHCCEEEEEECCCCHHHH
AGRDSLMHEITARAAATCEPEFVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWAKLTMD
CCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDIQPADVFWCTADIGWITGHTYVAYGPLAAGATQVIFEGIPTYPNAGRFWQMIEKHK
EEEECCCCCEEEEECCCCEEECCCEEEECCHHCCHHHHHHCCCCCCCCCHHHHHHHHHCC
VTIFYTAPTAIRSLIKAAEGDEKIHPARSDLSSLRILGTVGEPINPEAWMWYYKNIGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCHHHHHHEEEEEECCCCCCCCCEEHEECCCCCCC
CPIVDTFWQTESGGHMITPLPGATPLVPGSCTLPLPGIMAAIVDETGKDLPNGSGGLLVV
CCEEEHHCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEE
KRPWPSMIRGIWNDPERFKKSYFPEEMGGTMYLAGDGAVRNADNGYFRITGRIDDVLNVS
ECCCHHHHHHCCCCHHHHHHHCCHHHHCCEEEEECCCCEECCCCCEEEEEECCCHHHCCC
GHRMGTMEIESALVAHSTLVAEAAVVGRPDDLTGEAIVAFVVLKRSRPTGDEAKAIAKEL
CCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
RDWVGKEIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRGIAKGEALTQDTSTLENPAILDQ
HHHHCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCHHHHHH
LSENL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA