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The map label for this gene is paaH [H]

Identifier: 91787514

GI number: 91787514

Start: 1686401

End: 1687936

Strand: Direct

Name: paaH [H]

Synonym: Bpro_1632

Alternate gene names: 91787514

Gene position: 1686401-1687936 (Clockwise)

Preceding gene: 91787513

Following gene: 91787515

Centisome position: 32.43

GC content: 65.89

Gene sequence:

>1536_bases
ATGACCATGAACTCGACAGTCAACAAGCTCGACGAGGCGCCCCTGCTGGTGGTCGGCGCCGGTGTCATGGGGGTCGGTAT
TGCGCAGGTGGCGGCACAGGCCGGTCATGCGGTGATGCTTTACGACGCCCGCGAAGGCGCGGCTGCCGAAGCGAAAACCA
AGCTGGCCAAGAGCCTTGATGCACTGGTCGCGAAAGGCAAGCTGACGGCACAAGGCGTGTCGCAAACGCTGTCGCGCATT
GAGGCCATCGCCTCGCTGGCAGCGGCTGCCCCAGCGCGGCTGGTGATCGAAGCCATCGTCGAAAAGCTCGACGTCAAACG
CGGACTGTTCCAGCAGCTCGAAGCCATCGTGGCCGCCGATTGCGTGCTCGCCACCAACACCTCGTCGATCTCGGTCACGG
CCATTGCCAATGGCCTGCAACATCCGGCGCGCTTGGTCGGTATGCACTTTTTTAATCCGGTGCCGCAGATGCGGCTGGTC
GAGGTGGTCTCGGGCCTGCAGACCGACCCGGCGGTGGCGGCGCTCATTTTTGACCTGGCCGGCGTCTGGGGCAAGGTGGC
AGTGCATGCGCGCTCGACGCCGGGTTTCATCGTCAACCGCATCGCCCGGCCCTTTTACGCCGAAACGCTGGCACTGCTGC
AGGAGCAGGCTGCCACGCCTGCGGTGCTCGATGCCTGTCTGCGTGCCGTCGGGTTTCGCATGGGCCCCTGCGCCTTGATG
GACCTGATTGGCCACGACACCAATTTTGCGGTGACCAGTTCGGTCTATGAGGCTAATTTCTACGACAAGCGCTTTGCGCC
GTCACTGGTACAGCGTGAGCTCGTCGACGGTGGTTTGCTGGGGCGCAAGTCGGGCCGCGGTTTTTACGACTACACCGCGG
GTGCCGTTCAACCCGGGAACACCGATTTCGCACCGGTGCCTCTACCTGTCGCACCAGTCGCGCAATCCTTGTGCGTGCAG
GGAGTTGGGCCGGTGGCCGAGCGACTGGTTGCGGCACTGGCGCAGGCCGGCCGCGCTTTTGCGCGCGATGAAAGCAGTGA
CTGGGTCGGGCTGGCGATAGTCGCTGACGGTGCCGAACTGCGGCTGACTGACGGCAGGCCGGCTTCGCAGCTGGGCGCTG
AAGTGGCCGTGTTTGACCTGCCGGTGTCCAGCGAGACCGGCATCGCGCTGGCCTGGGCGCCGTCCTCGCGTGCCTCCGCG
GGGTGGTGTGCCGCCGCCGCCACCTGGCTGCAGGCGCTGGGCTTCAGCCCGCAGCGCATCGCCGATGTCCCGGGTCTGGT
GGTGGCGCGCACCCTCGCGATGCTGATCAATGAAGCGGCCGATGCGGTGCTGCACGGGGTGTGCACGCCGGAGGGCGCCG
ACGCCGCCATGAAGCTGGGAGTTAATTACCCAGCCGGGCCCTTTGAGTGGCTGGCGCAATGGGAAACCCGCAACGTCATT
GGCTGTTTAGACGCGCTGGACGCGCATTACCGTGGCGAGCGCTACCGCGTCAGCCCCTGGCTGCGCCAACGGGCCTGGCA
GGAGGGTGTGCAATGA

Upstream 100 bases:

>100_bases
AGTTGACCGCGCAAACGATCAGCCGCGTGCGGGGTACCGACGAGGCCCGCGAAGGCTTTGCGGCCTTTCTGGGAAAGCGG
CCACCGAACTGGATGGCGCA

Downstream 100 bases:

>100_bases
GCCGCAGAATCGACATCGCGCCCCATCTGCATGCGGAGATCGGCGACAACGGCGTGGCTGAACTGGTGTTGGGTCCCGAG
GGTGGCATGCCCACCACCGA

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MTMNSTVNKLDEAPLLVVGAGVMGVGIAQVAAQAGHAVMLYDAREGAAAEAKTKLAKSLDALVAKGKLTAQGVSQTLSRI
EAIASLAAAAPARLVIEAIVEKLDVKRGLFQQLEAIVAADCVLATNTSSISVTAIANGLQHPARLVGMHFFNPVPQMRLV
EVVSGLQTDPAVAALIFDLAGVWGKVAVHARSTPGFIVNRIARPFYAETLALLQEQAATPAVLDACLRAVGFRMGPCALM
DLIGHDTNFAVTSSVYEANFYDKRFAPSLVQRELVDGGLLGRKSGRGFYDYTAGAVQPGNTDFAPVPLPVAPVAQSLCVQ
GVGPVAERLVAALAQAGRAFARDESSDWVGLAIVADGAELRLTDGRPASQLGAEVAVFDLPVSSETGIALAWAPSSRASA
GWCAAAATWLQALGFSPQRIADVPGLVVARTLAMLINEAADAVLHGVCTPEGADAAMKLGVNYPAGPFEWLAQWETRNVI
GCLDALDAHYRGERYRVSPWLRQRAWQEGVQ

Sequences:

>Translated_511_residues
MTMNSTVNKLDEAPLLVVGAGVMGVGIAQVAAQAGHAVMLYDAREGAAAEAKTKLAKSLDALVAKGKLTAQGVSQTLSRI
EAIASLAAAAPARLVIEAIVEKLDVKRGLFQQLEAIVAADCVLATNTSSISVTAIANGLQHPARLVGMHFFNPVPQMRLV
EVVSGLQTDPAVAALIFDLAGVWGKVAVHARSTPGFIVNRIARPFYAETLALLQEQAATPAVLDACLRAVGFRMGPCALM
DLIGHDTNFAVTSSVYEANFYDKRFAPSLVQRELVDGGLLGRKSGRGFYDYTAGAVQPGNTDFAPVPLPVAPVAQSLCVQ
GVGPVAERLVAALAQAGRAFARDESSDWVGLAIVADGAELRLTDGRPASQLGAEVAVFDLPVSSETGIALAWAPSSRASA
GWCAAAATWLQALGFSPQRIADVPGLVVARTLAMLINEAADAVLHGVCTPEGADAAMKLGVNYPAGPFEWLAQWETRNVI
GCLDALDAHYRGERYRVSPWLRQRAWQEGVQ
>Mature_510_residues
TMNSTVNKLDEAPLLVVGAGVMGVGIAQVAAQAGHAVMLYDAREGAAAEAKTKLAKSLDALVAKGKLTAQGVSQTLSRIE
AIASLAAAAPARLVIEAIVEKLDVKRGLFQQLEAIVAADCVLATNTSSISVTAIANGLQHPARLVGMHFFNPVPQMRLVE
VVSGLQTDPAVAALIFDLAGVWGKVAVHARSTPGFIVNRIARPFYAETLALLQEQAATPAVLDACLRAVGFRMGPCALMD
LIGHDTNFAVTSSVYEANFYDKRFAPSLVQRELVDGGLLGRKSGRGFYDYTAGAVQPGNTDFAPVPLPVAPVAQSLCVQG
VGPVAERLVAALAQAGRAFARDESSDWVGLAIVADGAELRLTDGRPASQLGAEVAVFDLPVSSETGIALAWAPSSRASAG
WCAAAATWLQALGFSPQRIADVPGLVVARTLAMLINEAADAVLHGVCTPEGADAAMKLGVNYPAGPFEWLAQWETRNVIG
CLDALDAHYRGERYRVSPWLRQRAWQEGVQ

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=283, Percent_Identity=38.1625441696113, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI296179427, Length=300, Percent_Identity=36, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI20127408, Length=300, Percent_Identity=31.6666666666667, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI261878539, Length=286, Percent_Identity=29.3706293706294, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI68989263, Length=286, Percent_Identity=29.3706293706294, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=27.2340425531915, Blast_Score=83, Evalue=5e-16,
Organism=Escherichia coli, GI1787661, Length=503, Percent_Identity=42.3459244532803, Blast_Score=348, Evalue=4e-97,
Organism=Escherichia coli, GI1790281, Length=322, Percent_Identity=29.1925465838509, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1788682, Length=261, Percent_Identity=32.5670498084291, Blast_Score=128, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=37.5, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17549919, Length=283, Percent_Identity=38.5159010600707, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17553560, Length=282, Percent_Identity=38.6524822695035, Blast_Score=177, Evalue=9e-45,
Organism=Caenorhabditis elegans, GI17508951, Length=284, Percent_Identity=32.3943661971831, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17508953, Length=284, Percent_Identity=32.3943661971831, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI25144276, Length=284, Percent_Identity=32.3943661971831, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71985923, Length=284, Percent_Identity=27.4647887323944, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=305, Percent_Identity=25.9016393442623, Blast_Score=134, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17558304, Length=285, Percent_Identity=29.8245614035088, Blast_Score=129, Evalue=5e-30,
Organism=Drosophila melanogaster, GI19921000, Length=292, Percent_Identity=35.2739726027397, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24583077, Length=292, Percent_Identity=35.2739726027397, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24583079, Length=292, Percent_Identity=35.2739726027397, Blast_Score=165, Evalue=7e-41,
Organism=Drosophila melanogaster, GI45549573, Length=203, Percent_Identity=31.0344827586207, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129993, Length=196, Percent_Identity=29.5918367346939, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR011967
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 53650; Mature: 53519

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMNSTVNKLDEAPLLVVGAGVMGVGIAQVAAQAGHAVMLYDAREGAAAEAKTKLAKSLD
CCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
ALVAKGKLTAQGVSQTLSRIEAIASLAAAAPARLVIEAIVEKLDVKRGLFQQLEAIVAAD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVLATNTSSISVTAIANGLQHPARLVGMHFFNPVPQMRLVEVVSGLQTDPAVAALIFDLA
HHEEECCCCEEEHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
GVWGKVAVHARSTPGFIVNRIARPFYAETLALLQEQAATPAVLDACLRAVGFRMGPCALM
HHHHHEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
DLIGHDTNFAVTSSVYEANFYDKRFAPSLVQRELVDGGLLGRKSGRGFYDYTAGAVQPGN
HHHCCCCCCEEEHHHHHCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
TDFAPVPLPVAPVAQSLCVQGVGPVAERLVAALAQAGRAFARDESSDWVGLAIVADGAEL
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHCCCCCCEEEEEEEECCCEE
RLTDGRPASQLGAEVAVFDLPVSSETGIALAWAPSSRASAGWCAAAATWLQALGFSPQRI
EEECCCCHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
ADVPGLVVARTLAMLINEAADAVLHGVCTPEGADAAMKLGVNYPAGPFEWLAQWETRNVI
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCHHHHHHHHHCCHHH
GCLDALDAHYRGERYRVSPWLRQRAWQEGVQ
HHHHHHHHHHCCCCEEECHHHHHHHHHHCCC
>Mature Secondary Structure 
TMNSTVNKLDEAPLLVVGAGVMGVGIAQVAAQAGHAVMLYDAREGAAAEAKTKLAKSLD
CCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
ALVAKGKLTAQGVSQTLSRIEAIASLAAAAPARLVIEAIVEKLDVKRGLFQQLEAIVAAD
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CVLATNTSSISVTAIANGLQHPARLVGMHFFNPVPQMRLVEVVSGLQTDPAVAALIFDLA
HHEEECCCCEEEHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHH
GVWGKVAVHARSTPGFIVNRIARPFYAETLALLQEQAATPAVLDACLRAVGFRMGPCALM
HHHHHEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHH
DLIGHDTNFAVTSSVYEANFYDKRFAPSLVQRELVDGGLLGRKSGRGFYDYTAGAVQPGN
HHHCCCCCCEEEHHHHHCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCCCC
TDFAPVPLPVAPVAQSLCVQGVGPVAERLVAALAQAGRAFARDESSDWVGLAIVADGAEL
CCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCHHHHCCCCCCEEEEEEEECCCEE
RLTDGRPASQLGAEVAVFDLPVSSETGIALAWAPSSRASAGWCAAAATWLQALGFSPQRI
EEECCCCHHHHCCEEEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCHHHH
ADVPGLVVARTLAMLINEAADAVLHGVCTPEGADAAMKLGVNYPAGPFEWLAQWETRNVI
HCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCCCCCHHHHHHHHHCCHHH
GCLDALDAHYRGERYRVSPWLRQRAWQEGVQ
HHHHHHHHHHCCCCEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9748275; 9097039; 9278503; 10766858 [H]