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The map label for this gene is hemH

Identifier: 91787889

GI number: 91787889

Start: 2083892

End: 2084995

Strand: Reverse

Name: hemH

Synonym: Bpro_2013

Alternate gene names: 91787889

Gene position: 2084995-2083892 (Counterclockwise)

Preceding gene: 91787892

Following gene: 91787884

Centisome position: 40.09

GC content: 63.68

Gene sequence:

>1104_bases
ATGTCTTTTGCACCAGAACCGTCCTTCAGCCACGGCAAACCGCCGGCTGCATCCTGCGCCACCGCCATTCTGCTCTGCAA
CCTCGGTACACCCGATGCGCCCACCGCGCCCGCGCTGCGCCGCTACCTCGCTGAATTTTTAAGTGACCCGCGCGTGGTCG
AAATCCCCAGGCCCATCTGGTGGCTGATCCTGCACGGCATCATCCTGCGCCTGCGCCCCAAAAAATCCGCCACCAAATAC
GCCAGCATCTGGACACCAGAGGGCTCACCGCTGAAGGTCTGGACGCAAAAGCAGGCCCTGATGCTGCGCGGCTACCTGGG
CGCGCGCGGGCACACTGTCGAGGTGCGTTACGCGATGCGTTACGGCAACCCGTCGATTGCTTCGCAGTTGAACCAGCTCA
AGGCGGACGGTGCCACCCGCATCCTCATCCTGCCGGCCTACCCGCAGTACAGCGGCACCACCACCGCCAGCGTGTTCGAT
GCGGTGTATAGCTGGGCCGCGCGGGTACGCCGGATTCCCGAATTTCGCTTCGTCAACAACTACCACGATGACCCGGGCTA
CATCAGCGCGCTGGCCGAACGGGTTCGCACGCACTGGCGGCACTACGGCCAGGCCGGGCAACTGGTCATGAGCTTTCACG
GCGTGCCCGAGCGCACGCTCAAGCTGGGTGACCCCTACCACTGCGAATGCCACAAGACAGCGCGCCTGCTGGCCGAGAAA
CTGGGGCTGGGAAAGGACCGCTACAAGGTTACCTTCCAGTCGCGCTTTGGCAAGGCCAAATGGCTGGAACCCTACACCGA
ACCCACGCTGATCAGGATGGCGCAGGCCGGCATCGAGCGGGTTGATGTGGTGTGCCCCGGCTTTACCGGCGACTGCCTGG
AAACGCTGGAAGAAATCGCGATGGAAGCGCGCCACGCCTTTTTAAAGGCGGGTGGCAAGGAGTTCCATTACATCGAATGC
CTGAACGACAGCCCCACCTGGATAGCTGCGCTGGCAGAGTTCAGCGCACGACAACTGGCAGGCTGGCCCACACAAGCCCC
CCGGGATACGGAAGCGCTGCGCAAGTCAGGCGAGCGTGCCCTGGCCATGGGCGCACCTCGCTAG

Upstream 100 bases:

>100_bases
CAGGGTATCGTCGAGGTCCAGGGTAATGGCTTTGATAAGGGTCAGGTCAAGCATGGCGCAGTTTAGTGTGAGGGCACACA
AGCCCACACTAGAATAAACC

Downstream 100 bases:

>100_bases
CGTTCGCGCAAATCACGAAGCATTCCCGCGGGATCAGACAATCGCCGGGCTTCTCAGGCTTTCAACTTCAGCAGGTGAAC
CATCACCCGTGACGTCGTCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSFAPEPSFSHGKPPAASCATAILLCNLGTPDAPTAPALRRYLAEFLSDPRVVEIPRPIWWLILHGIILRLRPKKSATKY
ASIWTPEGSPLKVWTQKQALMLRGYLGARGHTVEVRYAMRYGNPSIASQLNQLKADGATRILILPAYPQYSGTTTASVFD
AVYSWAARVRRIPEFRFVNNYHDDPGYISALAERVRTHWRHYGQAGQLVMSFHGVPERTLKLGDPYHCECHKTARLLAEK
LGLGKDRYKVTFQSRFGKAKWLEPYTEPTLIRMAQAGIERVDVVCPGFTGDCLETLEEIAMEARHAFLKAGGKEFHYIEC
LNDSPTWIAALAEFSARQLAGWPTQAPRDTEALRKSGERALAMGAPR

Sequences:

>Translated_367_residues
MSFAPEPSFSHGKPPAASCATAILLCNLGTPDAPTAPALRRYLAEFLSDPRVVEIPRPIWWLILHGIILRLRPKKSATKY
ASIWTPEGSPLKVWTQKQALMLRGYLGARGHTVEVRYAMRYGNPSIASQLNQLKADGATRILILPAYPQYSGTTTASVFD
AVYSWAARVRRIPEFRFVNNYHDDPGYISALAERVRTHWRHYGQAGQLVMSFHGVPERTLKLGDPYHCECHKTARLLAEK
LGLGKDRYKVTFQSRFGKAKWLEPYTEPTLIRMAQAGIERVDVVCPGFTGDCLETLEEIAMEARHAFLKAGGKEFHYIEC
LNDSPTWIAALAEFSARQLAGWPTQAPRDTEALRKSGERALAMGAPR
>Mature_366_residues
SFAPEPSFSHGKPPAASCATAILLCNLGTPDAPTAPALRRYLAEFLSDPRVVEIPRPIWWLILHGIILRLRPKKSATKYA
SIWTPEGSPLKVWTQKQALMLRGYLGARGHTVEVRYAMRYGNPSIASQLNQLKADGATRILILPAYPQYSGTTTASVFDA
VYSWAARVRRIPEFRFVNNYHDDPGYISALAERVRTHWRHYGQAGQLVMSFHGVPERTLKLGDPYHCECHKTARLLAEKL
GLGKDRYKVTFQSRFGKAKWLEPYTEPTLIRMAQAGIERVDVVCPGFTGDCLETLEEIAMEARHAFLKAGGKEFHYIECL
NDSPTWIAALAEFSARQLAGWPTQAPRDTEALRKSGERALAMGAPR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=257, Percent_Identity=28.4046692607004, Blast_Score=105, Evalue=7e-23,
Organism=Homo sapiens, GI60499025, Length=257, Percent_Identity=28.4046692607004, Blast_Score=105, Evalue=7e-23,
Organism=Escherichia coli, GI1786681, Length=316, Percent_Identity=44.9367088607595, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6324750, Length=356, Percent_Identity=24.438202247191, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=24.8538011695906, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24651774, Length=263, Percent_Identity=24.7148288973384, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_POLSJ (Q12BZ9)

Other databases:

- EMBL:   CP000316
- RefSeq:   YP_548841.1
- ProteinModelPortal:   Q12BZ9
- SMR:   Q12BZ9
- STRING:   Q12BZ9
- GeneID:   4015344
- GenomeReviews:   CP000316_GR
- KEGG:   pol:Bpro_2013
- NMPDR:   fig|296591.1.peg.2593
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   IRPAKSA
- PhylomeDB:   Q12BZ9
- ProtClustDB:   CLSK951224
- BioCyc:   PSP296591:BPRO_2013-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 41080; Mature: 40948

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFAPEPSFSHGKPPAASCATAILLCNLGTPDAPTAPALRRYLAEFLSDPRVVEIPRPIW
CCCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHH
WLILHGIILRLRPKKSATKYASIWTPEGSPLKVWTQKQALMLRGYLGARGHTVEVRYAMR
HHHHHHHHHEECCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEEEE
YGNPSIASQLNQLKADGATRILILPAYPQYSGTTTASVFDAVYSWAARVRRIPEFRFVNN
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCC
YHDDPGYISALAERVRTHWRHYGQAGQLVMSFHGVPERTLKLGDPYHCECHKTARLLAEK
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHH
LGLGKDRYKVTFQSRFGKAKWLEPYTEPTLIRMAQAGIERVDVVCPGFTGDCLETLEEIA
HCCCCCCEEEEEHHHCCCCCCCCCCCCHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHH
MEARHAFLKAGGKEFHYIECLNDSPTWIAALAEFSARQLAGWPTQAPRDTEALRKSGERA
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCE
LAMGAPR
EECCCCC
>Mature Secondary Structure 
SFAPEPSFSHGKPPAASCATAILLCNLGTPDAPTAPALRRYLAEFLSDPRVVEIPRPIW
CCCCCCCCCCCCCCHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCCHHH
WLILHGIILRLRPKKSATKYASIWTPEGSPLKVWTQKQALMLRGYLGARGHTVEVRYAMR
HHHHHHHHHEECCCCCCCCEEEEECCCCCCEEEEHHHHHHHHHHHCCCCCCEEEEEEEEE
YGNPSIASQLNQLKADGATRILILPAYPQYSGTTTASVFDAVYSWAARVRRIPEFRFVNN
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCC
YHDDPGYISALAERVRTHWRHYGQAGQLVMSFHGVPERTLKLGDPYHCECHKTARLLAEK
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHCCCCCCCCCHHHHHHHHHHH
LGLGKDRYKVTFQSRFGKAKWLEPYTEPTLIRMAQAGIERVDVVCPGFTGDCLETLEEIA
HCCCCCCEEEEEHHHCCCCCCCCCCCCHHHHHHHHHCHHEEEEECCCCCHHHHHHHHHHH
MEARHAFLKAGGKEFHYIECLNDSPTWIAALAEFSARQLAGWPTQAPRDTEALRKSGERA
HHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCE
LAMGAPR
EECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA