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The map label for this gene is hemL [H]

Identifier: 91787361

GI number: 91787361

Start: 1517802

End: 1519142

Strand: Reverse

Name: hemL [H]

Synonym: Bpro_1467

Alternate gene names: 91787361

Gene position: 1519142-1517802 (Counterclockwise)

Preceding gene: 91787362

Following gene: 91787360

Centisome position: 29.21

GC content: 68.61

Gene sequence:

>1341_bases
ATGAACAAGCCGTCCACGTCTTCCATGCATTCCGCCACCGGAACCGCGCTTGATTCGGCGCTGGCCGAAACCACCGCACG
CTACCGCGCCCGCAACCCCGGCAGCGAACGGCTGCTGCGTAAGGCGGCCGACGTACTGCCCGCCGGCAATACCCGCAGCG
TGCTGTTTTACACGCCGTTTCCGCTCTACATGGCGCGGGGCGAAGGCTGCCATCTGTGGGACGCCGACGGCCACCGCTAC
CTGGACGCGCTGGGCGAGTTCACGGCAGGCATTTACGGCCACTCGAATCCGGTGATCCGGCAAGCCATCGTGGCCGCGTT
GCAGGACGGCCTGAGCCTGTCTTCACACACCGCGCGCGAGGCCGCGCTGGCGCATGAAATCCAGCGCCGCTTTCCCGGCA
TGGCGCTGCTGCGCTTCACCAACTCGGGCACCGAAGCCAACCTGATGGCGCTGGCGGCCGCCACCGCCCACACCGGCCGG
CGCAAGGTGCTGGTGTTCAATGGCGCCTACCACGGCGGCGTGCTGTCGTTTGGCGGTGGCGGCTCGCCGGTGAACGTGCC
GCACGACTTCGTGGTCGCGCCCTACAACGACCTGGACGCCGTGCGCGGGCTGGTCCAGACGCATGGCCCGCAGCTGGCGG
CCATCCTGGTCGAGCCCATGCTGGGCGCGGGTGGCTGCATTCCCGCAGAGCCCGCCTTTTTGCACGGCCTGCGCGCGCTG
GCCGATGCATGCGGCGCCTTGCTGATCCTCGACGAAGTCATGACCTCGCGTCTGTCCGGCGGTGGGCGGCAGGCCTTGCT
GGGTTTGAAGCCCGACCTCACCACGCTGGGCAAATATTTCGGCGGTGGACTTTCGTTTGGCGCGTTCGGTGGCCGGGTGG
ACGTGATGTCGCGTTTTGACCCGCGCCGCGCCGACGCGCTGGGCCATGCCGGCACCTTCAACAACAACACGCTGACCATG
GCCGCCGGCCTGGCGGGCCTCACGCAGGTGCTGACGCCGGCCGCGCTCGATGCGCTGAACCAGCGCGGCGAGCGCCTGCG
CGAGCGGCTCAATGGCGTGTTCAAACGCCACGCGGTGGGCCTGCAGTTCACCGGTCTGGGCTCGGTCATGCAACTGCATG
CCACCGACCGCCCCCTGCGCAACGCGGCCGACCTGGCCGGTGCCGACGACCGCGTCAAGGCGCTGCTGTTTTTTGATCTG
CTGGAGCGCGGCATTTTTCTGGCGCGGCGCGGGCTGGTGGCCTTGTCGCTGCCCTTCGGCGATGCCGAGGCTGATGAGTT
CGTTGCGGCGCTGGACGCCGTGGTTACGGCACGCCATGCGCTGTTGCCCGTTGCAGGTTGA

Upstream 100 bases:

>100_bases
GCCGGCAGAGCTGGCCCGGCACGGCGTCGAAGCGGCCGCGCTGTCACCGGCCCGCCTGCGTTGATAACGCCAGGTTGATT
GACACCGGGACATCACGACC

Downstream 100 bases:

>100_bases
ATCGTTTTCTTTTCTTTTCTTTTTACGAGAGGTCATCATGTCAAGCACGTTCAGAGCTCCAGGTACTTCAGGCACTTTCT
TCAACCCACTGCGCCGCGCA

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MNKPSTSSMHSATGTALDSALAETTARYRARNPGSERLLRKAADVLPAGNTRSVLFYTPFPLYMARGEGCHLWDADGHRY
LDALGEFTAGIYGHSNPVIRQAIVAALQDGLSLSSHTAREAALAHEIQRRFPGMALLRFTNSGTEANLMALAAATAHTGR
RKVLVFNGAYHGGVLSFGGGGSPVNVPHDFVVAPYNDLDAVRGLVQTHGPQLAAILVEPMLGAGGCIPAEPAFLHGLRAL
ADACGALLILDEVMTSRLSGGGRQALLGLKPDLTTLGKYFGGGLSFGAFGGRVDVMSRFDPRRADALGHAGTFNNNTLTM
AAGLAGLTQVLTPAALDALNQRGERLRERLNGVFKRHAVGLQFTGLGSVMQLHATDRPLRNAADLAGADDRVKALLFFDL
LERGIFLARRGLVALSLPFGDAEADEFVAALDAVVTARHALLPVAG

Sequences:

>Translated_446_residues
MNKPSTSSMHSATGTALDSALAETTARYRARNPGSERLLRKAADVLPAGNTRSVLFYTPFPLYMARGEGCHLWDADGHRY
LDALGEFTAGIYGHSNPVIRQAIVAALQDGLSLSSHTAREAALAHEIQRRFPGMALLRFTNSGTEANLMALAAATAHTGR
RKVLVFNGAYHGGVLSFGGGGSPVNVPHDFVVAPYNDLDAVRGLVQTHGPQLAAILVEPMLGAGGCIPAEPAFLHGLRAL
ADACGALLILDEVMTSRLSGGGRQALLGLKPDLTTLGKYFGGGLSFGAFGGRVDVMSRFDPRRADALGHAGTFNNNTLTM
AAGLAGLTQVLTPAALDALNQRGERLRERLNGVFKRHAVGLQFTGLGSVMQLHATDRPLRNAADLAGADDRVKALLFFDL
LERGIFLARRGLVALSLPFGDAEADEFVAALDAVVTARHALLPVAG
>Mature_446_residues
MNKPSTSSMHSATGTALDSALAETTARYRARNPGSERLLRKAADVLPAGNTRSVLFYTPFPLYMARGEGCHLWDADGHRY
LDALGEFTAGIYGHSNPVIRQAIVAALQDGLSLSSHTAREAALAHEIQRRFPGMALLRFTNSGTEANLMALAAATAHTGR
RKVLVFNGAYHGGVLSFGGGGSPVNVPHDFVVAPYNDLDAVRGLVQTHGPQLAAILVEPMLGAGGCIPAEPAFLHGLRAL
ADACGALLILDEVMTSRLSGGGRQALLGLKPDLTTLGKYFGGGLSFGAFGGRVDVMSRFDPRRADALGHAGTFNNNTLTM
AAGLAGLTQVLTPAALDALNQRGERLRERLNGVFKRHAVGLQFTGLGSVMQLHATDRPLRNAADLAGADDRVKALLFFDL
LERGIFLARRGLVALSLPFGDAEADEFVAALDAVVTARHALLPVAG

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=318, Percent_Identity=29.2452830188679, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1786349, Length=394, Percent_Identity=36.8020304568528, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1788044, Length=330, Percent_Identity=32.7272727272727, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789759, Length=330, Percent_Identity=29.3939393939394, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1789016, Length=416, Percent_Identity=28.8461538461538, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI145693181, Length=304, Percent_Identity=32.5657894736842, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1787560, Length=350, Percent_Identity=29.1428571428571, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1786991, Length=299, Percent_Identity=27.0903010033445, Blast_Score=82, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI25144271, Length=297, Percent_Identity=27.9461279461279, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=360, Percent_Identity=26.1111111111111, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323470, Length=335, Percent_Identity=28.6567164179104, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=335, Percent_Identity=25.0746268656716, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357415, Length=322, Percent_Identity=25.4658385093168, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356575, Length=438, Percent_Identity=25.1141552511416, Blast_Score=73, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46986; Mature: 46986

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPSTSSMHSATGTALDSALAETTARYRARNPGSERLLRKAADVLPAGNTRSVLFYTPF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
PLYMARGEGCHLWDADGHRYLDALGEFTAGIYGHSNPVIRQAIVAALQDGLSLSSHTARE
HHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
AALAHEIQRRFPGMALLRFTNSGTEANLMALAAATAHTGRRKVLVFNGAYHGGVLSFGGG
HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCC
GSPVNVPHDFVVAPYNDLDAVRGLVQTHGPQLAAILVEPMLGAGGCIPAEPAFLHGLRAL
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADACGALLILDEVMTSRLSGGGRQALLGLKPDLTTLGKYFGGGLSFGAFGGRVDVMSRFD
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCEEHHHHHCC
PRRADALGHAGTFNNNTLTMAAGLAGLTQVLTPAALDALNQRGERLRERLNGVFKRHAVG
CHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LQFTGLGSVMQLHATDRPLRNAADLAGADDRVKALLFFDLLERGIFLARRGLVALSLPFG
EEEECCCHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
DAEADEFVAALDAVVTARHALLPVAG
CCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNKPSTSSMHSATGTALDSALAETTARYRARNPGSERLLRKAADVLPAGNTRSVLFYTPF
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEECCC
PLYMARGEGCHLWDADGHRYLDALGEFTAGIYGHSNPVIRQAIVAALQDGLSLSSHTARE
HHEEECCCCCEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
AALAHEIQRRFPGMALLRFTNSGTEANLMALAAATAHTGRRKVLVFNGAYHGGVLSFGGG
HHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCC
GSPVNVPHDFVVAPYNDLDAVRGLVQTHGPQLAAILVEPMLGAGGCIPAEPAFLHGLRAL
CCCCCCCCCEEEECCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
ADACGALLILDEVMTSRLSGGGRQALLGLKPDLTTLGKYFGGGLSFGAFGGRVDVMSRFD
HHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCEEHHHHHCC
PRRADALGHAGTFNNNTLTMAAGLAGLTQVLTPAALDALNQRGERLRERLNGVFKRHAVG
CHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LQFTGLGSVMQLHATDRPLRNAADLAGADDRVKALLFFDLLERGIFLARRGLVALSLPFG
EEEECCCHHHEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCC
DAEADEFVAALDAVVTARHALLPVAG
CCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA